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Drug Discovery & Development  
 
DNA of Fatal Attraction Star Sequenced
Illumina, Inc. has sequenced the DNA of American actress Glenn Close, the first publicly named female to have her DNA sequenced to full coverage. ...continue

Pfizer Discontinues Cancer Drug Study
Pfizer Inc. said it discontinued a late-stage study of the drug candidate figitumumab in patients with late-stage lung cancer, citing a lack of effectiveness. ...continue

Democrats Facing Tough Choices in Health Care Debate
Top Democrats say they are resolving disputes over President Barack Obama's health overhaul plan, but they face decisions on subsidizing coverage and are still hunting votes to push the vast package through Congress. ...continue

PhRMA Spends $6.3M Lobbying in 4Q
The pharmaceutical industry's main trade group spent $6.3 million in the fourth quarter lobbying Congress, the White House and multiple government agencies on health care provisions and related issues, according to a quarterly disclosure report. ...continue

Walgreen In Talks To Directly Supply Drugs to Delta
Media reports indicated drugstore chain Walgreen Co. is in talks about a plan to offer prescription drugs directly to employees of Delta Air Lines Inc. ...continue

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Fume Hood
fumeThermo Fisher Scientific Inc., a leader in serving science, has introduced new lines to its Thermo Scientific Hamilton Infinity and Advantage Fume Hoods. ...continue

Flow Cytometer
BD Biosciences, a segment of BD, announced the launch of the BD FACSAria III Cell Sorting System, a next-generation flow cytometer with the ability to run complex multicolor experiments using up to six lasers. ...continue

TIRF Objective
tirfOlympus, a leader in objective-based total internal reflection fluorescence (TIRF) microscopy, continues to support scientists with three new high-performance TIRF objectives. ...continue

Precast Gels
Bio-Rad Laboratories, Inc. has launched Mini-PROTEAN TGX (Tris-Glycine eXtended) precast gels, providing researchers with the fastest running, long shelf life precast gels on the market for protein electrophoresis using the standard Laemmli buffer system. ...continue

Knockout Rat Models
Sigma Life Science extended its portfolio of knockout rat models with the announcement of a new suite of models designed to facilitate more predictive absorption, distribution, metabolism, excretion and toxicity (ADME/Tox) studies. ...continue

More New Technologies

FDA Approves Rituxan for CLL
The U.S. Food and Drug Administration approved Rituxan (rituximab) to treat certain patients with chronic lymphocytic leukemia (CLL), a slowly progressing blood and bone marrow cancer. ...continue

Tasigna Recieving Priority Review
Novartis AG said its leukemia drug candidate Tasigna received priority review by the Food and Drug Administration. ...continue

Researchers Target Self-Cannibalizing Cancer Cells
A team of scientists from Princeton University and The Cancer Institute of New Jersey has embarked on a major new project to unravel the secret lives of cancer cells that go dormant and self-cannibalize to survive periods of stress. ...continue

More Advances in Cancer Research

White Papers
Developing, executing and managing the transformation, analysis and submission of clinical research data with SAS® Drug Development
“The medical product development process is no longer able to keep pace with basic scientific innovation.”  Those are harsh words, especially coming from the U.S. Food and Drug Administration (Challenge and Opportunity on the Critical Path for New Medical Products, FDA, March 2004).  Discovery organizations are identifying a lot of promising compounds, but clinical research processes haven’t kept pace with timely testing of all those potential therapies.  The FDA’s Critical Path Initiative makes it clear—it is time for innovation. ...continue

Rotavirus: Multiple Serotypes and the Argument for Rotavirus Vaccination
National pediatric infectious disease experts address the latest scientific information available on rotavirus. ...continue

Peristaltic versus Piston Pumps for Biopharmaceutical Dispensing
Peristaltic versus Piston Pumps for Biopharmaceutical Dispensing, Watson-Warlow Flexicon Peristaltic pump design innovations have been developed to dispense injectable drugs, reducing cost of bringing new drugs to market. The pumps can can the way products are mass-produced. Read more of this white paper. ...continue

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Target: Teamwork
JanFebCovSuccessful marriages between drug developers and technology providers are changing the landscape of GPCR-targeted pharmaceuticals. Such partnerships offer a range of benefits to all parties involved, including expertise, services, and exchange of technology. ...continue

    Drug Discovery

    Drug Development

    Genomics & Proteomics

    Policy & Projections

    Technology Advances

Albemarle Announces Custom Manufacturing Alliance with PharmaCore
Albemarle Corporation will partner with PharmaCore to provide manufacturing capabilities for customers with projects that require high volume capacity. ...continue

Inhaled Product Testing
Copley InstrumentsCopley Scientific will introduce the DUSA shaker, which automates the rinsing of DUSA collection tubes, enhancing the reproducibility of drug recovery, especially for low solubility formulations. ...continue

Density and Refractive Index Meters
Mettler Toledo LiquiPhysicsMettler Toledo launched the LiquiPhysics Excellence instruments for density and refractive index determinations within the pharma industry. ...continue

Antimalarial Medicines Found to be Substandard
The first results from a large-scale study of key antimalarial medicines in ten Sub-Saharan African countries reveal that a high percentage of medicines circulating on national markets are of substandard quality. ...continue

Comparing Dispersion Techniques to Assess Particle Size
Malvern Instruments Morphologi G3Researchers from Solvay Pharmaceuticals Inc. have used the Morphologi G3 image analysis based particle characterization system from Malvern Instruments to examine an API manufactured at two different facilities to determine if they can be seen as equivalent. ...continue

Merck to Appoint Drug Safety Monitors to End Suits
Merck & Co. has agreed to settle Vioxx-related lawsuits brought by shareholders who lost billions by appointing two committees and a chief medical officer to monitor drug safety and keep the company honest. ...continue

Inhaler Testing
The NGI cup coater is a new tool from Copley Scientific for use in semi-automated inhaler product testing. ...continue

More Technology Spotlight

Variable Blood Pressure A Warning Sign For Stroke
People with occasional spikes in their blood pressure could be at higher risk of having a stroke than those with regularly high blood pressure, new studies said. ...continue

PET Imaging of Tumor Proliferation
Positron emission tomography (PET) is an imaging technology that produces three-dimensional images of positron-emitting radioisotope distribution, typically after an intravenous injection of a radioisotope-labeled tracer. ...continue

Imaging Disease with Near-Infrared Fluorescent Probes
In vivo imaging has enormous potential for drug development, and optical imaging with fluorophore-labeled probes is a popular approach. ...continue

More How It Works


 

BLP25 Liposome Vaccine for Lung And Breast Cancer
blp25BLP25 Liposome Vaccine is an investigational therapeutic cancer vaccine currently being evaluated for the treatment of unresectable, stage III non-small cell lung cancer (NSCLC) and inoperable, locally advanced, recurrent, or metastatic breast cancer. ...continue

Integrin Inhibitors For Targeting Cancer
emdseronoCilengitide is the first in a new class of investigational targeted anti-cancer therapies—called integrin inhibitors—to reach Phase 3 development. ...continue

PET Imaging of Tumor Proliferation
Positron emission tomography (PET) is an imaging technology that produces three-dimensional images of positron-emitting radioisotope distribution, typically after an intravenous injection of a radioisotope-labeled tracer. ...continue

Imaging Disease with Near-Infrared Fluorescent Probes
In vivo imaging has enormous potential for drug development, and optical imaging with fluorophore-labeled probes is a popular approach. ...continue

Dynamic Dual-Gated Preclinical PET Imaging
siemensAs is common in all drug discovery and development projects, upon the identification of promising lead compounds, the next steps usually involve initial safety tests in animal subjects. ...continue

More Recommended Reading

Divestiture of MDS Pharma Services Completed
MDS Inc., announced the completion of the divestiture of the remaining MDS Pharma Services (Discovery through Phase IIa) operations to Ricerca Biosciences LLC. ...continue

Ricerca to Acquire Early-Stage Portion of MDS Pharma
Ricerca Biosciences, LLC, announced its execution of a purchase agreement to acquire the Discovery and Preclinical business of MDS Pharma Services with facilities in Bothell, Washington; Lyon, France; and Taipei, Taiwan. ...continue

PPD Opens Research Facility in Ireland
PPD, Inc. has officially opened its contract research facility in Athlone, Ireland, which includes an 18,000-square-foot analytical testing laboratory and clinical supplies business. ...continue

More CRO News

Pfizer Discontinues Cancer Drug Study
Pfizer Inc. said it discontinued a late-stage study of the drug candidate figitumumab in patients with late-stage lung cancer, citing a lack of effectiveness. ...continue

Sutent Falls Short in Studies
Pfizer Inc. said the cancer drug Sutent did not meet key goals in two late-stage studies focusing on advanced breast cancer. ...continue

FDA Approves Generic Eloxatin
Caraco Pharmaceutical Laboratories Ltd. said it launched a generic version of Sanofi-Aventis' cancer treatment Eloxatin. ...continue

More Drug Pipeline




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