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Structured Drug Design
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Designing a new drug can be faster and more economical when researchers incorporate computational approaches. Software packages let scientists explore more structural options and even make predictions of the properties of new compounds. continue
Mike May, Contributing Editor

A Hands-On Approach

To explore the three-dimensional structures of compounds, many researchers use the open-source PyMOL, which is maintained by Schrödinger. continue
Mike May, Contributing Editor

Integrating Informatics
Every drug discovery organization seeks to improve the speed and success of its research efforts. But advances in the field—including high throughput screening, in silico modeling, biotherapeutics, and more—present a double-edged sword. continue
Matt Hahn, PhD, Senior Vice President, Research and Development; Accelrys, San Diego, Calif.

Multiple Choices

Pharma companies migrate to high-content screening approaches to screen for kinase inhibitors. continue
James Netterwald, PhD, MT (ASCP), Contributing Editor

Probing Proteins for Structure

Advances in crystallography and resonance reveal shapes in great detail. continue
Mike May, PhD, Contributing Editor

Automating Multiparametric Cell Analysis
New automated analysis software for benchtop flow cytometry systems allows researchers to conduct multiparametric cell analysis, regardless of their level of expertise or access to a core facility. continue
Jason Whalley, Flow Cytometry Manager Millipore Corporation, Billerica, Mass.

Aiming Antibodies at Cancer Research
In cancer research, antibodies provide an ever-expanding collection of tools that can be used in various ways, such as characterizing a drug target. continue
Mike May, PhD, Contributing Editor

Tax Credit Opportunity in Healthcare Reform Bill

Buried in the recently enacted Patient Protection and Affordable Care Act of 2010 is a significant tax benefit for small- and mid-sized biotech, pharmaceutical, and medical device companies. continue
William H. Kitchens

Building a Better Assay
A CRO demonstrates a new approach for an equilibrium protein binding LC-MS/MS assay. continue
Dahai Dong, Senior Scientist; Mike Koleto, Senior Scientist; Rohan A. Thakur, Associate Director; Richard LeLacheur, Vice President; Christopher Kemper, Business Director, Taylor Technology Inc., Princeton, N.J.

Enrich, Preserve, and Screen Low-Level Biomarkers
Biomarkers for early disease detection and therapeutic development are in high demand. However, the discovery process is hindered by several complex challenges. continue
Scott A. Kuzdzal, PhD, Life Sciences Business Leader, Shimadzu Scientific Instruments, Columbia, Md.

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Study Demonstrates Benefits of Cannabis for Pain

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Berries Activate Brain's Housekeeping Mechanism

Obama Stem Cell Regulations Temporarily Blocked

More Problems At J&J Subsidiary

Abnormal Weight A Colon Cancer Risk Factor

A Novel Approach to Treating Peripheral Arterial Disease

Japan Confirms Presence of Superbug Gene

NIH Finds Promising Staph Treatment

FDA Approves Tekamlo