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DDD Update

Daily news and top headlines for drug research professionals

Sanofi, Mannkind Announce Inhaled Insulin Afrezza Availability in U.S.

February 3, 2015 4:04 pm | News | Comments

Afrezza is approved by the U.S. Food and Drug Administration to control high blood sugar in adults with type 1 and type 2 diabetes. Read more...                    

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FDA Grants Breakthrough Therapy Designation to Roche's Lung Cancer Immunotherapy

February 3, 2015 3:54 pm | News | Comments

The designation was granted for the treatment of people with PD-L1-positive non-small cell lung cancer (NSCLC). Read more...                       

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Allergic Drug Reactions Traced to Single Protein

February 3, 2015 3:42 pm | by Ross Neitz - University of Alberta | News | Comments

The reactions can be so severe they may stop patients from taking their needed medications and sometimes can even prove fatal. Read more...                    

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Cocaine Study Raises Questions About Addictions

February 3, 2015 3:31 pm | by University of Adelaide | News | Comments

A team of researchers has discovered a mechanism in the body's immune system that amplifies addiction to cocaine. Read more..                       

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UK Moves Toward Making Babies From DNA of 3 People

February 3, 2015 3:18 pm | by Maria Cheng - AP Medical Writer | News | Comments

The technology aims to liberate future generations from inherited diseases, but critics say it crosses a fundamental scientific boundary and could lead to designer babies. Read more...             

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Ebola: Sierra Leone Officials Criticize Travel Relaxation

February 3, 2015 3:10 pm | by Clarence Roy-Macaulay - Associated Press | News | Comments

Although Ebola cases are declining in West Africa, Sierra Leone officials are worried that the president's decision to lift travel restrictions may re-ignite the spread of the deadly disease. Read more...          

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Some ARB Drugs Are More Effective Than Others at Treating Heart Failure

February 3, 2015 12:41 pm | by Nova Southeastern University | News | Comments

Millions of people take angiotensin receptor blockers (ARBs) to help treat heart failure. Read more...                           

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Maternal Pot Use Under Microscope in Colorado

February 3, 2015 12:28 pm | by Kristen Wyatt - Associated Press | News | Comments

Marijuana use by pregnant or nursing women might seem like a no-brainer of a bad idea, but a proposal in Colorado to step up such warnings is raising concern because of limited research on the dangers. Read more...        

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New Pathway for Stalling BRCA Tumor Growth Revealed

February 3, 2015 12:25 pm | by NYU Langone | News | Comments

Inhibiting the action of a particular enzyme dramatically slows the growth of tumor cells tied to BRCA1 and BRCA2 genetic mutations which, in turn, are closely tied to breast and ovarian cancers. Read more...         

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NY Attorney General Targets Popular Herbal Supplements

February 3, 2015 12:11 pm | by Mary Esch - Associated Press | News | Comments

Numerous store brand supplements aren't what their labels claim to be, an ongoing investigation of popular herbal supplements subjected to DNA testing has found. Read more...               

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Potential Therapy to Prevent Arrhythmias

February 3, 2015 9:11 am | by OHSU | News | Comments

A therapy currently under development for spinal cord injuries has been shown to stimulate nerve regeneration in the heart and provide resistance to arrhythmias following a heart attack, according to a new study published in the journal Nature Communications. Read more...

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Astellas Broadens Commitment to Clinical Trial Data Transparency

February 3, 2015 9:08 am | by Astellas | News | Comments

Astellas Pharma Inc. announced that the company will now make trial data available through www.clinicalstudydatarequest.com, an independent Web site that enables researchers to request and access clinical trial data after approval of a research proposal by an independent review panel. Read more...

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Obama's Budget Targets High Cost of Cutting-Edge Drugs

February 2, 2015 10:11 pm | by Ricardo Alonso-Zaldivar, Associated Press | News | Comments

With patients facing greater exposure to the high cost of new medications, President Barack Obama on Monday called for government to use its buying power to squeeze drug companies for lower prices. Read more..            

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Complex Incentives Drive Macular Degeneration Prescription Decisions

February 2, 2015 10:06 pm | by Stanford University | News | Comments

Two drugs that treat macular degeneration are practically interchangeable - except for the price. Ranibizumab costs up to $2,000 per dose, while bevacizumab is $50 per dose. Researchers at the Stanford University School of Medicine suspected that doctors treating Medicare patients would have a financial incentive to prescribe a more costly drug. Read more...

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New Mechanism of Resistance to Breast Cancer Drugs: Discovery

February 2, 2015 10:00 pm | by Dartmouth Univ. | News | Comments

In the search for new approaches to treat ERBB2 (also known as HER2) positive breast cancers that have become drug-resistant, Dartmouth's Norris Cotton Cancer Center investigator Manabu Kurokawa, PhD, led a team in discovery of a novel cancer resistance mechanism with findings published in Cell Cycle. Read more...

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