Millipore Corporation released their AllostericProfiler service for use by researchers developing new drugs using G-protein coupled receptors (GPCRs). Increasingly, drug makers are focusing on novel allosteric GPCR sites to open up new chemical spaces. Allosteric GPCR binding sites modulate native ligand binding sites and are potentially more specific. Millipore’s AllostericProfiler service is the first to provide drug developers with cell-based assays to evaluate the functional selectivity of drugs against GPCRs.

The AllostericProfiler service allows researchers to screen the selectivity of their allosteric compounds for over 150 different GPCRs. Millipore can also provide custom services (AllostericScreener service) to help researchers identify new positive allosteric modulators for a GPCR target of interest.

By using a two-step addition protocol, the AllostericProfiler service detects both orthosteric compounds as well as allosteric modulators.

www.millipore.com

Published in Drug Discovery & Development magazine: Vol. 12, No. 6, June, 2009, p.34.