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Emulate to Commercialize Organs-on-Chips Platform

July 28, 2014 | Comments

Emulate Inc. announced the company’s launch with a $12 million Series A financing to commercialize a first-in-kind, automated ‘Organs-on-Chips’ platform that mimics human physiology and diseases, while permitting real-time elucidation of molecular mechanisms of action and toxicity. Read more...

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DDD Update

Daily news and top headlines for drug research professionals

FDA Rejects Zalviso Pain Treatment System

July 28, 2014 12:45 pm | Comments

AcelRx Pharmaceuticals Inc. announced that the FDA has issued a Complete Response Letter (CRL) for the company's NDA for Zalviso. The CRL contains requests for additional information on the system to ensure proper use of the device. Read more... 

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AstraZeneca, QIAGEN Collaborate on Iressa Diagnostic Test

July 28, 2014 12:38 pm | Comments

AstraZeneca announced that it has entered into a collaboration with Netherlands-based QIAGEN to develop a non-invasive diagnostic test to identify non-small cell lung cancer patients who are suitable for treatment with Iressa. Read more...    

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Scientists Discover New Mechanism of Drug Resistance

July 28, 2014 12:31 pm | Comments

Microorganisms can evade treatment by acquiring mutations in the genes targeted by antibiotics or antifungal drugs. Now, a new study has shown that microorganisms can use a temporary silencing of drug targets to gain the benefits of drug resistance without the commitment. Read more...

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Cancer Drug Shows Promise as Infertility Treatment

July 28, 2014 12:26 pm | Comments

Physicians may have a new drug to treat infertility in women with polycystic ovary syndrome, according to a national, multi-center clinical trial. Read more...                          

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HIV Inhibitor May Also Block Herpes Infection

July 28, 2014 12:19 pm | Comments

Creating a successful vaccine against two members of the herpes virus family, the sexually transmitted herpes simplex virus 1 (HSV-1) and 2 (HSV-2), has proven to be challenging. But now, a clinical trial, based on an HSV-2 vaccine, is being conducted. Read more...

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MedImmune Fights Pediatricians' New Advice

July 28, 2014 12:13 pm | by Lindsey Tanner, AP Medical Writer | Comments

A costly drug given mostly to premature babies is at the center of a clash between the manufacturer and the nation's leading pediatrician's group, which recommends scaling back use of the medicine. Read more...            

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AstraZeneca, Roche Collaborate on Companion Diagnostic Test

July 28, 2014 10:41 am | Comments

AstraZeneca announced it has entered into collaboration with Roche to develop a plasma-based companion diagnostic test to support AZD9291, AstraZeneca’s investigational compound in clinical development for non-small-cell lung cancer (NSCLC). Read more...

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COSMOS Results Published on World Hepatitis Day

July 28, 2014 10:35 am | Comments

Medivir AB announced that results from the phase 2 COSMOS clinical study were published in The Lancet, demonstrating that 92% of genotype 1 chronic hepatitis C virus adult patients treated with simeprevir in combination with sofosbuvir achieved sustained virologic response 12 weeks after the end of treatment. Read more...

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Panel Backs Extended Use of Allergan's DME Treatment

July 25, 2014 2:53 pm | Comments

Allergan announced that the European Union's Committee for Medicinal Products for Human Use has recommended extending the Marketing Authorization for Ozurdex to treat adult patients with vision loss due to diabetic macular edema. Read more...   

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TTP Labtech Technology IDs Novel Drug Candidates for Neuropsychiatric Disorders

July 25, 2014 2:50 pm | Comments

The first high-resolution X-ray crystal structure of the metabotropic glutamate receptor 5 transmembrane domain was reported in Nature this week. The work was performed at Heptares Therapeutics using TTP Labtech’s innovative liquid handling technology for lipidic cubic phase crystallography. Read more...

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SRI Snags NIH Contract for HIV, AIDS Therapies

July 25, 2014 2:47 pm | Comments

SRI International has been awarded a new $49 million, seven-year contract with the NIAID, part of the NIH, to conduct preclinical development of potential therapies for HIV infection and AIDS. Read more...              

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EPFL, Nearmedic Pharma Partner to Fight Tuberculosis

July 25, 2014 2:42 pm | Comments

The pharmaceutical company Nearmedic is collaborating with EPFL to participate in the development of a treatment against tuberculosis. Read more...                             

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‘Broken Genes’ for a Broken System

July 25, 2014 2:30 pm | Comments

The recent discovery of a genetic mutation that protects against type 2 diabetes may offer hope in fighting more than just diabetes. It also illustrates how using the tools of genetics to hunt for “broken genes” can aid drug discovery, according to a Harvard professor. Read more...

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More U.S. Girls Now Getting Cervical Cancer Vaccine

July 25, 2014 2:20 pm | Comments

More teen girls are getting a controversial cervical cancer vaccine but the increase isn't much of a bump, the government reported Thursday. Read more...                            

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Humira Lifts AbbVie 2.8% in Q2

July 25, 2014 12:00 pm | by The Associated Press | Comments

Drugmaker AbbVie Inc.'s second-quarter profit increased nearly 3 percent and beat analysts' expectations, as sales soared for the world's top-selling drug, Humira. Read more...                      

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