A study shows long-term coffee consumption may be associated with a reduced risk for endometrial cancer, but it is emerging as a protective agent in cancers that are linked to obesity, estrogen and insulin.
“Coffee has already been shown to be protective against diabetes due to its effect on insulin,” says Edward Giovannucci, MD, ScD, professor of nutrition and epidemiology at the Harvard School of Public Health. “So we hypothesized that we’d see a reduction in some cancers as well.”
Giovannucci, along with Youjin Je, a doctoral candidate in his lab, and colleagues observed cumulative coffee intake in relation to endometrial cancer in 67,470 women who enrolled in the Nurses’ Health Study.
During the course of 26 years of follow-up, researchers documented 672 cases of endometrial cancer. Drinking more than four cups of coffee per day was linked with a 25% reduced risk for endometrial cancer. Drinking between two and three cups per day was linked with a 7% reduced risk.
A similar link was seen in decaffeinated coffee, where drinking more than two cups per day was linked with a 22% reduced risk for endometrial cancer. Giovannucci hopes this study will lead to further inquiries about the effect of coffee on cancer because in this and similar studies, coffee intake is self-selected and not randomized.
“Coffee has long been linked with smoking, and if you drink coffee and smoke, the positive effects of coffee are going to be more than outweighed by the negative effects of smoking,” says Giovannucci. “However, laboratory testing has found that coffee has much more antioxidants than most vegetables and fruits.”
The study was published in Cancer Epidemiology, Biomarkers & Prevention.
Release Date: Nov. 22, 2011
Source: Harvard School of Public Health