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Putting the Breaks on Cancer

December 19, 2014 1:38 pm | News | Comments

A study led by the University of Dundee, in collaboration with the University of Bath, has uncovered an important role played by a tumour suppressor gene, helping scientists to better understand how it combats the effects of mutations which drive cancer development. Read more...

10 Up-and-Coming Healthcare Medical Innovations

December 18, 2014 12:10 pm | by Christina Jakubowski, Managing Editor, Bioscience Technology | Articles | Comments

The Cleveland Clinic recently unveiled their annual Top 10 Medical Innovations for 2015– a list...

New Disease Mechanism Discovered in Lymphoma

December 18, 2014 11:34 am | by Technical University - Munich | News | Comments

Programmed cell death is a mechanism that causes defective and potentially harmful cells to...

Microcapsule Eliminates Toxic Punch of Experimental Anti-Cancer Drug

December 18, 2014 11:15 am | by Johns Hopkins | News | Comments

Johns Hopkins researchers have developed a sugar-based molecular microcapsule that eliminates...

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Chikungunya Virus Shuts Down Infected Cells

December 17, 2014 4:59 pm | by Wageningen University | News | Comments

Researchers from Wageningen University, part of Wageningen UR, in collaboration with colleagues from Leiden University and a research team in Australia, have revealed how chikungunya virus blocks essential processes in infected cells that normally would keep the virus under control. Read more...

Stem Cell Prompting Deadly Fibrosis Found

December 17, 2014 4:35 pm | by Cynthia Fox, Science Writer | Articles | Comments

Some 45% of deaths are caused by fibrosis (scar tissue) diseases, including idiopathic pulmonary fibrosis, cirrhosis, and heart and kidney failure. But a Harvard University group reports in Cell Stem Cell they have discovered a key cause of that fibrosis: a stem-cell-like perivascular cell called Gli1+, found in blood vessels. Read more...

New Insight Into How Motor Neurons in Brain Die During ALS

December 17, 2014 12:33 pm | News | Comments

Researchers look to understand the causes of amyotrophic lateral sclerosis (ALS), in the hope of finding new ways to treat the disease. A new study published online in the Cell Press journal Neuron shows that a common gene mutation in ALS generates a deadly protein that may cause the damage in the brain that leads to ALS. Read more...

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Clementia Launches First Natural History Study of Patients with FOP

December 17, 2014 10:04 am | News | Comments

Clementia Pharmaceuticals announced the initiation of a natural history study in patients with fibrodysplasia ossificans progressiva. Read more...                   

Altered White-Blood-Cell Motion in Burn Patients May Warn of Infection

December 16, 2014 11:54 am | by Harvard Medical School | News | Comments

A team of Harvard Medical School investigators at Massachusetts General Hospital has identified what may be a biomarker predicting the development of sepsis, a dangerous systemic infection in patients with serious burns. Read more..                          

Long noncoding RNAs: A Novel Prognostic Marker In AML

December 16, 2014 11:14 am | by Ohio State University Medical Center | News | Comments

A new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) describes a novel marker that might help doctors choose the least toxic, most effective treatment for many older patients with acute myeloid leukemia (AML). Read more...

NewGen Therapeutics: Activity of Targeted Anti-Cancer Drug

December 16, 2014 9:47 am | News | Comments

NewGen Therapeutics, Inc. announced the publication of preclinical research strongly supporting NT-113, the company's novel irreversible pan-erbB inhibitor (EGFR, HER2 and HER4), as a potential new treatment for glioblastoma multiforme (GBM), the most common and most aggressive malignant primary brain tumor in adults. Read more...

Going After Colon Cancer With Strep Bacteria

December 15, 2014 2:19 pm | by Skip Derra, Contributing Writer | Articles | Comments

A novel therapeutic to fight colon cancer by using the bacteria primarily responsible for causing strep throat is being explored in the labs of John McCormick of the Schulich School of Medicine & Dentistry at the University of Western Ontario, London, Ontario, Canada. Read more...

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Key Human Gene Modifies Immune Response to Flu Vaccine

December 12, 2014 11:24 am | News | Comments

How much protection the annual flu shot provides depends on how well the vaccine (which is designed based on a "best guess" for next season's flu strain) matches the actually circulating virus. However, it also depends on the strength of the immune response elicited by the vaccine. Read more...

Taming Inflammatory Response in Kidney Dialysis

December 12, 2014 11:02 am | News | Comments

Over the past several years, lead author John Lambris, PhD, the Dr. Ralph and Sallie Weaver Professor of Research Medicine, Perelman School of Medicine at the University of  Pennsylvania, and his colleagues have developed small molecule versions of the drug compstatin, which inhibits a component of the complement immune response called C3. Read more...

Targeting Enzyme May Reduce Chemo Drug's Cardiac Side Effects

December 10, 2014 4:56 pm | by Massachusetts General Hospital | News | Comments

MGH investigators identified two compounds that appear to block the cardiac damage caused by the important chemotherapy drug doxorubicin. Their report in the issue of Science Translational Medicine indicates that inhibiting the action of an enzyme that is key to the generation of cellular energy in mitochondria could prevent doxorubicin-induced damage to cardiac cells. Read more...

Pinpointing Part of Brain That Triggers Addiction

December 10, 2014 1:14 pm | by University of Michigan | News | Comments

Activating the brain's amygdala, an almond-shaped mass that processes emotions, can create an addictive, intense desire for sugary foods, a new University of Michigan study found. Rewards such as sweet tasty food or even addictive drugs like alcohol or cocaine can be extremely attractive when this brain structure is triggered. Read more...

Metal Test Could Help Diagnose Breast Cancer Early

December 10, 2014 1:06 pm | by University of Oxford | News | Comments

A team, led by Oxford University scientists, took techniques normally used to analyse trace metal isotopes for studying climate change and planetary formation and applied them to how the human body processes metals. Read more...                                    

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Developed Drug Effective Against Antibiotic-Resistant 'Superbugs'

December 10, 2014 12:45 pm | by University of Pittsburgh | News | Comments

A treatment pioneered at the University of Pittsburgh Center for Vaccine Research (CVR) is far more effective than traditional antibiotics at inhibiting the growth of drug-resistant bacteria, including so-called “superbugs” resistant to almost all existing antibiotics, which plague hospitals and nursing homes. Read more...

Supplement May Lower CVD Risk in People of Low Birth Weight

December 10, 2014 9:07 am | by University of Cambridge | News | Comments

A simple supplement could be a safe and cost-effective way of reducing heart disease in individuals born with a low birth weight. Read more...                    

Genetic Errors Linked to Aging Can Make Leukemia Appear After Treatment

December 9, 2014 1:23 pm | by Caroline Arbanas, Washington University in St. Louis | News | Comments

Treatment aimed at curing cancer can lead to a form of leukemia with a poor prognosis. Read more...                          

Trial Launched to Evaluate Amgen and Merck's Melanoma Treatment

December 9, 2014 9:04 am | News | Comments

Amgen announced the initiation of a trial of a new melanoma treatment. Read more...                              

New Agent Shrinks Small Cell Lung Tumors in Pre-Clinical Testing

December 8, 2014 1:20 pm | News | Comments

Researchers found that a new agent can disable the basic part of a tumor cell's survival mechanism. Read more...                         

Study Suggests Potential Therapy for Common Form of Dementia

December 5, 2014 12:56 pm | by Bob Shepard, University of Alabama at Birmingham | News | Comments

Drugs that boost the function of a specific type of neurotransmitter receptor may provide benefit to patients with the second most common type of dementia. Read more...                

Mylan Receives Tentative FDA Approval of HIV-1 Treatment

December 5, 2014 9:59 am | News | Comments

Mylan has received tentative FDA approval of its HIV-1 treatment for pediatric patients. Read more...                           

Gene Discovery: How Stem Cells Can Help Immune System Fight Infection

December 4, 2014 10:38 am | News | Comments

In a study led by Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research member Dr. Julian Martinez-Agosto, UCLA scientists have shown that two genes not previously known to be involved with the immune system play a crucial role in how progenitor stem cells are activated to fight infection. Read more... 

Peptide Has Promise for Treating Spinal Cord Injury

December 3, 2014 4:57 pm | by Case Western Reserve University | News | Comments

Case Western Reserve scientists have developed a new chemical compound that shows extraordinary promise in restoring function lost to spinal cord injury. The compound, which the researchers dubbed intracellular sigma peptide (ISP), allowed paralyzed muscles to activate in more than 80 percent of the animals tested. Read more...

PET Scans Help Identify Effective TB Drugs

December 3, 2014 4:41 pm | by University of Pittsburgh | News | Comments

Sophisticated lung imaging can show whether or not a treatment drug is able to clear tuberculosis (TB) lung infection in human and macaque studies, according to researchers at the University of Pittsburgh School of Medicine and their international collaborators. Read more...          

Chemo Effect on Brain Cells Identified

December 3, 2014 4:27 pm | by UNC | News | Comments

UNC School of Medicine researchers have found for the first time a biochemical mechanism that could be a cause of “chemo brain” – the neurological side effects such as memory loss, confusion, difficulty thinking, and trouble concentrating that many cancer patients experience while on chemotherapy to treat tumors in other parts of the body. Read more...

Cancer Uses Abdominal Stem Cells to Fuel Growth, Metastasis

December 3, 2014 12:28 pm | News | Comments

New research from Rice University and the University of Texas MD Anderson Cancer Center shows how ovarian tumors co-opt a specific type of adult stem cell from abdominal tissues to fuel their growth. Read more...

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