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DDD Update

Daily news and top headlines for drug research professionals

Journal Watch: Tamoxifen in the News Again

December 8, 2014 11:57 am | by Drug Discovery & Development Staff | Articles | Comments

Tamoxifen, the leading estrogen blocker, has done so well by hormone receptor-positive breast cancer patients that the American Society for Clinical Oncology (ASCO) changed its guidelines this year, advising certain patients to take the drug for ten years instead of five. Read more...

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BioDelivery Sciences: Phase 3 Trial of Diabetic Neuropathy Topical Gel

December 8, 2014 10:52 am | News | Comments

BioDelivery Sciences International, Inc. announced that it has completed the randomization of all patients in BDSI's ongoing initial pivotal Phase 3 clinical trial for Clonidine Topical Gel for the treatment of painful diabetic neuropathy (PDN). Read more...

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Norovirus Sickens 200 People on New Zealand Cruise

December 8, 2014 10:41 am | by Associated Press | News | Comments

Health authorities in New Zealand said that about 200 passengers on a cruise ship have been sickened by an outbreak of norovirus. Read more...                                                    

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Breakthrough in Fibrosis Research

December 8, 2014 10:33 am | by University of Bath, UK | News | Comments

Researchers from the Departments of Pharmacy & Pharmacology and Biology & Biochemistry have made an important discovery that might lead to novel therapies to combat chronic fibrotic diseases. Read more...                          

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Amgen, Onyx: Phase 3 Study Results in Myeloma Trial

December 8, 2014 10:26 am | News | Comments

Amgen and its subsidiary Onyx results of the Phase 3 ASPIRE trial, which evaluated Kyprolis (carfilzomib) for Injection plus Revlimid (lenalidomide) and dexamethasone (KRd) compared with Revlimid and dexamethasone (Rd) in patients with relapsed multiple myeloma. Read more...

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Seattle Genetics, Takeda: Clinical Trial Data in HL Patients

December 8, 2014 10:17 am | News | Comments

Seattle Genetics, Inc. and Takeda reported data demonstrating that Hodgkin lymphoma (HL) patients at risk of relapse following an autologous stem cell transplant (ASCT) who received Adcetris (brentuximab vedotin) as consolidation therapy immediately after ASCT had significant improvement in progression-free survival (PFS) compared to patients who received placebo (median of 43 months versus 24 months, respectively. Read more...

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VIDEO: Drug Development in a Time of Ebola

December 8, 2014 10:04 am | by Ryan Bushey, Associate Editor | Videos | Comments

This video from the Forbes Healthcare Summit focuses on the drug development process during a time of ebola. Watch it here...                       

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Merck's Cancer Therapy Receives Positive Results

December 8, 2014 10:03 am | News | Comments

Merck announced early study findings demonstrating that patients treated with pembrolizumab, the company's investigational anti-PD-1 cancer therapy, achieved an overall response rate of 66 percent, as assessed by International Harmonization Project response criteria. Read more...

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UCB Announces Phase 3 Data of Epilepsy Drug

December 8, 2014 9:52 am | News | Comments

UCB announced the primary efficacy and safety data from the latest Phase 3 study evaluating brivaracetam (fixed doses of 100 and 200 mg/day with no up-titration) as adjunctive treatment in adult epilepsy patients with partial-onset seizures. Read more...    

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Paralegal Claims Sanofi Fired Her for Whistleblowing

December 5, 2014 3:23 pm | News | Comments

The lawsuit accuses recently ousted Sanofi CEO Christopher Viehbacher and other execs of an alleged kickback scheme to increase sales of U.S. medicines. Read more...                

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CDC: Ebola Reports Rarely Panned Out

December 5, 2014 3:13 pm | by Mike Stobbe - AP Medical Writer | News | Comments

The Centers for Disease Control and Prevention report looked at Ebola-related calls the federal agency received this year from doctors, hospitals, and state and local health departments. Read more...          

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Oregon Hospital: Medication Error Killed Patient

December 5, 2014 3:00 pm | by Gosia Wozniacka - Associated Press | News | Comments

An Oregon hospital is acknowledging that it administered the wrong medication to a patient, causing her death. Read more...                       

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Jury Favors AstraZeneca in Nexium Antitrust Litigation

December 5, 2014 1:09 pm | News | Comments

A jury in the US District Court for the District of Massachusetts returned a verdict in favour of AstraZeneca in a Multi-District antitrust case. Read more...                 

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Study Suggests Potential Therapy for Common Form of Dementia

December 5, 2014 12:56 pm | by Bob Shepard, University of Alabama at Birmingham | News | Comments

Drugs that boost the function of a specific type of neurotransmitter receptor may provide benefit to patients with the second most common type of dementia. Read more...                

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Genetic Errors Linked to More ALS Cases Than Previously Thought

December 5, 2014 12:43 pm | by Michael C. Purdy, Washington University in St. Louis | News | Comments

Genetic mutations may cause more cases of ALS than scientists previously had realized. Read more...                          

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