Strategies & Technologies Driving Drug Discovery to Market
Dermal Delivery of Large-molecule Drugs
April 11, 2013 4:31 pm | by Bob Bruno, Principal; R.P. Bruno and Associates | Articles | CommentsScientists recently demonstrated that biphasic vesicles can deliver large-molecule or macromolecule drugs into the skin. Success with biphasic vesicles offers the potential for needle-free administration of many pharmaceuticals that could previously only be administered by injection.
Lilly Cutting Sales Staff
April 11, 2013 4:05 pm | News | CommentsEli Lilly plans to cut hundreds of workers from its U.S. sales force as the drugmaker prepares to deal with the loss of patent protection for two more top-selling drugs. Lilly spokesman Scott MacGregor declined to disclose the specific number of cuts, but did say it totals less than 1,000 full-time employees.
Assessing Cardiac Toxicity Using Stem Cell-derived Cardiomyocytes
April 11, 2013 4:02 pm | by Oksana Sirenko, Research Scientist; Carole Crittenden, Application Scientist; Evan F. Cromwell, Director of Assay Development; Molecular Devices LLC, Sunnyvale, Calif. | Articles | CommentsPredicting the side effects of drugs remains one of the industry’s greatest challenges, with a large percentage of new drugs failing in clinical studies due to cardiac toxicity. The overall success rate from Phase 1 studies is only 11%, with 30% of these failing for safety reasons.
Polyscience Releases Low-cost Coolers
April 11, 2013 12:34 pm | Product Releases | CommentsAvailable in both immersion probe and flow through styles, these compact systems are ideal for cooling exothermic reactions, freeze point determinations, freeze drying, impact testing, lyophilization, and vapor and solvent trapping.
Biosearch Adds RNA FISH-based Technologies
April 11, 2013 12:31 pm | Product Releases | CommentsBiosearch Technologies Inc. has announced the acquisition of exclusive worldwide rights to continuing Stellaris RNA FISH-based inventions from the University of Medicine and Dentistry of New Jersey.
Live-cell Imaging Camera Has High Acquisition Rate
April 11, 2013 12:23 pm | Product Releases | CommentsSPOT Imaging Solutions has released the ultra-sensitive SPOT Pursuit USB digital camera. The SPOT Pursuit camera combines high image quality with excellent temporal resolution for rapid time-lapse recordings, allowing researchers to document live cells and photobleaching fluorescence specimens with ease.
Scientists Find Fragile X Treatment
April 11, 2013 11:52 am | News | CommentsResearchers have discovered a new therapy for the fragile X chromosome syndrome (FXS). This therapy proposes the modulation of the cerebral endocannabinoid system in order to ameliorate the symptoms of the disease. Using Rimonabant normalizes cognitive alterations, sensitivity to pain, and epileptic crises.
Boston Therapeutics Wants IND Meeting
April 11, 2013 11:35 am | News | CommentsBoston Therapeutics Inc. has requested an Investigational New Drug application meeting with the U.S. Food and Drug Administration. The application will support a proposed indication of PAZ320 to reduce the elevation of post-meal blood sugar for treatment of patients with type 2 diabetes.
Actavis, Valeant Reach Generics Agreement
April 10, 2013 4:34 pm | by Linda A. Johnson | News | CommentsGeneric drugmaker Actavis Inc. and brand-name drugmaker Valeant Pharmaceuticals International Inc. said they have reached agreements allowing Actavis to sell copycat versions of two medicines for skin conditions years before their patents expire.
FDA Reviewing Merck Antifungal
April 10, 2013 2:19 pm | by Linda A. Johnson | News | CommentsMerck & Co. said that the Food and Drug Administration is reviewing its application to sell a pill form of its drug for preventing dangerous fungal infections in high-risk patients. Noxafil, known chemically as posaconazole, is already sold in a liquid form.
Palbociclib Granted Breakthrough Label
April 10, 2013 1:17 pm | by Linda A. Johnson | News | CommentsPfizer Inc. said that its experimental pill for advanced, often deadly breast cancer has been designated as a breakthrough therapy by the Food and Drug Administration. The breakthrough designation is meant to speed up development and review of treatments that are seen as big advances over existing therapies.
Companies Join to Create Next Gen Upcyte Cells
April 10, 2013 12:42 pm | Product Releases | CommentsMedicyte has signed a licensing agreement for the rights to use Lentiviral vector technology from Life Technologies to develop and market next generation, cell-based upcyte cell products to the biopharma and academic research markets.
Chemistry Workbench Get Major Update
April 10, 2013 12:36 pm | Product Releases | CommentsCresset announced the release of a new version of its computational chemistry workbench forgeV10. This release is the first major update following the launch of forgeV10 in 2012.
Mass Flow Controllers Designed for Industrial Applications
April 10, 2013 12:25 pm | Product Releases | CommentsMKS Instruments Inc. announced the introduction of the I-Series of mass flow controllers designed for use in harsh environments where resistance to liquid or dust ingress (IP66 rated) is essential.
Lilly Debuts New Oncology Data
April 10, 2013 11:32 am | News | CommentsEli Lilly and Company unveiled data from four key molecules that represent the next generation of its oncology pipeline at the American Association for Cancer Research (AACR) Annual Meeting held in Washington, D.C. this week. The data reflect Lilly's diverse oncology pipeline via molecules that target several pathways...
