Waters Corporation introduced the Waters PATROL UPLC Process Analyzer, a real-time Process Analytical Technology (PAT) System able to detect and quantify complex multiple component manufacturing samples and final product on the production floor.

using the technology platform as Waters ACQUITY Ultra-Performance Liquid Chromatography (UPLC) System, PATROL UPLC moves existing liquid chromatography (LC) analysis from off-line Quality Control (QC) laboratories directly to the manufacturing stream resulting in significant improvements in production efficiency with real-time analysis, reducing both process cycle times and assuring product quality.

Waters is collaborating with several global pharmaceutical companies to quantify PATROL UPLC’s impact on the manufacturing process. A goal of real-time PAT is to produce more product with existing resources compared to a time-consuming, off-line QC process. Early analysis supports PATROL UPLC can enable process recovery increases during major manufacturing steps, virtually eliminating the need for any reprocessing, according to Waters.

Waters PATROL UPLC provides highly reproducible QC laboratory capabilities such as automated purity and yield results, automated sign-off, and real-time release. The system integrates and automates sample preparation capabilities, liquid chromatography instrumentation, a portfolio of column chemistries, process control communication interfaces, and chromatography data software.

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