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Drug Discovery & Development  
 
Key Roadblock to Gene Expression Mapped
Penn State Gene Expression RoadblockA detailed map of how the building blocks of chromosomes are organized in the fruit fly Drosophila melanogaster identifies a critical stop sign for transcription. ...continue

Game On! Fold Proteins Online
Researchers around the work can now "compete" in an online game to design proteins. ...continue

Technique Determines Number of Fat Cells Remains Constant in All Body Types
The radioactive carbon-14 produced by above-ground nuclear testing in the 1950s and ’60s has helped researchers determine that the number of fat cells in a human’s body, whether lean or obese, is established during the teenage years. ...continue

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Nikon BioStationCT Cell Culture Observation
The BioStation CT allows imaging experiments to be conducted without removing the cells from the incubator. Get a "bird's eye" color macro view from above. ... continue
 

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White Papers
Improving Productivity in the Determination of Parameters for Early in vitro ADME
The authors demonstrate high throughput quantification of drug compounds, which increases productivity in determining parameters for early in vitro ADME studies. ...continue

Microarray Gene Expression Data Quality Assessment
Review quality assessment techniques, parameters, and practical applications in gene expression microarray data. ...continue

Measuring Electrical Performance in Nanodevices and Detecting Single Electron Transfer at Room Temperature
Exotic carbon nanotube(CNT) structures have generated a great deal of interest in the scientific community. There are many potential applications for CNTs, but much of the current focus in nanotechnology research ...continue

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Super Drugs for Super Bugs
DDD May, 2008 CoverPhysicians fighting the antimicrobial resistance epidemic look to researchers and drug developers to join the fight. But, will the microbial invaders win the game outright? Increased research efforts toward understanding mechanisms of resistance, as well as identifying new antimicrobial targets, is greatly needed to ensure they don't. ...continue

    Drug Discovery

    Drug Development

    Genomics & Proteomics

    Policy & Projections

    Technology Advances

Proteins that Stop Signaling Pathway Can Generate New Proteins
Duke University Medical Center researchers were able to define the way in which proteins called beta arrestins also turn on pathways that ultimately lead to the production of new proteins in virtually all tissues in the body. ...continue

Protein Detection System
Millipore SNAP idMillipore Corporation introduces the SNAP i.d. protein detection system that produces higher quality Western blots 80% more quickly than with conventional immunodetection protocols. ...continue

A Spectrum of Possibilities
Custom-built MS systemMass spectroscopy and nuclear magnetic resonance go head-to-head in a battle for dominance in the world of proteomics. ...continue

RNA Research Reagents
Applied Biosystems has developed a line of reagents for streamlining the process of quantitative reverse transcription PCR in RNA-based research applications. ...continue

Protein Biomarker Screening
SomaPlex slides from Protein BioTechnologies, for screening protein biomarkers in human tumors, are arrays prepared from a vast collection of total protein lysates derived from numerous human tissues representing a range of cancer subtypes. ...continue

Tyrosine Kinases
Millipore launched its Tyrosine Kinases with BioForm Technology developed by P.A. Technologies. BioForm Technology enables the unique assembly of histidine-tagged proteins in an environment that mimics that created by a cell membrane. ...continue

Chromatin Immunoprecipitation
Promega’s HaloCHIP SystemPromega’s HaloCHIP System works without the use of antibodies and delivers results in less time than standard ChIP methods. ...continue

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High-Throughput Screening for Kinase Inhibitors
Who Likes Kinases?Free Webcast 
How are leading Pharma researchers using HTS to identify kinase inhibitors? Join an in-depth discussion with leading Pharma researchers who are targeting kinases for the development of new drugs.
...continue

Battling Bad Bugs
Microbes vs.AntibioticsThe latest weapons for the war on microbes are coming from new players in the biotech arena. What are the incentives and challenges to developing new antibiotics? ...continue

It's Tox Season
ADME-Tox gets a new face as more efficient systems are brought on board and collaborations with regulators ensue. ...continue

Welcome to the Club
Beckman Coulter PA-800Researchers tip their caps to capillary electrophoresis—a pretty powerful method of separating analytes that has found its place in the hearts of old school chromatographiles. ...continue

Biologicals Advance
Policy & Projections May, 2008Prospects in Congress have improved this year for passage of landmark legislation that would allow the US Food and Drug Administration (FDA) to approve marketing of follow-on biologics or biosimilar drugs once patents had expired on pioneer biopharmaceuticals. ...continue

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