Advertisement
Preclinical Studies
Subscribe to Preclinical Studies

The Lead

Synthetic Biologics Improves Enzyme for C.diff Prevention

August 29, 2014 8:30 am | News | Comments

Synthetic Biologics, Inc. and FUJIFILM Diosynth Biotechnologies UK Limited have announced confirmation of exceptional results from the initial phase of cGMP manufacturing of SYN-004, Synthetic Biologics' proprietary oral beta-lactamase enzyme for the prevention of Clostridium difficile (C. difficile) infections. Read more...

New Drug Ups OS in Stage III Colon Cancer

August 28, 2014 2:00 pm | News | Comments

A subset of patients with Stage III colon cancer had improved survival rates when treated with...

Two-Drug Combo Speeds Wound Healing, Reduces Scar Tissue

August 28, 2014 9:53 am | News | Comments

A combination of two drugs already approved by the U.S. Food and Drug Administration for...

Marijuana Compound May Slow, Halt Alzheimer’s

August 27, 2014 3:00 pm | News | Comments

Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC...

View Sample

FREE Email Newsletter

Daily news and top headlines for drug research professionals

Potential Therapy for Sudan Ebola Strain May Contain Future Outbreaks

August 27, 2014 2:45 pm | News | Comments

Ebola is a rare, but deadly disease that exists as five strains, none of which have approved therapies. One of the most lethal strains is the Sudan ebolavirus (SUDV). In a new study, researchers report a possible therapy that could someday help treat patients infected with SUDV. Read more...

Compound Suppresses Binge Eating in Mice

August 27, 2014 2:26 pm | News | Comments

Researchers found that the hormone estrogen can specifically trigger brain serotonin neurons to inhibit binge eating, which affects about 5 to 10 percent of U.S. adults, in female mice. Read more...               

Drug Promising as Potential Anemia Treatment

August 27, 2014 2:21 pm | News | Comments

An experimental drug designed to help regulate the blood’s iron supply shows promise as a viable first treatment for anemia of inflammation, according to results from the first human study of the treatment. Read more...         

Advertisement

Targeted Neuroblastoma Therapy One Step Closer

August 27, 2014 10:52 am | News | Comments

Researchers have uncovered new targets for therapy in the childhood cancer neuroblastoma, bringing hope for the development of novel treatments. Read more...                           

Drug Cured 16 of 16 Monkeys with Viral Ebola Relative

August 26, 2014 11:31 am | by Cynthia Fox, Science Editor | Articles | Comments

An experimental drug saved the lives of 16 of 16 monkeys with the Marburg virus, a killer near-indistinguishable from Ebola, just as symptoms broke out, said a new study. Read more...                   

New Ebola Vaccine Study Delivers Promising Results

August 26, 2014 10:44 am | News | Comments

Immunovaccine Inc. announced positive results for a vaccine formulated in its DepoVax technology in an Ebola virus challenge study performed by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH). Read more...

Protein Family Can Inhibit HIV Release

August 26, 2014 10:30 am | News | Comments

A family of proteins that promotes virus entry into cells also has the ability to block the release of HIV and other viruses, researchers have found. Read more...                         

DNA Repair Drug Could Help Treat Leukemia, Other Cancers

August 25, 2014 10:19 am | News | Comments

A team of scientists found that a drug originally designed for killing a limited type of cancer cells with DNA repair defects could potentially be used to treat leukemia and other cancers. Read more...              

Advertisement

Pomegranate-Based Drug May Stem Alzheimer’s, Parkinson’s

August 22, 2014 3:31 pm | News | Comments

The onset of Alzheimer’s disease can be slowed and some of its symptoms curbed by a natural compound that is found in pomegranate, according to new findings. Read more...                        

Botox Injections Slow Growth of Stomach Tumors

August 21, 2014 1:00 pm | News | Comments

New research shows that nerves may play a critical role in stomach cancer growth and that blocking nerve signals using Botox (onabotulinumtoxinA) could be an effective treatment for the disease. Read more...             

Emergent, MorphoSys Collaborate on Prostate Cancer Drug

August 21, 2014 11:39 am | News | Comments

Emergent BioSolutions and MorphoSys announced an agreement for the joint development and commercialization of Emergent’s preclinical bi-specific antibody, ES414, targeting prostate cancer, under the terms of which Emergent will receive an upfront payment of US$20 million and milestone payments of up to US$163 million. Read more...

Novan’s Topical Treatment Shows Efficacy Against Drug-resistant Bugs

August 20, 2014 2:29 pm | News | Comments

Novan Therapeutics announced that the company’s Nitricil platform technology has been shown to be efficacious against several of the most multi-drug resistant pathogens plaguing civilian and military health care providers across the globe. Read more...

New Vaccine Promising Weapon Against TB, Leprosy

August 20, 2014 2:09 pm | News | Comments

The currently available century-old vaccine Bacille Calmette-Guerin, or BCG, provides only partial protection against both tuberculosis and leprosy. Now, researchers may have found a stronger weapon against both diseases. Read more...     

Advertisement

Drug Candidate Blocks 'Chili-pepper Receptor'

August 20, 2014 1:59 pm | News | Comments

As anyone who has bitten into a chili pepper knows, its burning spicinesscan be intolerable. Scientists exploring the chili pepper’s effect are using their findings to develop a new drug candidate for many kinds of pain. Read more...     

Stemedica International Posts Alzheimer’s Stem Cell Data

August 20, 2014 10:24 am | News | Comments

Stemedica International, a Stemedica Cell Technologies subsidiary developing stem cell therapies for Alzheimer’s disease and dementia, revealed the first results of an intravenous administration of allogeneic, human, ischemia-tolerant mesenchymal stem cells in a pre-clinical animal model of Alzheimer’s disease. Read more...

Small Molecules, Stem Cells Can Improve Hearing

August 18, 2014 3:14 pm | by Cynthia Fox, Science Editor | Articles | Comments

A scientist has found that a compound, LY-411575, can restore 20% of hearing in deaf mice, or ten decibels. Since electroacoustic hearing aids, at best, improve hearing by five decibels, there is a “good chance” the work will lead to help for deafened patients.

Potential Drug Therapy for Kidney Stones Identified

August 14, 2014 3:10 pm | News | Comments

Anyone who has suffered from kidney stones is keenly aware of the lack of drugs to treat the condition, which often causes excruciating pain. Now, a new mouse study suggests that a class of drugs approved to treat leukemia and epilepsy also may be effective against kidney stones, researchers report. Read more...

Injection of Modified Bacteria Shrinks Tumors

August 14, 2014 3:00 pm | News | Comments

A modified version of the Clostridium novyi (C. novyi-NT) bacterium can produce a strong and precisely targeted anti-tumor response in rats, dogs and now humans, according to a new report. Read more...              

Heart Attack Drug Reduces Tissue Damage, Minimizes Bleeding Risk

August 13, 2014 2:13 pm | News | Comments

An investigational drug studied in animals significantly reduced damage to heart muscle from a heart attack and minimized the risk of bleeding during follow-up treatments, according to a new study. Read more...           

Epizyme Presents Early-Phase Data on Cancer Drug

August 13, 2014 11:24 am | News | Comments

Epizyme Inc. reported pre-clinical data and early clinical observations from an ongoing Phase 1 trial, being conducted in collaboration with Eisai, the Institut Gustave Roussy, and the Institut Bergonie, of EZH2 inhibitor EPZ-6438 (E7438) in patients with advanced solid tumors and B-cell lymphomas. Read more...

TNI BioTech, Hubei Qianjiang Agree to Collaborate

August 13, 2014 11:17 am | News | Comments

TNI BioTech Inc. a biotechnology company pioneering the manufacturing and marketing of innovative therapies for autoimmune diseases in emerging nations, announced the signing of a supplemental agreement with Hubei Qianjiang Pharmaceutical Co. Ltd, China, on behalf of Cytocom, TNI BioTech's wholly owned subsidiary. Read more...

MJFF Highlights Promising Parkinson's Disease Drug Research

August 12, 2014 3:21 pm | News | Comments

Research projects from five groups active in Parkinson's research comprise the 2014 first half (1H 2014) of The Michael J. Fox Foundation for Parkinson's Research (MJFF) Partnering Program. Read more...                

Long-Sought Drug Candidate Can Halt Tumor Growth

August 12, 2014 2:50 pm | News | Comments

It’s a trick any cat burglar knows: to open a locked door, slide a credit card past the latch. Scientists tried a similar strategy when they attempted to disrupt the function of MYC, a cancer regulator thought to be “undruggable." Read more...   

Mirati Lymphoma Drug Designated Orphan Drug

August 11, 2014 3:03 pm | News | Comments

Mirati Therapeutics Inc. announced that the U.S. FDA has granted Orphan Drug Designation - which provides seven years of market exclusivity - to mocetinostat, a spectrum selective HDAC inhibitor, for diffuse large B-cell lymphoma (DLBCL). Read more...

Results Show Anthrax Vaccine is Potent with Rapid Onset

August 8, 2014 3:25 pm | News | Comments

Soligenix Inc., a clinical stage biopharmaceutical company focused on developing products to treat serious inflammatory diseases where there remains an unmet medical need, as well as developing several biodefense vaccines and therapeutics, announced results demonstrating the improved immunogenicity and rapid action of its anthrax vaccine, VeloThrax. Read more...

X
You may login with either your assigned username or your e-mail address.
The password field is case sensitive.
Loading