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Warehouse Holding Ebola Supplies in Guinea Catches Fire

December 18, 2014 11:28 am | by Boubacar Diallo - Associated Press | News | Comments

A Guinean official says a fire at a warehouse at the Conakry airport has destroyed crucial medicine to help fight Ebola. Dr. Moussa Konate, head of logistics for Guinea's Ebola response, said that the fire on Thursday morning engulfed a building holding medicine, like anti-malarials and antibiotics. Read more...

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DDD Update

Daily news and top headlines for drug research professionals

New Report: Hep C's Decades of Drug Research Failures, Successes

December 18, 2014 5:18 pm | by PhRMA | News | Comments

PhRMA released a new report, "Twenty-Five Years of Progress Against Hepatitis C: Setbacks and Stepping Stones," that examines the scientific challenges and setbacks researchers have faced on the path to developing new medicines with the potential to transform treatment for hepatitis C patients and how these so-called "failures" are an integral part of the drug discovery process. Read more...

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New Disease Mechanism Discovered in Lymphoma

December 18, 2014 11:34 am | by Technical University - Munich | News | Comments

Programmed cell death is a mechanism that causes defective and potentially harmful cells to destroy themselves. It serves a number of purposes in the body, including the prevention of malignant tumor growth. Read more...                          

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Hypertension Medication that Targets Stress May Help Smokers Quit

December 18, 2014 11:23 am | by Daniel Jones, Yale University | News | Comments

Smokers trying to quit often light up a cigarette to deal with stress. Now an interdisciplinary team of Yale researchers has shown that guanfacine, a medication approved for treating hypertension that reduces stress and enhances cognition, shows promise as a smoking cessation aid. Read more...

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Microcapsule Eliminates Toxic Punch of Experimental Anti-Cancer Drug

December 18, 2014 11:15 am | by Johns Hopkins | News | Comments

Johns Hopkins researchers have developed a sugar-based molecular microcapsule that eliminates the toxicity of an anticancer agent developed a decade ago at Johns Hopkins, called 3-bromopyruvate, or 3BrPA, in studies of mice with implants of human pancreatic cancer tissue. Read more..

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Inovio Initiates DNA Immunotherapy Trial for Cancers

December 18, 2014 10:48 am | News | Comments

Inovio Pharmaceuticals, Inc. announced it has initiated a phase 1 trial of its hTERT DNA immunotherapy (INO-1400) alone or in combination with Inovio's 1L-12 immune activator (INO-9012) in adults with breast, lung, or pancreatic cancer at high risk of relapse after surgery and other cancer treatments. Read more...

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GSK Shingles Vaccine Hits Goal in Major Study

December 18, 2014 9:02 am | News | Comments

GSK announced that a pivotal phase 3 study to assess the efficacy of HZ/su, an investigational vaccine for the prevention of shingles, has met its primary endpoint. Read more...                                 

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Fresh Setback For Efforts to Cure HIV Infection

December 18, 2014 8:12 am | by Marilynn Marchione - AP Chief Medical Writer | News | Comments

Researchers are reporting another disappointment for efforts to cure infection with the AIDS virus. Read more...                         

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Chikungunya Virus Shuts Down Infected Cells

December 17, 2014 4:59 pm | by Wageningen University | News | Comments

Researchers from Wageningen University, part of Wageningen UR, in collaboration with colleagues from Leiden University and a research team in Australia, have revealed how chikungunya virus blocks essential processes in infected cells that normally would keep the virus under control. Read more...

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Despite Risks, Benzodiazepine Use Highest in Older People

December 17, 2014 4:50 pm | by NIH | News | Comments

Prescription use of benzodiazepines — a widely used class of sedative and anti-anxiety medications — increases steadily with age, despite the known risks for older people, according to a comprehensive analysis of benzodiazepine prescribing in the United States. Read more...

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Stem Cell Prompting Deadly Fibrosis Found

December 17, 2014 4:35 pm | by Cynthia Fox, Science Writer | Articles | Comments

Some 45% of deaths are caused by fibrosis (scar tissue) diseases, including idiopathic pulmonary fibrosis, cirrhosis, and heart and kidney failure. But a Harvard University group reports in Cell Stem Cell they have discovered a key cause of that fibrosis: a stem-cell-like perivascular cell called Gli1+, found in blood vessels. Read more...

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Study: Removing Clot Helps Limit Stroke Disability

December 17, 2014 2:25 pm | by Marilynn Marchione - AP Chief Medical Writer | News | Comments

A new treatment has been shown to limit the damage from a common type of stroke. Read more...                           

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Rio Organizers Create 'Super Bacteria' Task Force

December 17, 2014 2:12 pm | by Jenny Barchfield - Associated Press | News | Comments

Brazilian organizers of the 2016 Olympics are creating a task force to deal with a so-called "super bacteria" discovered in Olympic sailing waters. Read more...                 

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Napster Co-Founder Makes Investment in Allergy Research

December 17, 2014 2:03 pm | by Olga R. Rodriguez - Associated Press | News | Comments

The former Facebook president said he wants to help find a lasting cure to allergies. Read more...                           

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Emerging Markets Gain New Prominence as Innovation, Development Hotspots

December 17, 2014 12:52 pm | by Roger Humphrey, Executive Managing Director, Life Sciences Americas, JLL | Articles | Comments

Patent origin location has become the latest way patent applications can inform business strategy, and recent analysis shows where innovation hubs are on the rise. The United States and Europe have enjoyed long deep-seated roots as the leaders of high-value aspects of the biopharmaceutical development cycle, such as new product research and development (R&D). Read more...

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New Insight Into How Motor Neurons in Brain Die During ALS

December 17, 2014 12:33 pm | News | Comments

Researchers look to understand the causes of amyotrophic lateral sclerosis (ALS), in the hope of finding new ways to treat the disease. A new study published online in the Cell Press journal Neuron shows that a common gene mutation in ALS generates a deadly protein that may cause the damage in the brain that leads to ALS. Read more...

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