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Daily news and top headlines for drug research professionals

Microbial 'Assembly Line' Makes Antibiotics, Other Drugs

June 19, 2014 11:15 am | News | Comments

Researchers at the University of Michigan have obtained for the first time three-dimensional snapshots of the “assembly line” within microorganisms that naturally produces antibiotics and other drugs, but the structure was not what the scientists had anticipated. Read more...

Horizon Licenses CRISPR Gene Editing Technology from Broad Institute

June 13, 2014 11:22 am | News | Comments

Horizon Discovery Group plc announced it has entered into a non-exclusive license agreement with the Broad Institute to access intellectual property related to the CRISPR/Cas9 gene editing system.  Read more...          

Researchers Discover Enzyme’s Role in DNA Repair

June 9, 2014 2:20 pm | News | Comments

Twelve years ago, UNC School of Medicine researcher Brian Strahl, Ph.D., found that a protein called Set2 plays a role in how yeast genes are expressed, specifically, how DNA gets transcribed into messenger RNA, and now his lab has found that Set2 is also a major player in DNA repair. Read more...

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Researchers Discover Three Possible Autism Treatment Targets

June 6, 2014 2:38 pm | News | Comments

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism. These networks may offer attractive targets for developing new autism drugs or repurposing existing drugs that act on components of the networks. Read more...

Scientists Find New Breast Cancer Targets

June 6, 2014 2:19 pm | News | Comments

Scientists from the Florida campus of The Scripps Research Institute have found new targets for potential intervention in breast cancer using an advanced technology known as hydrogen-deuterium exchange mass spectrometry to measure the intricate interactions between the AF1 and AF2 domains of the progesterone receptor. Read more...

Huntington's Mutant Protein Spreads from Sick to Healthy Cells

June 5, 2014 2:35 pm | News | Comments

A recent study published in Annals of Neurology reported that healthy human tissue grafted to the brains of patients with Huntington's disease in the hopes of treating the neurological disorder also developed signs of the illness, several years after the graft. Read more...

ImStem Advances MS Treatment with Embryonic Stem Cells

June 5, 2014 2:30 pm | News | Comments

ImStem Biotechnology Inc. announced it has successfully treated an animal model of multiple sclerosis - a chronic neuroinflammatory disease with no cure - using human embryonic stem cells (hESC) derived mesenchymal stem cells (MSCs), called hES-MSCs. Read more...

Ventana, MedImmune Collaborate on Custom Assay for Clinical Trials

June 4, 2014 2:47 pm | News | Comments

Ventana Medical Systems Inc. and MedImmune announced they are jointly developing a PD-L1 (SP263) immunohistochemistry assay to enroll patients in clinical trials for MedImmune's MEDI4736 anti-PD-L1 therapy for non-small cell lung carcinoma. Read more...

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EGFR Inhibitor Looks Promising in Lung Cancer

June 4, 2014 2:39 pm | News | Comments

Data from the ongoing Phase 1 AURA study in patients with EGFRm+, advanced NSCLC, demonstrate that the overall disease control rate was 94% for patients with EGFR T790M+ tumors - meaning that their tumors shrank or became stable - following treatment with the investigational drug AZD9291. Read more...

Personalized Cancer Therapies Come of Age

June 3, 2014 8:44 am | by Sean Harper, M.D., Executive Vice President of Research and Development, Amgen | Articles | Comments

For many decades, scientific advances in cancer treatment were characterized by a slow, non-linear progress that resulted in treatments with a less than stellar ability to target cancer cells. Now, the advent of biomarker-driven drug development and the drive toward personalized medicine have provided a new approach to the treatment of advanced cancer. Read more...

Breakthrough Advances Understanding of DNA Editing

May 27, 2014 2:51 pm | News | Comments

An international team of scientists from the Universities of Bristol, Münster and the Lithuanian Institute of Biotechnology has made a major step forward in our understanding of how enzymes 'edit' genes, paving the way for correcting genetic diseases in patients. Read more...

Scientists ID New Drug Targets for Triple Negative Breast Cancer

May 27, 2014 2:13 pm | News | Comments

The suppression of two genes reduce breast cancer tumor formation and metastasis by interfering with blood vessel formation and recruitment, report scientists from Houston Methodist and five other institutions in the Proceedings of the National Academy of Sciences. Read more...

Genetic Switching Element Differentiates Stem Cells

May 22, 2014 2:14 pm | News | Comments

Slight modifications in their genome sequences play a crucial role in the conversion of pluripotent stem cells into various differentiated cell types, and an LMU team has now identified the factor responsible for one class of modification. Read more...

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Scientists ID New Way to Fight Drug Resistance in Skin Cancer

May 22, 2014 10:49 am | News | Comments

Rapid resistance to vemurafenib– a treatment for a type of advanced melanoma, the deadliest form of skin cancer– could be prevented by blocking a druggable family of proteins, according to new research. Read more...          

Family Donates Research Funds for Rare Neurological Disorder

May 20, 2014 3:08 pm | News | Comments

A rare and mysterious neurological disorder inspired the Wilsey family of San Francisco to fund researchers at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and the Department of Molecular & Human Genetics at Baylor College of Medicine to study and develop treatments for NGLY1 deficiency. Read more...

Researchers Find Key Factor in Early Auditory Development

May 20, 2014 2:48 pm | News | Comments

Researchers at the National Institute on Deafness and Other Communication Disorders of the National Institutes of Health have uncovered a molecule, known as Bmp7, in an animal model that acts as a key player in establishing the organization of the auditory system. Read more...

IU, Paradigm Team Up on Breast Cancer Genomic Sequencing

May 16, 2014 1:03 pm | News | Comments

Indiana University cancer researchers, in partnership with Paradigm, are testing whether therapy incorporating advanced genomic technology will provide better outcomes than current treatments for those with an aggressive form of breast cancer. Read more...

Researchers Attack Parkinson's from Different Angle

May 16, 2014 12:36 pm | News | Comments

Instead of trying to restore dopamine contents in the brain, researchers at Lund University are attacking Parkinson's disease through early activation of a protein that improves the brain's capacity to cope with a host of harmful processes. Read more…

Novel Nanoinjector Avoids Cell Death During DNA Transfer

May 14, 2014 2:17 pm | News | Comments

The ability to transfer a gene or DNA sequence from one animal into the genome of another plays a critical role in a wide range of medical research—including cancer, Alzheimer's disease, and diabetes. Now, there's a way to avoid cell death when introducing DNA into egg cells. Read more...

Berg, MUSC Collaborate on Lupus Biomarker

May 13, 2014 1:11 pm | News | Comments

Berg and the Medical University of South Carolina announced a strategic partnership, designed to identify new therapeutic pathways and potential biomarkers to treat Lupus, the autoimmune disease affecting one in every 2,000 people and one in every 250 young African American women. Read more...

Monoclonal Antibody Shows Promise in Childhood Brain Tumor

May 9, 2014 2:12 pm | News | Comments

Tumors shrank or disappeared in some patients with advanced neuroblastoma in a Phase 1 study of an immune therapy manufactured at St. Jude Children's Research Hospital, prompting St. Jude to expand clinical trials to include patients newly diagnosed with neuroblastoma. Read more...

Synthorx Opens with Breakthrough Synthetic DNA Technology

May 8, 2014 1:29 pm | News | Comments

Synthorx Inc. announced the official launch of the company, which will be focused on using synthetic biology to improve the discovery and development of new medicines, diagnostics and vaccines, and a publication in Nature describing the first example of the in vivo replication of a synthetic DNA base pair. Read more...

Researchers Urge Caution in Stem Cell Heart Attack Trials

May 8, 2014 1:02 pm | News | Comments

A new study in Nature challenges research data that form the scientific basis of clinical trials in which heart attack patients are injected with stem cells to try and regenerate damaged heart tissue, because cardiac stem cells used in clinical trials do not regenerate heart muscle cells at high enough rates. Read more...

SARomics, InSili.com Enter Discovery Alliance

May 7, 2014 2:44 pm | News | Comments

SARomics Biostructures and inSili.com announced that they have entered into a strategic drug discovery partnership, within which the two companies will perform joint research with the goal of finding novel bioactive agents against therapeutic drug targets. Read more...

biOasis Delivers siRNA Across the Blood-Brain Barrier

May 7, 2014 2:38 pm | News | Comments

Bioasis Technologies Inc., a pioneering biopharmaceutical company focused on overcoming the blood-brain barrier, has shown that a newly discovered peptide vector form of Transcend - Transcendpep - effectively delivers siRNA across the blood-brain barrier and into brain cells. Read more...

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