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DDD Update

Daily news and top headlines for drug research professionals

Drug Repositioning: A Union of Patient Interests, Pipeline Development and Innovation

March 29, 2011 7:59 am | by Aris Persidis, PhD, President; Biovista, Inc., Charlottesville, Va. | Articles | Comments

The tremendous pressures on pharmaceutical company pipelines are always in the news. Constant reorganizations and acquisitions of late-stage clinical candidates or of entire companies are seen as a major solution going forward.

New Insight into How 'Tidying Up' Enzymes Work

March 29, 2011 7:53 am | News | Comments

When a tablet of medicine is taken, the active molecules get absorbed into the bloodstream through the gut and make their way around the body, including to the cells in which they are intended to act; however, it's important they don't stay in the body forever.

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Y-90 Treatment Shown Safe and Effective

March 29, 2011 7:48 am | News | Comments

New results from a large study show that treating liver tumors with higher doses of Y-90 than previously tried is safe, provides results when chemotherapies have failed, preserves the patient's quality of life, and can be done on an outpatient basis.

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New Tool Enables Detailed Phenotypic Analyses of Human Cells

March 29, 2011 7:43 am | News | Comments

To generate energy, cells have multiple enzymatic pathways for producing NADH, which can then be converted to ATP and other useful forms of energy. Scientists have developed new redox dye chemistries that yield a purple color as cells generate NADH.

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Vertex CF Drug Meets Study Goals

March 29, 2011 7:38 am | News | Comments

Vertex Pharmaceuticals Inc. said that its potential cystic fibrosis drug improved lung function in a key late-stage study. The company said VX-770 prompted a 12.5 percent improvement in lung function in the study.

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High Court Limits Drug Price Lawsuits

March 29, 2011 7:32 am | News | Comments

The Supreme Court says hospitals and clinics that serve the poor cannot sue prescription drug manufacturers over allegations that the companies charged too much for their medicines.

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Lipid-based Reagent

March 28, 2011 8:53 am | Product Releases | Comments

GenePORTER Gold from AMSBIO is a new highly efficient and reproducible lipid-based reagent for effective transfection of a wide variety of cell lines.

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Automatic Titrators

March 28, 2011 8:43 am | Product Releases | Comments

ITT Corporation announced that its SI Analytics brand has launched the TitroLine titrator series for advanced titration and dosing applications.

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New Model of DNA Repair Complex

March 28, 2011 8:36 am | News | Comments

Over the last years, two teams of researchers have steadily built a model of how a powerful DNA repair complex works. Now, their latest discovery provides revolutionary insights into the way the molecular motor inside the complex functions.

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Sindbis Virus Used to Destroy Tumors

March 28, 2011 8:32 am | News | Comments

Alpha viruses, such as Sindbis virus, carry their genetic information on a single strand of RNA. On infection they use a protein, replicase, to produce double stranded RNA (dsRNA) which is used as genetic material to make more viruses.

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J & J Subsidiary Involved in New Recall

March 28, 2011 8:27 am | News | Comments

Johnson & Johnson's Ethicon unit is recalling a group of medical drainage products because of concerns about the sterility of the products. Ethicon said it received customer complaints that the sterile barrier in the product packaging was compromised.

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BioFocus And Almac Working on Compound Screening

March 28, 2011 8:20 am | News | Comments

BioFocus and Almac have initiated a collaboration which will provide BioFocus customers with compound screening and profiling services using Almac’s FLEXYTETM fluorescence lifetime assays.

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Three Running for PPD Board of Directors

March 28, 2011 8:14 am | News | Comments

Drug development contractor PPD Inc. said that three people would stand for election to its board of directors at its annual meeting on May 18. The three are Vaughn D. Bryson, Robert A. Ingram and Dr. Ralph Snyderman.

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Upheld Fentora Patent Staves Off Generic

March 28, 2011 8:03 am | News | Comments

A U.S. District Court upheld one of the patent's supporting Cephalon Inc.'s drug Fentora, preventing competitor Watson Pharmaceuticals Inc. from selling a generic version of the powerful painkiller.

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FDA Approves BMS Melanoma Drug

March 28, 2011 7:55 am | News | Comments

The Food and Drug Administration has approved a breakthrough cancer medication from Bristol-Myers Squibb Co. that researchers have heralded as the first drug shown to prolong the lives of patients with advanced skin cancer.

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