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Daily news and top headlines for drug research professionals

Research Team Finds Key to Blood Clotting

May 1, 2014 12:28 pm | News | Comments

An international team led by scientists at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM) has found the detailed structure of a receptor that plays a key role in platelet activation and blood clotting. Read more...  

Experimental Drug Extends Life Span in Mice

May 1, 2014 10:28 am | News | Comments

Scientists have newly identified a protein’s key role in cell and physiological aging and have developed an experimental drug that inhibits the protein’s effect and prolonged the lifespan in a mouse model of accelerated aging. Read more...    

First ALD Patient Gets New Gene Therapy

April 29, 2014 1:12 pm | News | Comments

If successful, Neuralgene's PRCN-323 treatment could significantly change the prognosis for everyone with the rare genetic disorder known as adrenoleukodystrophy, or ALD, an inherited genetic disease linked to the X chromosome, specifically a mutation of the ABCD-1 gene. Read more...

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Researchers Advance Brain Cancer Treatment with Nanoparticles

April 29, 2014 12:43 pm | News | Comments

Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable “nanoparticles” able to carry DNA to brain cancer cells in mice that might one day be given to brain cancer patients during neurosurgery. Read more...

Clean Genome Editing Without Off-Target Mutations

April 29, 2014 10:46 am | Product Releases | Comments

Transposagen’s NextGEN CRISPR technology is the first truly dimeric RNA-guided FokI nuclease. NextGEN CRISPR technology has all the advantages of the CRISPR-Cas9 system, but has eliminated the problems with off-site targeting.

Champions Oncology Personalizes Cancer Treatment

April 28, 2014 1:39 pm | News | Comments

Results from a study published in Clinical Cancer Research demonstrate that oncologists were able to accurately predict which therapies patients would respond to by using a combination of next-generation sequencing and drug sensitivity testing in mouse avatars developed by Champions Oncology. Read more...

Scientists Publish Tsetse Fly Genome

April 25, 2014 2:26 pm | News | Comments

An international team of scientists has published the genome of the tsetse fly Glossina morsitans, a pest native to sub-Saharan Africa that transmits parasitic infections such as trypanosomiasis (sleeping sickness) to humans and animals. Read more...

Aspirin Reduces Colon Cancer Risk for Those with Specific Gene

April 24, 2014 10:02 am | News | Comments

The humble aspirin may have just added another beneficial effect beyond its ability to ameliorate headaches and reduce the risk of heart attacks: lowering colon cancer risk among people with high levels of a specific type of gene. Read more...  

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'Chaperone' Compounds Offer New Approach to Alzheimer’s Treatment

April 21, 2014 10:53 am | News | Comments

A team of researchers has devised a wholly new approach to the treatment of Alzheimer’s disease involving the so-called retromer protein complex. Read more...                           

New Gene Technology Has Therapeutic Implications

April 17, 2014 12:16 pm | News | Comments

For thousands of years humans have been tinkering with plant genetics, even when they didn’t realize that is what they were doing, in an effort to make stronger, healthier crops that endured climates better, and produced more. Read more...   

Protein Partnership Inflames Immune Cells in Cancer

April 15, 2014 12:53 pm | News | Comments

Scientists have identified two unlikely partners in a type of immune cell called a macrophage that work together in response to cancer drugs to increase inflammation in a way that may alter tumor growth. Read more...         

Expression of Tumor Suppressor Linked to Breast Cancer Survival

April 11, 2014 1:18 pm | News | Comments

A tumor-suppressing protein acts as a dimmer switch to dial down gene expression. It does this by reading a chemical message attached to another protein that's tightly intertwined with DNA, a team led by scientists at The University of Texas MD Anderson Cancer Center reported at the AACR Annual Meeting 2014. Read more...

Study Findings May Drive Parkinson’s Treatment Research

April 11, 2014 12:51 pm | News | Comments

Scientists at Johns Hopkins University and the Institute for Cell Engineering may have discovered how the most common genetic cause of Parkinson’s disease destroys brain cells and devastates many patients worldwide. Read more...  

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Yeast Provides Genetic Clues to Drug Response

April 11, 2014 10:45 am | News | Comments

Why do people respond differently to the same drug? For the first time, researchers have untangled genetic and environmental factors related to drug reactions, bringing us a step closer to predicting how a drug will affect us. Read more...   

Plant Nanotubes May Improve Chemotherapy Treatment

April 4, 2014 1:52 pm | News | Comments

Researchers took what some would consider garbage and made a remarkable scientific tool, one that could someday help to correct genetic disorders or treat cancer without chemotherapy’s nasty side effects. Read more...         

How Personalized Medicine Works: Bioinformaticians to the Rescue

April 3, 2014 10:23 am | Videos | Comments

In our third video, Rob Fee is back to discuss how informatics can help to overcome one of the biggest challenges in personalized medicine: organizing and examining the mountains of data that are generated during the gene sequencing process. Rob's advice? Find a bioinformatician...fast!

Celgene, Forma Announce Multi-Year Strategic Alliance

April 1, 2014 2:13 pm | News | Comments

Forma Therapeutics, an R&D organization in pursuit of medicines in oncology and other therapeutic areas, announced a second strategic collaboration and option agreement with Celgene Corp. Read more...        

Experimental Cancer Drug Reverses Schizophrenia in Mice

April 1, 2014 1:17 pm | News | Comments

Johns Hopkins researchers say that an experimental anticancer compound appears to have reversed behaviors associated with schizophrenia and restored some lost brain cell function in adolescent mice with a rodent version of the devastating mental illness. Read more...

New Initiative Aims to Improve Outcomes in Metastatic Colorectal Cancer

April 1, 2014 8:53 am | News | Comments

Merck Serono, the biopharmaceutical division of Merck, announced the formation of the global Oncology Partnership and Education Network (OPEN). Read more...                

Discovery May Help Predict Lung Cancer Treatment Success

March 25, 2014 10:01 am | News | Comments

Scientists have discovered the structure of an abnormal protein which causes an aggressive type of lung cancer, according to new research. Read more...                             

Dog DNA Plays Role in Developing New Human Therapies

March 18, 2014 2:35 pm | News | Comments

Using genomic analysis to study cancer in dogs can help develop new therapies for humans with cancer, according to a new proof-of-concept study. Read more...                           

Study Proposes New Ovarian Cancer Targets

March 13, 2014 3:31 pm | News | Comments

Proteins called TAFs were once thought to be generic cogs in the machinery of gene expression, but in a new study scientists propose that they may be important suspects in the progression of ovarian cancer that should not continue to be overlooked. Read more...

Program Simulates Activation of Cancer Protein, May Lead to New Drug Design

March 7, 2014 1:12 pm | News | Comments

Folding@home, a program that taps the idle processing time of 200,000 personal computers to elucidate the 3-D shape of proteins, has simulated a protein transitioning between its inactive and active configurations. Read more...       

Doctors Make Strides Toward HIV Cure, Gene Treatment

March 6, 2014 2:27 pm | by Marilynn Marchione, AP Chief Medical Writer | News | Comments

A second baby born with the AIDS virus may have had her infection put into remission and possibly cured by very early treatment- in this instance, four hours after birth. In other AIDS research, scientists have modified genes in the blood cells of a dozen adults to help them resist HIV. Read more...

New Probes Quantify Folded and Misfolded Protein Levels in Cells

March 4, 2014 2:29 pm | News | Comments

Scientists at The Scripps Research Institute (TSRI) have invented small-molecule folding probes that enable them to quantify functional, normally folded and disease-associated misfolded conformations (shapes) of a protein-of-interest in cells under different conditions.

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