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Daily news and top headlines for drug research professionals

PTH Testing Inaccuracy Demonstrates the Need for Mass Spec in the Clinical Lab

October 28, 2015 8:30 am | by Mary F. Lopez, Bryan Krastins, Gregory Byram, Maryann Vogelsang, Gouri Vadali; at Nuclea Biotechnologies | Articles | Comments

Mass spectrometry (MS) is revolutionizing the way that biomarkers are detected and quantified, with proven application in clinical laboratories in toxicology, endocrinology, and biochemical genetics. The detection of parathyroid hormone, (PTH) in human blood is a new case in point. Read more...


Researchers Identify an Enzyme as a Major Culprit of Autoimmune Diseases

October 27, 2015 5:04 pm | by UT Southwestern Medical Center | News | Comments

Activating an enzyme that sounds an alarm for the body's innate immune system causes two lethal autoimmune diseases in mice, while inhibiting the same enzyme rescues them, UT Southwestern Medical Center researchers report. Read more...


Manipulating the Antennae on Cells Promises New Treatments for Osteoarthritis

October 27, 2015 4:59 pm | by Queen Mary University of London | News | Comments

Bioengineers from Queen Mary University of London (QMUL) have shown for the first time that lithium chloride, a common drug used to treat mental health disorders, could offer an effective treatment against osteoarthritis by disrupting the length of the cells' antennae called primary cilia. Read more...


3-D Pancreatic Cancer Organoid May Help Predict Critical Responses, Personalize Treatments

October 27, 2015 4:53 pm | by Beth Israel Deaconess Medical Center | News | Comments

The development of a new method to grow three-dimensional organoid cultures of pancreatic tumors directly from patients' surgical tissue offers a promising opportunity for testing targeted therapies and drug responses and personalizing treatments in a rapid, cost-effective manner.  Read more...


Researchers Discover More Than 3,000 Genes in a Little-studied Part of the Human Genome

October 27, 2015 11:15 am | by UCLA | News | Comments

Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered more than 3,000 previously unknown genes in a poorly understood part of the genome. These genes, found in rare cells in bone marrow and in the thymus, give scientists a new understanding of how the human immune system develops. Read more...


Intestine-Specific Delivery of Insulin Demonstrates Promise with New Oral Formulation

October 27, 2015 10:50 am | by American Association of Pharmaceutical Scientists (AAPS) | News | Comments

An intestinal patch device containing insulin that can be swallowed in the form of a capsule, in development by researchers at University of California Santa Barbara, has demonstrated efficacy of blood glucose management in diabetic rats. Read more...


GSK Heart Drug Fails in Study; Shingles Vaccine Shows Benefits

October 27, 2015 10:13 am | by Stephanie Guzowski, Editor | News | Comments

GlaxoSmithKline’s experimental heart drug failed in the first part of a large clinical trial, the company said on Tuesday. In better news for GSK, the company's experimental shingles vaccine Shingrix succeeded in a second pivotal Phase 3 study. Read more...


The Role of the FDA's Office of Pharmaceutical Quality

October 27, 2015 9:43 am | by Ryan Bushey, Associate Editor | News | Comments

AAPS continued on Monday with a 90-minute presentation from three representatives at the Food and Drug Administration’s Office of Pharmaceutical Quality. Read more...


Scientists Discover a 'Switchboard' of Molecules that Protect Against Parkinson's Disease

October 27, 2015 9:40 am | by University of Dundee | News | Comments

A `switchboard' of molecules that play a vital role in protecting the brain against Parkinson's disease has been uncovered by a research team led by the University of Dundee. Read more...


Pipeline Update: The Emergence of Biosimilars

October 27, 2015 8:30 am | by Meg Snyder, Editor, Pharmaceutical Processing | Articles | Comments

Today’s pharmaceutical market is growing exponentially in potential. Not only has there been new brand-name and generic drugs produced for a myriad of medical conditions, but also the arrival of biosimilars in the United States. All of these changes only serve to engender a competitive environment, thriving on quantitative and qualitative productivity and rapidity, among manufacturers. Read more...


AAPS 2015: How to Properly Price Innovative Medicines

October 27, 2015 8:09 am | by Ryan Bushey, Associate Editor | News | Comments

The session examined how pharmaceutical companies can establish realistic drug prices that benefit the company as well as the consumer. Read more...


Researchers Discover an Epilepsy Switch

October 26, 2015 1:39 pm | by University of Bonn | News | Comments

Scientists at the University of Bonn and the Hebrew University of Jerusalem (Israel) have decoded a central signal cascade associated with epileptic seizures. If the researchers blocked a central switch in epileptic mice, the frequency and severity of the seizures decreased. Using a novel technology, it was possible to observe the processes prior to the occurrence of epileptic seizures in living animals. Read more...


Use of Benzodiazepines and Related Drugs Common around Alzheimer's Diagnosis

October 26, 2015 1:32 pm | by University of Finland | News | Comments

Benzodiazepines and related drugs are initiated frequently in persons with Alzheimer's disease already before the diagnosis, and their use becomes even more common after the diagnosis, shows a recent study from the University of Eastern Finland. Read more...


Stopping Tuberculosis Requires New Strategy

October 26, 2015 1:28 pm | by Harvard T.H. Chan School of Public Health | News | Comments

Unless there is a major shift in the way the world fights tuberculosis—from a reliance on biomedical solutions to an approach that combines biomedical interventions with social actions—the epidemic and drug resistance will worsen, say researchers at Harvard T.H. Chan School of Public Health. Read more...


WHO Removes Nigeria From List of Polio-Endemic Countries

October 26, 2015 1:23 pm | by Associated Press | News | Comments

The U.N. World Health Organization is formally removing Nigeria from the list of polio-endemic countries, meaning the entire African continent is free of the crippling disease. Read more....



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