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Daily news and top headlines for drug research professionals

Immuno-Oncolytic Therapies: Compelling Tumor Cells to Mediate Their Own Destruction

May 29, 2015 9:17 am | by Brian Champion, Senior Vice President of R&D at PsiOxus Therapeutics | Articles | Comments

The answer may be found in immune-oncolytic viral therapies. Similar to cancer immunotherapy, the concept of oncolytic viruses is not new. The concept was first noted over a century ago when it was discovered that occasionally, tumor regression would follow a viral infection. The search then turned to finding a virus that could “selectively” replicate and kill tumor cells. Read more...

Antibiotic Approved for Treating Infant Abdominal Infections

May 29, 2015 9:16 am | by National Institute of Health | News | Comments

This NIH-funded study evaluated meropenem in children under 3 months. Read more...

Genelux Announces Positive Phase 1 Data for Viral-Based Cancer Therapy

May 28, 2015 2:29 pm | by Ryan Bushey, Associate Editor | Articles | Comments

Genelux is exploring the area of cancer virotherapy, where one disease is harnessed and used to attack another, with GL-ONC1. Read more...

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Autism Linked to Genetic Mutation – and Researchers Say They Can Undo It

May 28, 2015 12:49 pm | by Seth Augenstein, Digital Reporter | News | Comments

The genetic roots of autism have been investigated for more than a decade, as DNA sequencing has continued to improve. A new, early study points to a particular mutation in mice causing autistic-like behavior, adding to a list of potential causes. Read more...

Sleeping Cancer Can ‘Wake Up’ Years Later

May 28, 2015 10:27 am | by Seth Augenstein, Digital Reporter | News | Comments

Years, even decades, after remission some cancers return without warning. The “sleeping” cancer cells reactivate, “waking up” decades later, according to a British team of scientists, who say they may have found the molecular key to the change. Read more...

New Online Tool to Predict Genetic Resistance to TB Drugs

May 28, 2015 9:46 am | by London School of Hygiene & Tropical Medicine | News | Comments

Finding out what drugs can be used to treat a patient with tuberculosis (TB) can be sped up by days or weeks, thanks to a new free online tool. Read more...

Scientists Identify Key to Preventing Secondary Cancers

May 28, 2015 9:36 am | by University of Sheffield | News | Comments

Scientists have identified a possible key to preventing secondary cancers in breast cancer patients, after discovering an enzyme which enhances the spread of the disease. Read more...

EMA Validates Gilead's Marketing Application for HIV Treatment

May 28, 2015 9:26 am | News | Comments

Review of the MAA will be conducted by the EMA under the centralized procedure, which, when finalized, may lead to the grant of marketing authorization by the European Commission, which is valid in all 28 member states of the European Union. Read more...

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Diagnosing Cancer with Help From Bacteria

May 28, 2015 9:07 am | by MIT | News | Comments

The earlier doctors can find these tumors, the more likely that they can successfully treat them. Read more...

Genetically Modified Herpes Virus to Treat Skin Cancer

May 27, 2015 1:13 pm | by Stephanie Guzowski, Editor | News | Comments

An experimental treatment using a genetically modified strain of the herpes simplex 1 virus has been shown to be effective in killing skin cancer cells and halting tumor growth, according to new research. The oncolytic virus immunotherapy, called T-VEC, was used to treat patients with melanoma in a Phase 3 clinical trial. Read more...

Research Challenges Assumption that Arthritis Patients Take Medication Regularly

May 27, 2015 9:20 am | by University of Manchester | News | Comments

New UK research has challenged the assumption that people with rheumatoid arthritis always take their medication as prescribed. Read more...

Genomic Data Reveals Emergence of Drug Resistant Typhoid Strain in Africa

May 27, 2015 9:08 am | by University of Liverpool | News | Comments

Scientists have revealed the emergence of a novel strain of Typhoid fever in Malawi, Africa. Read more...

WHO to Fight Resistance to Antibiotic Resistance

May 27, 2015 8:43 am | by Seth Augenstein, Digital Reporter | News | Comments

The World Health Organization will now coordinate an international effort to stop the growth of resistant germs worldwide. Read more...

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Team Finds Two New and Very Large Classes of RNAs Linked to Cancer Biomarker

May 26, 2015 11:37 am | by University of Pittsburgh Schools of the Health Sciences | News | Comments

Researchers at the University of Pittsburgh School of Medicine have identified two new classes of RNAs that are closely associated with a protein known to be a prognostic biomarker for breast cancer and could play a role in progression of prostate cancer. Their findings were published in the June issue of the scientific journal RNA. Read more....

Master Gene Regulator Could be New Target for Schizophrenia Treatment

May 26, 2015 10:51 am | by MIT News | News | Comments

Researchers at MIT’s Picower Institute for Learning and Memory have identified a master genetic regulator that could account for faulty brain functions that contribute to schizophrenia. Read more...

Stem Cell Therapy for Inherited Skin Blistering

May 26, 2015 8:21 am | by King's College London | News | Comments

The therapy, involving infusions of stem cells, was found to provide pain relief and to reduce the severity of this skin condition for which no cure currently exists. Read more...

Scientists Unveil Prostate Cancer's 'Rosetta Stone'

May 26, 2015 7:57 am | by Institute of Cancer Research | News | Comments

Almost 90 percent of men with advanced prostate cancer carry genetic mutations in their tumors that could be targeted by either existing or new cancer drugs. Read more...

Proteins May Slow Memory Loss in People with Alzheimer's

May 22, 2015 10:12 am | by Iowa State University | News | Comments

Certain proteins may slow the devastating memory loss caused by Alzheimer’s disease, according to a groundbreaking Iowa State University study. Read more...

Freshly Squeezed Vaccines

May 22, 2015 8:39 am | by MIT | News | Comments

Researchers have shown that they can use a microfluidic cell-squeezing device to introduce specific antigens inside the immune system’s B cells. Read more...

Shining a New Light on The Immune System

May 22, 2015 8:24 am | by University of St. Andrews | News | Comments

Researchers used a light scattering technique to identify important types of white blood cells. Read more...

Brain Plaque Forecasts Alzheimer’s Years in Advance, Studies Confirm

May 20, 2015 1:49 pm | by Stephanie Guzowski, Editor | News | Comments

Brain plaques may appear up to 30 years prior to developing Alzheimer’s disease, according to the largest analysis to date of beta amyloid in people’s brains. Findings from two new meta-analyses  also confirm that amyloid screening, by PET scan or cerebral spinal fluid test, can help identify the best participants for clinical trials of Alzheimer’s drugs. Read more...

Promising Malaria and Dengue Vaccines Will Not Defeat Diseases

May 20, 2015 8:54 am | by Christopher J. Pace, Ph.D., GlobalData Managing Analyst, Infectious Diseases | Articles | Comments

Some industry pundits rightfully question the modest protective efficacies of CYD-TDV and RTS,S/AS01. Read more...

Sanofi, Regeneron Announce Positive Phase 2 Data for Asthma Drug

May 20, 2015 8:42 am | News | Comments

Based on discussions with the U.S. Food and Drug Administration (FDA), this Phase 2b study may be considered one of two pivotal efficacy studies required for a potential dupilumab biologics license application (BLA) in asthma. Read more...  

New Alzheimer's Drug to Enter Clinical Trials

May 20, 2015 8:39 am | by Lancaster University | News | Comments

A new drug developed at Lancaster University that may help to prevent the early stages of Alzheimer’s disease is to enter clinical trials. Read more...

Abcodia Raises $8M to Launch Ovarian Cancer Screening Test

May 19, 2015 1:14 pm | by Ryan Bushey, Associate Editor | Articles | Comments

The test will officially be on the market in the U.S. and U.K. later this year. Read more...

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