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Daily news and top headlines for drug research professionals

Beta-Blockers, Nitrates Are Not Ideal for Heart Disease

November 6, 2013 1:35 pm | News | Comments

Findings from a new study suggest that neither beta-blockers nor nitrates in their current form are ideal to treat heart failure. Could new drugs aimed specifically at a target that triggers the death of heart cells protect the heart from progressive disease? Find out...

Breast Cancer Drug May Be Effective in Colorectal Cancer

November 6, 2013 10:49 am | News | Comments

Researchers have found that around 10% of colorectal cancer patients harbor an aberration in the gene called TOP2A in their cancer cells. Could these tumors benefit from treatment with a specific chemotherapeutic drug, which is already used in breast cancer patients with this gene aberration? Find out...

Enchanced Protein-Protein Interactions in Living Cells using the NanoBRET Assay and CLARIOstar

November 5, 2013 4:25 pm | Webinars | Comments

In this webinar we introduce NanoBRET™ using a donor/accpetor combination consisting of NanoLuc™ luciferase and Halotag® labeling technology.


Mutations Linked to Breast Cancer Treatment Resistance

November 4, 2013 2:25 pm | News | Comments

Researchers at the University of Michigan Comprehensive Cancer Center have identified a type of mutation that develops after breast cancer patients take anti-estrogen therapies. Could these mutations explain why patients often become resistant to this therapy? Find out...

Fast Genetic Analysis Uncovers New Drug Targets

October 31, 2013 1:14 pm | News | Comments

A study shows that, even for patients with advanced and rapidly transforming cancer, researchers can find potential therapeutic targets using the latest advances in genomic sequencing. Could next-generation sequencing be applied more globally to advanced cancer patients? Find out...

Old Drug May Treat Infectious Diseases, Cancer

October 31, 2013 11:52 am | News | Comments

Meclizine, an over-the-counter drug used for decades to treat nausea and motion sickness, has the potential for new uses to treat certain infectious diseases and some forms of cancer, according researchers. How was the drug's new purpose discovered? Find out...

Researchers Increase Gene Therapy Success

October 30, 2013 1:29 pm | News | Comments

Scientists in The Research Institute at Nationwide Children's Hospital have found a way to overcome one of the biggest obstacles to using viruses to deliver therapeutic genes. So how did they keep patient immune systems from neutralizing a virus before it can deliver its genetic payload? Find out...

Dynamic Metabolite Regulatory System Increases Drug Production

October 30, 2013 1:08 pm | News | Comments

The first dynamic regulatory system that prevents the build-up of toxic metabolites in engineered microbes has been reported by a team of researchers. How does this system double the production of amorphadiene, a precursor to the premier antimalarial drug artemisinin? Find out...


New Cold Virus Structure Explains Drug Failures

October 29, 2013 12:21 pm | News | Comments

In a pair of studies that exploit the genetic sequencing of the cold virus rhinovirus C, scientists at the University of Wisconsin-Madison have constructed a 3-D model of the pathogen that shows why there is no cure yet for the common cold. With a structure in hand, could drugs designed to effectively thwart colds be in the offing? Find out...

Eleven New Genetic Alzheimer's Drug Targets Found

October 28, 2013 9:48 am | News | Comments

The largest international Alzheimer's disease genetics collaboration to date has found 11 new genetic areas of interest that contribute to late onset Alzheimer's Disease (LOAD), doubling the number of potential genetics-based therapeutic targets to interrogate.

Janssen Joins Structural Genomics Consortium

October 25, 2013 12:24 pm | News | Comments

Janssen Pharmaceuticals NV has joined the Structural Genomics Consortium's (SGC) group to partner in the investigation of epigenetics-based drug research, a new and burgeoning field in the development of future medicines. What is the goal of this partnership? Find out...

Ninety-Six Wells of Flies on a Plate

October 25, 2013 9:39 am | by Andrew S. Wiecek, Editor | Articles | Comments

A growing number of researchers in the Drosophila community are pioneering the use of Drosophila screens to identify potential drug candidates for cancer, cardiovascular disease and neurodegenerative diseases. Is the pharmaceutical industry missing out by not adopting this technique? Find out...

Metformin Effectiveness Depends on Glucose

October 24, 2013 2:09 pm | News | Comments

A study published online in the journal Cell Cycle shows that breast cancer cell growth, motility and aggression is promoted by excess glucose, as experienced by patients with diabetes and metabolic syndrome. So do patients with high glucose require higher doses of the drug metformin to achieve the same anti-cancer activity as patients with normal glucose levels? Find out...


Fatal Dapsone Allergy Caused by Genes

October 24, 2013 10:37 am | News | Comments

A team of researchers has discovered that the presence of a gene allele known as HLA-B*13:01 could cause a severe adverse drug reaction (ADR) to dapsone, which could be fatal.                     

Why Antibody Lots Differ Significantly

October 23, 2013 1:59 pm | News | Comments

One production lot of antibodies can differ significantly from the next in terms of performance, leading to incorrect conclusions about mechanisms of action for some diseases, which can be costly to pharmaceutical companies pursuing the wrong leads during drug development. So why does this lot-to-lot variability exist? Find out...

New Inhibitor Shows Promising Results in Drug-Resistant Cancers

October 21, 2013 2:41 pm | News | Comments

LEE011, a small-molecule inhibitor of cyclin-dependent kinases (CDK) 4/6 being developed by Novartis Oncology, showed promising results in drug-resistant melanoma and drug-resistant breast cancer when tested in combination with other targeted therapies. So what is the company currently doing based on those preclinical results? Find out...

Bristol Myers-Squibb Researcher Committed Misconduct

October 21, 2013 2:25 pm | by Andrew S. Wiecek, Editor | Articles | Comments

A Bristol Myers-Squibb (BMS) researcher engaged in research misconduct as a graduate student at the Medical College of Wisconsin (MCW) and as an assistant scientist at the University of Wisconsin-Madison (UWM), the U.S. Office of Research Integrity (ORI) has found. What was he specifically found guilty of? Find out...

Western Blot Detection System

October 16, 2013 11:25 am | Product Releases | Comments

Molecular Devices' ScanLater western blot detection system combines western blot membrane detection with a multimode microplate reader platform, eliminating the need to acquire a separate dedicated western blot system.

New Approach to Drug-Resistant Infections

October 15, 2013 2:44 pm | News | Comments

A new type of antibiotic called a PPMO, which works by blocking genes essential for bacterial reproduction, successfully killed a multidrug-resistant germ common to health care settings. Could the technology and new approach offer potential promise against the growing problem of antibiotic resistance? Find out...

Automated Protein Denaturation System

October 14, 2013 2:51 pm | Product Releases | Comments

The new Model 2304 Automated Protein Denaturation System is designed to automate protein stability determinations using chemical denaturation. 

Reactivating Aging Can Kill Tumor Cells

October 14, 2013 1:36 pm | News | Comments

Scientists have shown that diffuse large B-cell lymphoma (DLBCL) may be susceptible to treatment by reactivating the normal aging program in tumor cells so they can no longer divide. So which protein did the study find to have a novel, tumor-suppressive role? Find out...

Vaccination Campaign Doubles HBV Mutation Rate

October 8, 2013 12:52 pm | News | Comments

A universal infant vaccination campaign in China has led the Hepatitis B virus (HBV) to more than double its rate of breakout mutations. These mutations may enable the virus to elude the vaccine. So what new vaccination strategies might be needed? Find out... 

Why Diabetic Retinopathy Is Difficult to Treat

October 8, 2013 12:43 pm | News | Comments

Damage to the retina due to diabetes can be ameliorated only partially, despite treatment with the standard drug metformin. Scientists of Helmholtz Zentrum München have discovered that metformin treatment normalizes the alterations induced by diabetes in only about half of the altered retinal proteins. So how might this diabetes complication be treated? Find out...

Massive DNA Study Points to New Heart Drug Targets

October 7, 2013 2:31 pm | News | Comments

A global hunt for genes that influence heart disease risk has uncovered 157 changes in human DNA that alter the levels of cholesterol and other blood fats–a discovery that could lead to new medications. Each of the changes points to genes that can modify levels of cholesterol and other blood fats and are potential drug targets. So what other diseases were a surprising number of these variations associated with? Find out...

Two Mutations Help Leukemia Escape Drugs

October 7, 2013 12:12 pm | News | Comments

In a paper published in the Journal of Experimental Medicine, a group of scientists from the Max Delbrück Center for Molecular Medicine in Berlin now show that CML cells with activating beta-catenin mutations are particularly resistant to imatinib. Could a combo drug treatment force these cells to surrender? Find out...

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