MorphoSys AG announced in November, 2007 a multi-year technology development program to enhance its antibody generation platform. The new technology suite will include enhancements involving substantially faster and more direct access to high affinity antibody drug candidates in the full IgG format.

At the core of MorphoSys's technology offering is HuCAL, the Human Combinatorial Antibody Library, a collection of more than 12 billion functional, distinct, fully human antibodies. The new technology platform will comprise an upgrade of MorphoSys's current antibody library HuCAL GOLD to an enhanced version HuCAL Platinum, as well as established screening and selection methods such as AutoCAL and CysDisplay, the RapMAT technology for faster antibody optimization, the antigen expression system AgX and the sequence analysis software SAS and additional technology modules currently in development.

One enhancement in the HuCAL Platinum library was a complete sequence alignment using the latest human genome data for immunoglobulins. The underlying database is five-fold larger than that used for the construction of HuCAL GOLD.

MorphoSys