Strategies & Technologies Driving Drug Discovery to Market
Can RNAi Deliver?
October 10, 2007 6:01 pm | by Mohammad Azab, MD, MSc, MBA, President and chief executive officer, Intradigm Corporation | Articles | CommentsRNAi has great promise as a therapeutic but biological hurdles must be overcome before the dream is realized.
Warning! . . .Warning!
October 10, 2007 5:36 pm | by Neil Canavan, Contributing Editor | Articles | CommentsFDA and drug companies alike want ADME-tox testing performed earlier and earlier in a drug’s life cycle.
My PET Marker
October 10, 2007 5:00 pm | by James Netterwald, PhD, MT (ASCP), Senior Editor | Articles | CommentsNeuroimaging has become a powerful biomarker and helps researchers study mental illness. What impact will real-time imaging have in unraveling the mysteries of neurological diseases?
On the Mark
October 10, 2007 4:18 pm | by Daniel M. Skovronsky, MD, PhD, CEO and founder of Avid Radiopharmaceuticals | Articles | CommentsThe search for the perfect blockbuster biomarker for Alzheimer’s Disease is on. Pharmaceutical companies need better tools to develop novel therapeutics. Patients and physicians need better tools for early and accurate diagnosis.
Marked for Visualization
October 10, 2007 4:04 pm | by Mike May, PhD, Conributing Editor | Articles | CommentsIn many areas of life science, researchers want to work on living cells and track interactions such as how proteins interact and where. That often requires fluorescent markers, and scientists keep making new ones.
Small World, Big Dreams
October 10, 2007 3:47 pm | by Ted Agres, Contributing Editor | Articles | CommentsThe US Food and Drug Administration (FDA) appears to be taking a cautious, deliberative approach as it approaches the myriad of scientific and regulatory issues involving nanobiotechnology and nanomedicine.
Tear Down to Build Up
October 10, 2007 3:37 pm | Articles | CommentsIf, like other readers, your top priority is to accelerate the drug discovery and development process, we have some new features in this issue to help you find information faster.
Abusus non tollit usum
October 10, 2007 1:08 pm | Articles | CommentsAs more drug discovery and development processes cross borders, drug researchers must make sure that drug safety does not get lost in translation.
RNA Transcript Jumble Adds Splice to Life
October 10, 2007 12:47 pm | by Alan Dove, PhD, contributing Editor | Articles | CommentsWhen researchers discovered that some genes could produce multiple forms of mRNA, they thought the phenomenon was rare. Now, alternative splicing of gene transcripts may be the rule, not the exception, and genomics researchers need to adapt their experimental strategies.
Gene Expression and the Search for Fountain of Youth
October 10, 2007 12:16 pm | by Bill Schu, Senior Editor | Articles | CommentsAs they learn more about the genetic reasons for aging and cell death, researchers have already made aging a "curable disease" in model organisms. If similar successes can be achieved in humans, science will once again confront an ethical barrier.
Do You Compute?
October 10, 2007 12:06 pm | Articles | CommentsPK/PD scientists are using computer-assisted modeling more than ever.
Opening a Portal: The Strange New World of MicroRNA
October 10, 2007 12:05 pm | by Alan Dove, PhD, Contributing Editor | Articles | CommentsWith the discovery of RNAi in the late 1990s, researchers had a whole new collection of experimental and therapeutic tools. Recent work on microRNA is now uncovering a surprising new level of natural gene regulation.
Symbiosis at Work
October 10, 2007 11:51 am | by Tanuja Koppal, Editor in Chief | Articles | CommentsG&P June, 2005 Editorial
Users, Creators Wonder How Open Are Open-Source Tools
October 10, 2007 11:22 am | by Bernard Tulsi, Contributing Editor | Articles | CommentsDespite constraints, the solid commitment of federal funding, along with a willing army of code contributors, bode well for the future of open-source bioinformatics. However, standardization and quality control remain concerns for this decentralized phenomenon.
In Silico Techniques Tell How the Protein Turns
October 10, 2007 11:09 am | by Elizabeth Tolchin, Life Science News Editor | Articles | CommentsComputational methods that can predict the structure of a protein from its amino acid sequence are improving. Developers of such programs say that the technology may one day completely supplant experimental structure determination.
