Genomics/Proteomics
Data Demonstrates GSO Technology
May 3, 2011 6:56 am | News | CommentsA study describes how gene-silencing oligonucleotides (GSOs) from Idera Pharmaceuticals efficiently inhibited gene expression while overcoming some of the issues associated with other gene-silencing technologies.
Researchers Identify Genes Causing Antimalarial Drug Resistance
April 22, 2011 7:17 am | News | CommentsResearchers have identified several genes that may be implicated in the malaria parasite's notorious ability to rapidly evade drug treatments.
Scientists Observe Single Gene Activity in Living Cells
April 22, 2011 7:13 am | News | CommentsResearchers have for the first time observed the activity of a single gene in living cells, following the process of gene transcription.
Telomeres Protected by DNA Caps
April 21, 2011 8:11 am | News | CommentsResearchers have demonstrated how telomeres can be protected by caps made up of specialized proteins and stacks of DNA called G-quadruplexes, or G4 DNA.
A New Roadmap
April 8, 2011 7:28 am | by John A. Wass, PhD, Consulting Statistician; Quantum Cat Consultants, Lake Forest, Ill.; Cele Abad-Zapatero, PhD, Adjunct Professor, Center for Pharmaceutical Biotechnology; University of Illinois at Chicago | Articles | CommentsFor many years now, researchers and business analysts have observed the number of new drug approvals fall as the money spent in developing these drugs has risen sharply.
DNA Sequencing: From Revolutionary to Routine
April 8, 2011 6:42 am | by Alan Dove, PhD, Contributing Editor | Articles | CommentsDNA sequencing has become a common laboratory chore, and companies are increasingly outsourcing it to contractors. Here’s how to pick a good one.
Detecting Multiple miRNA Markers with Microarrays
April 5, 2011 10:40 am | by John Keefe, Sr. Product Manager-RNA; Affymetrix, Santa Clara, Calif. | Articles | CommentsSmall non-coding RNA has become a very important class of molecules for understanding cellular development, differentiation, and the mechanisms of disease for genetic disorders such as cancer.
Small RNA Discovery and Profiling with Next-Generation Sequencing
April 5, 2011 10:32 am | Articles | CommentsAs next-generation sequencing continues to evolve as a research tool, it is being adopted for examining gene regulation at the transcriptional and post-transcriptional levels.
A Long Way to the Bedside
March 9, 2011 10:13 am | by Catherine Shaffer, Contributing Editor | Articles | CommentsRecent years have seen rapid technological progress in the fields supporting personalized medicine, from biomarker discovery to mapping the genome to pushing back the frontiers of mass spec sensitivity.
Roche, RainDance Collaborate in Targeted Sequencing for ADME Research
March 7, 2011 7:04 am | News | CommentsRainDance Technologies, Inc., and 454 Life Sciences announced a collaboration for the development and commercialization of a targeted next-generation sequencing (NGS) solution for the investigation of drug absorption, distribution, metabolism, and excretion (ADME).
Advanced Imaging Software for Western Blot Analysis
January 13, 2011 5:06 am | by Stephanie R. Noles, PhD, Global In Vitro Product Manager Carestream Molecular Imaging, Woodbridge, Conn. | Articles | CommentsProtein analysis has quickly become as integral a component of the drug discovery process as genomics. The examination of protein expression levels and post-translational modifications helps identify new drug targets.
Fluorescent Western Blotting: A Quantitative Approach
January 13, 2011 4:54 am | by Amy Schutz-Geschwender, PhD, Principal Scientist; LI-COR Biosciences, Lincoln, Neb. | Articles | CommentsFor decades, researchers have used Western blotting to confirm the presence of a target protein in a complex sample. After gel electrophoresis, proteins are transferred to a membrane and interrogated with antibodies.
High Throughput Western Blotting
January 13, 2011 4:32 am | by Jeff Xu, Product Manager, Blotting and Stains, Bio-Rad Laboratories, Inc., Hercules, Calif. | Articles | CommentsWestern blotting involves the transfer of proteins from a gel matrix to a membrane following protein electrophoresis. This process serves as a bridge between protein separation and identification.
New Test Aids Breast Cancer Patients
December 6, 2010 7:18 am | News | CommentsA team of scientists has collaborated with Pfizer Inc. to develop a test to select which patients with ovarian cancer will benefit from drugs called PARP inhibitors, according to research.
Cancer GWAS and Data Analysis Grant Program
November 9, 2010 4:43 am | News | CommentsExpression Analysis and Illumina, Inc. are jointly funding a Cancer GWAS (Genome-Wide Association Study) and Data Analysis Grant program to support cutting-edge projects that show promise in identifying genetic elements important to cancer research and treatment.
Sigma Partnering With JAX to Distribute Mouse Models
November 4, 2010 8:22 am | News | CommentsSigma Life Science and The Jackson Laboratory, a not-for-profit genetics research institution, announced a joint agreement allowing JAX to distribute mouse models created using Sigma Life Science’s proprietary zinc finger nuclease technology.
The Search for CNS Cures
October 14, 2010 12:58 pm | Digital Editions | CommentsAdvances in medicine and healthcare are helping people live longer. However, healthcare systems and governments may not be prepared to deal with the medical, economic, and social challenges of an aging population.
Personal Genetic Profiling Services Lack Evidence For Claims
October 13, 2010 8:32 am | News | CommentsDirect-to-consumer personal genetic profiling services that claim to predict people's health risks by analysing their DNA are often inconclusive and companies that sell them should provide better information about the evidence on which the results are based.
Laying the IT Foundations
October 11, 2010 7:36 am | by David Chiang, Chief Executive Officer, Sage-N Research, Milpitas, Calif. | Articles | CommentsThe development of effective data analysis and storage solutions for high-throughput mass spectrometry.
Genomic and Metabolic Data Harnessed to Fight TB
October 8, 2010 6:49 am | News | CommentsResearchers at the Institute for Genomic Biology at the University of Illinois have developed a way to harness the prodigious quantities of both genomic and metabolic data being generated with high-throughput genomics and other techniques.
An X-ray for Your Genes
October 8, 2010 6:45 am | News | CommentsNot every patient reacts to a medicine in the same way. The personal genetic characteristics of individuals and populations can explain why a specific prescription successfully treats one patient and not another.
Human Genome Sequencing on a Grand Scale
September 15, 2010 6:29 am | by Radoje Drmanac, PhD, Chief Scientific Officer and Co-founder; Complete Genomics, Inc., Mountain View, Calif. | Articles | CommentsGenetic variations—the way in which genes and proteins differ between individuals—can have important medical consequences. As a result, complete human genome sequencing has many potential drug discovery applications.
NGS Delivers Fundamental Research Shift
September 15, 2010 6:20 am | by Elaine Wong-Ho, Associate Product Marketing Manager; Caliper Life Sciences, Hopkinton, Mass. | Articles | CommentsThe three current NGS platforms share a common feature—massively parallel sequencing of spatially separated, clonally amplified DNA molecules. This is fundamentally different than Sanger technology, in which individual sequencing reactions are separated by capillary electrophoresis.
The Blueprints for Personalized Medicine: A Genome Approach
September 15, 2010 5:50 am | by Edward L. Erickson, President and CEO; BioNanomatrix, Inc., Philadelphia, Pa. | Articles | CommentsResearchers are constantly searching for a better understanding of fundamental disease mechanisms and tools for early diagnosis and even pre-diagnosis of disease.
Ambry Adds HiSeq and BeadXpress Instruments
August 27, 2010 8:19 am | News | CommentsAmbry Genetics, a global leader in genomic services, announced that it has acquired the Illumina HiSeq 2000 Next Generation Sequencing System as well as received the first 510(K) approved Illumina BeadXpress Genotyping System.
