A study describes how gene-silencing oligonucleotides (GSOs) from Idera Pharmaceuticals efficiently inhibited gene expression while overcoming some of the issues associated with other gene-silencing technologies.
Researchers have identified several genes that may be implicated in the malaria parasite's notorious ability to rapidly evade drug treatments.
Researchers have for the first time observed the activity of a single gene in living cells, following the process of gene transcription.
Researchers have demonstrated how telomeres can be protected by caps made up of specialized proteins and stacks of DNA called G-quadruplexes, or G4 DNA.
For many years now, researchers and business analysts have observed the number of new drug approvals fall as the money spent in developing these drugs has risen sharply.
DNA sequencing has become a common laboratory chore, and companies are increasingly outsourcing it to contractors. Here’s how to pick a good one.
Small non-coding RNA has become a very important class of molecules for understanding cellular development, differentiation, and the mechanisms of disease for genetic disorders such as cancer.
As next-generation sequencing continues to evolve as a research tool, it is being adopted for examining gene regulation at the transcriptional and post-transcriptional levels.
Recent years have seen rapid technological progress in the fields supporting personalized medicine, from biomarker discovery to mapping the genome to pushing back the frontiers of mass spec sensitivity.
RainDance Technologies, Inc., and 454 Life Sciences announced a collaboration for the development and commercialization of a targeted next-generation sequencing (NGS) solution for the investigation of drug absorption, distribution, metabolism, and excretion (ADME).
Protein analysis has quickly become as integral a component of the drug discovery process as genomics. The examination of protein expression levels and post-translational modifications helps identify new drug targets.
For decades, researchers have used Western blotting to confirm the presence of a target protein in a complex sample. After gel electrophoresis, proteins are transferred to a membrane and interrogated with antibodies.
Western blotting involves the transfer of proteins from a gel matrix to a membrane following protein electrophoresis. This process serves as a bridge between protein separation and identification.
A team of scientists has collaborated with Pfizer Inc. to develop a test to select which patients with ovarian cancer will benefit from drugs called PARP inhibitors, according to research.
Expression Analysis and Illumina, Inc. are jointly funding a Cancer GWAS (Genome-Wide Association Study) and Data Analysis Grant program to support cutting-edge projects that show promise in identifying genetic elements important to cancer research and treatment.
Sigma Life Science and The Jackson Laboratory, a not-for-profit genetics research institution, announced a joint agreement allowing JAX to distribute mouse models created using Sigma Life Science’s proprietary zinc finger nuclease technology.
Advances in medicine and healthcare are helping people live longer. However, healthcare systems and governments may not be prepared to deal with the medical, economic, and social challenges of an aging population.
Direct-to-consumer personal genetic profiling services that claim to predict people's health risks by analysing their DNA are often inconclusive and companies that sell them should provide better information about the evidence on which the results are based.
The development of effective data analysis and storage solutions for high-throughput mass spectrometry.
Researchers at the Institute for Genomic Biology at the University of Illinois have developed a way to harness the prodigious quantities of both genomic and metabolic data being generated with high-throughput genomics and other techniques.
Not every patient reacts to a medicine in the same way. The personal genetic characteristics of individuals and populations can explain why a specific prescription successfully treats one patient and not another.
Genetic variations—the way in which genes and proteins differ between individuals—can have important medical consequences. As a result, complete human genome sequencing has many potential drug discovery applications.
The three current NGS platforms share a common feature—massively parallel sequencing of spatially separated, clonally amplified DNA molecules. This is fundamentally different than Sanger technology, in which individual sequencing reactions are separated by capillary electrophoresis.
Researchers are constantly searching for a better understanding of fundamental disease mechanisms and tools for early diagnosis and even pre-diagnosis of disease.
Ambry Genetics, a global leader in genomic services, announced that it has acquired the Illumina HiSeq 2000 Next Generation Sequencing System as well as received the first 510(K) approved Illumina BeadXpress Genotyping System.