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Genomics/Proteomics
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The Lead

Gene Variants Show Potential in Predicting Rheumatoid Arthritis Outcomes

April 29, 2015 4:29 pm | by University of Manchester | News | Comments

New cohort studies have shown that certain genetic variants are associated with higher or lower risks of increased disease severity. Read more...

Biomarkers Could Predict Response to Antipsychotic Treatment

April 29, 2015 4:22 pm | by King's College London | News | Comments

Only half of patients with psychosis respond to current medications and there is still a lack of...

Breaking Ground on Biologics

April 29, 2015 11:01 am | by Ryan Bushey, Associate Editor | Articles | Comments

One of the final sessions for the 2015 Experimental Biology Conference in Boston, Massachusetts...

3 Ways Technology is Changing the Face of Drug Discovery & Development

April 29, 2015 9:04 am | by Merrilyn Datta, PhD, President and General Manager, Definiens | Articles | Comments

While personalized medicine has been a goal for some time, there have been several obstacles....

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Action Against Antibiotic Resistance Begins with Community

April 28, 2015 4:43 pm | by Wellcome Sanger Institute | News | Comments

To combat antibiotic resistance, scientists need to understand the evolution of bacteria and examine this alongside the characteristics of the populations they infect. Read more...

Scientists Uncover Surprising New Details of Potential Alzheimer’s Treatment

April 28, 2015 1:26 pm | by The Scripps Research Institute | News | Comments

Taking a new approach, scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered some surprising details of a group of compounds that have shown significant potential in stimulating the growth of brain cells and memory restoration in animal models that mimic Alzheimer’s disease. Read more...

Scientists Use Gene Editing to Correct Mutation in Cystic Fibrosis

April 27, 2015 12:25 pm | News | Comments

Yale researchers successfully corrected the most common mutation in the gene that causes cystic fibrosis, a lethal genetic disorder. Read more..

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Scientists Pinpoint Brain-Swelling Mechanism

April 27, 2015 8:41 am | by University of British Columbia | News | Comments

Discovery paves way for treatments to prevent brain damage or death following head trauma. Read more...

Fragile X Syndrome: Building a Case for an Alternative Treatment Strategy

April 24, 2015 12:01 pm | by Emory Health Sciences | News | Comments

New research strengthens a potential strategy for treating fragile X syndrome, the most common inherited form of intellectual disability. Read more...

Manchester Joins European Consortium to Develop Liquid Biopsies

April 24, 2015 8:47 am | by University of Manchester | News | Comments

An international project to validate blood-based biomarkers for cancer has added a new member. Read more...

Protein Links Point to Future Alzheimer's Treatments

April 24, 2015 8:29 am | by University of Cambridge | News | Comments

Researchers have identified how proteins that play a key role in Alzheimer’s disease are linked in a pathway that controls its progression. Read more....

Majority of Lung Cancer Treatment Decisions Not Guided by Genetics: Survey

April 23, 2015 1:47 pm | News | Comments

Despite the majority of newly diagnosed advanced non-small cell lung cancer (NSCLC) patients being tested for genetic mutations, a gap still exists for providing a personalized treatment plan for patients based on their cancer type and mutation subtype, according to a new international survey. Read more...

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New Candidate Drug 'Dials Down' Protein Synthesis

April 22, 2015 12:07 pm | by University at Buffalo | News | Comments

UB researcher contributes to study on new candidate drug that may help treat misfolded protein diseases like CMT, Alzheimer’s and Parkinson’s. Read more...

Scientists Turn Cancer Cells into Normal Cells

April 21, 2015 11:49 am | by Sanford-Burnham Medical Research Institute | News | Comments

A new research study has shown that pancreatic cancer cells can be coaxed to revert back toward normal cells by introducing a protein called E47. E47 binds to specific DNA sequences and controls genes involved in growth and differentiation. Read more...

Genetic Variance Explains Poor Response to Asthma Medications

April 21, 2015 11:42 am | News | Comments

Researchers have identified a biological basis for asthmatic children who do not respond well to corticosteroid treatment - currently the most effective treatment for chronic asthma and acute asthma attack. Read more...

Childhood Syndrome Combining Lung Disease, Arthritis Identified

April 20, 2015 11:07 am | by UCSF | News | Comments

Discovery suggests mechanism, possible therapies for severe disorder. Read more...

Rare, Deadly Lymphoma Demystified

April 17, 2015 10:46 am | by Columbia University | News | Comments

The first-ever systematic study of the genomes of patients with ALK-negative anaplastic large cell lymphoma (ALCL), a particularly aggressive form of non-Hodgkin’s lymphoma (NHL), shows that many cases of the disease are driven by alterations in the JAK/STAT3 cell signaling pathway. Read more...

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California Launches Initiative to Advance Precision Medicine

April 17, 2015 10:35 am | by UCSF | News | Comments

Gov. Jerry Brown is launching a statewide initiative with the University of California, to advance the field of precision medicine. The effort will involve collaborating with other academic and industry partners and starting to build the infrastructure and assemble the resources necessary to further develop the field. Read more...

The Placebome?

April 17, 2015 10:29 am | by Harvard Medical School | News | Comments

How genomics might influence the role of the placebo in patient care and clinical research...

Impact of Label-Free Cell-Based Assays and the Holistic Calorimetry Approach

April 17, 2015 10:23 am | by Magnus Jansson, Ph.D., CSO, SymCel Sverige AB | Articles | Comments

New, innovative technology solves challenges in antibiotic resistance and the drug development cycle. Read more...

Gene Variant Linked to Cancer

April 17, 2015 8:11 am | by Washington University in St. Louis | News | Comments

Smokers with a specific genetic variation are more likely to keep smoking longer than those who don’t have the gene variant. Read more...

Scientists Discover Protein That Boosts Immunity to Viruses and Cancer

April 17, 2015 8:10 am | by Imperial College London | News | Comments

Scientists have discovered a protein that plays a central role in promoting immunity to viruses and cancer, opening the door to new therapies. Read more...

Tumor-Only Genetic Sequencing May Mislead Cancer Therapy

April 15, 2015 2:03 pm | by Stephanie Guzowski, Editor | News | Comments

When it comes to sequencing patients’ tumor genomes to personalize cancer therapy, one very important step may be missing, suggest Johns Hopkins researchers: a point of comparison to patients’ noncancerous genomes. Read more...

How Molecule Protects Brain Cells in Parkinson’s Disease Model

April 15, 2015 11:35 am | by Scripps Research Institute | News | Comments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found how a widely known but little-studied enzyme protects brain cells in models of Parkinson’s disease. Read more...

Heart Metabolics, FDA Agree on Special Protocol Assessment for Perhexiline Single Phase 3 Trial

April 15, 2015 9:23 am | News | Comments

The FDA has agreed to a single, randomized, pivotal Phase 3 trial of 350 patients evaluating perhexiline for the treatment of moderate-to-severe HCM. Read more...

Scientific Breakthrough Unlocks Potential Novel Tendon Therapy

April 14, 2015 11:00 am | by University of Glasgow | News | Comments

Scientists are investigating a new therapy for the treatment of tendon injuries such as tennis elbow and Achilles tendinitis after gaining new insight into the condition. Read more..

Central Signaling Pathway in Lymphoma Blocked Successfully

April 14, 2015 8:19 am | by University of Zurich | News | Comments

Cancer researchers from the University of Zurich have identified a key signaling pathway in B-cell lymphoma, a malignant type of blood cancer. Read more...

Eisai, Genomics Plc to Team Up on Large Scale Genotype/Phenotype Data Analysis Project

April 14, 2015 8:18 am | News | Comments

Both companies believe that human genetics and genomics can add great value to the drug development process. Read more...

NIH, South African Medical Research Council Award $8M in HIV, TB Grants

April 14, 2015 8:17 am | by National Institutes of Health | News | Comments

The National Institutes of Health and the South African Medical Research Council (SAMRC) are awarding 31 grants to U.S. and South African scientists to support research targeting HIV/AIDS, tuberculosis and HIV-related co-morbidities and cancers. Read more...

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