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Promising Malaria and Dengue Vaccines Will Not Defeat Diseases

May 20, 2015 | by Christopher J. Pace, Ph.D., GlobalData Managing Analyst, Infectious Diseases | Comments

Some industry pundits rightfully question the modest protective efficacies of CYD-TDV and RTS,S/AS01. Read more...

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Optimizing Safety Surveillance During Clinical Trials Using Data Visualization Tools

October 6, 2015 10:23 am | by Laura McKain, M.D., Medical Director, Pharmacovigilance; Tammy Jackson, Director, Preclarus Development, Clinical Innovation; Cindy Elko-Simms, M.D., Vice President, Pharmacovigilance, of PPD | Comments

Pharmaceutical companies must continuously monitor the safety of investigational products in development for adverse events that may be unexpected, occur at an increased frequency or severity, or result in an unexpected outcome. Ongoing safety signal detection leads to optimal patient protection and is essential to obtaining regulatory approval. Read more...


“Shocking” JAMA Studies Offer Key to Grasping Science Gender Inequities

October 2, 2015 10:00 am | by Cynthia Fox, Science Editor | Comments

Two JAMA studies on female scientists and bias are eliciting stunned reactions. One JAMA study, which found women launching labs receive almost three times less funding than men,was “totally shocking” to Massachusetts Institute of Technology (MIT) emeritus professor Nancy Hopkins, M.D., she told Drug Discovery & Development.  Hopkins was uninvolved in that study. Read more...


How Technology is Transforming Personalized Medicine

September 30, 2015 9:17 am | by Troy Moore, chief scientific officer of Kailos Genetics | Comments

These are exciting times. Every day science and technology advancements offer new insights into the mechanics of human genetics. Maybe more importantly, the space is also rapidly evolving ways to use that information to deliver personalized medicine. Over the next decade, scientists likely will focus on deeply sequencing parts of the genome that prove to have a high degree of clinical utility. Read more...


Best Data Yet Show Fewer Seniors Get Flu When Others Vaccinate

September 30, 2015 9:06 am | by Cynthia Fox, Science Editor | Comments

The elderly are 21 percent less likely to get the flu if younger neighbors (aged 18 to 64) are vaccinated, according to a large and well-designed observational study. Read more...


Five “Scientist Artists” Paint Exciting Future for Cancer Research

September 25, 2015 9:12 am | by Cynthia Fox, Science Editor | Comments

At a recent New York Academy of Science (NYAS) panel, five leading "scientist artists” as they were called by NYAS moderator Brooke Grindlinger discussed the not-too-distant future of cancer research, painting a world where current technologies will be leveraged to the point where most cancers will be captured in the earliest pre-cancer stages, routinely at annual physicals, via a simple blood test. Read more...


We Need a New Golden Age of Antibiotics

September 24, 2015 9:43 am | by Alice Erwin, microbiologist, and scientific consultant with InnovaTID | Comments

In the race between resistant bacteria and the drugs that can treat them, humanity is losing ground.  Antibiotics are rapidly losing their effectiveness as microbes evolve to resist them. As the United Kingdom’s Chief Medical Officer Professor Dame Sally Davies has said, “We have reached a critical point and must act now on a global scale to slow down antimicrobial resistance.” Read more...


Clinical Need for Diabetic Kidney Disease Treatment Options

September 17, 2015 9:29 am | by James F. List, M.D., Ph.D., Global Therapeutic Area Head of Cardiovascular & Metabolism (CVM) at Janssen Research & Development | Comments

The skyrocketing global incidence of type 2 diabetes mellitus (T2DM) has created a clinical need and developmental opportunity to better address the growing impact of diabetic kidney disease, or kidney damage caused by diabetes, on the patient community and health care system. Read more...


“Cured” Breast Cancer Patients With Tumor DNA in Blood: 12 Times Likelier to Relapse

September 8, 2015 10:22 am | by Cynthia Fox, Science Editor | Comments

A highly accurate blood test, which fishes the blood of breast cancer patients for circulating tumor DNA fragments, appears to predict who will relapse, according to a new prospective study in Science Translational Medicine. Read more...


Computing Power vs. Usability – If They Don’t Use It, It’s Not Useful

August 27, 2015 10:04 am | by Trish Meek, Director of Product Strategy, Thermo Fisher Scientific | Comments

Since information technology first went mainstream in laboratories decades ago, many believe that the primary limiting factor on its value has been raw computing power. In the past several years, however, cloud computing and the availability of infrastructure-as-a-service (IaaS), for example, have lowered the cost of computing power so much so that bandwidth and database size are considered commodities. Read more...


Molecular Imaging and its Impact on Drug Development

August 17, 2015 10:44 am | by Dustin Kentala, Associate Study Director in Molecular Imaging, MPI Research | Comments

With the success rates in clinical development from Phase 2 to 3 at 39 percent, preclinical and clinical development teams are implementing alternatives to traditional paradigms to improve efficiency, success, and reduce cost. Read more...


Schizophrenia and Omega-3 Supplement Study Has “Enormous Potential,” Says NIMH Director

August 14, 2015 9:47 am | by Cynthia Fox, Science Editor | Comments

A mere 12 weeks of taking omega-3 fish oil capsules can ward off schizophrenia and other psychoses in at-risk children for 6.7 years, suggests a new Nature Communications paper. Of 41 at-risk young people taking three months of omega-3 supplements, most not only did not show severe functional impairment, but no longer experienced warning signs of psychosis, nearly seven years later. Read more...


Patient-Reported Outcomes in Cancer Drug Development

August 13, 2015 11:34 am | by Stephanie Guzowski, Editor | Comments

When it comes to balancing the risks with the benefits of a drug, it’s vital to have the full picture of a patient’s treatment experience. In an effort to give patients a stronger voice, researchers have created and implemented a system to enable patients to directly report their symptoms during cancer drug development, according to a study published in JAMA Oncology. Read more...


A Single Germline Stem Cell “Switch” May be Anti-Aging Drug Target

August 11, 2015 3:50 pm | by Cynthia Fox, Science Editor | Comments

Aging is not gradual in the C. elegans roundworm. It begins suddenly at reproductive maturity (or roundworm puberty), according to a provocative new study in Molecular Cell by a Northwestern University team. Read more...


Vitamin Supplement May Prolong Onset of Psychosis

August 11, 2015 11:00 am | by Ryan Bushey, Associate Editor | Comments

Results from this study were published today in the journal Nature Communications. Read more...


Searching for a Functional Cure for HIV

August 6, 2015 10:11 am | by Lindsay Hock, Editor | Comments

In 2014, more than 1.2 million people in the U.S. were noted by the Centers for Disease Control and Prevention (CDC) as living with HIV infection. Almost one in eight, or 12.8 percent, are unaware of their infection. The CDC estimates that 1,218,400 person aged 13 and older are living with HIV infection, including 156,300 who are unaware of their infection. Read more...



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