While tailor-made drugs have not yet materialized on a broader scale, the tools and technologies that emerged during or subsequent to the ground-breaking Human Genome Project are having a growing impact on the development of novel diagnostic tests.
Metal-peptide complexes play an important role in understanding the mechanisms behind complex...
Researchers at Penn State University have developed a chemical model that mimics a possible step...
A positive genotoxicity result can throw the fate of a promising drug candidate—in which a firm has invested significant time and money—into doubt. The statistical improbability and challenges of bringing a drug to market become paramount.
Recent meetings have provided a showcase for many potential druggable tumor targets. The range of potential new drug targets has been expansive, especially if one counts the whole-exome sequencing work being performed for the Cancer Genome Atlas project.
While the latest antiviral treatments can drop HIV levels to near undetectable levels, these drugs are a life sentence. Stop taking them and the virus comes raging back. New techniques are offering patients something previously thought impossible: a drug-free cure.
Quantitative real-time PCR is one of the most widely used laboratory techniques in biotech, pharmaceutical, and academic research labs. However, digital PCR is beginning to stake its claim in the laboratory due to its increased sensitivity, precision, and reproducibility.
While RNA-Seq has demonstrated advantages over conventional methods of small RNA analysis, researchers still need to overcome some of the unique challenges it presents such as the handling of tremendous amounts of data. Despite this, miRNA discovery continues to advance and with the advent of RNA-Seq, shows no signs of slowing.
Respiratory conditions that restrict breathing such as asthma and chronic obstructive pulmonary disease are common killers worldwide. Now, researchers have described the molecular pathway responsible for excess mucus in airway cells and have used that information to design a series of new drugs that inhibit that pathway.
The Thermo Scientific MYECL Imager from Thermo Fisher Scientific Inc. is an imaging instrument that delivers one-touch image capture and analysis of protein and nucleic acid gels and Western blots.
As next-generation technology ratchets the price of sequencing lower and lower, users from academic labs to Big Pharma are finding themselves drowning in data. What used to be gigabytes worth of information has become terabytes or petabytes.
Microarrays are a collection of DNA sequences that are immobilized onto a solid support. Microarrays—along with pharmacogenomics—are playing a significant role in the genomics and proteomics revolution. DNA and RNA are now viewed as dynamic molecules that can undergo structural changes.
After a quick nod to the laborious ways of the old, let us ring in the new innovations in multiplex assays with what is quite literally, a new ring.
While quantitative PCR is used for applications such as expression profiling, traditional end-point PCR is most commonly used to amplify DNA and RNA for downstream applications.
The growing demand for biomarker screening experiments has created a greater need for instruments that enable high-throughput capabilities coupled with high accuracy and low cost.
Large-scale, PCR-based gene analysis is only possible when signals are generated, captured, and analyzed accurately and reproducibly.
From the moment of its inception, the Human Genome Project was expected to yield substantial benefits in diagnostics. But the genome is only part of the story.
Agilent Technologies Inc. has made the HaloPlex target enrichment system available on Ion Torrent’s Personal Genome Machine, a benchtop sequencing solution.
Bio-Rad Laboratories Inc. announced the launch of two surface plasmon resonance kits for the ProteOn XPR36 protein interaction analysis system.
Sandia Biotech's split-Green Fluorescent Protein technology allows researchers to analyze proteins and peptides with greater accuracy and fewer steps than current methods.
A team of bioethics experts has created ELSI 2.0, an international "collaboratory" to better respond to the global aspects of the ethical, legal and social implications (ELSI) of modern genomics.
Agilent Technologies Inc. has released GeneSpring 12.0, allowing GeneSpring users to analyze next-generation sequencing data and conduct joint analysis at the pathway level across multiple “omics” platforms.
Protein Technologies Inc. has introduced infrared heating on the Tribute peptide synthesizer. This technology produces rapid, precise heating like microwaves, with the high throughput and scalability of conventional heating methods.
A recent TV program examined the rapidly moving developments in genetics research and the impact on the public and patients.
Though next-generation DNA sequencing provides very high levels of coverage even on complex genomes, it is still advantageous to reduce the complexity of samples.
Next-generation sequencing (NGS) has revolutionized genomics, enabling entire genomes and exomes to be sequenced more efficiently than ever before.
Integromics has launched its latest tool for qPCR analysis, RealTime StatMiner 4.3 on TIBCO Spotfire. This version allows users to upload and analyze data from a large range of qPCR vendors.
Scientists at Washington University School of Medicine in St. Louis are using DNA sequencing to identify mutations at the root of a patient's tumor—considered key to personalizing cancer treatment—and to map the genetic evolution of disease and monitor response to treatment.