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DDD Update

Daily news and top headlines for drug research professionals

Investigational Drug Could be Treatment for AML, Multiple Myeloma

September 23, 2014 1:57 pm | News | Comments

The investigational drug CX-5461 prolonged survival in mouse models of highly aggressive AML and multiple myeloma, according to data presented at the AACR special conference Hematologic Malignancies: Translating Discoveries to Novel Therapies. Read more...

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Clampdown on Tax Maneuver Leaves its Mark on Pharma

September 23, 2014 1:46 pm | News | Comments

A handful of big companies pursuing overseas mergers to lower their tax bills - including pharmaceutical company AbbVie - came under pressure Tuesday after the U.S. unveiled rules to discourage them. Read more...           

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TKIs May Improve Treatment for Ph-Like ALL

September 23, 2014 11:28 am | News | Comments

Tyrosine kinase inhibitors (TKIs) may improve treatment outcome for children and young adults with Ph-like acute lymphoblastic leukemia (Ph-like ALL), a disease with dismal prognosis, according to new data. Read more...         

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New Approach Aims to Silence Cancer 'Survival Genes'

September 23, 2014 11:20 am | News | Comments

Scientists are working on a promising new approach for tackling colorectal cancer, the second most common cause of cancer-related death. Read more...                             

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FDA Fast Tracks MedImmune’s Pneumonia Drug

September 23, 2014 11:07 am | News | Comments

AstraZeneca announced that its global biologics research and development arm, MedImmune, has received fast track designation from the FDA for its investigational monoclonal antibody MEDI3902 for the prevention of nosocomial pneumonia. Read more...

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New Awards Apply Sex, Gender Lens to NIH-Funded Research

September 23, 2014 10:57 am | News | Comments

The NIH has invested $10.1 million in supplemental funding to bolster the research of 82 grantees to explore the effects of sex in preclinical and clinical studies. Read more...                     

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Ebola Drug Trials to be Fast-Tracked in West Africa

September 23, 2014 10:48 am | News | Comments

Potential new treatments for Ebola are to be tested in West Africa for the first time as part of an international initiative to fast-track trials of the most promising drugs against the disease that has already led to over 2,600 deaths. Read more...

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WHO: 21,000 Ebola Cases by November if No Changes

September 23, 2014 10:33 am | by Maria Cheng, AP Medical Writer | News | Comments

New estimates from the WHO warn the number of Ebola cases could hit 21,000 in six weeks unless efforts to curb the outbreak are ramped up, according to an analysis published by the New England Journal of Medicine. Read more...       

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Pterostilbene Prevents Skin Damage from UV Exposure in Mouse Study

September 22, 2014 4:04 pm | News | Comments

ChromaDex Corp. announced the completion of an animal skincare study of pterostilbene by researchers at The University of California Irvine (UCI). Read more...                          

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Metformin Linked to Risk of Low Levels of Thyroid Hormone

September 22, 2014 4:03 pm | News | Comments

Metformin, a commonly used drug for treating type 2 diabetes, is linked to an increased risk of low thyroid-stimulating hormone (TSH) levels in patients with underactive thyroids (hypothyroidism), according to a new study. Read more...      

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New Chip Promising for Tumor-Targeting Research

September 22, 2014 3:59 pm | News | Comments

Researchers have developed a chip capable of simulating a tumor's "microenvironment" and plan to use the new system to test the effectiveness of nanoparticles and drugs that target cancer. Read more...              

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Battling Superbugs

September 22, 2014 3:57 pm | News | Comments

Engineers have turned a powerful new weapon on superbugs. Using a gene-editing system that can disable any target gene, they have shown that they can selectively kill bacteria carrying harmful genes that confer antibiotic resistance or cause disease. Read more...

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Amgen Submits BLA for Investigational Cancer Immunotherapy

September 22, 2014 3:54 pm | News | Comments

Amgen announced submission of a Biologics License Application (BLA) to the FDA seeking approval for its investigational bispecific T cell engager (BiTE) antibody construct, blinatumomab. Read more...                

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Tekmira’s Ebola Drug Gets Regulatory Framework

September 22, 2014 2:56 pm | News | Comments

Tekmira Pharmaceuticals Corp. announced that the FDA has authorized Tekmira to provide TKM-Ebola for treatment under expanded access protocols to subjects with confirmed or suspected Ebola virus infections. Read more...          

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Researchers Describe New Cancer Drug Target Involving Lipid Chemical Messengers

September 22, 2014 10:11 am | News | Comments

More than half of human cancers have abnormally upregulated chemical signals related to lipid metabolism, yet how these signals are controlled during tumor formation is not fully understood. Researchers are reporting that TIPE3, a newly described oncogenic protein, promotes cancer by targeting these pathways. Read more...

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