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The Lead

Mutated Polio Virus Breaches Vaccine Protection

August 22, 2014 10:48 am | News | Comments

Scientists of the University of Bonn, together with colleagues from Gabon, are reporting alarming findings: a mutated polio virus that was able to resist the vaccine protection to a considerable extent was found in victims of an outbreak in the Congo in 2010. Read more...

The Case for Orphan Drugs

August 22, 2014 10:34 am | by By Louise Rozik, Editor | Articles | Comments

Neglected by the pharmaceutical industry before the Orphan Drug Act of 1983, rare diseases are...

Botox Injections Slow Growth of Stomach Tumors

August 21, 2014 1:00 pm | News | Comments

New research shows that nerves may play a critical role in stomach cancer growth and that...

Researchers Restore Protein in Muscular Dystrophy

August 21, 2014 11:19 am | News | Comments

For the first time, a research team has succeeded in restoring a missing repair protein in...

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Ebola: Slum Calm; Aid Worker Recovers

August 21, 2014 11:12 am | by Jonathan Paye-Layleh, Associated Press | News | Comments

Calm returned Thursday to a slum in the Liberian capital that was sealed off in the government's attempt to halt the spread of Ebola, a day after clashes erupted between residents and security forces, and in the United States, an aid worker who was infected in Liberia has recovered. Read more...

New Vaccine Promising Weapon Against TB, Leprosy

August 20, 2014 2:09 pm | News | Comments

The currently available century-old vaccine Bacille Calmette-Guerin, or BCG, provides only partial protection against both tuberculosis and leprosy. Now, researchers may have found a stronger weapon against both diseases. Read more...     

Liberia Seals Slum to Halt Ebola

August 20, 2014 10:09 am | by Jonathan Paye-Layleh, Abbas Dulleh, Associated Press | News | Comments

Security forces blocked off a seaside slum in Liberia's capital Wednesday, stepping up the government's fight to stop the spread of Ebola, unnerving residents and reportedly sparking a protest by disgruntled youths opposed to the quarantine. Read more...

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Unlocking the Power of Big Data in R&D, Part Two

August 19, 2014 11:23 am | by Sharon Benzeno, PhD, MBA, Senior Director, Business Development Bioinformatics, Elsevier | Articles | Comments

Big data is one of the hottest topics in R&D as its potential to accelerate successful drug development becomes more widely recognized. Part 2 of this two-part article analyses the new data-driven decision-making approaches make a difference to life science R&D. Read more...

Breaking News: All Missing Ebola Patients Are Back

August 19, 2014 10:16 am | by Jonathan Paye-Layleh, John Heilprin, Associated Press | News | Comments

All the people who were being screened for Ebola when they fled a health center during looting are now back in a hospital, a Liberian official said Tuesda, but it is still not clear where the stolen bloody sheets and mattresses are. Read more...

Microchip Tracks Cancer Cell Migration

August 18, 2014 10:50 am | News | Comments

Using a microengineered device that acts as an obstacle course for cells that leaves just enough space for the cells to weave their way through, researchers have shed new light on a cellular metamorphosis thought to play a role in tumor cell invasion throughout the body. Read more...

Ebola Quarantine Escapees Return

August 18, 2014 10:39 am | by Jonathan Paye-Layleh, Associated Press | News | Comments

Some of the people who fled an Ebola quarantine center in a Liberian slum when it was looted over the weekend are again under observation at a hospital Monday, as authorities struggle to contain the spread of an Ebola outbreak in West Africa. Read more...

Watch Yourself: Device Data May Improve Parkinson's Research, Monitoring

August 15, 2014 2:01 pm | Videos | Comments

The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and Intel Corporation announced a collaboration aimed at improving research and treatment for Parkinson’s disease. Read more...                  

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10 Things You Might Not Know About Ebola

August 15, 2014 1:09 pm | by Christina Jakubowski, News Editor | News | Comments

The 2014 outbreak of Ebola virus in West Africa has the world on high alert. Currently deemed an international public health emergency by the WHO, the virus has racked up more than 1,060 deaths and sickened 1,975 – making it the deadliest Ebola outbreak ever.

HIV Patients in Developing Countries Face New Health Threats

August 15, 2014 10:11 am | News | Comments

Health care systems that keep HIV patients from dying early in low- and middle-income nations need urgently to be repurposed to treat the chronic diseases that many of these patients now have, according to recommendations resulting from a multidisciplinary conference sponsored by the National Institutes of Health. Read more...

Chikungunya Vaccine Induces Robust Antibody Response

August 15, 2014 9:55 am | News | Comments

An experimental vaccine to prevent the mosquito-borne viral illness chikungunya elicited neutralizing antibodies in all 25 adult volunteers who participated in a recent early-stage clinical trial conducted by researchers at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. Read more...

NSAIDs May Lower Breast Cancer Recurrence Rate

August 14, 2014 3:30 pm | News | Comments

Recurrence of hormone-related breast cancer was cut by half in overweight and obese women who regularly used aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), according to new data. Read more...            

Injection of Modified Bacteria Shrinks Tumors

August 14, 2014 3:00 pm | News | Comments

A modified version of the Clostridium novyi (C. novyi-NT) bacterium can produce a strong and precisely targeted anti-tumor response in rats, dogs and now humans, according to a new report. Read more...              

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Breaking News: NewLink Genetics to Test Ebola Vaccine

August 14, 2014 12:48 pm | by Tom Murphy, AP Business Writer | News | Comments

An Iowa drug developer is preparing to test a possible Ebola vaccine in humans, as scientists race to develop ways to prevent or fight a virus that has killed more than 1,000 people in a West African outbreak and for which there is no proven treatment or vaccine. Read more...

Study Reveals How Ebola Blocks Immune System

August 14, 2014 10:28 am | News | Comments

The Ebola virus, in the midst of its biggest outbreak on record, is a master at evading the body’s immune system, but researchers at Washington University School of Medicine in St. Louis and elsewhere have learned one way the virus dodges the body’s antiviral defenses, providing important insight that could lead to new therapies. Read more...

UN: OK to Use Untested Ebola Drugs in Outbreak

August 13, 2014 10:57 am | by Maria Cheng, Ciaran Giles, Associated Press | News | Comments

The World Health Organization declared it's ethical to use untested drugs and vaccines in the ongoing Ebola outbreak in West Africa, although the tiny supply of one experimental treatment has been depleted and it could be many months until more is available. Read more...

Epigenetic Cancer Cell Markers Could Improve Treatment

August 12, 2014 3:05 pm | News | Comments

Scientists have known for decades that cancer can be caused by genetic mutations, but more recently they have discovered that chemical modifications of a gene can also contribute to cancer. These alterations, known as epigenetic modifications, control whether a gene is turned on or off. Now, a team engineers has developed a fast, reliable method to detect this type of modification. Read more...

Bioengineers Create 3-D Brain-Like Tissue

August 12, 2014 11:17 am | News | Comments

Bioengineers have created three-dimensional brain-like tissue that functions like and has structural features similar to tissue in the rat brain, can be kept alive in the lab for more than two months and could provide a superior model for studying normal brain function as well as injury and disease. Read more...

Liberian Doctors to Get Experimental Ebola Drug

August 12, 2014 11:02 am | by Jonathan Paye-Layleh, Maria Cheng, Associated Press | News | Comments

Liberia announced Monday that it would soon receive doses of an experimental Ebola drug and give it to two sick doctors, making them the first Africans to receive some of the scarce treatment in a spiraling outbreak, which has claimed the lives of 1,013 people in West Africa. Read more...

Discovery May Provide Key to Treating CHF

August 11, 2014 2:38 pm | News | Comments

Researchers have discovered a previously unknown cardiac molecule -- a long non-coding RNA called myosin heavy-chain-associated RNA transcript or Myheart  -- that could provide a key to treating, and preventing, heart failure. Read more...

First US Ebola Outbreak Stopped 25 Years Ago

August 11, 2014 2:24 pm | by Matthew Barakat, Associated Press | News | Comments

It had all the makings of a public-health horror story: an outbreak of a wildly deadly virus on the doorstep of the nation's capital, with dozens of lab monkeys dead, multiple people testing positive, and no precedent in this country on how to contain it. Read more...

Stiffness Matters in Stem Cell Differentiation

August 11, 2014 10:41 am | News | Comments

Bioengineers at the University of California, San Diego have proven that when it comes to guiding stem cells into a specific cell type, the stiffness of the extracellular matrix used to culture them really does matter and also found that a protein binding the stem cell to the hydrogel is not a factor in the differentiation of the stem cell as previously suggested. Read more...

Venom Gets Good Buzz as Potential Cancer Drug

August 11, 2014 10:16 am | News | Comments

Bee, snake or scorpion venom could form the basis of a new generation of cancer-fighting drugs, reported scientists who have devised a method for targeting venom proteins specifically to malignant cells while sparing healthy ones. Read more...

Ethical Questions Emerge Over Who Gets Ebola Drug

August 11, 2014 10:00 am | by Ciaran Giles, Maria Cheng, Associated Press | News | Comments

In a development that raises a host of ethical issues, Spain announced it had obtained a scarce U.S.-made experimental Ebola drug to treat a Spanish missionary priest infected with the killer virus, despite the U.S. Centers for Disease Control and Prevention having said there were virtually no doses available of the drug. Read more...

New Culprit Identified in Metabolic Syndrome

August 8, 2014 3:11 pm | by Julia Evangelou Strait | News | Comments

A new study suggests uric acid - a normal waste product removed from the body by the kidneys and intestines and released in urine and stool - may play a role in causing metabolic syndrome, a cluster of risk factors that increases the risk of heart disease and type 2 diabetes. Read more...

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