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DDD Update

Daily news and top headlines for drug research professionals

Genetically Modified Herpes Virus to Treat Skin Cancer

May 27, 2015 1:13 pm | by Stephanie Guzowski, Editor | News | Comments

An experimental treatment using a genetically modified strain of the herpes simplex 1 virus has been shown to be effective in killing skin cancer cells and halting tumor growth, according to new research. The oncolytic virus immunotherapy, called T-VEC, was used to treat patients with melanoma in a Phase 3 clinical trial. Read more...

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Sanofi, Regeneron Annouce Positive Phase 3 Data for Arthritis Drug

May 27, 2015 9:26 am | News | Comments

No unexpected safety findings were observed. Read more...

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Research Challenges Assumption that Arthritis Patients Take Medication Regularly

May 27, 2015 9:20 am | by University of Manchester | News | Comments

New UK research has challenged the assumption that people with rheumatoid arthritis always take their medication as prescribed. Read more...

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Genomic Data Reveals Emergence of Drug Resistant Typhoid Strain in Africa

May 27, 2015 9:08 am | by University of Liverpool | News | Comments

Scientists have revealed the emergence of a novel strain of Typhoid fever in Malawi, Africa. Read more...

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AbbVie Presents Phase 3 Data in Japan from Hepatitis C Treatment Study

May 27, 2015 9:01 am | News | Comments

Across all study arms, three patients discontinued treatment due to adverse events. Read more...

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Man Diagnosed with Lassa Fever Dies in U.S. After Liberia Trip

May 27, 2015 8:48 am | by Mike Stobbe, AP Medical Writer | News | Comments

Generally speaking, Lassa fever is far less likely to be fatal than Ebola and less likely to be spread from person to person. Read more...

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WHO to Fight Resistance to Antibiotic Resistance

May 27, 2015 8:43 am | by Seth Augenstein, Digital Reporter | News | Comments

The World Health Organization will now coordinate an international effort to stop the growth of resistant germs worldwide. Read more...

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Amgen Terminates Co-Development of Brodalumab with AstraZeneca

May 26, 2015 1:16 pm | by Stephanie Guzowski, Editor | News | Comments

Amgen ended its co-development of brodalumab with AstraZeneca after some patients who took the experimental psoriasis drug experienced suicidal thoughts or behavior, which Amgen believes would likely require restrictive labeling. Read more...

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Team Finds Two New and Very Large Classes of RNAs Linked to Cancer Biomarker

May 26, 2015 11:37 am | by University of Pittsburgh Schools of the Health Sciences | News | Comments

Researchers at the University of Pittsburgh School of Medicine have identified two new classes of RNAs that are closely associated with a protein known to be a prognostic biomarker for breast cancer and could play a role in progression of prostate cancer. Their findings were published in the June issue of the scientific journal RNA. Read more....

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Study Suggests New Way of Preventing Diabetes-Associated Blindness

May 26, 2015 11:05 am | by Johns Hopkins | News | Comments

Reporting on their study with lab-grown human cells, researchers at The Johns Hopkins University and the University of Maryland say that blocking a second blood vessel growth protein, along with one that is already well-known, could offer a new way to treat and prevent a blinding eye disease caused by diabetes. Read more...

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Master Gene Regulator Could be New Target for Schizophrenia Treatment

May 26, 2015 10:51 am | by MIT News | News | Comments

Researchers at MIT’s Picower Institute for Learning and Memory have identified a master genetic regulator that could account for faulty brain functions that contribute to schizophrenia. Read more...

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Peeking into Healthy Brains to See If Alzheimer's is Brewing

May 26, 2015 10:34 am | by Lauren Neergaard, AP Medical writer - Associated Press | News | Comments

Now researchers are adding tau brain scans to an ambitious study that's testing if an experimental drug might help healthy but at-risk people stave off Alzheimer's. Whether that medication works or not, it's the first drug study where scientists can track how both of Alzheimer's signature markers begin building up in older adults before memory ever slips. Read more...

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Statins May Have Slowed Advanced Prostate Cancer Growth by 10 Months

May 26, 2015 10:08 am | by Cynthia Fox, Science Editor | Articles | Comments

When starting androgen deprivation therapy, advanced prostate cancer patients who were taking statins—popular cholesterol-lowering heart drugs—experienced 10 more months of cancer control, according to data published in JAMA Oncology. Read more..

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Stem Cell Therapy for Inherited Skin Blistering

May 26, 2015 8:21 am | by King's College London | News | Comments

The therapy, involving infusions of stem cells, was found to provide pain relief and to reduce the severity of this skin condition for which no cure currently exists. Read more...

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Cellular Biomedicine Reports Positive Phase 1 Study Results for T-Cell Therapy

May 26, 2015 8:11 am | News | Comments

The results of this trial to date demonstrated that five out of seven patients responded to the treatment. CD30-directed CAR-T cell therapy was demonstrated in this trial to be safe, feasible and efficient. Read more...

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