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January
11, 2006
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Digital Microscopy…3-D Imaging, Profiling, Measurement and More
Keyence's VHX-100 Video Digital Microscope provides sharp 3-D images up to 5000x. The handheld CCD camera provides 20 times the depth-of-field of conventional microscopes while eliminating cutting or processing of targets. Great for group viewing and discussion of images. An easy-to-carry handle on the body adds mobility no other conventional microscopes offer. Includes 3-D profiling & measurement. An excellent tool for R & D, QC, QA in pharmaceutical, medical and industrial applications.
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Working
Memory Circuit Proposed
Researchers at Brandeis University, Waltham, Mass.,
say they have created a computational model of the brain’s
working memory that can be used to understand the effects
of drugs that modulate cognition. Full
Article
Alternative
HIV Vaccine Proposed
Researchers at Baylor College of Medicine, Houston,
believe that inhibiting a molecule called suppressor
of cytokine signaling-1 could lead to a new approach
to creating a vaccine against HIV and other chronic
infectious pathogens. Full
Article
Enzyme
Demethylates Histones
New published research from the University of North
Carolina at Chapel Hill School of Medicine shows that
its biochemists demonstrated that covalent histone methylation,
which can activate or repress gene function, can be
reversed by a specific enzyme. Full
Article
MIRIAM
Makes Models More Accessible
Researchers from 14 international organizations devised
a standard to define, exchange, and understand computer-generated
biochemical models. Four major biochemical model databases
are currently working to meet MIRIAM’s criteria.
Full Article
Drug-in-a-Box?
Scientists at Johns Hopkins University, Baltimore, have
developed a tiny metal container that functions as a
self-assembling, new encapsulation and delivery device
to transport medications and cell therapies to precise
areas in the body.
Full Article
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NIST Upgrades Mass Spectra Library
The National Institute of Standards and Technology (NIST)
announced a major upgrade of the widely used NIST/EPA/NIH
Mass Spectral Library. The new edition, NIST 05, brings
the number of compounds found in the database to 163,000,
and adds two new classes of chemical reference data:
a gas-phase "retention index" and a collection of 2,000
tandem mass spectrometry (MS/MS) spectra.
Molecule
of the Year Named
The International Society for Molecular and Cell Biology
Protocols and Researches Inc., Iloilo, Philippines,
named 4E10, a molecule solved by scientists at The Scripps
Research Institute, La Jolla, Calif., as Molecule of
the Year 2005 "for being the broadest acting neutralizing
antibody against HIV" and "for forming a detailed molecular
complex with its specific target thus unraveling clearly
its structural-functional configuration."
Dow
Corning Named Specialty Chemicals Company of 2005
Dow Corning Corp., Midland, Mich., was named Specialty
Chemicals Company of the Year for 2005 by Frost & Sullivan,
New York, because of its innovative practices, customer
solutions approach, continued growth, and positive financial
results.
MIT
Receives Pilot Plant Funding
The National Institute of Environmental Health Sciences,
Research Triangle Park, N.C., has agreed to support
several pilot projects at the The MIT Center for Environmental
Health Sciences, Cambridge, Mass., including support
for Catherine Drennan, associate professor of chemistry,
who will focus on "structural studies of the AlkB family
of proteins," and Patrick Doyle, assistant professor
of chemical engineering, who will study "technologies
to rapidly scan single genomic DNA molecules."
Can
Christmas Trees Become Flu Drug?
Biolyse Pharma Corp., St. Catharines, Ontario, Canada,
says that shikimic acid, used to make oseltamivir, marketed
as Tamiflu, can be found in pine, spruce, and fir needles,
which can yield up to 40 grams of the element per kilogram
of needles. The company that has the contract to haul
away half a million used Christmas trees in the Toronto
area, will donate the needles to Biolyse.
Synthetic
Molecule Generates Neurons
Researchers at The Scripps Research Institute and the
Salk Institute for Biological Studies, both in La Jolla,
Calif., determined that a synthetic molecule, neuropathiazol,
can generate functional neurons from adult neural stem
cells, which could be used to develop small molecule
therapeutics to regenerate neurons in patients with
neurodegenerative disorders, such as Alzheimer's or
brain injuries.
New
UK Medicinal Chemistry Training Program Funded
Cancer Research UK, London, UK, awarded £10M for a Medicinal
Chemistry Training Program that will be funded at five
UK universities. The grants will provide funding for
60 PhD studentships in medicinal chemistry over the
next five years..
Acumen
and deCODE Collaborate on Alzheimer’s Research
Acumen Pharmaceuticals, South San Francisco and deCODE
Chemistry, Woodridge, Ill., are collaborating in a drug
discovery program to identify potential treatments for
Alzheimer’s Disease. Acumen will identify hits using
its its small molecule anti-ADDL platform, while deCODE
Chemsitry will conduct lead optimization and provide
medicinal chemistry services to Acumen on a fee- for-service
basis.
ChemAxon
to Provide Free Cheminformatics Toolkit
ChemAxon Ltd., Budapest, Hungary, will provide its chemical
editing, viewing, search, property calculation, and
database management toolkits free to accessible web
resources operated for non-commercial purposes. In addition,
unlimited licenses, upgrades, and support will be provided
to increase the quality and capabilities of publicly
accessible online chemical research resources.
Instrument
to Identify Chemicals Being Developed
Using condensation nucleation light scattering detection
techniques refined at Southern Illinois University Carbondale,
Carbondale, Ill., Fluid Measurement Technologies Inc.,
Vadnais Heights, Minn., and Quant Technologies LLC,
Blaine, Minn., are developing an analytical instrument
that will be able to detect a few molecules of virtually
any chemical. The National Institutes of Health is funding
the work and it is expected to be commercially available
within two years.
Microwaves
Make Combichem Really Cook
Microwave-assisted chemistry, which can accelerate chemical
reaction times, is an easy, inexpensive technique that’s
beginning to heat up combinatorial chemistry.
Full Article
Focus
on Alliances
Full
Article
It's
Not Too Late
You can still register FREE for the archived version
of BioDiscovery Expo,
an online conference and exhibition held October 26,
2005. Discover exciting talks given by experts in High-Throughput
Screening Technologies, High-Content Screening Tools,
and Automation and Informatics. The conference features
12 sessions including a video keynote talk by Janet
Woodcock, MD, Deputy Commissioner for Operations and
Chief Operating Officer, U.S. Food and Drug Administration,
who spoke on "Improving the Success of Drug Development:
Can We Find Better Predictive Markers?" The BioDiscovery
Expo hall showcases the leading tools and technologies
used in today's labs. REGISTER TODAY at www.biodiscoveryexpo.com
for the archived version of this exciting and unique
educational event.
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Archived
Webcasts Now Available
The RNAi Workflow from In
Vitro to In Vivo, held December
14, 2005, features three experts discussing the latest
solutions for the various phases of RNAi experimentation,
from design and validation of RNAi reagents in cell
culture to use in vivo in model organisms and, ultimately,
as therapeutics. Panelists Mark Kay, MD, PhD, Professor,
Departments of Pediatrics and Genetics, Stanford University;
Gavin Robertson, PhD, Assistant Professor of Pharmacology,
Pathology and Dermatology, Penn State College of Medicine;
and Peter Welch, PhD, Director of R&D, Gene Regulation,
Invitrogen; discuss diverse applications for state-of-the-art
RNAi tools, troubleshooting for RNAi, critical experimental
design parameters, downstream analysis and follow-up
methods, and more. For more information and to register
for the archived Webcast, go to www.dddmag.com/RNAi/
How Reliable Is Your qPCR Data?,
an interactive, streaming audio and video Webcast, held
November 15, 2005, features three experts on Quantitative
PCR (qPCR), a powerful and sensitive technology for
the quantification and validation of genetic data. Panelists
Stephen Bustin, PhD, Queen Mary’s School of Medicine
and Dentistry, University of London; Maurice Exner,
PhD, Infectious Diseases, Quest Diagnostics; and Mark
Andersen, PhD, Invitrogen Corp.; discuss the key factors
that affect assay performance and lead to data variability,
the comparability of qPCR results obtained using different
cDNA priming strategies and protocols, the value of
multiplexing, and challenges related to normalization
of data and experimental conditions, and more. Go to
www.dddmag.com/qpcr
to register to view the archived version of this Webcast.
The
Quest for an Ideal Multiplexed Protein Profiling Tool,
held June 29, 2005 featured a panel of experts discussing
what to consider when choosing multiplexed protein profiling
technologies, including cost, throughput, standardization,
ease of use, data analysis, etc. There are several platforms
that have been applied toward answering these challenges,
ranging from approaches like 2D gel electrophoresis,
2D-DIGE, mass spec affinity tagging, and multi-dimensional
liquid chromatography for protein profiling. The panel,
consisting of David W. Speicher, PhD, Professor and
Chair, Systems Biology Division, Director, Proteomics
Laboratory, The Wistar Institute; David Friedman, PhD,
Associate Director, Proteomics Laboratory, Mass Spectrometry
Research Center, Vanderbilt University; and Michael
Pisano, PhD, President & Co-Founder, Proteome Research
Services Inc., considered which of these offers the
best capability for comparing and contrasting samples.
For more information and to register for the archived
Webcast, go to: www.genpromag.com
LabAutomation's
Tenth Anniversary Conference
LabAutomation 2006,
to be held January 21-25, 2006, at the Palm Springs
Convention Center in Palm Springs, Calif., brings laboratory
automation international business leaders and scientists
together with more than 300 exhibits of laboratory technologies.
LabAutomation 2006 offers content and perspectives on
emerging laboratory technologies from a broad range
of industries, including biotechnology, pharmaceutical,
forensics, molecular diagnostics, food and agricultural
sciences, and others. For more information on the conference
and registration, go to labautomation.org/LA/LA06/index.php
January
2006
CBI
Protein Drugs
West Conshohocken, Pa. - January 19-20
View
Event Listing
LabAutomation
2006
Palm Springs, Calif. - January 21-25, 2006
View
Event Listing
Drug
Delivery Partnerships
Phoenix, Ariz. - January 25-27
View
Event Listing
Advances
in Protein Crystallography
San Francisco, Calif. - January 26-27
View
Event Listing
Pharmaceutical
Leadership Summit
Orlando, Fla. - January 30 - February 1
View
Event Listing
Medical Design & Manufacturing West
Anaheim, Calif. - January 30 - February 2
View
Event Listing
CHI
High-Content Analysis 2006
San Francisco, Calif. - January 31 - February 3
View
Event Listing
February
2006
IIR Clinical Trials Congress
Orlando, Fla. - February 13-15
View
Event Listing
Screening Europe 2006
Prague, Czech Republic - February 20-22
View
Event Listing
MedChem Europe 2006
Prague, Czech Republic - February 21-22
View
Event Listing
13th
Annual Molecular Medicine Tri-Conference
San Francisco - February 21-24
View
Event Listing
Third Annual Technology Transfer Summit for Pharmaceutical and Biotech Industries
Philadelphia, Pa. - February 27 - March 1
View
Event Listing
March
2006
Pittcon: 57th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy
Orlando, Fla. - March 12-17
View
Event Listing
Transcriptomics, Proteomics and Metabolomics in Dietary Supplement and Nutrition Research
Kauai, Hawaii - March 20-21
View
Event Listing
Interphex 2006
New York - March 21-23
View
Event Listing
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