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The Lead

Treatment Combo Benefits Lung Cancer Patients

July 30, 2014 2:04 pm | News | Comments

A combination of the EGFR-targeted anticancer therapeutics Gilotrif and Erbitux yielded clinical responses in 29% of patients who had lung cancer harboring epidermal growth factor receptor mutations that had stopped responding to other inhibitors, according to new data. Read more...

Researchers to Study BRCA1-Related Breast Cancer

July 30, 2014 10:26 am | by Ashley WennersHerron, Virginia Tech | News | Comments

Deborah Kelly and Zhi Sheng, assistant professors at the Virginia Tech Carilion Research...

Cancer Challenge Attracts Anonymous $100M Gift

July 29, 2014 2:54 pm | News | Comments

Oregon Health & Science University’s Knight Cancer Institute has received a $100 million...

Forced Mutations Doom HIV

July 29, 2014 2:32 pm | News | Comments

Fifteen years ago, researchers thought if they could induce the HIV virus to mutate...

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Artes, Burnet Institute Partner on Malaria Vaccine

July 29, 2014 11:13 am | by Catherine Somerville | News | Comments

Artes Biotechnology and Burnet Institute have joined forces to develop a new type of malaria vaccine in a project funded by the PATH Malaria Vaccine Initiative (MVI), which will produce purified vaccine antigens as virus-like particles, a type of nano-particle, for testing in laboratory studies. Read more...

Biologists Think Stem Cells May “Talk” to Each Other

July 29, 2014 10:47 am | News | Comments

Biologists at the University of Sheffield’s Centre for Stem Cell Biology led by Prof. Peter Andrews and engineers in the Complex Systems and Signal Processing Group led by Prof. Daniel Coca have completed a landmark study of human pluripotent stem cells. Read more...

Scientists Discover New Mechanism of Drug Resistance

July 28, 2014 12:31 pm | News | Comments

Microorganisms can evade treatment by acquiring mutations in the genes targeted by antibiotics or antifungal drugs. Now, a new study has shown that microorganisms can use a temporary silencing of drug targets to gain the benefits of drug resistance without the commitment. Read more...

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Cancer Drug Shows Promise as Infertility Treatment

July 28, 2014 12:26 pm | News | Comments

Physicians may have a new drug to treat infertility in women with polycystic ovary syndrome, according to a national, multi-center clinical trial. Read more...                          

Liberia’s President Tries to Contain Ebola Outbreak

July 28, 2014 10:17 am | by Jonathan Paye-Layleh, Associated Press | News | Comments

Liberia's president has closed all but three land border crossings, restricted public gatherings and quarantined communities heavily affected by the Ebola outbreak in the West African nation, which has killed 129 people in the country and more than 670 across the region. Read more...

SRI Snags NIH Contract for HIV, AIDS Therapies

July 25, 2014 2:47 pm | News | Comments

SRI International has been awarded a new $49 million, seven-year contract with the NIAID, part of the NIH, to conduct preclinical development of potential therapies for HIV infection and AIDS. Read more...              

‘Broken Genes’ for a Broken System

July 25, 2014 2:30 pm | News | Comments

The recent discovery of a genetic mutation that protects against type 2 diabetes may offer hope in fighting more than just diabetes. It also illustrates how using the tools of genetics to hunt for “broken genes” can aid drug discovery, according to a Harvard professor. Read more...

Metastatic Brain Tumor Treatment Could Be on the Horizon

July 24, 2014 3:19 pm | News | Comments

Over half of patients being seen in the clinic for a diagnosed brain tumor have metastatic cancer, which has no treatment and detrimental outcomes in most cases. However, a new study provides hope that previously studied SapC-DOPS could be used for treatment of brain cancer that has spread. Read more...

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Researchers Create Vaccine for Dust-Mite Allergies

July 24, 2014 3:05 pm | News | Comments

If you’re allergic to dust mites (and chances are you are), help may be on the way. Researchers have developed a vaccine that can combat dust-mite allergies by naturally switching the body’s immune response. Read more...         

Research Shows that One CF Drug Counteracts Another

July 24, 2014 11:08 am | News | Comments

In lab experiments using tissue samples cultured from cystic fibrosis patients, scientists at the UNC School of Medicine and the UNC Marsico Lung Institute have shown that a new CF drug counteracts the intended beneficial molecular effect of another CF drug. Read more...

TCGA Identifies Four Stomach Cancer Subtypes

July 24, 2014 10:51 am | News | Comments

Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas (TCGA) Network have found: a discovery that could change how researchers think about developing treatments for stomach cancer, also called gastric cancers or gastric adenocarcinomas. Read more...

Developing Multi-Functional Anti-Inflammatory Drugs

July 24, 2014 10:44 am | by Gur Roshwalb, M.D., Chief Executive Officer of Celsus Therapeutics | Articles | Comments

Recent years have witnessed the development of novel, non-steroidal anti-inflammatory drugs termed Multi-Functional Anti-Inflammatory Drugs (MFAIDs) focusing has been on one of the most sought-after pharmaceutical targets in inflammation research: the secretory phospholipase A2 family. Read more...

Head of Troubled CDC Anthrax Lab Resigns

July 23, 2014 2:09 pm | News | Comments

The head of the government lab which potentially exposed workers to live anthrax has resigned, an agency spokesman said Wednesday. Michael Farrell was head of the Centers for Disease Control and Prevention lab since 2009. He submitted his resignation Tuesday, the spokesman said. Read more...

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Survey Finds Sharp Increase in Teen HGH Use

July 23, 2014 1:31 pm | by David Crary, AP National Writer | News | Comments

Experimentation with human growth hormones by America's teens more than doubled in the past year, as more young people looked to drugs to boost their athletic performance and improve their looks, according to a new survey. Read more...     

Genes Play a Role in Radiation Survival

July 23, 2014 11:16 am | News | Comments

A team of researchers from the University of Wisconsin have identified 46 genes in Escherichia coli that are necessary for its survival at exceptionally high levels of radiation. The paper appears ahead of print in the Journal of Bacteriology. Read more...

Autoimmune Disorders, Cancer Share Apoptosis Inhibitors

July 23, 2014 10:53 am | News | Comments

Autoimmune disorders may share certain pathogenic mechanisms with cancer, according to a new report by George Washington University researcher Linda Kusner, Ph.D., published in PLOS ONE, showing that the very same inhibitors of apoptosis, or cell destruction, in tumors are also expressed in cells that produce autoimmune diseases. Read more...

Potential Flu Drugs Target Immune Response, Not Virus

July 22, 2014 2:07 pm | News | Comments

The seriousness of disease often results from the strength of immune response, rather than with the virus, itself. Turning down that response, rather than attacking the virus, might be a better way to reduce that severity. Read more...         

Easing Drug-Induced Fatty Liver Disease in HIV Patients

July 22, 2014 1:40 pm | News | Comments

The only drug to receive FDA approval for reduction of the abdominal fat deposits that develop in some patients receiving antiviral therapy for HIV infection may also reduce the incidence of fatty liver disease. Read more...        

Metabolic Enzyme Stops Renal Cancer Progression

July 22, 2014 10:52 am | News | Comments

In an analysis of small molecules called metabolites used by the body to make fuel in normal and cancerous cells in human kidney tissue, a research team from the Perelman School of Medicine at the University of Pennsylvania identified an enzyme key to applying the brakes on tumor growth. Read more...

Genetic Mapping Triggers Hope for Schizophrenia

July 22, 2014 10:40 am | by Seth Borenstein, AP Science Writer | News | Comments

Scientists have linked more than 100 spots in our DNA to the risk of developing schizophrenia, casting light on the mystery of what makes the disease tick, providing the first hard genetic evidence to bolster a theory connecting the immune system to the disease. Read more...

Antipsychotic Drugs Linked to Decreased Brain Volume

July 21, 2014 3:18 pm | News | Comments

A new study has confirmed a link between antipsychotic medication and a slight, but measureable, decrease in brain volume in patients with schizophrenia. Read more...                        

Gold Nanoparticles Penetrate Cells, Show Promise for Drug Delivery

July 21, 2014 3:09 pm | Videos | Comments

A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells. Read more...                          

Researchers Aim to Help Doctors Attack Metastases

July 21, 2014 11:22 am | News | Comments

Researchers at the University of Arkansas have been awarded $1.5 million from the National Cancer Institute at the National Institutes of Health to develop new molecules and biopharmaceuticals that enhance a patient’s immune response against tumors. Read more...

Researchers ID Possible Target for Early-Stage Breast Cancer Immunotherapy

July 18, 2014 2:59 pm | News | Comments

Researchers used a new molecular analysis tool to accurately detect the level of an important target for immunotherapy in early-stage breast cancers. Read more...                         

Breakthrough May Benefit Bowel Cancer Treatments

July 18, 2014 2:50 pm | News | Comments

Researchers have made a significant breakthrough that may benefit patients with bowel cancer: how two genes cause bowel cancer cells to become resistant to treatments used against the disease. Read more...          

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