Using the ActiPix Dissolution Imager from Paraytec, formulation scientists are able 'to see' in real-time what is happening at a tablet surface during the process of dissolution. The imager offers pharmaceutical companies a tool that can reduce the time it takes a drug to come to market, thereby offering significant potential gains in earnings, according to Paraytec.

Using a specially designed tablet holder - controlled release pharmaceuticals can be studied using Paraytec's ActiPix D-100 UV area imager. The holder is placed inside the ActiPix D-100 which enables real time recording and review of data. When liquid flows over the surface of the formulation, release of the active ingredient can be quantitatively monitored directly at the tablet surface.

The ActiPix D100 is a quantitative UV area imaging system. The miniature detector contains a high resolution 1280x1024 Active Pixel sensor. Compact in design, the ActiPix D100 consists of a control box connected via a fiber optic cable and communications cable to a remote sensor head. The sensor head holds easily exchangeable, application-specific cartridges. The cartridges are used in conjunction with powerful software, enabling the end-user to easily switch between applications. The detector can be used as a 'plug and play' accessory linked in-line to single or multiple peripheral devices, such as syringe pumps, existing CE or nanoLC instrumentation. These can be further coupled to other devices such as mass spectrometers giving a greater depth of information. Detection is performed at a selected wavelength by means of interchangeable filters. The detector wavelength range is 190 to 1100 nm.

Visit Paraytec Ltd at Pittcon 2009 at Booth #4040

www.paraytec.com