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The Lead

Fragile X Syndrome: Building a Case for an Alternative Treatment Strategy

April 24, 2015 12:01 pm | by Emory Health Sciences | News | Comments

New research strengthens a potential strategy for treating fragile X syndrome, the most common inherited form of intellectual disability. Read more...

Finding Points to a Cause of Chronic Lung Disease

April 23, 2015 1:58 pm | by Washington University in St. Louis | News | Comments

Scientists have long suspected that respiratory viruses — the sort that cause common colds or...

Harnessing the Clinical Potential of Microvesicles Released from Cancer Cells

April 22, 2015 12:14 pm | by William G. Gilroy, University of Notre Dame | News | Comments

Over the past few years, extracellular vesicles, or membrane sacs secreted from cells, have...

A New Lease on Life for Prostate Tissue

April 21, 2015 11:19 am | by Rutgers University | News | Comments

What if a prostate cancer patient could learn which anti-cancer treatments would work best for...

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Daily news and top headlines for drug research professionals

Cancer Drug Shows Promise for Treating Hepatitis B

April 20, 2015 4:46 pm | by Walter + Eliza Hall Research Institute | News | Comments

​Australian scientists have found a potential cure for hepatitis B virus (HBV) infections. Read more...

Childhood Syndrome Combining Lung Disease, Arthritis Identified

April 20, 2015 11:07 am | by UCSF | News | Comments

Discovery suggests mechanism, possible therapies for severe disorder. Read more...

Electronic Micropump Could Deliver Treatment to Specific Brain Region

April 17, 2015 10:13 am | by Stephanie Guzowski, Editor | News | Comments

There is an exactness that must be taken into account when treating neurological disorders. In treating epilepsy, for example, a condition in which nerve cell activity in the brain is disturbed, causing seizures, a drug needs to be delivered directly to a specific brain region—but without negatively affecting healthy brain regions. Read more...

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How Molecule Protects Brain Cells in Parkinson’s Disease Model

April 15, 2015 11:35 am | by Scripps Research Institute | News | Comments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found how a widely known but little-studied enzyme protects brain cells in models of Parkinson’s disease. Read more...

Recruiting the Entire Immune System to Attack Cancer

April 14, 2015 10:48 am | by MIT News | News | Comments

The human immune system is poised to spring into action at the first sign of a foreign invader, but it often fails to eliminate tumors that arise from the body’s own cells. Cancer biologists hope to harness that untapped power using an approach known as cancer immunotherapy. Read more..

Tau is the Main Culprit in Alzheimer’s, say Two Studies

April 7, 2015 5:17 pm | by Cynthia Fox, Science Writer | Articles | Comments

Two recent studies have concluded that tau, not amyloid, is the main driver behind Alzheimer’s disease (AD). Read more...

Experimental Cancer Drug Restores Memory in Mouse Model of Alzheimer’s

April 1, 2015 12:37 pm | by Yale University | News | Comments

Memory and as well as connections between brain cells were restored in mice with a model of Alzheimer’s given an experimental cancer drug, Yale School of Medicine researchers reported in the journal Annals of Neurology. Read more...

Medieval Remedy Found to be Highly Effective Against MRSA

March 31, 2015 1:37 pm | by Stephanie Guzowski, Editor | News | Comments

British researchers recently found that a thousand-year-old Anglo-Saxon treatment for eye infections works as an antibiotic against MRSA. Read more...

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Common Bacteria on Verge of Becoming Antibiotic-Resistant Superbugs

March 26, 2015 1:29 pm | by Michael C. Purdy, Washington Univ. | News | Comments

Antibiotic resistance is poised to spread globally among bacteria frequently implicated in respiratory and urinary infections in hospital settings, according to new research at Washington University School of Medicine in St. Louis. Read more...

FDA Approves Anthrax Treatment

March 25, 2015 1:10 pm | by Stephanie Guzowski, Editor | News | Comments

The Food and Drug Administration (FDA) yesterday approved Emergent BioSolutions’ infusible drug Anthrasil for use in combination with antibiotics to treat inhalational anthrax, which happens when bacterial spores that carry anthrax are breathed in. Read more...

Nanotechnology Platform Shows Promise for Treating Pancreatic Cancer

March 24, 2015 12:48 pm | by UCLA | News | Comments

Scientists at UCLA’s California NanoSystems Institute and Jonsson Comprehensive Cancer Center have combined their nanotechnology expertise to create a new treatment that may solve some of the problems of using chemotherapy to treat pancreatic cancer. Read more...

New Hope for Beating Deadly Hereditary Stomach and Breast Cancers

March 20, 2015 10:11 am | by University of Otago | News | Comments

Deadly familial stomach and lobular breast cancers could be successfully treated at their earliest stages, or even prevented, by existing drugs. Read more...

Capturing the Living Picture of Cancer: Proteomic Testing in the Clinical Lab

March 19, 2015 12:46 pm | by Richard Hockett, M.D., Chief Medical Officer at Biodesix, a molecular diagnostics company | Articles | Comments

If genetic sequencing provides the script of life, then proteomics is the live video capturing biology in action. Proteomics moves beyond the static information provided by genomics and tells the story in real-time of proteins, which result from the individual genes within a cell. Read more...

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Potential Treatment for Most Common Form of Muscular Dystrophy

March 17, 2015 12:02 pm | by University of Virginia Health System | News | Comments

A doctor who was one of the discoverers of the gene responsible for myotonic muscular dystrophy has now identified a therapeutic that could slow progression of muscle damage and muscle dysfunction associated with the disease – issues that cause patients significant disability and deterioration in quality of life. Read more...

GSK Announces Start of Phase 3 Program for Retosiban Evaluation

March 17, 2015 8:46 am | News | Comments

Retosiban is an investigational oxytocin antagonist. Read more...

Researchers Unlock the Mysteries of Wound Healing

March 16, 2015 11:49 am | by Jill Goetz, UA News | News | Comments

A multidisciplinary research team discovers how cells know to rush to a wound and heal it – opening the door to new treatments for diabetes, heart disease and cancer. Researchers at the University of Arizona have discovered what causes and regulates collective cell migration, one of the most universal but least understood biological processes in all living organisms. Read more...

Anti-Herpes Drug May Help Control HIV

March 13, 2015 1:56 pm | by Stephanie Guzowski, Editor | News | Comments

A drug that’s used to control herpes simplex virus 2 (HSV-2) could reduce levels of HIV in patients who do not have genital herpes, finds a National Institutes of Health (NIH) study. Read more...

Stem Cells Lurking in Tumors Can Resist Treatment

March 13, 2015 11:35 am | by Washington University in St. Louis | News | Comments

Scientists are eager to make use of stem cells’ extraordinary power to transform into nearly any kind of cell, but that ability also is cause for concern in cancer treatment. Malignant tumors contain stem cells, prompting worries among medical experts that the cells’ transformative powers help cancers escape treatment. Read more...

Skin Tumors Develop Specific Mutations to Resist Drug, Researchers Say

March 11, 2015 10:51 am | by Krista Conger, Stanford University | News | Comments

Basal cell carcinomas develop mutations in a protein on the Hedgehog pathway to evade a common drug therapy. Targeting another portion of the pathway may be an effective alternative treatment. Read more...                     

Takeda Announces Transfer of License Agreement for HPV Vaccine to Kaketsuken

March 11, 2015 8:38 am | News | Comments

Kaketsuken will continue research efforts to support future commercialization of this vaccine. Read more...                         

Scientists Open Door for HIV Drug

March 10, 2015 1:06 pm | News | Comments

Salk scientists have gotten one step closer to creating such a drug by customizing a powerful defense system used by many bacteria and training this scissor-like machinery to recognize the HIV virus. Read more...

Innovative Light Therapy Reaches Tumors

March 9, 2015 4:53 pm | by Julia Evangelou Strait, Washington University in St. Louis | News | Comments

Light long has been used to treat cancer. Read more...                                  

Tiny Nanoparticles Could Make Impact for Cornea Transplant Patients

March 9, 2015 10:13 am | by Johns Hopkins | News | Comments

Animal study shows that a nanoparticle applied at the time of surgery slowly releases needed medicine to reduce risk of rejection after eye surgery. Read more...                                

Stem Cell Researchers Develop Method to Treat Sickle Cell Disease

March 9, 2015 9:55 am | by UCLA | News | Comments

UCLA stem cell researchers have shown that a novel stem cell gene therapy method could lead to a one-time, lasting treatment for sickle cell disease—the nation's most common inherited blood disorder. Read more...

A New Stem Cell Advance

March 3, 2015 12:03 pm | by Hannah Robbins, Harvard | News | Comments

Collaborating with scientists from New York, Toronto, and Tokyo, Harvard Stem Cell Institute (HSCI) researchers have devised two methods for using stem cells to generate the type of neurons that help regulate behavioral and basic physiological functions in the human body, such as obesity and hypertension, as well as sleep, mood, and some social disorders. Read more...

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