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Japan Starts World-First Stem Cell Trial, Plans More

October 2, 2014 | by Cynthia Fox, Science Editor | Comments

The first patient has been treated, by Japan’s Riken Institute, in the world’s first clinical study of stem cells made from ordinary mature cells. The cells were retinal pigment epithelial (RPE) cells, but they began as a macular-degeneration patient’s skin cells.

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DDD Update

Daily news and top headlines for drug research professionals

ESMO: Cancer Immunotherapy on the Road

October 29, 2014 12:20 pm | by Neil Canavan | Comments

Since cancer immunotherapy was declared the Breakthrough of the Year in 2013 by Science magazine the field has been on fire, and its relatively few experts have been on the run– explaining the nascent technology and related data to oncologists at venues from the April meeting of AACR in San Diego, to the June meeting of ASCO in Chicago, to the September meeting of ESMO in Madrid.  Read more...

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Monitoring Lipid, Detergent Content in Biological Samples Using IR-Based Spectrometry

October 27, 2014 4:01 pm | by Chandreyee Das, Ph.D., Senior Technical Writer, Protein Detection, EMD Millipore | Comments

Many biological samples in the course of drug development research are rich in lipid content, such as adipose tissue homogenates, brain and liver tissue extracts, lipemic samples and breast milk. Read more...

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Embryonic Stem Cells in Trial for Diabetes

October 20, 2014 4:08 pm | by Cynthia Fox, Science Editor | Comments

As San Diego’s ViaCyte was in the midst of launching the first FDA-approved embryonic stem (ES) cell clinical trial for diabetes last week, Boston’s Harvard University reported that beta cells from ES cells “cured” diabetic mouse-models. Read more...

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A Novel Approach to Alzheimer’s Disease

October 17, 2014 9:57 am | by Daniel L. Alkon, M.D.,Chief Scientific Officer, Neurotrope Inc. and Toyota Chair in Neurodegenerative Disease, Scientific Director and Professor, Blanchette Rockefeller Neurosciences Institute | Comments

Alzheimer's disease (AD) afflicts more than 5 million people in the U.S. and 40 million worldwide, generating annual healthcare costs that exceed $200 billion in the U.S. and $600 billion globally. By 2050, AD is expected to strike more than 115 million patients per year, according to the Alzheimer’s Association. Read more...

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FDA Fast Tracks Approval of Two ‘Historic’ IPF Drugs

October 16, 2014 4:22 pm | by Cynthia Fox, Science Editor | Comments

Two historic drugs for idiopathic pulmonary fibrosis (IPF) received “fast track, priority review, orphan product, and breakthrough designation” approval Wednesday from the Food and Drug Administration (FDA). Read more...

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Targeted Payload Therapies Using RIT Hit the Right Marks

October 13, 2014 4:50 pm | by Dragan Cicic, M.D., MBA, Chief Operating Officer and Chief Medical Officer, Actinium Pharmaceuticals | Comments

For patients with acute myeloid leukemia (AML), there is both good news and bad news – the good news is that standard induction therapy, using cytarabine and an anthracycline, produces complete responses in half to almost three-quarters of cases. The bad news? Read more...

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Shaping the Future of Immunotherapy: Four Trends to Watch

October 10, 2014 8:30 am | by Merrilyn Datta, Ph.D., Chief Commercial Officer, Definiens | Comments

Just four years after the drug sipuleucel-T was approved for clinical adoption, the field of immunotherapy is on the cusp of a number of exciting advancements. Read more...                           

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Drug Cured 16 of 16 Monkeys with Viral Ebola Relative

October 8, 2014 11:31 am | by Cynthia Fox, Science Editor | Comments

An experimental drug saved the lives of 16 of 16 monkeys with the Marburg virus, a killer near-indistinguishable from Ebola, just as symptoms broke out, said a new study. Read more...                   

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Advances in Protein Detection and Quantitation Methods

October 7, 2014 8:30 am | by Nuno Goncalves, Manager of Novel Biomolecular Detection, EMD Millipore | Comments

Protein detection and quantitation is required daily in thousands of laboratories worldwide for activities ranging from protein characterization to clinical diagnostic testing to drug dosing. Read more...                

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Potential Therapy Spotted for Sudan Strain of Ebola

October 3, 2014 11:04 am | by Stephanie Guzowski, Editor | Comments

As the deadly Ebola outbreak in West Africa continues to grip headlines around the world, researchers move steadily forward with drug development. But as essential as it is to contain the current Ebola outbreak, researchers are looking at the bigger picture— and highlighting the need for therapy development to extend beyond the wake of the current epidemic. Read more...

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Two Anti-Ebola Vaccines in Historic Race

September 11, 2014 2:41 pm | by Cynthia Fox, Science Editor | Comments

One of the most rapidly fast-tracked vaccines in history— an anti-Ebola “ChAd3” vaccine— just started clinical trial in humans, and may be done as soon as November. But a second fast-tracked anti-Ebola vaccine— called an “rVSV” vaccine— is hot on its heels. Read more...

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New Extractor Optimized for Processing Medicinal Marijuana

September 9, 2014 9:30 am | by Dr. Kenneth James, Supercritical Fluid Technologies, Inc. | Comments

The need for pharmaceutical grade cannabis oil has increased as researchers continue to investigate its use for the treatment of various ailments such as muscle spasms, glaucoma, nausea, mood and behavioral disorders, sleep disorders and chronic pain. Read more...

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How Outsourcing Can Accelerate the Drug Development Process

September 4, 2014 10:36 am | by Matthew Weinberg, CEO, The Weinberg Group | Comments

Outsourcing is an old concept in the healthcare industry that has recently been applied to a new area: regulatory affairs. Traditionally conducted in-house, regulatory affairs is extremely critical to a product’s success. For certain companies, this entire function can and should be outsourced in its entirety, not just for discrete projects. Read more...

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ZMapp: Best Anti-Ebola Drug Yet

September 3, 2014 10:15 am | by Cynthia Fox, Science Editor | Comments

ZMapp, the experimental drug that may have already have saved a few patients in Africa, is the most effective anti-Ebola therapy yet, according to a recent Nature paper on rhesus macaques monkeys. Read more...           

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Accelerate Drug Development with Optimized Content Management

August 29, 2014 8:30 am | by Steve Scribner, Principal Consultant – Life Sciences, EMC Information Intelligence Group | Comments

Getting a new drug from the laboratory to the pharmacy takes years of testing, applications and information sharing. One way to shorten the drug development life cycle is to optimize content management. Read more...          

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