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DDD Update

Daily news and top headlines for drug research professionals

Sildenafil Reduces Raynaud's Frequency in lcSSc

March 9, 2011 6:33 am | News | Comments

Researchers in Europe reported that treatment with modified-release sildenafil significantly reduced the frequency of attacks of Raynaud's phenomenon in patients with limited cutaneous systemic sclerosis, also known as scleroderma.

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Roundworm Could Provide Sepsis Treatment

March 9, 2011 6:30 am | News | Comments

Researchers have found that systemic inflammation caused by sepsis can be suppressed by a protein which occurs naturally in the roundworm Acanthocheilonema viteae.

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Malaria's Weakest Link

March 9, 2011 6:27 am | News | Comments

A group of researchers has discovered that a class of chemotherapy drugs originally designed to inhibit key signaling pathways in cancer cells also kills the parasite that causes malaria.

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No Clear Evidence of Increased Efficacy In RA Treatment

March 9, 2011 6:21 am | News | Comments

A recent trial of rituximab in combination with a tumor necrosis factor inhibitor and methotrexate in patients with active rheumatoid arthritis found the safety profile to be consistent with other RA trials with TNF inhibitors.

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Conflicts-of-Interest Return to Medical Literature

March 9, 2011 6:17 am | News | Comments

Hidden financial conflicts-of-interest are sneaking into published drug research through the back door, warns an international team of investigators.

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DILI Assay Cartridge

March 8, 2011 7:32 am | Product Releases | Comments

Thermo Fisher Scientific Inc. has introduced the ToxInsight DILI Assay Cartridge, a tool for assessing the liver toxicity risk of chemical compounds. It will help pharmaceutical companies better assess liver toxicity early in the drug development process.

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Toxikon Completes Kevetrin Toxicity Studies

March 8, 2011 7:27 am | News | Comments

Toxikon Corp. has completed toxicity studies in two species for Cellceutix Corp.’s Kevetrin, a compound being developing for the treatment of resistant lung and breast cancers.

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Hepatocyte Array Kit

March 8, 2011 7:23 am | Product Releases | Comments

Transparent Inc. announced that it has developed a more advanced medium for Cell-able, a human hepatocyte array kit that has the potential to reduce drug development costs and time-to-market for pharmaceutical companies.

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Battelle Unveils Multi-Scale Toxicology Initiative

March 8, 2011 7:18 am | News | Comments

Battelle experts will debut a new industry-leading, multi-scale toxicology program as a way to more effectively advance drug development during a Battelle symposium on March 7-10 at the 2011 Society of Toxicology Annual Meeting.

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RainDance-Ambry Collaborate on ADME for NGS

March 8, 2011 7:15 am | News | Comments

RainDance Technologies, Inc. and Ambry Genetics announced a new collaboration focused on the development and commercialization of a comprehensive drug absorption, distribution, metabolism, and excretion genetic screening panel for use on next-generation sequencing systems.

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Filtration Products

March 8, 2011 7:11 am | Product Releases | Comments

Highlights of Pall’s product showcase include AcroPrep Advance Filter Plates, Microsep Advance and Macrosep Advance Ultrafiltration Centrifugal Devices, and acrodisc PSF Syringe Filters.

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Water Purification System

March 8, 2011 7:06 am | Product Releases | Comments

EMD Millipore announced the introduction of an all-in-one water purification system designed specifically for clinical analyzers. The Elix Gulfstream Clinical water purification system will provide up to 100 liters per hour of clinical laboratory reagent water daily.

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Covance Working Together with ISB

March 8, 2011 6:57 am | News | Comments

Covance Inc. announced that its Seattle-based genomics laboratory has initiated a collaboration with the Institute for Systems Biology to further understand the area of brain tumor biology.

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Hospira Hires Former Allergan President

March 8, 2011 6:54 am | News | Comments

Specialty drug maker Hospira Inc. said that it had hired Allergan Inc. President F. Michael Ball to become its new chief executive and member of the board.

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Potent New Drug Class Discovered

March 8, 2011 6:51 am | News | Comments

Working as part of a public program to screen compounds to find potential medicines and other biologically useful molecules, scientists have discovered an extremely potent class of potential anti-cancer and anti-neurodegenerative disorder compounds.

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