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Ebola Drug Trials to be Fast-Tracked in West Africa

September 23, 2014 10:48 am | News | Comments

Potential new treatments for Ebola are to be tested in West Africa for the first time as part of an international initiative to fast-track trials of the most promising drugs against the disease that has already led to over 2,600 deaths. Read more...

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DDD Update

Daily news and top headlines for drug research professionals

TKIs May Improve Treatment for Ph-Like ALL

September 23, 2014 11:28 am | News | Comments

Tyrosine kinase inhibitors (TKIs) may improve treatment outcome for children and young adults with Ph-like acute lymphoblastic leukemia (Ph-like ALL), a disease with dismal prognosis, according to new data. Read more...         

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New Approach Aims to Silence Cancer 'Survival Genes'

September 23, 2014 11:20 am | News | Comments

Scientists are working on a promising new approach for tackling colorectal cancer, the second most common cause of cancer-related death. Read more...                             

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Pterostilbene Prevents Skin Damage from UV Exposure in Mouse Study

September 22, 2014 4:04 pm | News | Comments

ChromaDex Corp. announced the completion of an animal skincare study of pterostilbene by researchers at The University of California Irvine (UCI). Read more...                          

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Metformin Linked to Risk of Low Levels of Thyroid Hormone

September 22, 2014 4:03 pm | News | Comments

Metformin, a commonly used drug for treating type 2 diabetes, is linked to an increased risk of low thyroid-stimulating hormone (TSH) levels in patients with underactive thyroids (hypothyroidism), according to a new study. Read more...      

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New Chip Promising for Tumor-Targeting Research

September 22, 2014 3:59 pm | News | Comments

Researchers have developed a chip capable of simulating a tumor's "microenvironment" and plan to use the new system to test the effectiveness of nanoparticles and drugs that target cancer. Read more...              

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Battling Superbugs

September 22, 2014 3:57 pm | News | Comments

Engineers have turned a powerful new weapon on superbugs. Using a gene-editing system that can disable any target gene, they have shown that they can selectively kill bacteria carrying harmful genes that confer antibiotic resistance or cause disease. Read more...

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Amgen Submits BLA for Investigational Cancer Immunotherapy

September 22, 2014 3:54 pm | News | Comments

Amgen announced submission of a Biologics License Application (BLA) to the FDA seeking approval for its investigational bispecific T cell engager (BiTE) antibody construct, blinatumomab. Read more...                

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Tekmira’s Ebola Drug Gets Regulatory Framework

September 22, 2014 2:56 pm | News | Comments

Tekmira Pharmaceuticals Corp. announced that the FDA has authorized Tekmira to provide TKM-Ebola for treatment under expanded access protocols to subjects with confirmed or suspected Ebola virus infections. Read more...          

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Researchers Describe New Cancer Drug Target Involving Lipid Chemical Messengers

September 22, 2014 10:11 am | News | Comments

More than half of human cancers have abnormally upregulated chemical signals related to lipid metabolism, yet how these signals are controlled during tumor formation is not fully understood. Researchers are reporting that TIPE3, a newly described oncogenic protein, promotes cancer by targeting these pathways. Read more...

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Japan Approves Bayer's Eylea for Myopic Choroidal Neovascularization

September 22, 2014 9:58 am | News | Comments

Bayer HealthCare has received approval from the Ministry of Health, Labor and Welfare (MHLW) in Japan for Eylea (aflibercept solution for injection) for the treatment of myopic choroidal neovascularization (myopic CNV). Read more...     

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'Evolved' Protein Created to Stop Cancer from Spreading

September 22, 2014 9:25 am | News | Comments

A team of researchers has developed a protein therapy that disrupts the process that causes cancer cells to break away from original tumor sites, travel through the bloodstream and start aggressive new growths elsewhere in the body. Read more... 

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Spain: Ebola Test Drug Out of Supply Worldwide

September 22, 2014 9:19 am | News | Comments

Doctors treating a Spanish priest who was repatriated from West Africa on Monday after being diagnosed with the Ebola virus said there were no samples of experimental drug ZMapp available in the world right now. Read more...        

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Auxilium Rejects Endo's Takeover Offer

September 22, 2014 8:40 am | News | Comments

Auxilium Pharmaceuticals Inc.'s board has rejected an approximately $1.4 billion unsolicited takeover offer from Ireland's Endo International PLC. Read more...                          

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Germany's Merck to Buy Sigma Aldrich for $17B

September 22, 2014 7:40 am | by David McHugh, AP Business Writer | News | Comments

German drug company Merck says it has agreed to buy St. Louis-based chemical firm Sigma-Aldrich Corp. for $17 billion. Darmstadt-based Merck KGaA said Monday it is paying $140 per share in cash for all of Sigma-Aldrich's share. Read more...

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Soligenix Gets $24.7M for Development of Heat-Stable RiVax Vaccine

September 19, 2014 10:28 am | News | Comments

Soligenix Inc. announced that it has been awarded a contract valued at up to $24.7 million to advance the development of Soligenix’s thermostabilization technology, ThermoVax, combined with the company’s ricin toxin vaccine, RiVax. Read more...  

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