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Tue, 03/31/2009 - 7:48am
     

A rotating three-dimensional view of an HIV infected T cell (green) forming virological synapses with three healthy CD4+ cells (red). Viral structural protein, Gag, shown in green accumulates in button shaped structures at the contact sites.
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High speed imaging of HIV transfer across a virological synapse. Movie begins with a still view of two T cells with transmitted light and an outline of a spot where a synaptic button has formed between them. The movie then shows the movement of fluorescent viral protein into the synaptic button, followed by transfer of material from the button into the target cells. Note the movie focuses on the movement of the viral protein without indicating the outlines of the recipient cell. Elapsed time is depicted in minutes:seconds.
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