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DDD Update

Daily news and top headlines for drug research professionals

Scientists Trap, Kill Malaria Parasite

July 17, 2014 10:45 am | by Michael C. Purdy | News | Comments

Scientists may be able to entomb the malaria parasite, Plasmodium falciparum, in a prison of its own making, researchers at Washington University School of Medicine in St. Louis report in Nature, which in another story highlights the importance of a pore to the parasite’s survival. Read more...

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Reoviruses: The Discovery of Their Potential in Cancer Therapeutics

July 17, 2014 10:23 am | by Brad Thompson, Ph.D., President and Chief Executive Officer of Oncolytics Biotech | Articles | Comments

Reoviruses - first isolated in 1951 - are benign viruses with an important property: they are oncolytic, meaning they are capable of infecting and destroying many kinds of cancer cells. The story of how this discovery was made is an exciting one. Read more...

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FDA Grants QIDP Designation to Astellas Candidiasis Treatment

July 16, 2014 1:35 pm | News | Comments

Astellas announced that the U.S. Food and Drug Administration (FDA) designated isavuconazole as a Qualified Infectious Disease Product (QIDP) for the treatment of invasive candidiasis. Read more...               

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Isis Earns $1M from GSK for Advancing ISIS-TTR Rx

July 16, 2014 1:21 pm | News | Comments

Isis Pharmaceuticals Inc. announced that it has earned a $1 million milestone payment from GSK, related to the advancement of the Phase 2/3 study of ISIS-TTRRx in patients with familial amyloid polyneuropathy. Read more...        

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Pfizer to Acquire InnoPharma for $225M

July 16, 2014 1:07 pm | News | Comments

Pfizer Inc. and InnoPharma Inc., a privately held pharmaceutical development company, announced that they have entered into an agreement under which Pfizer will acquire InnoPharma. Read more...                 

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New Brain Protein Tied to Alzheimer's Disease

July 16, 2014 1:01 pm | by Marilynn Marchione, AP Chief Medical Writer | News | Comments

Scientists have linked a new protein to Alzheimer's disease, which could give a new target for developing drugs and other treatments for Alzheimer's, the most common form of dementia. Read more...                

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Genentech Alzheimer's Drug Misses Goals in Studies

July 16, 2014 12:27 pm | by Marilynn Marchione, AP Chief Medical Writer | News | Comments

An experimental drug from the biotech company Genentech failed to slow mental decline in mid-stage studies on more than 500 people with mild to moderate Alzheimer's disease, but showed some promise in the least-impaired participants who received a higher dose. Read more...

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Arena Gets U.S. Cannabinoid Receptor Modulator Patent

July 16, 2014 11:14 am | News | Comments

Arena Pharmaceuticals Inc. announced that it was granted U.S. Patent No. 8,778,950, entitled "Cannabinoid Receptor Modulators," by the United States Patent and Trademark Office for APD371, an agonist of the cannabinoid receptor 2 (CB2). Read more...

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Novartis, Banner Alzheimer's Institute to Study Disease Prevention

July 16, 2014 11:10 am | News | Comments

Novartis announced a collaboration with Banner Alzheimer's Institute on a pioneering clinical study in Alzheimer's disease prevention that will determine whether two Novartis investigational anti-amyloid treatments can prevent or delay the emergence of symptoms of AD. Read more...

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Pfizer Posts Positive Phase 3 Results for Hemophilia Drug

July 16, 2014 11:03 am | News | Comments

Pfizer Inc. announced the positive results of a Phase 3 study comparing a prophylaxis regimen of BeneFix Coagulation Factor IX (Recombinant) 100 IU/kg once-weekly to on-demand treatment in people with moderately severe to severe hemophilia B. Read more...

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Lilly, Immunocore Collaborate on Cancer Immunotherapies

July 16, 2014 10:59 am | News | Comments

Eli Lilly and Company and Immunocore Ltd. announced they have entered into a co-discovery and co-development collaboration to research and potentially develop novel T cell-based cancer therapies using Immunocore's Immune Mobilizing Monoclonal T-Cell Receptor Against Cancer technology. Read more...

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International Conference Advances Alzheimer’s Research

July 16, 2014 10:53 am | News | Comments

Results from four research studies reported as "developing topics" at the Alzheimer's Association International Conference 2014 include significant advances in evidence regarding treatment and early detection of Alzheimer's disease and dementia, as well as new ideas in the basic brain science of dementia that may lead to new diagnostic and treatment targets. Read more...

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Scientists Apply “Game Theory” to Cancer Research

July 16, 2014 10:47 am | News | Comments

Cancer’s no game, but researchers at Johns Hopkins are borrowing ideas from evolutionary game theory to learn how cells cooperate within a tumor to gather energy, so that they can identify the ideal time to disrupt metastatic cancer cell cooperation and make a tumor more vulnerable to anti-cancer drugs. Read more...

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Abbott 2Q Revenue Up

July 16, 2014 10:25 am | by The Associated Press | News | Comments

Abbott Laboratories (ABT) said Wednesday that its second-quarter profit declined 2.1%, hampered by higher taxes. Adjusted profit and revenue topped Wall Street expectations, however, and the company boosted its full-year earnings forecast. Read more...

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Avastin Gets Priority Review for Certain Types of Cervical Cancer

July 15, 2014 3:12 pm | News | Comments

Genentech announced that the FDA has accepted the company's supplemental Biologics License Application and granted Priority Review for Avastin plus chemotherapy for the treatment of women with persistent, recurrent or metastatic cervical cancer. Read more...

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