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DDD Update

Daily news and top headlines for drug research professionals

Study Shows Tapentadol Effective for Osteoarthritis

September 1, 2010 7:50 am | News | Comments

Phase 3 safety and efficacy data comparing tapentadol extended release tablets, an investigational pain medication, to placebo in patients with moderate to severe chronic osteoarthritis knee pain have been recently published.

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New Mountain Purchases Mallinckrodt Baker

September 1, 2010 7:35 am | News | Comments

An affiliate of New Mountain Capital, LLC announced the completion of its acquisition of Mallinckrodt Baker, Inc. from Covidien for approximately $280 million.

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NIH Finds Promising Staph Treatment

September 1, 2010 7:29 am | News | Comments

Scientists have found that by neutralizing a key toxin associated with the Staphylococcus aureus bacteria, they found they could greatly reduce the damaging effects of the infection on skin and soft tissue.

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Donated Malaria Drugs Being Resold on Black Market

September 1, 2010 7:15 am | by Maria Cheng | News | Comments

Millions of free malaria drugs are sent to Africa every year by international donors. New research is now providing evidence for what health workers have long suspected: some of the donated medication is being stolen and resold on commercial markets.

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FDA Examines Cough Syrup Restrictions

September 1, 2010 7:12 am | News | Comments

Federal health regulators are weighing restrictions on Robitussin, NyQuil and other cough suppressants to curb cases of abuse that send thousands of people to the hospital each year.

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Botox Case Settled for $600M

September 1, 2010 7:03 am | by Matthew Perrone | News | Comments

Allergan Inc., the maker of wrinkle-smoothing Botox, says it will pay $600 million to settle a yearslong federal investigation into its marketing of the top-selling, botulin-based drug.

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Thermoreversible Gel

August 31, 2010 8:38 am | Product Releases | Comments

The thermo-reversible mountant CyGEL, from Biostatus Ltd. in the UK, enables high resolution imaging of live 3D tumor spheroids cultured in low-adherence conditions and without fixation or cytospin centrifugation.

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KYTHERA And Intendis Ink Potential $373M Deal

August 31, 2010 8:25 am | News | Comments

KYTHERA Biopharmaceuticals, Inc. and Intendis, Bayer HealthCare’s dermatology business, have entered into a licensing agreement granting Intendis rights to KYTHERA’s lead product candidate, ATX-101, outside of the US and Canada.

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Halozyme Completes Hylenex Probe

August 31, 2010 8:22 am | News | Comments

Halozyme Therapeutics Inc. said it completed an investigation into manufacturing problems behind its Hylenex product and has drawn up a corrective action plan and market relaunch strategy.

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Gene Affecting Clopidogrel Not Issue With Ticagrelor

August 31, 2010 8:19 am | News | Comments

A substudy of PLATO showed that the effects of ticagrelor on acute coronary syndrome patients who received the investigational oral antiplatelet treatment were maintained, whether or not they had the genetic variability that has been previously shown to affect a patient’s response to clopidogrel.

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Trius Begins Phase 3 Antibiotic Trial

August 31, 2010 8:09 am | News | Comments

Trius Therapeutics, Inc. announced that the first patient has been dosed in its Phase 3 clinical study of the oral dosage form of torezolid phosphate for the treatment of acute bacterial skin and skin structure infections.

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Amino Acid Vital to Fight Against Infection

August 31, 2010 7:24 am | News | Comments

Two University of Alberta researchers may be able to explain why proper nutrition is so vital in fighting infection. They have discovered an amino acid, called arginine, is required to let the body know that it's being attacked by an infection.

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Structural Defects Precede Decline In Heart Muscle

August 31, 2010 7:20 am | News | Comments

The disruption of a structural component in heart muscle cells, which is associated with heart failure, appears to occur even before heart function starts to decline, according to a new study.

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Nearby Cancer Cells Could Help Spread Melanoma

August 31, 2010 6:59 am | News | Comments

New research on how skin cancer begins has identified adjacent cancer cells that scientists are calling "co-conspirators" in the genesis of melanoma, findings that could someday allow the prediction, prevention, and treatment of this hard-to-treat cancer.

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Research Shows How Trypanosomes Evade Immune System

August 31, 2010 6:54 am | News | Comments

Trypanosomes are parasites responsible for many deaths, primarily in tropical climates. A team of researchers has shown, for the first time, how one such species evades the human innate defenses. The finding could open the way for new classes of drugs to treat the epidemic.

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