Advertisement
Preclinical Studies
Subscribe to Preclinical Studies

The Lead

Study Could Lead to Vaccines and Treatment of Dengue Virus

July 2, 2015 2:08 pm | by Vanderbilt University Medical Center | News | Comments

Researchers at Vanderbilt University and the National University of Singapore have determined the structure of a human monoclonal antibody which, in an animal model, strongly neutralizes a type of the potentially lethal dengue virus. Read more...

Stem Cell Gene Therapy Holds Promise for Eliminating HIV Infection

July 1, 2015 10:32 am | by UCLA | News | Comments

Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell...

BiondVax Announces Positive Preliminary Phase 2 Results for Universal Flu Vaccine

July 1, 2015 8:29 am | News | Comments

These results support BiondVax’s claim that M-001 provides a broaden and improved coverage...

Treatment With PI3K Inhibitors May Cause Cancers to Become Aggressive, Metastatic

June 30, 2015 11:43 am | by The Wistar Institute | News | Comments

The enzyme phosphatidylinositol-3 kinase (PI3K) appears to be exploited in almost every type of...

View Sample

FREE Email Newsletter

Daily news and top headlines for drug research professionals

Delivering Drugs to the Right Place

June 26, 2015 9:27 am | by UC Santa Barbara | News | Comments

For the 12 million people worldwide who suffer from polycystic kidney disease (PKD), an inherited disorder with no known cure, a new treatment option may be on the horizon. Read more...

Cancer Drug Makes Fruit Flies Live Longer

June 26, 2015 8:33 am | by University College London | News | Comments

The drug targets a specific cellular process that occurs in animals, including humans, delaying the onset of age-related deaths by slowing the ageing process. Read more...

Experimental Treatment Sends Deadly Leukemia Into Remission

June 25, 2015 12:09 pm | by University of Virginia Health System | News | Comments

An experimental new treatment approach for a rare, deadly leukemia can send the disease into remission even in patients for whom the standard therapy has failed, buying them more time to have the stem cell transplant that could save their lives, a small pilot study has found. Read more...

Advertisement

Researchers ID Best Source of Stem Cells to Block Diabetic Blindness

June 24, 2015 12:52 pm | by UVA | News | Comments

University of Virginia School of Medicine researchers have taken a significant step forward in their efforts to use stem cells to block vision loss caused by diabetic retinopathy, a condition that affects millions of people with diabetes. Read more...

Nanowire Implants Offer Remote-Controlled Drug Delivery

June 24, 2015 12:34 pm | by Seth Augenstein, Digital Reporter | News | Comments

A team of researchers has created a new implantable drug-delivery system using nanowires that can be wirelessly controlled. Read more...

Medication May Stop Drug and Alcohol Addiction

June 24, 2015 8:55 am | by University of Texas at Austin | News | Comments

Researchers at The University of Texas at Austin have successfully stopped cocaine and alcohol addiction in experiments using a drug already approved by the U.S. Food and Drug Administration (FDA) to treat high blood pressure. If the treatment is proven effective in humans, it would be the first of its kind—one that could help prevent relapses by erasing the unconscious memories that underlie addiction. Read more...

More Evidence for Possible Link between Cocaine Use and HIV Infection

June 22, 2015 1:37 pm | by UCLA | News | Comments

New UCLA research offers further evidence that cocaine use disrupts the immune system, making people who use it more likely to become infected with HIV. Read more...

AIDS Vaccine Candidate Successfully ‘Primes’ Immune System in Mice

June 22, 2015 1:22 pm | by Scripps Research Institute | News | Comments

New research led by scientists at The Scripps Research Institute (TSRI), International AIDS Vaccine Initiative (IAVI) and The Rockefeller University shows in mice that an experimental vaccine candidate designed at TSRI can stimulate the immune system activity necessary to stop HIV infection. The findings could provide key information for the development of an effective AIDS vaccine. Read more...

Advertisement

Reversing Depression

June 18, 2015 11:27 am | by MIT | News | Comments

The researchers believe this kind of targeted approach could have fewer side effects than most existing antidepressant drugs, which bathe the entire brain. Read more...

The Rise of Syngeneic Models in Cancer Immunotherapy

June 17, 2015 10:06 am | by Sheri Barnes, Ph.D., Study Director, Charles River | Articles | Comments

With cancer immunotherapy a major focus of oncology research over the past several years, a blockbuster drug will likely target the immune system. The industry is responding in kind by developing new tools that can be employed in this rapidly expanding field. One tool oncology researchers are exploring is actually not new at all—the murine tumor model. Read more...

Scientists Identify a Potential New Treatment for Osteoporosis

June 12, 2015 1:57 pm | News | Comments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a new therapeutic approach that, while still preliminary, could promote the development of new bone-forming cells in patients suffering from bone loss. Read more...

Petri Dish Tumor Test Could Personalize Drug Therapy for Cancer Patients

June 12, 2015 11:56 am | by University of Wisconsin-Madison | News | Comments

In a highly successful, first-of-its-kind endeavor, a multidisciplinary team of University of Wisconsin-Madison researchers has created a "tumor in a dish:" an ex vivo microenvironment that can accurately anticipate a multiple myeloma patient's response to a drug. Read more...

Gene Variants Linked to MS Disrupt Key Regulator of Inflammation

June 11, 2015 10:54 am | News | Comments

With genetic roots of many autoimmune diseases pinpointed, scientists are zeroing in on the variety of molecular mechanisms triggered by these harmful variants. A team led by Yale School of Medicine researchers has implicated a central regulator of inflammation as a cause of many cases of multiple sclerosis (MS) — and intriguingly, the researchers note — ulcerative colitis as well. Read more...

Advertisement

Z-Pak Can Kill ‘Superbugs,’ Says New Study

June 10, 2015 12:09 pm | by Seth Augenstein, Digital Reporter | News | Comments

Antibiotic resistance is sweeping the globe, with so-called “superbugs” sickening 2 million people and killing 20,000 in the U.S. alone each year. But a key weapon might have been under everyone’s nose for years, according to a new study, which may prove to be controversial. Read more...

Scientists Show Antitumor Agent Can Be Activated by Natural Response to Cell Stress

June 9, 2015 12:45 pm | by Scripps Research Institute | News | Comments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that a drug candidate with anticancer potential can be activated by one of the body’s natural responses to cellular stress. Once activated, the agent can kill prostate cancer cells. Read more...

An Immune System Marker for Therapy-Resistant Prostate Cancer

June 5, 2015 1:52 pm | by Cold Spring Harbor Laboratory | News | Comments

Interleukin-6 signaling plays role in switching mouse prostate cancer to more aggressive, therapy-resistant form. Read more...

Study Could Explain Why Ovarian Cancer Treatments Fail

June 1, 2015 8:42 am | by University of Queensland | News | Comments

Ovarian cancer cells can lock into survival mode and avoid being destroyed by chemotherapy, an international study reports. Read more...

Clementia Advances Natural History Study of Patients with FOP

May 29, 2015 9:10 am | News | Comments

The multi-center, non-interventional, two-part longitudinal study is designed to measure disease progression over three years in patients with FOP. Read more...

Autism Linked to Genetic Mutation – and Researchers Say They Can Undo It

May 28, 2015 12:49 pm | by Seth Augenstein, Digital Reporter | News | Comments

The genetic roots of autism have been investigated for more than a decade, as DNA sequencing has continued to improve. A new, early study points to a particular mutation in mice causing autistic-like behavior, adding to a list of potential causes. Read more...

Scientists Win $2.2 Million to Expand Study of Innovative Obesity Therapy

May 28, 2015 11:33 am | by The Scripps Research Institute | News | Comments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded nearly $2.2 million by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH) to advance an innovative approach to the treatment of obesity, a serious health problem that affects more than one-third of all Americans. Read more...

AbbVie Presents Phase 3 Data in Japan from Hepatitis C Treatment Study

May 27, 2015 9:01 am | News | Comments

Across all study arms, three patients discontinued treatment due to adverse events. Read more...

Vitamin D Levels Help Predict Survival of Sick Cats

May 15, 2015 12:48 pm | by Bevin Fletcher, Associate Editor | News | Comments

Vitamin D could give your sickly feline friend its 10th life, according to a recent study. New research from the University of Edinburgh found that higher levels of vitamin D were linked to increased survival changes for hospitalized cats. Read more...

Early Obesity Research Finds Leptin Hormone May Not Be Overeating Culprit

May 15, 2015 12:42 pm | by University of Cincinnati | News | Comments

For years, scientists have pointed to leptin resistance as a possible cause of obesity. Research led by investigators at the University of Cincinnati (UC) Metabolic Diseases Institute, however, found that leptin action isn't the culprit. Read more...

PharmaMar Announces New Oncology Advances with Yondelis, PM1183 Compounds

May 15, 2015 9:18 am | News | Comments

The studies were selected for oral discussion session and poster presentation at the American Society of Clinical Oncology's meeting later this month. Read more...

Findings Should Enhance Treatments for Stopping Immune System Attacks

May 15, 2015 9:12 am | by University of Manchester | News | Comments

Scientists have made an important discovery about an immune cell which is already being used in immunotherapy to treat diseases such as type I diabetes. Read more...

X
You may login with either your assigned username or your e-mail address.
The password field is case sensitive.
Loading