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DDD Update

Daily news and top headlines for drug research professionals

A ‘Second Revolution’ in Drug Discovery and Development

August 27, 2014 9:58 am | by Seth Lederman, M.D., CEO, Tonix Pharmaceuticals | Articles | Comments

Drugs can be discovered and developed in two very different ways: at an evolutionary pace and at a revolutionary pace. The “first revolution” in biological psychiatry took place in the 1950s, and now, in the 21st century, a “second revolution” of drug development and discovery is taking place, driven by repurposing. Read more...

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New Statin Guidelines are an Improvement, Study Shows

August 26, 2014 3:18 pm | News | Comments

New national guidelines can improve the way statin drugs are prescribed to patients at risk for cardiovascular disease, a study has found. Read more...                             

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FDA Approves Additional Promacta Indication

August 26, 2014 3:14 pm | News | Comments

GSK announced that the FDA has approved a supplemental New Drug Application for the once-daily use of Promacta (eltrombopag) in patients with severe aplastic anemia (SAA) who have had an insufficient response to immunosuppressive therapy (IST). Read more...

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Alkermes Launches Phase 1 Pain Treatment Study

August 26, 2014 3:08 pm | News | Comments

Alkermes plc announced the initiation of a Phase 1 clinical study of ALKS 7106, a proprietary, novel, oral, small-molecule drug candidate for the treatment of pain. Read more...                       

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Kite Pharma's Lymphoma Drug Excels in Trial

August 26, 2014 3:03 pm | News | Comments

Shares of Kite Pharma surged before markets opened Tuesday after the drug developer detailed promising results for its most advanced product, a potential treatment for an aggressive form of non-Hodgkin's lymphoma. Read more...       

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Pfizer, Merck to Explore Novel Anti-Cancer Combo

August 26, 2014 2:55 pm | News | Comments

Pfizer Inc. and Merck & Co. Inc. announced that they have entered into an agreement to explore the therapeutic potential of the combination of Pfizer’s crizotinib with Merck’s investigational anti-PD-1 antibody pembrolizumab. Read more...   

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Cancer-Fighting Drugs Might Also Stop Malaria Early

August 26, 2014 2:47 pm | News | Comments

Scientists searching for new drugs to fight malaria have identified a number of compounds- some of which are currently in clinical trials to treat cancer- that could add to the anti-malarial arsenal. Read more...            

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Drug Cured 16 of 16 Monkeys with Viral Ebola Relative

August 26, 2014 11:31 am | by Cynthia Fox, Science Editor | Articles | Comments

An experimental drug saved the lives of 16 of 16 monkeys with the Marburg virus, a killer near-indistinguishable from Ebola, just as symptoms broke out, said a new study. Read more...                   

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Cardiome, Eurolab Partner on Brinavess Distribution

August 26, 2014 11:00 am | News | Comments

Cardiome Pharma Corp. announced that its subsidiary, Correvio International Sàrl, has entered into an agreement with Eurolab Especialidades Medicinales de Eurofar S.R.L. to sell and distribute Brinavess exclusively in Argentina. Read more…    

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New Ebola Vaccine Study Delivers Promising Results

August 26, 2014 10:44 am | News | Comments

Immunovaccine Inc. announced positive results for a vaccine formulated in its DepoVax technology in an Ebola virus challenge study performed by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH). Read more...

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Protein Family Can Inhibit HIV Release

August 26, 2014 10:30 am | News | Comments

A family of proteins that promotes virus entry into cells also has the ability to block the release of HIV and other viruses, researchers have found. Read more...                         

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Avanir Launches Phase 2 MDD Drug Study

August 26, 2014 10:23 am | News | Comments

Avanir Pharmaceuticals Inc. announced the enrollment of the first patient into a Phase 2 study to evaluate the efficacy, safety and tolerability of AVP-786 for the adjunctive treatment of major depressive disorder (MDD). Read more...     

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US Health Official: Ebola Has 'Upper Hand'

August 26, 2014 10:14 am | by Jonathan Paye-Layleh | News | Comments

The Ebola virus has the "upper hand" in an outbreak that has killed more than 1,400 people in West Africa, a top American health official said, adding that experts have the tools to stop it. Read more...             

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U.S. Army Funds PTSD Treatment Trial

August 25, 2014 3:16 pm | News | Comments

NeuroSigma Inc. announced that the U.S. Department of the Army has funded a Phase 2 clinical trial at UCLA that will examine the use of external trigeminal nerve stimulation (eTNS) as treatment for PTSD. Read more...          

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Regado Biosciences Permanently Halts Phase 3 Trial

August 25, 2014 3:08 pm | News | Comments

Regado Biosciences Inc. announced the permanent termination of enrollment in its REGULATE-PCI Phase 3 trial for its lead program, Revolixys Kit. Read more...                           

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