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Stem Cell Prompting Deadly Fibrosis Found

December 17, 2014 | by Cynthia Fox, Science Writer | Comments

Some 45% of deaths are caused by fibrosis (scar tissue) diseases, including idiopathic pulmonary fibrosis, cirrhosis, and heart and kidney failure. But a Harvard University group reports in Cell Stem Cell they have discovered a key cause of that fibrosis: a stem-cell-like perivascular cell called Gli1+, found in blood vessels. Read more...

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DDD Update

Daily news and top headlines for drug research professionals

Meet The Newest Surgeon General

December 19, 2014 12:37 pm | by Ryan Bushey, Associate Editor | Comments

President Obama's pick for the position turned out to be controversial. Read more...                              

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10 Up-and-Coming Healthcare Medical Innovations

December 18, 2014 12:10 pm | by Christina Jakubowski, Managing Editor, Bioscience Technology | Comments

The Cleveland Clinic recently unveiled their annual Top 10 Medical Innovations for 2015– a list that casts an optimistic light on up-and-coming healthcare advances that may reach consumers next year. Their number one? Read more...                         

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Emerging Markets Gain New Prominence as Innovation, Development Hotspots

December 17, 2014 12:52 pm | by Roger Humphrey, Executive Managing Director, Life Sciences Americas, JLL | Comments

Patent origin location has become the latest way patent applications can inform business strategy, and recent analysis shows where innovation hubs are on the rise. The United States and Europe have enjoyed long deep-seated roots as the leaders of high-value aspects of the biopharmaceutical development cycle, such as new product research and development (R&D). Read more...

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Women in Cell Biology Award Winners Announced at ASCB Meeting

December 15, 2014 4:47 pm | by Stephanie Guzowski, Editor | Comments

Three exceptional women were given awards for their achievements and contributions to the scientific community at the 2014 ASCB (American Society for Cell Biology) meeting recently held in Philadelphia, Pa. Read more...                               

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Supporting Drug Development Process with Raman Spectroscopy

December 11, 2014 11:25 am | by Kathleen A. Martin, Ph.D., Senior Research Chemist, McCrone Associates, Inc. | Comments

Raman spectroscopy has steadily gained a wider role in the pharmaceutical industry because of its applicability to several important aspects of drug development and manufacturing. Read more...                         

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Journal Watch: Tamoxifen in the News Again

December 8, 2014 11:57 am | by Drug Discovery & Development Staff | Comments

Tamoxifen, the leading estrogen blocker, has done so well by hormone receptor-positive breast cancer patients that the American Society for Clinical Oncology (ASCO) changed its guidelines this year, advising certain patients to take the drug for ten years instead of five. Read more...

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Building Personalized Approaches to Patient Care

December 5, 2014 9:43 am | by Jonathan Sheldon, PhD, global vice president, Oracle Health Sciences | Comments

With the evolution of electronic medical records (EMR) systems, and the integration of genomic data with multi-dimensional longitudinal clinical data, the opportunity is rife to build truly personalized approaches to patient care. 

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Predicting Alzheimer’s Disease With Blood Tests: Early Detection, Ethical Concerns

December 2, 2014 9:52 am | by Stephanie Guzowski, Editor | Comments

If you could take a blood test that could detect — with nearly 100% accuracy — whether you were genetically destined to get Alzheimer’s disease, would you take that test? Read more...

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Cloning Pioneer Proposes Global Network of IPS Cell Banks

November 28, 2014 9:55 am | by Cynthia Fox, Science Editor | Comments

Ian Wilmut, father of the cloned Dolly the Sheep, is now proposing to father a global induced pluripotent stem (iPS) cell handbook— to go with a proposed new global network of iPS cell haplobanks. Read more...                                   

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The Cystic Fibrosis Foundation's Controversial New Cash

November 26, 2014 12:00 pm | by Ryan Bushey, Associate Editor | Comments

Concerns have been raised relating to a lucrative investment the Cystic Fibrosis Foundation made in a biotechnology company. Read more...                    

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Exciting Gains in Fighting Breast Cancer Hormone-Therapy Resistance

November 25, 2014 8:55 am | by Cynthia Fox, Science Editor | Comments

Guided by breakthrough research on the Estrogen Receptor 1 (ESR1) gene, many researchers and pharmaceutical companies are in hot pursuit of the next big anti-resistance breast cancer drug. Read more...                 

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Researchers Seek New Regulations for Digital Pharma Marketing

November 24, 2014 2:22 pm | by Ryan Bushey, Associate Editor | Comments

The researchers feel that the current policies for pharmaceutical marketing need to be updated as soon as possible. Read more...                      

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Beta-Blockers Show No Survival Benefits After Heart Attack

November 21, 2014 8:48 am | by Drug Discovery & Development Staff | Comments

Beta blockers offer no survival advantages to patients, post-heart attack, but they do improve survival among some heart failure patients. Read more...                                                          

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Mental Health Problems Increase Heart Disease Risk

November 20, 2014 9:42 am | by Cynthia Fox, Science Editor | Comments

People with mental health problems are “significantly” more likely to have stroke or heart disease, according to a study unveiled at a recent Canadian Cardiovascular Congress. Read more...

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Maximizing the Power of Preclinical Cancer Research Tools

November 19, 2014 11:29 am | by Guizhong Liu, Senior Director of Cancer Biology, Crown Bioscience Inc. | Comments

Drug discovery is a protracted and uncertain process that needs to overcome many hurdles during preclinical and clinical development before it finally achieves regulatory approval for patient treatment. For every drug that reaches the marketplace, well over 100 have been abandoned at some point in their development. Read more...

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