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The Lead

Lpath, Walter Reed Collaborate on Brain Injury Drug

April 23, 2014 11:23 am | News | Comments

Lpath Inc., the industry leader in bioactive lipid-targeted therapeutics, and scientists from the Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research (WRAIR), have initiated a study that is the focus of a collaborative research agreement. Read more...

Molecules Discovered for Neurodegenerative Diseases

April 22, 2014 1:02 pm | News | Comments

Researchers from NeuroPhage Pharmaceuticals Inc. have engineered a series of molecules with the...

MSU Physicists Push Parkinson’s Drug Toward Clinical Trials

April 21, 2014 12:56 pm | News | Comments

The most effective way to tackle debilitating diseases is to punch them at the start and keep...

Measles Drug Lowers Viral Load

April 16, 2014 2:00 pm | News | Comments

A novel antiviral drug may protect people infected with the measles from getting sick and...

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Ex Vivo Data Supports Mast's Sickle Cell Treatment

April 14, 2014 2:19 pm | News | Comments

Mast Therapeutics Inc. announced that, in an ex vivo study, MST-188 reduced the mean erythrocyte sedimentation rate (ESR) by 50% relative to control in blood collected from individuals with sickle cell disease. Read more...         

Inhibiting Lactate Production Halts Tumor Growth

April 11, 2014 11:00 am | News | Comments

A research team has found that targeting the enzyme responsible for the final step of glucose metabolism not only halts tumor growth in non-small-cell lung cancer, but also leads to the regression of established tumors. Read more...       

Lung Fibrosis and Survival Improved in Preclinical Study of Genkyotex’s GKT137831

April 10, 2014 3:03 pm | News | Comments

Genkyotex, the leading developer of selective NOX enzyme inhibitors, announced the publication of data showing that GKT137831, a first in class NOX1 and 4 inhibitor, was able to reverse lung fibrosis associated with aging in a new model of idiopathic pulmonary fibrosis. Read more...

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Faking Fluorescence

April 9, 2014 11:05 am | by Takeharu Nagai, Ph.D., Osaka University, Japan | Articles | Comments

The world’s brightest luminescent protein, a discovery dubbed the “Nano-lantern,” is lighting up the future of in vivo imaging– without the use of external light. This could benefit more advanced applications, such as high-throughput drug screening and single-cell tracking in live animals and plants.

Glucosamine Promotes Longevity in Mice

April 9, 2014 10:35 am | News | Comments

Feeding glucosamine to mice extended their lifespan by almost 10%, reflecting around eight additional years of human lifespan. Moreover, the supplement improved glucose metabolism in elderly mice, indicating that it may provide protection from diabetes. Read more...

Compound Holds Potential to Treat Drug-Resistant Leukemias

April 9, 2014 10:06 am | News | Comments

Research in mice and human cell lines has identified an experimental compound dubbed TTT-3002 as potentially one of the most potent drugs available to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia.  Read more...

Curis, Debiopharm Report Anti-Tumor Activity, Synergy with Debio 0932

April 8, 2014 1:39 pm | News | Comments

Curis Inc. and Debiopharm Group announced the presentation of data for Debio 0932 at the Annual Meeting of the AACR that demonstrated synergy between Debio 0932 and various standard of care (SOC) agents in multiple in vitro and xenograft models of NSCLC and RCC. Read more...

Calithera Glutaminase Inhibition Assay Shows Promise

April 8, 2014 1:17 pm | News | Comments

Calithera Biosciences, a clinical-stage biotechnology company focused on the development of novel cancer therapeutics, announced that data for its lead clinical candidate, CB-839, were featured in two presentations at the 2014 AACR Annual Meeting. Read more...

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New Lilly Drug Promising Against Metastatic Breast Cancer

April 7, 2014 1:48 pm | News | Comments

The new oral drug LY2835219, an inhibitor of cyclin-dependent kinases 4 and 6, showed early promise as monotherapy for patients with metastatic breast cancer, particularly for those with hormone receptor-positive disease. Read more...     

CRT, Teva Collaboration IDs New Cancer Drug Candidate

April 7, 2014 10:41 am | News | Comments

Cancer Research Technology announced a successful outcome to their existing collaboration with Teva through the identification of a novel atypical Protein Kinase C (aPKC) inhibitor pre-clinical candidate, licensed by Teva. Read more...     

Nanoparticles Cause Cancer Cells to Self-Destruct

April 4, 2014 10:42 am | Videos | Comments

Using magnetically controlled nanoparticles to force tumor cells to "self-destruct: sounds like science fiction, but could be a future part of cancer treatment, according to new research. Read more...               

Cell Metabolism Discovery May Lead to Cancer, Cold Treatments

April 2, 2014 3:12 pm | News | Comments

Scientists at UCLA's Jonsson Comprehensive Cancer Center have published the first study explaining in detail how viruses reprogram the metabolism of the cells they invade to promote continued viral growth within an organism. Read more...   

Immunovaccine, Pfenex Post Positive Anthrax Vaccine Results

April 1, 2014 1:58 pm | News | Comments

Immunovaccine Inc. and Pfenex Inc. announced positive results from anthrax challenge studies in rabbits using Pfenex's mutant recombinant Protective Antigen (mrPA) formulated with Immunovaccine's DepoVax delivery system. Read more...   

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Experimental Cancer Drug Reverses Schizophrenia in Mice

April 1, 2014 1:17 pm | News | Comments

Johns Hopkins researchers say that an experimental anticancer compound appears to have reversed behaviors associated with schizophrenia and restored some lost brain cell function in adolescent mice with a rodent version of the devastating mental illness. Read more...

Gene Therapy May Thwart Effects of MS

March 28, 2014 3:25 pm | News | Comments

Researchers have received a grant from the National Multiple Sclerosis Society to test a gene therapy technique in mice that aims to help the body not treat itself like a foreign invader. Read more...               

Women with BRCA1 Mutation Could Use Drugs to Cut Cancer Risk

March 28, 2014 2:46 pm | News | Comments

Cancer researchers have discovered that women affected with BRCA1 mutation could use drugs, which are already available, to reduce their risk of developing the disease, rather than undergo irreversible surgery. Read more...       

New Research Seeks DNA Vaccine Against HIV, Hep C

March 25, 2014 11:29 am | News | Comments

Plans for a new type of DNA vaccine to protect against the deadly HIV and Hepatitis C viruses have taken an important step forward, with researchers applying for a patent based on groundbreaking new research. Read more...         

Drugs Fail to Reawaken Dormant HIV Infection

March 24, 2014 2:34 pm | News | Comments

Scientists report that compounds they hoped would “wake up” dormant reservoirs of HIV inside immune system T cells— a strategy designed to reverse latency and make the cells vulnerable to destruction— have failed to do so in laboratory tests. Read more...

Substance Makes Glioblastoma Cells Explode

March 21, 2014 2:39 pm | News | Comments

Researchers have discovered that a substance called Vacquinol-1 makes cells from glioblastoma, the most aggressive type of brain tumor, literally explode. When mice were given the substance, tumor growth was reversed and survival was prolonged. Read more...

Study Finds Stem Cell Combo Therapy Improves TBI Outcomes

March 20, 2014 10:45 am | News | Comments

In an effort to find an effective therapy for traumatic brain injury, neuroscientists have conducted several preclinical studies aimed at finding combination therapies to improve TBI outcomes. Read more...              

Study IDs New Therapeutic Target to Control High Blood Sugar

March 19, 2014 3:18 pm | News | Comments

A recent study has identified a new potential therapeutic target for controlling high blood sugar, a finding that could help the estimated 25 million Americans with type 2 diabetes. Read more...                

Room-Temp Spray Vaccine May Curb Diseases in Remote Areas

March 19, 2014 11:02 am | News | Comments

A new kind of single-dose vaccine that comes in a nasal spray and doesn’t require refrigeration could dramatically alter the public health landscape, get more people vaccinated around the world and address the looming threats of emerging and re-emerging diseases. Read more...

New Therapeutic Target Discovered for Alzheimer’s

March 18, 2014 3:09 pm | News | Comments

A team of scientists is reporting that cathepsin B gene knockout or its reduction by an enzyme inhibitor blocks creation of key neurotoxic pGlu-A-beta peptides linked to Alzheimer’s disease. Read more...              

An End to Animal Testing for Drug Discovery?

March 18, 2014 2:15 pm | News | Comments

As some countries and companies roll out new rules to limit animal testing in pharmaceutical products designed for people, scientists are stepping in with a new way to test therapeutic drug candidates and determine drug safety and drug interactions— without using animals. Read more...

Antibiotic Resistance Targeted by Molecular 'Drill Bits'

March 17, 2014 2:40 pm | News | Comments

In response to drug-resistant superbugs that send millions of people to hospitals around the world, scientists are building tiny, “molecular drill bits” that kill bacteria by bursting through their protective cell walls. Read more...      

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