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First-in-Human Study of Antibody for AML Kicks Off

November 26, 2014 12:00 pm | News | Comments

Oxford BioTherapeutics and Berlin Chemie/Menarini Biotech/Menarini Ricerche announced that they have initiated the first-in-human clinical study of OBT357 (MEN1112), a novel enhanced antibody for the treatment of acute myeloid leukemia (AML). Read more...

A Reason to be Thankful: Turkeys May be Lifesavers

November 26, 2014 12:00 pm | News | Comments

While the turkey you eat on Thursday will bring...

Exciting Gains in Fighting Breast Cancer Hormone-Therapy Resistance

November 25, 2014 8:55 am | by Cynthia Fox, Science Editor | Articles | Comments

Guided by...

Pre-Empting Flu Evolution May Make Better Vaccines

November 21, 2014 9:37 am | News | Comments

An international team of researchers has shown that it may be possible to improve the...

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Daily news and top headlines for drug research professionals

Breakthrough Found to Help Manage Yellow Fever

November 21, 2014 9:24 am | News | Comments

Yellow fever is a disease that can result in symptoms ranging from fever to severe liver damage. Read more...                         

Promising One-Two Punch for Lung Cancer

November 20, 2014 10:19 am | News | Comments

Scientists at the Salk Institute have discovered a powerful one-two punch for countering a common genetic mutation that often leads to drug-resistant cancers. The dual-drug therapy–with analogs already in use for other diseases–doubled the survival rate of mice with lung cancer and halted cancer in pancreatic cells. Read more...

Bacterial Infections Suppress Immune Response in Neurodermatitis

November 20, 2014 9:31 am | by Technische Universität München | News | Comments

The skin condition neurodermatitis affects nearly one in four children and also occurs frequently in adults. Many patients also develop infections in the dry, open patches of skin, for example due to colonization by the pathogenic bacterium Staphylococcus aureus, which is particularly abundant on the skin of neurodermatitis patients. Read more...

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Light-Responding Blood Vessel Receptor May Be New Target

November 19, 2014 12:46 pm | by Johns Hopkins | News | Comments

A team of researchers from Johns Hopkins Medicine has discovered a receptor on blood vessels that causes the vessel to relax in response to light, making it potentially useful in treating vascular diseases. In addition, researchers discovered a previously unknown mechanism by which blood vessel function is regulated through light of a specific wavelength. Read more...

Maximizing the Power of Preclinical Cancer Research Tools

November 19, 2014 11:29 am | by Guizhong Liu, Senior Director of Cancer Biology, Crown Bioscience Inc. | Articles | Comments

Drug discovery is a protracted and uncertain process that needs to overcome many hurdles during preclinical and clinical development before it finally achieves regulatory approval for patient treatment. For every drug that reaches the marketplace, well over 100 have been abandoned at some point in their development. Read more...

New Laser Therapy Helps Slow Macular Degeneration

November 19, 2014 9:36 am | News | Comments

This new faster laser did not result in damage to the retina. Read more...                               

Study Will Test Survivors' Blood to Treat Ebola

November 19, 2014 9:19 am | by Marilynn Marchione - AP Chief Medical Writer | News | Comments

Plasma from survivors contains antibodies, substances the immune system makes to fight the virus. Read more...                         

New Insight Into Cells Could Lead to Better Drugs

November 19, 2014 9:11 am | News | Comments

Researchers investigated how different types of immune cells communicate with each other – and how they kill cancerous or infected cells. Read more...                   

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Reprogramming Cells, Long Term

November 18, 2014 2:07 pm | by B. D. Colen, Harvard Staff Writer | News | Comments

Harvard Stem Cell Institute (HSCI) researchers, representing five Harvard departments and affiliated institutions as well as the Massachusetts Institute of Technology (MIT), have demonstrated that adult cells, reprogrammed into another cell type in a living animal, can remain functional over a long period. Read more...

‘Big Data’ Approach to Help Pinpoint New Stent Drug

November 18, 2014 1:40 pm | by Tracie White, Stanford University | News | Comments

Replacing the current drug used to coat artery-opening stents with a drug more targeted to the actual cause of stent disease could reduce blood clots and heart attacks, researchers say. Read more...

Statins Reverse Learning Disabilities Caused By Genetic Disorder

November 17, 2014 1:08 pm | News | Comments

Scientists have discovered that statins reverse the learning disabilities caused by a genetic disorder. Read more...                        

Genzyme's MS Drug Gains FDA Approval

November 17, 2014 12:56 pm | News | Comments

The FDA approved Genzyme's new drug for the treatment of multiple sclerosis. Read more...                             

Going Purple: 5 Cutting-edge Breakthroughs in Alzheimer’s Research

November 17, 2014 9:03 am | by Christina Jakubowski, Managing Editor, Bioscience Technology | Articles | Comments

November is already halfway over— which means we’re also halfway through National Alzheimer's Disease Awareness Month, which celebrates and raises awareness for the nearly 5.4 million people who have this condition. Read more...

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Tiny Needles Could Treat Two Major Eye Diseases

November 14, 2014 1:09 pm | by John Toon, Georgia Institute of Technology | News | Comments

Needles almost too small to be seen with the unaided eye could be the basis for new treatment options for two of the world’s leading eye diseases: glaucoma and corneal neovascularization. Read more...

Biopsy Direct Drug Screening Could Overcome Targeted Therapy Resistance

November 14, 2014 12:48 pm | News | Comments

A new screening platform using cells grown directly from tumor biopsy samples may lead to truly individualized treatment strategies that would get around the problem of treatment resistance, which limits the effectiveness of current targeted therapy drugs. Read more...

Method Could Prevent, Cure Rotavirus Infection

November 14, 2014 12:36 pm | by Georgia State University | News | Comments

Activation of the innate immune system with the bacterial protein flagellin could prevent and cure rotavirus infection, which is among the most common causes of severe diarrhea, says a Georgia State University research team that described the method as a novel means to prevent and treat viral infection. Read more...

Potential Target to Prevent Leukemia Identified

November 14, 2014 12:19 pm | by Indiana University | News | Comments

Researchers have identified two proteins that appear crucial to the development — and patient relapse — of acute myeloid leukemia. They have also shown they can block the development of leukemia by targeting those proteins. Read more...               

New Insight Into Common Cause of Blindness

November 14, 2014 10:44 am | News | Comments

Scientists identified an important new factor behind one of the major causes of blindness. Read more...                           

When Tobacco Saved Lives

November 13, 2014 10:21 am | by Skip Derra | Articles | Comments

Will ZMapp’s Ebola success force big pharma to take plant-based drugs seriously? Read more...                                                      

Measuring PD-L1 Expression in CTCs in Lung Cancer Patients

November 12, 2014 2:34 pm | News | Comments

Epic Sciences will present an analysis of PD-L1 protein expression on circulating tumor cells (CTCs) from non-small cell lung cancer (NSCLC) patients.  Read more...                                               

Next-Gen Melanoma Drug Excels in Lab Tests

November 12, 2014 2:16 pm | by Garth Sundem, University of Colorado | News | Comments

A University of Colorado Cancer Center study published online in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.  Read more...

Targets, Tests May Develop Treatments for Memory Disorders

November 12, 2014 1:38 pm | by Scripps Research Institute | News | Comments

In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a number of new therapeutic targets for memory disorders and have developed a new screening test to uncover compounds that may one day work against those disorders. Read more...

Abbvie's Hep C Therapy Shows Strong Cure Rate

November 12, 2014 10:37 am | News | Comments

AbbVie announced positive results for its therapy for chronic hepatitis C patients and liver transplant recipients. Read more...                     

Amgen and AstraZeneca's Psoriasis Drug Receives Positive Results

November 12, 2014 9:57 am | News | Comments

This drug is intended for patients with moderate-to-severe plaque psoriasis. Read more...                             

Study Identifying Tumor Cell Origin May Help Develop Therapies

November 11, 2014 1:12 pm | News | Comments

UT Southwestern Medical Center researchers have determined the specific type of cell that gives rise to large, disfiguring tumors called plexiform neurofibromas, a finding that could lead to new therapies for preventing growth of these tumors. Read more...

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