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DDD Update

Daily news and top headlines for drug research professionals

Expression Analysis Expands Services

October 13, 2010 8:26 am | News | Comments

Expression Analysis, a leading provider of genomic services for clinical trials and research, announced that it has expanded its sequencing services to include single-lane sequencing with guaranteed turn-around-times and, firm fixed pricing.

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Merck Presents Positive Erbitux Data

October 13, 2010 8:20 am | News | Comments

Merck KGaA announced data presented that showed that patients with KRAS wild-type metastatic colorectal cancer who experienced early tumor shrinkage during first-line Erbitux-based treatment lived a median of 28.3 months.

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Prosensa Gets Milestone Payment from GSK

October 13, 2010 8:09 am | News | Comments

Prosensa received a £7.5m milestone payment from GlaxoSmithKline as a result of achieving a data milestone in its Phase 2a open label extension trial of GSK2402968 (PRO051), being developed to treat Duchenne Muscular Dystrophy.

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FDA Approves Vivitrol for Drug Addiction

October 13, 2010 8:06 am | News | Comments

Drugmaker Alkermes Inc. said it has received U.S. approval to market its addiction medication for use in patients addicted to narcotics like heroin and morphine.

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HIV Patients To Be Screened for TB

October 13, 2010 8:04 am | by Jenny Gross | News | Comments

Health officials in South Africa said they recommend screening all HIV patients for tuberculosis and want automatic TB tests for HIV patients to become normal procedure within five years.

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Treating Relapsing-Remitting Multiple Sclerosis

October 13, 2010 7:43 am | by Kate Dawson, MD, Senior Director, Medical Research, Biogen Idec, Cambridge, Mass. | Articles | Comments

Biogen Idec’s BG-12 is an oral formulation of dimethyl fumarate. This is the first compound in clinical trials to activate the Nrf2 transcriptional pathway, a central mechanism of cellular defense against oxidative and metabolic stress.

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Therapeutic Promise of Human Neural Stem Cells

October 13, 2010 7:39 am | by Stephen Huhn, MD, FACS, FAAP, Vice President, Head of the CNS Program, StemCells, Inc., Palo Alto, Calif. | Articles | Comments

Stem cells have the potential to treat a broad range of human disorders. While approaches based on embryonic stem cells and induced pluripotent stem cells have attracted the most media attention, they are complicated by specific challenges.

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Unlocking the Therapeutic Potential of the NMDA Receptor

October 13, 2010 7:36 am | by Joseph R. Moskal, PhD, President and CSO; J. David Leander, PhD, Chief Scientific Advisor; and Ronald M. Burch, MD, PhD, CMO, Naurex, Inc., Evanston, Ill. | Articles | Comments

The glutamate receptor subtype known as N-methyl-D-aspartic acid (NMDA) plays a central role in modulating aspects of brain activity. Naurex is developing a pipeline that modulates the NMDA receptor (NMDAR) at the glycine site.

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Glutamate Modulation as Parkinson’s Therapy

October 13, 2010 7:28 am | by Chris Maggos, Investor Relations & Communication, Addex Pharmaceuticals, Geneva, Switzerland | Articles | Comments

Glutamate is a critical neurotransmitter that is involved in a multitude of biological functions and disease processes. Despite its rich therapeutic potential, the glutamatergic system has historically been a challenge for drug discoverers.

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HuCAL Antibody Combats Alzheimer’s Disease

October 13, 2010 7:22 am | by Marlies Sproll, PhD, CSO MorphoSys AG Planegg, Germany | Articles | Comments

A major challenge for Alzheimer’s disease drug candidates, particularly for therapeutic antibodies, is the blood-brain barrier. Once considered impermeable for large molecules, recent evidence has shown that they are in fact able to pass through.

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Insulin Resistance Linked to Stroke

October 12, 2010 7:27 am | News | Comments

Insulin resistance, a condition in which insulin produced by the body becomes less effective in reducing blood glucose levels, appears to be associated with an increased risk of stroke in individuals without diabetes.

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New Drugs for AMD Just As Safe As Older Treatments

October 12, 2010 7:11 am | News | Comments

Newer treatments for age-related macular degeneration do not appear to be associated with an increased risk of cardiovascular complications or death when compared with existing therapies.

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Briakinumab Effective at Clearing Plaques

October 12, 2010 6:54 am | News | Comments

A greater percentage of moderate to severe chronic plaque psoriasis patients treated with briakinumab, Abbott's investigational IL-12/23 inhibitor, achieved 75% or better skin clearance rates than those treated with etanercept, methotrexate, or placebo.

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Merck Appealing EMA Ruling

October 12, 2010 6:34 am | News | Comments

Merck KGaA has notified the European Medicines Agency of its intention to request a re-examination of the opinion issued by the Committee for Medicinal Products for Human Use regarding Cladribine Tablets for relapsing-remitting multiple sclerosis.

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Court Won't Stop Hormone Replacement Lawsuits

October 12, 2010 6:18 am | News | Comments

The Supreme Court won't reconsider a decision to reinstate more than 100 lawsuits filed by women who claimed that hormone replacement therapy caused breast cancer.

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