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Daily news and top headlines for drug research professionals

Protein May Prevent Antibody-Mediated Transplant Rejection

July 31, 2014 8:40 am | News | Comments

A study presented at the 2014 World Transplant Congress evaluated the safety and efficacy of CSL Behring's C1 Inhibitor (C1-INH) concentrate in preventing antibody-mediated rejection following kidney transplants in highly sensitized patients. Read more...

Researchers ID New Malaria Vaccine Candidates

July 31, 2014 8:29 am | News | Comments

Researchers have discovered new vaccine targets that could help in the battle against malaria. Taking a new, large-scale approach to this search, researchers tested a library of proteins from the Plasmodium falciparum parasite with antibodies produced by the immune systems of a group of infected children. Read more...

Sage Licenses Gene Editing Tool from the Broad Institute

July 30, 2014 11:06 am | News | Comments

Sage Labs Inc., a leading provider of products, services and technologies in the field of genome engineering, announced that they have licensed CRISPR/Cas9 technology from the Broad Institute enabling them to use the CRISPR/Cas9 system to engineer cell and animal models for their clients as well as distribute validated CRISPR reagents. Read more...

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AstraZeneca, Kyowa Hakko Kirin Partner on Immuno-Oncology Study

July 30, 2014 10:48 am | News | Comments

AstraZeneca announced that it has entered into a clinical study collaboration with Kyowa Hakko Kirin for a Phase 1/1b immuno-oncology study that will evaluate the safety and efficacy of two separate combinations of three investigational compounds in multiple solid tumors. Read more...

Researchers to Study BRCA1-Related Breast Cancer

July 30, 2014 10:26 am | by Ashley WennersHerron, Virginia Tech | News | Comments

Deborah Kelly and Zhi Sheng, assistant professors at the Virginia Tech Carilion Research Institute, recently received a grant from the Commonwealth Health Research Board to investigate hereditary breast cancer, an effort that may lead to new treatment approaches. Read more...

AstraZeneca, QIAGEN Collaborate on Iressa Diagnostic Test

July 28, 2014 12:38 pm | News | Comments

AstraZeneca announced that it has entered into a collaboration with Netherlands-based QIAGEN to develop a non-invasive diagnostic test to identify non-small cell lung cancer patients who are suitable for treatment with Iressa. Read more...    

Scientists Discover New Mechanism of Drug Resistance

July 28, 2014 12:31 pm | News | Comments

Microorganisms can evade treatment by acquiring mutations in the genes targeted by antibiotics or antifungal drugs. Now, a new study has shown that microorganisms can use a temporary silencing of drug targets to gain the benefits of drug resistance without the commitment. Read more...

TTP Labtech Technology IDs Novel Drug Candidates for Neuropsychiatric Disorders

July 25, 2014 2:50 pm | News | Comments

The first high-resolution X-ray crystal structure of the metabotropic glutamate receptor 5 transmembrane domain was reported in Nature this week. The work was performed at Heptares Therapeutics using TTP Labtech’s innovative liquid handling technology for lipidic cubic phase crystallography. Read more...

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Genomics Reveals Mechanism for Malaria Drug Resistance

July 25, 2014 10:58 am | News | Comments

Researchers have uncovered a way the malaria parasite becomes resistant to an investigational drug, a  discovery made at Washington University School of Medicine in St. Louis that also is relevant for other infectious diseases including bacterial infections and tuberculosis. Read more...

TCGA Identifies Four Stomach Cancer Subtypes

July 24, 2014 10:51 am | News | Comments

Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas (TCGA) Network have found: a discovery that could change how researchers think about developing treatments for stomach cancer, also called gastric cancers or gastric adenocarcinomas. Read more...

Shire to Spend About $225M on Drug Collaboration

July 23, 2014 11:20 am | News | Comments

The drugmaker Shire plans to spend about $225 million in a joint effort with a privately held, U.S. firm to develop a potential treatment for the rare and life-threatening genetic disorder Hunter syndrom, said the British company Wednesday. Read more...

Metabolic Enzyme Stops Renal Cancer Progression

July 22, 2014 10:52 am | News | Comments

In an analysis of small molecules called metabolites used by the body to make fuel in normal and cancerous cells in human kidney tissue, a research team from the Perelman School of Medicine at the University of Pennsylvania identified an enzyme key to applying the brakes on tumor growth. Read more...

Genetic Mapping Triggers Hope for Schizophrenia

July 22, 2014 10:40 am | by Seth Borenstein, AP Science Writer | News | Comments

Scientists have linked more than 100 spots in our DNA to the risk of developing schizophrenia, casting light on the mystery of what makes the disease tick, providing the first hard genetic evidence to bolster a theory connecting the immune system to the disease. Read more...

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Breakthrough May Benefit Bowel Cancer Treatments

July 18, 2014 2:50 pm | News | Comments

Researchers have made a significant breakthrough that may benefit patients with bowel cancer: how two genes cause bowel cancer cells to become resistant to treatments used against the disease. Read more...          

Unrecognized Layer of Biology Promises New Drug Targets

July 18, 2014 11:24 am | News | Comments

Scientists at The Scripps Research Institute and Hong Kong University of Science and Technology and their collaborators have found that ancient enzymes, known for their fundamental role in translating genetic information into proteins, evolved myriad other functions in humans. Read more...

Researchers Create Biological Pacemakers with Gene Therapy

July 18, 2014 10:59 am | News | Comments

Cardiologists at the Cedars-Sinai Heart Institute have developed a minimally invasive gene transplant procedure that changes unspecialized heart cells into “biological pacemaker” cells that keep the heart steadily beating, potentially leading lead to clinical trials for humans with heart rhythm disorders but suffer side effects. Read more...

Scientists Trap, Kill Malaria Parasite

July 17, 2014 10:45 am | by Michael C. Purdy | News | Comments

Scientists may be able to entomb the malaria parasite, Plasmodium falciparum, in a prison of its own making, researchers at Washington University School of Medicine in St. Louis report in Nature, which in another story highlights the importance of a pore to the parasite’s survival. Read more...

New Brain Protein Tied to Alzheimer's Disease

July 16, 2014 1:01 pm | by Marilynn Marchione, AP Chief Medical Writer | News | Comments

Scientists have linked a new protein to Alzheimer's disease, which could give a new target for developing drugs and other treatments for Alzheimer's, the most common form of dementia. Read more...                

New Technology Delivers Cargo, Doesn’t Disrupt Cell

July 14, 2014 10:59 am | News | Comments

Portage Biotech announced that Portage Pharmaceuticals has successfully validated a new proprietary cell permeable peptide platform technology derived from human genes that delivers an active pharmacological agent or cargo into a cell without disrupting the cell membrane. Read more...

NIH Awards SBIR Grant for Epigenetic Database

July 7, 2014 2:25 pm | News | Comments

Reaction Biology Corp. (RBC) announced that it has been awarded a Phase 1 SBIR grant from the National Center for Advancing Translational Sciences to create a database of epigenetic drug interactions. Read more...           

Pseudogenes May Help in the Discovery of Biomarkers

July 7, 2014 11:06 am | News | Comments

Alas, the thankless pseudogene: dysfunctional, unloved and seemingly of little use, these poor-cousin relatives of genes have lost their protein-coding abilities, contain material not essential for an organism’s survival and are the “last stop” for removal of genomic waste. Read more...

Some 500 Genes Differ in Bipolar Patients’ Neurons

July 2, 2014 3:16 pm | by Cynthia Fox, Science Editor | Articles | Comments

Neurons of patients with bipolar disorder (BP) differ from the norm in a “striking” 500 or so genes, according to preliminary data generated using the Nobel-Prize-winning iPSC (induced pluripotent stem cell) approach, by Salk Institute neuroscientist Fred Gage. Read more...

Scientists Reconstruct Life History of a Single Cell

June 30, 2014 10:50 am | News | Comments

Researchers have developed new methods to trace the life history of individual cells back to their origins in the fertilized egg by looking at the copy of the human genome present in healthy cells and building a picture of each cell's development from the early embryo to part of an adult organ. Read more...

Scientists Use Cancer Drug in Gene Therapy

June 27, 2014 1:28 pm | News | Comments

Scientists working to make gene therapy a reality have solved a major hurdle - how to bypass a blood stem cell’s natural defenses and efficiently insert disease-fighting genes into the cell’s genome - with rapamycin, which is commonly used to slow cancer growth and prevent organ rejection. Read more...

Human Longevity Supports Innovation to Advance Treatment of Cancer, Other Diseases

June 26, 2014 11:10 am | News | Comments

Human Longevity Inc., a genomics and cell therapy-based diagnostic and therapeutic company focused on extending the healthy, high performance human life span, called on physicians, the insurance industry and political leaders to support promising new avenues of medical discovery on behalf of patients with life-threatening diseases including cancer. Read more...

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