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Genomics/Proteomics
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Researchers ID New Genetic Target for a Different Kind of Cancer Drug

September 9, 2014 11:13 am | News | Comments

Researchers have discovered that the protein RBM4, a molecule crucial to the process of gene splicing, is drastically decreased in multiple forms of human cancer, including lung and breast cancers. Read more...            

Single Animal-to-Human Transmission Event Sparked 2014 Ebola Outbreak

September 2, 2014 10:32 am | News | Comments

Scientists used advanced genomic sequencing technology to identify a single point of infection...

The Future of Genome Analysis

August 28, 2014 9:30 am | by Maxim Mikheev, M.D., Ph.D., Co-Founder and Chief Technical Officer at BioDatomics | Articles | Comments

As technological improvements have changed the way we study...

Protein Family Can Inhibit HIV Release

August 26, 2014 10:30 am | News | Comments

A family of proteins that promotes virus entry into cells also has the ability to block the...

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AstraZeneca, Illumina Partner on Gene Sequencing

August 21, 2014 4:12 pm | News | Comments

AstraZeneca announced that it has entered into a collaboration with gene sequencing company, Illumina Inc., to develop its next generation sequencing platform for companion diagnostic tests applicable across AstraZeneca’s oncology portfolio. Read more…

Roche, Garvan Partner on Genomics Technologies

August 20, 2014 10:18 am | News | Comments

Roche and the Garvan Institute of Medical Research announced a collaboration to develop new technologies for targeted epigenomic analysis using DNA sequencing, bringing together the genomics expertise and infrastructure at the Garvan Institute and target enrichment products from Roche NimbleGen. Read more...

Unlocking the Power of Big Data in R&D, Part Two

August 19, 2014 11:23 am | by Sharon Benzeno, PhD, MBA, Senior Director, Business Development Bioinformatics, Elsevier | Articles | Comments

Big data is one of the hottest topics in R&D as its potential to accelerate successful drug development becomes more widely recognized. Part 2 of this two-part article analyses the new data-driven decision-making approaches make a difference to life science R&D. Read more...

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Unlocking the Power of Big Data in R&D, Part One

August 15, 2014 9:09 am | by Sharon Benzeno, PhD, MBA, Senior Director, Business Development Bioinformatics, Elsevier | Articles | Comments

Big data promises big insights for drug discovery and development, but its intrinsic value will be unlocked only if R&D organizations have the tools to make sense of it. Part 1 of this two-part article looks at how new models are changing the world of R&D. Read more...

Study Reveals How Ebola Blocks Immune System

August 14, 2014 10:28 am | News | Comments

The Ebola virus, in the midst of its biggest outbreak on record, is a master at evading the body’s immune system, but researchers at Washington University School of Medicine in St. Louis and elsewhere have learned one way the virus dodges the body’s antiviral defenses, providing important insight that could lead to new therapies. Read more...

Epigenetic Cancer Cell Markers Could Improve Treatment

August 12, 2014 3:05 pm | News | Comments

Scientists have known for decades that cancer can be caused by genetic mutations, but more recently they have discovered that chemical modifications of a gene can also contribute to cancer. These alterations, known as epigenetic modifications, control whether a gene is turned on or off. Now, a team engineers has developed a fast, reliable method to detect this type of modification. Read more...

23andMe, Pfizer Collaborate on Genetics of IBD

August 12, 2014 11:24 am | News | Comments

23andMe announced an agreement with Pfizer Inc. in which the companies will aim to enroll 10,000 people with Inflammatory Bowel Disease (IBD) in a research initiative designed to explore the genetic factors associated with the onset, progression, severity and response to treatments for IBD. Read more...

Cure to Lung Cancer May Depend on Your DNA

August 7, 2014 1:00 pm | News | Comments

The Northside Hospital Cancer Institute announced its participation in a unique National Cancer Institute clinical collaboration to treat lung cancer based on a person’s genetic makeup. Read more...               

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Ventana Paves the Way for Companion Diagnostics in China

August 6, 2014 10:39 am | News | Comments

Ventana Medical Systems Inc., a member of the Roche Group, announced a new agreement with Quintiles Inc. to offer College of American Pathology-standard companion diagnostic testing services in China for pharmaceutical and biotech companies conducting early phase clinical trials. Read more...

Paradigm Kicks Off Genomic Profiling for Cancer Registry

August 5, 2014 2:16 pm | News | Comments

Paradigm has announced they have initiated genomic testing for Pharmatech's AccessPPM Cancer Registry, which is designed to collect EMR data and genomic information to help best match cancer patients with targeted clinical trials. Read more... 

Scientists Use Subcellular Imaging to Visualize Glutamate Receptors

August 5, 2014 2:08 pm | News | Comments

Scientists at the National Institutes of Health have created high-resolution images of the glutamate receptor, a protein that plays a key role in nerve signaling. The advance, published online in the journal Nature, opens a new window to study protein interactions in cell membranes in exquisite detail. Read more...

BGI Buys Genome Mapping System

July 31, 2014 2:21 pm | News | Comments

BioNano Genomics announced the purchase of an Irys System by BGI, the world's largest genomics organization. BGI selected BioNano's platform to enable comprehensive exploration of human structural variation and to provide vastly improved assemblies for various organisms of interest, including those where no reference exists. Read more...

Replikin Count Predicts Ebola Outbreaks

July 31, 2014 2:14 pm | News | Comments

Replikins Ltd. released new data on changes in the gene structure of the Ebola virus showing that before the current outbreaks, the mean Ebola Reston gene Replikin Count between 1995 and 2002 was 1.1; the mean Replikin Count increased two-fold in 2010, three-fold in 2012, and sixteen-fold in 2013. Read more...

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Protein Fuels Repair of Treatment-Resistant Cancer Cells

July 31, 2014 1:31 pm | News | Comments

In some highly treatment-resistant cancers, such as head and neck cancer, some cancer cells repair themselves, survive and thrive during radiation and chemotherapy. Now, University of Michigan researchers have found that a particular protein— TRIP13— encourages those cancer cells to repair themselves. Read more...

New NIH Program Will Find Potential Drug Targets

July 31, 2014 1:23 pm | News | Comments

National Institutes of Health leaders have announced a new collaborative initiative to improve human health by exploring poorly understood genes that have the potential to be modified by medicines. Read more...            

Biorepository Management Today

July 31, 2014 1:21 pm | by Louise Rozik, Editor | Articles | Comments

Scientists are accustomed to the fickle nature of research, but sometimes it can get to even the most seasoned researcher. One especially poignant example – the Cancer Genome Atlas – starts with the completion of the Human Genome Project in 2003. Read more...

Protein May Prevent Antibody-Mediated Transplant Rejection

July 31, 2014 8:40 am | News | Comments

A study presented at the 2014 World Transplant Congress evaluated the safety and efficacy of CSL Behring's C1 Inhibitor (C1-INH) concentrate in preventing antibody-mediated rejection following kidney transplants in highly sensitized patients. Read more...

Researchers ID New Malaria Vaccine Candidates

July 31, 2014 8:29 am | News | Comments

Researchers have discovered new vaccine targets that could help in the battle against malaria. Taking a new, large-scale approach to this search, researchers tested a library of proteins from the Plasmodium falciparum parasite with antibodies produced by the immune systems of a group of infected children. Read more...

Sage Licenses Gene Editing Tool from the Broad Institute

July 30, 2014 11:06 am | News | Comments

Sage Labs Inc., a leading provider of products, services and technologies in the field of genome engineering, announced that they have licensed CRISPR/Cas9 technology from the Broad Institute enabling them to use the CRISPR/Cas9 system to engineer cell and animal models for their clients as well as distribute validated CRISPR reagents. Read more...

AstraZeneca, Kyowa Hakko Kirin Partner on Immuno-Oncology Study

July 30, 2014 10:48 am | News | Comments

AstraZeneca announced that it has entered into a clinical study collaboration with Kyowa Hakko Kirin for a Phase 1/1b immuno-oncology study that will evaluate the safety and efficacy of two separate combinations of three investigational compounds in multiple solid tumors. Read more...

Researchers to Study BRCA1-Related Breast Cancer

July 30, 2014 10:26 am | by Ashley WennersHerron, Virginia Tech | News | Comments

Deborah Kelly and Zhi Sheng, assistant professors at the Virginia Tech Carilion Research Institute, recently received a grant from the Commonwealth Health Research Board to investigate hereditary breast cancer, an effort that may lead to new treatment approaches. Read more...

AstraZeneca, QIAGEN Collaborate on Iressa Diagnostic Test

July 28, 2014 12:38 pm | News | Comments

AstraZeneca announced that it has entered into a collaboration with Netherlands-based QIAGEN to develop a non-invasive diagnostic test to identify non-small cell lung cancer patients who are suitable for treatment with Iressa. Read more...    

Scientists Discover New Mechanism of Drug Resistance

July 28, 2014 12:31 pm | News | Comments

Microorganisms can evade treatment by acquiring mutations in the genes targeted by antibiotics or antifungal drugs. Now, a new study has shown that microorganisms can use a temporary silencing of drug targets to gain the benefits of drug resistance without the commitment. Read more...

TTP Labtech Technology IDs Novel Drug Candidates for Neuropsychiatric Disorders

July 25, 2014 2:50 pm | News | Comments

The first high-resolution X-ray crystal structure of the metabotropic glutamate receptor 5 transmembrane domain was reported in Nature this week. The work was performed at Heptares Therapeutics using TTP Labtech’s innovative liquid handling technology for lipidic cubic phase crystallography. Read more...

Genomics Reveals Mechanism for Malaria Drug Resistance

July 25, 2014 10:58 am | News | Comments

Researchers have uncovered a way the malaria parasite becomes resistant to an investigational drug, a  discovery made at Washington University School of Medicine in St. Louis that also is relevant for other infectious diseases including bacterial infections and tuberculosis. Read more...

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