Drug Discovery & Development

Genomics/Proteomics

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Site-Directed Mutagenesis via Gibson Assembly

May 21, 2013 12:11 pm | by Ezra Schildkraut, PhD; Peichung Hsieh, PhD, Applications and Product Development Scientists; New England Biolabs, Ipswitch, Mass. | Articles | Comments

Gibson Assembly is a rapid and reliable method for the assembly of DNA fragments in a single-tube, isothermal reaction without reliance upon the presence of restriction sites within the target sequence. The technique is readily adaptable for site-directed mutagenesis.

Model Shows How First Life Forms Might Have Packaged RNA

October 16, 2012 6:19 pm | News | Comments

Researchers at Penn State University have developed a chemical model that mimics a possible step...

NIH Seeking Infant Sequencing Proposals

August 10, 2012 12:07 pm | News | Comments

The National Institutes of Health is seeking proposals for projects on the implications of...

Peptide Synthesizer

April 19, 2012 11:41 am | Product Releases | Comments

Protein Technologies Inc. has introduced infrared heating on the Tribute peptide synthesizer....

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Daily news and top headlines for drug research professionals

A Target Rich Environment

May 9, 2013 11:45 am | by Cynthia Fox, Science Editor | Articles | Comments

Recent meetings have provided a showcase for many potential druggable tumor targets. The range of potential new drug targets has been expansive, especially if one counts the whole-exome sequencing work being performed for the Cancer Genome Atlas project.

Engineering a Cure

March 7, 2013 12:05 pm | by Cynthia Fox, Science Editor | Articles | Comments

While the latest antiviral treatments can drop HIV levels to near undetectable levels, these drugs are a life sentence. Stop taking them and the virus comes raging back. New techniques are offering patients something previously thought impossible: a drug-free cure.

Which PCR Is Right for Your Research?

February 7, 2013 4:47 pm | by George Karlin-Neumann, Director of Scientific Affairs, Bio-Rad’s Digital Biology Center, Pleasanton, CA; Rachel Scott, Marketing Manager, Gene Expression Division, Bio-Rad, Hercules, Calif. | Articles | Comments

Quantitative real-time PCR is one of the most widely used laboratory techniques in biotech, pharmaceutical, and academic research labs. However, digital PCR is beginning to stake its claim in the laboratory due to its increased sensitivity, precision, and reproducibility.

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Starting Small

December 3, 2012 3:32 pm | by Chris Hebel, VP of Business Development, LC Sciences, Houston, Texas | Articles | Comments

While RNA-Seq has demonstrated advantages over conventional methods of small RNA analysis, researchers still need to overcome some of the unique challenges it presents such as the handling of tremendous amounts of data. Despite this, miRNA discovery continues to advance and with the advent of RNA-Seq, shows no signs of slowing.

Drugs Limiting Excess Mucus Could Save Lives

November 25, 2012 7:00 pm | by WUSTL | News | Comments

Respiratory conditions that restrict breathing such as asthma and chronic obstructive pulmonary disease are common killers worldwide. Now, researchers have described the molecular pathway responsible for excess mucus in airway cells and have used that information to design a series of new drugs that inhibit that pathway. 

Western Blot Imager

October 16, 2012 5:49 pm | Product Releases | Comments

The Thermo Scientific MYECL Imager from Thermo Fisher Scientific Inc. is an imaging instrument that delivers one-touch image capture and analysis of protein and nucleic acid gels and Western blots. 

DNA Microarray Technology for Pharmacogenomics Research

August 9, 2012 3:53 pm | by Claude E. Gagna, PhD, Assistant Professor; New York Institute of Technologies; W. Clark Lambert, MD, PhD, Professor; New Jersey Medical School; Peter Lambert, Medical Student; St. Georges University School of Medicine | News | Comments

Microarrays are a collection of DNA sequences that are immobilized onto a solid support. Microarrays—along with pharmacogenomics—are playing a significant role in the genomics and proteomics revolution. DNA and RNA are now viewed as dynamic molecules that can undergo structural changes.

Expanding Targets, Saving Time

June 13, 2012 4:58 pm | by Neil Canavan, Contributing Editor | Articles | Comments

After a quick nod to the laborious ways of the old, let us ring in the new innovations in multiplex assays with what is quite literally, a new ring.

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PCR Thermal Cycler Enables Rapid Optimization

June 13, 2012 1:20 pm | by Charles Joseph, PCR Portfolio Product Manager; Agilent Technologies, Santa Clara, Calif. | Articles | Comments

While quantitative PCR is used for applications such as expression profiling, traditional end-point PCR is most commonly used to amplify DNA and RNA for downstream applications.

Real-time PCR System Enables Small- and Large-Scale Experiments

June 13, 2012 12:14 pm | by Vanee Pho, Product Manager for Life Technologies; Kathleen Hayashibara, Senior Applications Specialist; Life Technologies Corp., Carlsbad, Calif. | Articles | Comments

The growing demand for biomarker screening experiments has created a greater need for instruments that enable high-throughput capabilities coupled with high accuracy and low cost.

High Throughput Real-Time PCR for Large-Scale Gene Analysis

June 13, 2012 12:09 pm | by John R. Ogden, PhD, Director, Applications & Technical Services; Roche Diagnostics, Indianapolis, Ind. | Articles | Comments

Large-scale, PCR-based gene analysis is only possible when signals are generated, captured, and analyzed accurately and reproducibly.

A Better Route for Diagnostics?

June 11, 2012 10:08 am | by Jeffrey M. Perkel, Contributing Editor | Articles | Comments

From the moment of its inception, the Human Genome Project was expected to yield substantial benefits in diagnostics. But the genome is only part of the story.

HaloPlex Spreads to Ion Torrent

June 6, 2012 11:28 am | News | Comments

Agilent Technologies Inc. has made the HaloPlex target enrichment system available on Ion Torrent’s Personal Genome Machine, a benchtop sequencing solution.

Surface Plasmon Resonance Kits

June 5, 2012 10:55 am | Product Releases | Comments

Bio-Rad Laboratories Inc. announced the launch of two surface plasmon resonance kits for the ProteOn XPR36 protein interaction analysis system.

Protein Tag

May 22, 2012 11:51 am | Product Releases | Comments

Sandia Biotech's split-Green Fluorescent Protein technology allows researchers to analyze proteins and peptides with greater accuracy and fewer steps than current methods.

Bioethics Experts Form Global "Collaboratory"

May 11, 2012 11:39 am | News | Comments

A team of bioethics experts has created ELSI 2.0, an international "collaboratory" to better respond to the global aspects of the ethical, legal and social implications (ELSI) of modern genomics.

Bioinformatics Software

April 24, 2012 11:27 am | Product Releases | Comments

Agilent Technologies Inc. has released GeneSpring 12.0, allowing GeneSpring users to analyze next-generation sequencing data and conduct joint analysis at the pathway level across multiple “omics” platforms.

Hype, Hope, Reality

April 12, 2012 4:09 pm | by Rita C. Peters, Editorial Director | Articles | Comments

A recent TV program examined the rapidly moving developments in genetics research and the impact on the public and patients.

Microarray-Synthesized Oligos for Targeted Sequencing

April 12, 2012 3:28 pm | by Chris Hebel, Vice President of Business Development; LC Sciences, Houston | Articles | Comments

Though next-generation DNA sequencing provides very high levels of coverage even on complex genomes, it is still advantageous to reduce the complexity of samples.

Automation of Next-Generation Sequencing Sample Preparation

April 12, 2012 3:20 pm | by Alicia Burt, Senior Product Manager; Agilent Technologies, Santa Clara, Calif. | Articles | Comments

Next-generation sequencing (NGS) has revolutionized genomics, enabling entire genomes and exomes to be sequenced more efficiently than ever before.

qPCR Analysis

April 5, 2012 12:02 pm | Product Releases | Comments

Integromics has launched its latest tool for qPCR analysis, RealTime StatMiner 4.3 on TIBCO Spotfire.  This version allows users to upload and analyze data from a large range of qPCR vendors.

DNA Sequencing Lays Foundation for Personalized Cancer Treatment

April 3, 2012 9:20 am | News | Comments

Scientists at Washington University School of Medicine in St. Louis are using DNA sequencing to identify mutations at the root of a patient's tumor—considered key to personalizing cancer treatment—and to map the genetic evolution of disease and monitor response to treatment.

TALE Proteins

March 22, 2012 10:03 am | Product Releases | Comments

Life Technologies Corporation has launched GeneArt Precision TALs which will allow researchers the ability to edit genomes and control gene activity with unprecedented precision and reliability.

Armed with Peptides, Drug Developers Aim for Tumors

March 16, 2012 3:06 pm | by Alan Dove, PhD, Contributing Editor | Articles | Comments

Oncology is a tricky balancing act, striving to kill the tumor without killing the patient. It often fails. To address this, researchers have tried a variety of strategies to deliver drugs specifically to tumors.

Protein Sample Preparation

March 13, 2012 9:43 am | Product Releases | Comments

The Perfinity Integrated Digestion Platform from Shimadzu Scientific Instruments automates key proteomics workflow steps to significantly reduce sample preparation times and enhance reproducibility.

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