Drug Discovery & Development provides readers with an inside look at how leading pharmaceutical and biotechnology researchers are applying the latest discovery tools and development techniques. In every issue, readers view:
- Feature articles cover the full continuum of drug discovery and development, including genomics and proteomics reporting on research, applications, technologies, and strategies to accelerate the pace and productivity of drug research and development.
- Technology Focus highlights the latest news, products, services, and applications for specific discovery, development, genomics, and proteomics technologies.
- Industry Issues features focus on strategies and topics that impact pharma and biotech business both inside and outside the lab including two monthly columns.
- Technology Advances previews new technology trends.
- Policy & Projections analyzes current legislative and regulatory issues in Congress, the FDA, the courts, and other governing bodies.
Preview the 2008 Editorial Calendar or review upcoming topics:
April, 2008 | May, 2008 | June, 2008
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April, 2008 Issue
Discovery
COVER STORY
Beating Drug Resistance: Cancer Drugs
Drug resistance is a major impediment to successful strategies for cancer therapy. New tools for gene expression profiling are now converging with the world of small non-coding RNAs (ncRNAs). Strategies to overcome drug resistance will be reviewed generally and with respect to Onconase (ranpirnase) from Alfacell.
Data Mining
This article outlines some of the issues with safety data and describes some data mining methods that address challenges. Statistical data mining models include hierarchical generalized linear models and inside-out machine learning models. Graphical analysis and reporting also is covered.
Development
Advances in HIV Drug Development
Senior editor James Netterwald will discuss current and emerging HIV treatment modalities. Special focus will be placed on emerging HIV treatments that utilize new strategies including new targets, new drug delivery options, and combination therapies.
Insect Bioreactors
Senior editor James Netterwald will discuss how insect cells are used to product biopharmaceuticals. Types of cells, bioreactor vessels, conditions, and new drugs developed in insect bioreactors will be the described in detail.
Genomics and Proteomics
MS vs. NMR for Protein Analysis
This article will discuss the pros and cons of using NMR or MS for protein analysis. Issues such as sensitivity of these methods and how bioinformatics is used to organize data resulting from them will be addressed in the context of proteomics research.
Real-time qPCR
This article discusses how preparation of RNA can affect qPCR results. Current RNA sample prep technologies are discussed. Examples illustrate the strengths and weaknesses of each technology with regard to the effects of RNA sample prep on qPCR.
Industry Issues
Building a Better Drug: New Development Strategies
For those suffering from migraine pain, relief cannot come soon enough. TorreyPines Therapeutics’s Tezampanel has completed Phase IIb clinical trials, representing the first novel treatment option in more than a decade. The company will discuss its strategy of developing versatile product candidates capable of treating a number of different diseases and disorders.
Departments
Technology Advances
Contributing Editor Mike May will discuss advances in Chemistry.
Policy & Projections
Contributing Editor Ted Agres will examine current issues before Congress and pending FDA regulations.
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SUPPLEMENT:
Trends in the Adoption of Life Science Technology 2008 (April distribution)
In this special supplement,
Drug Discovery and Development and
Bioscience Technology magazines will examine many aspects of how researchers in biological research laboratories use technology, evaluate their organizations, conduct their research, and use media. Additional research will detail funding levels, budgets, specific technology needs, and more. Feature articles will cover the ways in which specific technologies are being used by scientists to advance their research projects.
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May, 2008 IssueDiscovery
COVER STORY
Beating Drug Resistance: Infectious Diseases
“Bad Bug” microbes have evolved a wide range of resistance mechanisms and the pipeline of new antibiotic products is very limited. Increasingly, the supply of antibiotic products is emerging from smaller, specialized pharmaceutical companies that are cash-constrained and face uncertainties in the regulatory paths for developing antibiotic drugs. Antibiotic discovery and development challenges on the scientific, business, and regulatory fronts will be examined.
in silico Models
Experts say in silico models can reduce drug discovery and development costs up to 50%. How are drug research organizations using in software, modeling tools, and expertise to test and analyze data and accelerate the drug discovery process? A contributing editor will explore trends and practices.
Development
Immunotherapy
Will there ever be a cure for cancer? Antibody-based therapies are both commercially and clinically successful in the treatment of cancer. A new class of antibodies—BiTEs—bear a second antibody unit that specifically grabs the body’s most potent killer cells, T cells. Micromet Inc.’s Patrick A. Baeuerle, Ph.D., will discuss current strategies and science in immunotherapy research.
ADME-Tox
Evaluation of ADME and toxicity remains a primary focus of drug researchers. The goal is to conduct the studies earlier in the development process. A contributing editor will examine the tools, assays, processes, and challenges facing researchers, including in vitro, in vivo, and in silico practices.
Genomics and Proteomics
Electrophoresis
Senior editor James Netterwald will discuss the latest developments in nucleic acid (DNA and RNA) electrophoresis including the types of gel materials, power supply boxes, and buffer systems used by researchers.
HPLC
A contributing editor will discuss emerging technologies that enable protein separation by HPLC. The coupling of HPLC instrumentation and mass spectrometry will be the focus.
Departments
Technology Advances
Contributing Editor Mike May will discuss advances in bioinformatics.
Policy & Projections
Contributing Editor Ted Agres will examine current issues before Congress and pending FDA regulations.
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June, 2008 Issue
Development
COVER STORY
in vivo Models
Senior editor James Netterwald will discuss the use of animal models for the study of viral infections. Emphasis will placed on the SCID-hu models for the study of in vivo events of viral infection.
Drug Delivery for RNAi
Results from animal studies have demonstrated that, with appropriate delivery methods, silencing of genes in vivo, with corresponding functional consequences, is possible. However, to reach its full potential, methods for delivering siRNA safely, effectively, and conveniently to the right tissues are needed. This article summarizes recent progress in RNAi-based drug delivery, and discusses promising approaches.
Discovery
HTS Compound Library Screening
Inventory management is a challenge in any industry, especially when it involves millions of complex chemical compounds and a myriad of assays. A contributing editor will examine the latest trends, technologies, and practices, exploring the success rate of HTS library screening approaches.
Cell Culture Challenges
Information gleaned from cell-based assays can be skewed or completely corrupted by mycoplasma contamination. The introduction of mycoplasma into an otherwise healthy cell culture can come from a variety of sources, and symptoms are difficult to detect. A range of detection methods and treatments are available to reduce or eliminate the infection.
Genomics and Proteomics
Structural Proteomics
A contributing editor will explore how nuclear magnetic resonance (NMR) spectroscopy is used to determine a protein’s structure. The pros, cons, challenges and advantages of using this technology will be examined through interviews with technology suppliers and end-users/researchers of NMR.
Microarrays
Senior editor James Netterwald will describe the use of Tiling microarrays used for analysis of gene expression. Features, strengths, weaknesses, and applications in genomics research will be discussed in detail.
Departments
Technology Advances
Contributing Editor Mike May will discuss advances in diagnostics.
Policy & Projections
Contributing Editor Ted Agres will examine current issues before Congress and pending FDA regulations.
SUPPLEMENTEmerging Trends in Cell Biology (June, 2008)
Bioscience Technology and
Drug Discovery & Development will examine—through a custom survey and editorial content—the science, applications, tools, and technologies used in studies of cell biology including the reagents, chemistries, assay tools, cell lines, and imaging equipment. Developments in stem cell research will be featured.
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