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The Lead

New Understanding of Alzheimer’s

February 26, 2015 11:25 am | by Peter Reuell, Harvard | News | Comments

Although natural selection is often thought of as a force that determines the adaptation of replicating organisms to their environment, Harvard researchers have found that selection also occurs at the level of neurons, which are post-mitotic cells, and plays a critical role in the emergence of Alzheimer’s disease. Read more...

Hair Cells From Stem Cells

February 25, 2015 10:23 am | by Drug Discovery & Development Staff | Articles | Comments

In a research area that will generate blockbuster profits if/when it pans out, a science team...

Small Molecule May Help Reduce Cancer in At-Risk Population

February 25, 2015 9:51 am | by Kimberless D'Ardenne, Stanford University | News | Comments

Scientists have shown that small molecules can “hijack” enzyme function in mice, suggesting a...

Obesity-Type 2 Diabetes Molecular Link Reveals Potential Therapy

February 23, 2015 4:49 pm | News | Comments

Obesity causes inflammation, which can in turn lead to type 2 diabetes. What isn’t well...

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Customized DNA Rings Aid Early Cancer Detection in Mice

February 23, 2015 4:43 pm | by Bruce Goldman, Stanford | News | Comments

Imagine: You pop a pill into your mouth and swallow it. It dissolves, releasing tiny particles that are absorbed and cause only cancerous cells to secrete a specific protein into your bloodstream. Two days from now, a finger-prick blood sample will expose whether you’ve got cancer and even give a rough idea of its extent. Read more...

The Next Generation of Antibiotics Might Be Right Under Our Feet

February 23, 2015 10:21 am | News | Comments

The discovery of a new antibiotic called teixobactin was announced by international team of researchers, in January this year. It is the most significant new antibiotic to be discovered in more than 30 years, and it may help combat the growing number of drug-resistant bacteria. Read more...

The Journey to an HIV Vaccine Endures

February 19, 2015 12:46 pm | by Stephanie Guzowski, Editor | Articles | Comments

Despite more than 30 years of efforts, scientists have not yet come up with a reliably effective HIV vaccine — in part, because of the inherently complicated nature of the virus. Here are where their research efforts stand today.

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Tadpole Model Links Drug Exposure to Autism-Like Effects

February 18, 2015 10:31 am | by Brown University | News | Comments

Research suggests that fetal exposure to chemicals or drugs can cause neurological problems. Babies whose mothers take the epilepsy drug valporic acid (VPA) during pregnancy, for example, appear to have an elevated risk of developing an autism spectrum disorder. Read more...

Taking Technology from the Lab to the Patient

February 18, 2015 10:17 am | by MIT | News | Comments

After finishing his PhD in molecular genetics in the late 1990s, Daniel Anderson found himself conflicted about what to do next: He enjoyed science, but wanted to find a way to have a direct impact on human health. Read more...

Link Between Genetic Switch, Autoimmune Diseases

February 17, 2015 12:53 pm | by NIH | News | Comments

Investigators with the National Institutes of Health have discovered the genomic switches of a blood cell key to regulating the human immune system. The findings, published in Nature, open the door to new research and development in drugs and personalized medicine to help those with autoimmune disorders such as inflammatory bowel disease or rheumatoid arthritis. Read more...

Molecular Inhibitor Breaks Cycle that Leads to Alzheimer's

February 17, 2015 10:19 am | News | Comments

A molecule that can block the progress of Alzheimer’s disease at a crucial stage in its development has been identified by researchers in a new study, raising the prospect that more such molecules may now be found. Read more...

Marvel Molecule Could Lead to Inflammatory Disease Treatments

February 17, 2015 10:13 am | by Trinity College Dublin | News | Comments

Scientists from Trinity College Dublin believe that the marvel molecule — MCC950 — could one day be used to treat a myriad of these diseases. Read more...

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Precision Medicine: Why a New Approach is Needed

February 13, 2015 10:49 am | by Columbia University | News | Comments

Precision medicine is a way to make medical care more personalized and individualized. Read more...                           

Cow Immune System Inspires Potential New Therapies

February 10, 2015 4:46 pm | by Scripps Research Institute | News | Comments

To help people with hormone deficiencies, scientists at The Scripps Research Institute (TSRI) have developed a potential new therapy based on an unlikely model: immune molecules from cows. Read more...                   

Stem Cells Boost Cognition Following Cancer Radiation: Studies

February 10, 2015 2:13 pm | by Cynthia Fox, Science Editor | Articles | Comments

A solid run of preclinical work is finding that human stem cell transplants can significantly—and in some cases, completely—restore cognitive and motor deficits associated with cancer irradiation in animal models. Read more...                           

Reducing Animal Testing One Chip at a Time

February 10, 2015 9:19 am | by Michelle Taylor, Editor-in-Chief, Lab Equipment | Articles | Comments

Speaking to a room of pharmaceutical scientists, Donald Ingber started off his Keynote presentation at SLAS 2015 in Washington D.C. by saying that “the current drug development model is broken.” He pointed to Eroom’s Law (Moore’s law backward) as proof. Read more...

Insight Into Nerve Cells Could Lead to Alzheimer's Drugs

February 6, 2015 4:12 pm | by University of Queensland | News | Comments

New insights into how nerves cells in the brain maintain efficient communication with each other may help offset the effects of Alzheimer’s disease. Read more...                                            

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Evaluating Strategies for HIV Vaccinations

February 6, 2015 4:03 pm | by Anne Trafton, MIT | News | Comments

Through an investigation of a fundamental process that guides the maturation of immune cells, researchers have revealed new insights into possible ways to vaccinate people to generate potent antibodies of the type that are predicted to offer protection against diverse strains of the highly mutable HIV. Read more...

Drug Combinations May be Good Approach for Infectious Fungus

February 6, 2015 2:12 pm | by University of Toronto | News | Comments

Researchers at the University of Toronto have discovered that Candida albicans—a leading cause of potentially fatal hospital-acquired infections—rarely develops resistance to combination drug therapy and, when it becomes resistant, it also becomes less dangerous. Read more...

New Molecule Protects Heart from Toxic Breast Cancer Drugs

February 4, 2015 3:51 pm | News | Comments

A new molecule has been found that protects the heart from toxic breast cancer drugs and also kills the cancerous tumour. The research from Italy addresses the burgeoning problem of heart disease in cancer survivors and is announced by the European Society of Cardiology (ESC). Read more...

Researchers Discover Key to Lung Cancer's Spread

February 4, 2015 11:11 am | by University of Virginia | News | Comments

Researchers have identified a substance secreted by lung cancer cells that enables them to metastasize, beginning their deadly march to other sites in the body. Read more...               

New Mechanism of Resistance to Breast Cancer Drugs: Discovery

February 2, 2015 10:00 pm | by Dartmouth Univ. | News | Comments

In the search for new approaches to treat ERBB2 (also known as HER2) positive breast cancers that have become drug-resistant, Dartmouth's Norris Cotton Cancer Center investigator Manabu Kurokawa, PhD, led a team in discovery of a novel cancer resistance mechanism with findings published in Cell Cycle. Read more...

How Immune Cells Hone Skills to Fight Disease

February 2, 2015 11:41 am | by Scripps Institute | News | Comments

Now, a new study from scientists at The Scripps Research Institute (TSRI) helps explain how booster shots prompt immune "memory" to improve, an important step toward the development of more effective, longer-lasting vaccines. The findings were published online ahead of print on in the journal Nature Immunology. Read more...

New Blood for TB Treatment

February 2, 2015 11:29 am | by Sue McGreevy, Harvard | News | Comments

The same antiangiogenesis drugs that have improved treatment of some cancers could also help surmount persistent difficulties in treating tuberculosis.  Read more...                  

How Cells Use Signaling Mechanisms to Control Interferon Production

February 2, 2015 10:59 am | by The Howard Hughes Medical Center | News | Comments

The immune system has a delicate balance to maintain. When certain infected cells detect an invader, they use a molecule called interferon to rally the body's defenses. The immune system responds to this rallying cry by immediately boosting its general antiviral defenses and simultaneously initiating a more specialized secondary response. Read more...

Master Switch May Halt Tumor Growth by Inducing Dormancy

February 2, 2015 10:53 am | by The Mount Sinai Hospital | News | Comments

Two existing cancer drugs turn on a gene that tells tumor cells to remain inactive, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published in Nature Communications. Read more...           

Study Shows Tamiflu Gets Patients Back on Their Feet Faster

January 30, 2015 10:30 am | by University of Michigan | News | Comments

New evidence about a popular antiviral—often criticized as ineffective—shows that it can alleviate symptoms and prevent respiratory complications. Read more...                 

Immune Cells are Ally, Not Enemy, in Battle Against Alzheimer's

January 29, 2015 10:33 am | by Yale University | News | Comments

Beta-amyloid is a sticky protein that aggregates and forms small plaques in the brains of the elderly and is thought to be a cause of Alzheimer's disease. Because specialized immune cells always surround these plaques, many have theorized that these cells are responsible for inflammation and damage to surrounding brain cells. Read more..

3D Enzyme Model Provides New Tool for Drug Development

January 29, 2015 10:16 am | by UC San Diego | News | Comments

Phospholipase A2 (PLA2) enzymes are known to play a role in many inflammatory diseases, including asthma, arthritis and atherosclerosis. It then stands to reason that PLA2 inhibitors could represent a new class of anti-inflammatory medication. Read more...

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