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The Lead

Embryonic Stem Cells in Trial for Diabetes

October 20, 2014 4:08 pm | by Cynthia Fox, Science Editor | Articles | Comments

As San Diego’s ViaCyte was in the midst of launching the first FDA-approved embryonic stem (ES) cell clinical trial for diabetes last week, Boston’s Harvard University reported that beta cells from ES cells “cured” diabetic mouse-models. Read more...

Lab-Developed Intestinal Organoids Form Mature Human Tissue in Mice

October 20, 2014 2:19 pm | News | Comments

Researchers have successfully transplanted “...

New Front in War on Alzheimer’s, Other Protein-Folding Diseases

October 17, 2014 10:12 am | News | Comments

A surprise discovery that overturns decades of...

Scientists Develop Decoy Drug to Form New Connections

October 16, 2014 12:18 pm | News | Comments

A team of Stanford Bio-X scientists has restored...

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Daily news and top headlines for drug research professionals

Study Finds Neurons "Fine Tune" At Genetic Level

October 15, 2014 1:16 pm | News | Comments

Neurons are electrically charged cells in the nervous system that interpret and transmit information using electrical and chemical signals. A neuron’s electrical charge is determined by the flow of ions – charged atoms – in and out of the cell through pores, called ion channels. Read more...

DNA-based ‘Nano-Cocoons’ Attack, Kill Cancer Cells

October 15, 2014 12:55 pm | News | Comments

Biomedical engineering researchers have developed a drug delivery system consisting of nanoscale “cocoons” made of DNA that target cancer cells and trick the cells into absorbing the cocoon before unleashing anticancer drugs. Read more...

Reversing Idiopathic Pulmonary Fibrosis

October 15, 2014 10:14 am | by Cynthia Fox, Science Editor | News | Comments

Lethal fibrosis in lungs of idiopathic pulmonary fibrosis (IPF) mouse models can be reversed, say Yale University researchers. Read more...                                      

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Combating Bladder Cancer With Approved Drug

October 14, 2014 1:53 pm | News | Comments

A drug that activates targets of the hedgehog signaling pathway, which is lost when bladder cancer invades, could prevent the progression of the disease in humans. Clinical trials are planned. Read more...                  

Researchers Treat Pulmonary Hypertension Through the Leaves of Plants

October 14, 2014 10:18 am | News | Comments

Researchers at the University of Pennsylvania and the University of Florida have identified a drug that can be used to treat pulmonary hypertension, a disease for which few therapy options exist. Read more...                            

New Cancer Drug to Begin Trials in Multiple Myeloma Patients

October 13, 2014 3:11 pm | News | Comments

Scientists at Imperial College London have developed a new cancer drug which they plan to trial in multiple myeloma patients by the end of next year. Read more...                            

Giant Step Toward New Diabetes Treatment

October 10, 2014 9:55 am | News | Comments

Harvard stem cell researchers announced that they have made a giant leap forward in the quest to find a truly effective treatment for type 1 diabetes, a condition that affects an estimated 3 million Americans at a cost of about $15 billion annually Read more...

Cancer Drug Destroys Tumors in Pre-Clinical Trials

October 9, 2014 3:18 pm | News | Comments

Scientists at QIMR Berghofer Medical Research Institute have used an experimental drug produced from the seeds of a rainforest plant to cure solid cancer tumors in preclinical trials. Read more...                     

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Researchers Find that Drug Used for Another Disease Slows Parkinson’s Progression

October 9, 2014 10:24 am | News | Comments

A new study from University of California, Los Angeles (UCLA) found that a drug being evaluated to treat an entirely different disorder helped slow the progression of Parkinson’s disease in mice. Read more...

Drug Cured 16 of 16 Monkeys with Viral Ebola Relative

October 8, 2014 11:31 am | by Cynthia Fox, Science Editor | Articles | Comments

An experimental drug saved the lives of 16 of 16 monkeys with the Marburg virus, a killer near-indistinguishable from Ebola, just as symptoms broke out, said a new study. Read more...                   

'Unsung' Cells Double the Benefits of a New Osteoporosis Drug

October 8, 2014 10:48 am | News | Comments

Experiments in mice with a bone disorder similar to that in women after menopause show that a scientifically overlooked group of cells are likely crucial to the process of bone loss caused by the disorder, according to Johns Hopkins researchers. Read more...

Green Tea-based ‘Missiles’ May Kill Cancer Cells

October 7, 2014 3:31 pm | News | Comments

Green tea has long been known for its anti-oxidant, anti-cancer, anti-aging and anti-microbial properties. A group of researchers from the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR has taken the health benefits of green tea to the next level by using one of its ingredients to develop a drug delivery system, which kills cancer cells more efficiently. Read more...

‘Programmable’ Antibiotic Harnesses Enzyme to Attack Drug-Resistant Microbes

October 6, 2014 10:12 am | News | Comments

The multitude of microbes scientists have found populating the human body have good, bad and mostly mysterious implications for our health. But when something goes wrong, we defend ourselves with the undiscriminating brute force of traditional antibiotics, which wipe out everything at once, regardless of the consequences. Read more...

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Potential Therapy Spotted for Sudan Strain of Ebola

October 3, 2014 11:04 am | by Stephanie Guzowski, Editor | Articles | Comments

As the deadly Ebola outbreak in West Africa continues to grip headlines around the world, researchers move steadily forward with drug development. But as essential as it is to contain the current Ebola outbreak, researchers are looking at the bigger picture— and highlighting the need for therapy development to extend beyond the wake of the current epidemic. Read more...

Ancient Protein-Making Enzyme Moonlights as DNA Protector

October 3, 2014 10:54 am | News | Comments

Scientists at TSRI have found that an enzyme best known for its fundamental role in building proteins has a second major function: to protect DNA during times of cellular stress. Read more...

Osteoporosis Treatment May also Benefit Breast Cancer Patients

October 3, 2014 10:39 am | News | Comments

Treatment approaches to reduce the risk of metastasis associated with breast cancer may be one step closer to becoming a reality. According to a study led by a team at the Research Institute of the MUCH, findings show that medication used to treat bone deterioration in post-menopausal women may also slow skeletal metastasis caused from breast cancer. Read more...

Researchers Engineer New Mouse Model to Study Disease

September 26, 2014 3:33 pm | News | Comments

Researchers from the Broad Institute and MIT have created a new mouse model to simplify application of the CRISPR-Cas9 system for genome-editing experiments in living animals. Read more...

Chemists Recruit Anthrax to Deliver Cancer Drugs

September 25, 2014 1:58 pm | News | Comments

Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. A team of MIT researchers has now hijacked that delivery system for a different purpose: administering cancer drugs. Read more...

Inovio Pharma Plans Humans Trials of Ebola Vaccine

September 24, 2014 2:45 pm | News | Comments

Inovio Pharmaceuticals plans to initiate human testing of a DNA-based vaccine for the Ebola virus in the first half of 2015. Read more...                                

NIH Funds Next Phase of Tissue Chip for Drug Screening Program

September 24, 2014 10:40 am | News | Comments

The National Institutes of Health will award funds to support the next phase of its Tissue Chip for Drug Screening program to improve ways of predicting drug safety and effectiveness. Read more...                            

Investigational Drug Could be Treatment for AML, Multiple Myeloma

September 23, 2014 1:57 pm | News | Comments

The investigational drug CX-5461 prolonged survival in mouse models of highly aggressive AML and multiple myeloma, according to data presented at the AACR special conference Hematologic Malignancies: Translating Discoveries to Novel Therapies. Read more...

New Approach Aims to Silence Cancer 'Survival Genes'

September 23, 2014 11:20 am | News | Comments

Scientists are working on a promising new approach for tackling colorectal cancer, the second most common cause of cancer-related death. Read more...                             

Pterostilbene Prevents Skin Damage from UV Exposure in Mouse Study

September 22, 2014 4:04 pm | News | Comments

ChromaDex Corp. announced the completion of an animal skincare study of pterostilbene by researchers at The University of California Irvine (UCI). Read more...                          

Battling Superbugs

September 22, 2014 3:57 pm | News | Comments

Engineers have turned a powerful new weapon on superbugs. Using a gene-editing system that can disable any target gene, they have shown that they can selectively kill bacteria carrying harmful genes that confer antibiotic resistance or cause disease. Read more...

Vaccine Stops Catheter-Linked UTIs in Mice

September 18, 2014 4:13 pm | News | Comments

The most common type of hospital-associated infection may be preventable with a vaccine, new research in mice suggests. The experimental vaccine prevented urinary tract infections associated with catheters. Read more...          

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