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DDD Update

Daily news and top headlines for drug research professionals

FDA Says No to Simponi Expansion

July 25, 2011 7:35 am | by Linda A. Johnson | News | Comments

Healthcare giant Johnson & Johnson plans to meet with U.S. regulators after they refused to approve a new use for the company's immune disorder drug, Simponi.


Generics to Slash Prescription Costs

July 25, 2011 7:31 am | by Linda A. Johnson | News | Comments

The cost of prescription medicines used by millions of people every day is about to plummet. The next 14 months will bring generic versions of seven of the world's 20 best-selling drugs.


Sherpa Clinical Packaging Opens Production Facility

July 25, 2011 7:10 am | News | Comments

Sherpa Clinical Packaging, a provider of clinical trial material management services, opened its newly constructed CGMP production facility co-located adjacent to the Althea Technologies campus; Sherpa and Althea entered into a co-marketing agreement in March 2011.


PharmaNet Names New Vice President

July 25, 2011 7:04 am | News | Comments

PharmaNet Development Group, Inc. has appointed George Scott, PhD, as vice president, Bioanalytical Services.


LC Low-Pressure Gradient Unit

July 25, 2011 6:53 am | Drug Discovery & Development | Product Releases | Comments

Shimadzu has integrated a low-pressure gradient (LPGE) unit to its Nexera ultra high-performance liquid chromatograph, allowing users to switch automatically between four mobile phases with solvent delivery units.


UHPLC System

July 25, 2011 6:47 am | Drug Discovery & Development | Product Releases | Comments

Thermo Fisher Scientific Inc. offers the EASY-nLC 1000 split-free nano-flow system  that increases chromatographic resolution and protein and peptide identifications with high pressure operation.


Erythropoietin Impurity Analysis

July 25, 2011 6:39 am | Product Releases | Comments

Phenomenex Inc. has published a method for the analysis of aggregates of EPO, a recombinant biosimilar protein therapeutic. The gel filtration chromatography (GFC) method quantifies aggregates in recombinant therapeutics using a BioSep-SEC-s2000 series column, which provides a separation window for low-molecular-weight proteins.


PET-Specific Chromatography Data System

July 25, 2011 6:33 am | Product Releases | Comments

LabLogic’s chromatography data system specifically for PET applications, Laura for PET can control and collect data generated by gas, thin-layer, and high pressure chromatography and multi-channel analysis.


Reversed-Phase UHPLC Column

July 25, 2011 6:24 am | Drug Discovery & Development | Product Releases | Comments

Agilent Technologies Inc.’s Zorbax RRHD 300SB-C18 1.8 micron column for UHPLC systems is a silica reversed-phase column that can be used for higher-order reversed-phase characterization of intact proteins and protein digests.


Cardio Instrument Estimates Risk of Proarrhythmia

July 22, 2011 8:17 am | News | Comments

Cardiotoxicity, which results when drugs adversely affect the heart, explains why roughly one-third of new pharmaceuticals are withdrawn from the market and why many compounds fail in late-stage clinical testing.


Epigenetic Detection Reagents

July 22, 2011 8:13 am | Drug Discovery & Development, Drug Discovery & Development | Product Releases | Comments

PerkinElmer offers screening assays for epigenetics that are built upon homogeneous assay platforms—LANCE Ultra detection assays for peptide substrates and AlphaLISA detection assays for peptide or full-length proteins.


Integration Kit for Mouse Genome

July 22, 2011 8:10 am | Product Releases | Comments

Sigma Life Science’s CompoZr Targeted Integration Kit,  mRosa26, can integrate transgenes into the mouse genome at the Rosa26 safe harbor locus.


Sequencing Preparation Kit

July 22, 2011 8:07 am | Product Releases | Comments

EMD Millipore’s Magna ChIP-Seq preparation kit is designed to simplify genome-wide profiling of DNA-protein interactions by chromatin immunoprecipitation and next generation sequencing


Gardening in the Brain

July 22, 2011 8:01 am | News | Comments

Gardeners know that some trees require regular pruning: some branches must be cut so that others can grow stronger. The same is true of the developing brain: cells called microglia prune the connections between neurons, shaping how the brain is wired, scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, discovered.


Dificid Tablets Launched for C. Difficile-Associated Diarrhea

July 22, 2011 7:55 am | News | Comments

Optimer Pharmaceuticals, Inc. launched Dificid (fidaxomicin) tablets for the treatment of Clostridium difficile-associated diarrhea (CDAD) in patients 18 years of age and older.



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