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DDD Update

Daily news and top headlines for drug research professionals

Mental Health Problems Increase Heart Disease Risk

November 20, 2014 9:42 am | by Cynthia Fox, Science Editor | Comments

People with mental health problems are “significantly” more likely to have stroke or heart disease, according to a study unveiled at a recent Canadian Cardiovascular Congress. Read more...

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Maximizing the Power of Preclinical Cancer Research Tools

November 19, 2014 11:29 am | by Guizhong Liu, Senior Director of Cancer Biology, Crown Bioscience Inc. | Comments

Drug discovery is a protracted and uncertain process that needs to overcome many hurdles during preclinical and clinical development before it finally achieves regulatory approval for patient treatment. For every drug that reaches the marketplace, well over 100 have been abandoned at some point in their development. Read more...

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Society for Neuroscience Annual Meeting Showcases Strides in Exploring the Brain

November 18, 2014 10:56 am | by Christina Jakubowski, Managing Editor, Bioscience Technology | Comments

More than 30,000 brain advocates from academia, industry and media converged on Washington, D.C. this week for the 44th annual meeting of the Society for Neuroscience (SfN). Read more...

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Journal Watch: Top 100 Cited Papers of All Time

November 18, 2014 9:52 am | by Drug Discovery & Development Staff | Comments

In honor of the SCI’s 50th anniversary, the journal Nature asked Thomson Reuters for the 100 most highly cited papers of all time.  Read more...                                  

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Glenn Beck's Health Struggle

November 14, 2014 12:53 pm | by Ryan Bushey, Associate Editor | Comments

The former Fox News anchor surprised his audience with some shocking news earlier this week. Read more...                          

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When Tobacco Saved Lives

November 13, 2014 10:21 am | by Skip Derra | Comments

Will ZMapp’s Ebola success force big pharma to take plant-based drugs seriously? Read more...                                                      

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The Odd Ouster of Sanofi's Former CEO

November 12, 2014 2:16 pm | by Ryan Bushey, Associate Editor | Comments

This high-flying pharma executive had his career derailed for a variety of surprising factors. Read more...                          

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Fighting HIV with Stem Cells and Cutting-edge Genetics

November 11, 2014 10:51 am | by Cynthia Fox, Science Editor | Comments

“Berlin Patient” Timothy Brown was cured of HIV after he received stem cells from a patient naturally immune to the disease. His story inspired two companies to try and recreate that natural immunity in HIV patients using stem cells and two (then-new) gene-editing techniques. Read more...

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Ebola Health Lessons: A Wake-up Call

November 6, 2014 12:02 pm | by Stephanie Guzowski, Editor | Comments

After months of delayed, fragmented responses, the international medical community recognized Ebola as a threat to global health security. Here’s where the situation stands today as well as questions raised and lessons learned. Read more… 

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Google's Next Business Venture: The Human Body

November 4, 2014 2:07 pm | by Ryan Bushey, Associate Editor | Comments

Google is working on a slew of ambitious projects that could drastically revolutionize healthcare as we know it. Read more...                       

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Using Real-World Data for Outcomes Research and Comparative Effectiveness Studies

November 4, 2014 10:17 am | by Christina Mack, Ph.D., MSPH, Associate Director, Epidemiology, Real-World & Late Phase Research, Quintiles, and Kathy Lang, Ph.D., Senior Director, Emerging Businesses Data & Analytics, Real-World & Late Phase Research, Quintiles | Comments

Biopharma is increasingly harnessing the power of data collected outside of a controlled clinical environment to generate valuable insights to support products throughout their lifecycle. Read more...

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Regulatory Data: Vital for DDI Risk-Mitigation Efforts

November 3, 2014 11:04 am | by Philip MacLaughlin, Product Director, PharmaPendium, Elsevier | Comments

Unanticipated adverse drug-drug interactions (DDIs) have led to the withdrawal of several high-profile drugs that had been available for a number of years, including terfenadine, astemizole, cisapride, grepafloxacin and mibefradil.  Read more... 

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Special Report: Many Stem Cell Clinical Trials for Macular Degeneration

October 31, 2014 11:22 am | by Cynthia Fox, Science Editor | Comments

The most potent stem cells are coming to patients after helping blind (and nearly blind) mice see for years. Read more...                                                                                

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ESMO: Cancer Immunotherapy on the Road

October 29, 2014 12:20 pm | by Neil Canavan | Comments

Since cancer immunotherapy was declared the Breakthrough of the Year in 2013 by Science magazine the field has been on fire, and its relatively few experts have been on the run– explaining the nascent technology and related data to oncologists at venues from the April meeting of AACR in San Diego, to the June meeting of ASCO in Chicago, to the September meeting of ESMO in Madrid.  Read more...

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Monitoring Lipid, Detergent Content in Biological Samples Using IR-Based Spectrometry

October 27, 2014 4:01 pm | by Chandreyee Das, Ph.D., Senior Technical Writer, Protein Detection, EMD Millipore | Comments

Many biological samples in the course of drug development research are rich in lipid content, such as adipose tissue homogenates, brain and liver tissue extracts, lipemic samples and breast milk. Read more...

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