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Neurotrope: Last Patient Dosed in Phase 2a Alzheimer's Study

November 21, 2014 11:41 am | News | Comments

Neurotrope, Inc. announced that the last patient has been dosed in its Phase 2a clinical trial of Bryostatin-1 for the treatment of patients with Alzheimer's disease (AD). The trial is being conducted under an Investigational New Drug (IND) application filed by the Company's licensor, the Blanchette Rockefeller Neuroscience Institute (BRNI). Read more...

Researcher Who Found Cause of Lyme Disease Dies

November 21, 2014 11:32 am | by Associated Press | News | Comments

The Swiss-born...

FDA Approves New, Hard-to-Abuse Hydrocodone Pill

November 21, 2014 11:27 am | by Matthew Perrone, AP Health Writer - Associated Press | News | Comments

Federal health...

Powerful Method to Speed Cancer Drug Discovery

November 21, 2014 11:22 am | by Salk Institute | News | Comments

For decades,...

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Daily news and top headlines for drug research professionals

HIV/AIDS Drugs Could Be Repurposed to Treat AMD

November 21, 2014 11:01 am | by Ann Blackford, University of Kentucky | News | Comments

A study published in the journal Science by an international group of scientists, led by the laboratory of Dr. Jayakrishna Ambati, professor and vice chair of the Department of Ophthalmology & Visual Sciences at the University of Kentucky, reports that HIV/AIDS drugs that have been used for the last 30 years could be repurposed to treat AMD. Read more...

UK Investment to Develop Lung Cancer Drugs

November 21, 2014 9:58 am | News | Comments

A new collaboration in the UK will develop a promising class of cancer inhibitors. Read more...                            

Pre-Empting Flu Evolution May Make Better Vaccines

November 21, 2014 9:37 am | News | Comments

An international team of researchers has shown that it may be possible to improve the effectiveness of the seasonal flu vaccine by ‘pre-empting’ the evolution of the influenza virus. Read more...           

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Breakthrough Found to Help Manage Yellow Fever

November 21, 2014 9:24 am | News | Comments

Yellow fever is a disease that can result in symptoms ranging from fever to severe liver damage. Read more...                         

Beta-Blockers Show No Survival Benefits After Heart Attack

November 21, 2014 8:48 am | by Drug Discovery & Development Staff | Articles | Comments

Beta blockers offer no survival advantages to patients, post-heart attack, but they do improve survival among some heart failure patients. Read more...                                                          

New Approach for Treating ALS

November 20, 2014 1:45 pm | News | Comments

Researchers show that the brain’s machinery for pumping out toxins is ratcheted up in ALS patients. Read more...                         

Global Obesity Costs Hits $2 Trillion

November 20, 2014 12:35 pm | by Danica Kirka - Associated Press | News | Comments

The global cost of obesity has risen to to nearly as much as smoking or the combined aspect of armed violence, war and terrorism. Read more...                    

Virus Discovery Could Impact HIV Drug Research

November 20, 2014 12:23 pm | News | Comments

A research team has unlocked the structure of an unusual virus that lives in volcanic hot springs. Read more...                         

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Promising One-Two Punch for Lung Cancer

November 20, 2014 10:19 am | News | Comments

Scientists at the Salk Institute have discovered a powerful one-two punch for countering a common genetic mutation that often leads to drug-resistant cancers. The dual-drug therapy–with analogs already in use for other diseases–doubled the survival rate of mice with lung cancer and halted cancer in pancreatic cells. Read more...

Early Statin Use May Give Long-Term Heart Benefits

November 20, 2014 10:06 am | by Marilynn Marchione, AP Chief Medical Writer - Associated Press | News | Comments

Taking a cholesterol-lowering drug for five years in middle age can lower heart and death risks for decades afterward, and the benefits seem to grow over time, a landmark study finds. Doctors say it's the first evidence that early use of a statin can have a legacy effect, perhaps changing someone's odds of disease for good. Read more...

Mental Health Problems Increase Heart Disease Risk

November 20, 2014 9:42 am | by Cynthia Fox, Science Editor | Articles | Comments

People with mental health problems are “significantly” more likely to have stroke or heart disease, according to a study unveiled at a recent Canadian Cardiovascular Congress. Read more...

Bacterial Infections Suppress Immune Response in Neurodermatitis

November 20, 2014 9:31 am | by Technische Universität München | News | Comments

The skin condition neurodermatitis affects nearly one in four children and also occurs frequently in adults. Many patients also develop infections in the dry, open patches of skin, for example due to colonization by the pathogenic bacterium Staphylococcus aureus, which is particularly abundant on the skin of neurodermatitis patients. Read more...

WHO: Ebola Transmission 'Intense' in Sierra Leone

November 20, 2014 9:24 am | by Clarence Roy-Macaulay - Associated Press | News | Comments

The spread of Ebola remains "intense" in most of Sierra Leone even as things have improved somewhat in the two other countries hardest hit, the World Health Organization says. Read more...                             

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Regeneron, Sanofi: New Positive Results for Cholesterol-Lowering Drug

November 20, 2014 9:06 am | News | Comments

Regeneron Pharmaceuticals, Inc. and Sanofi announced new detailed positive results from six Phase 3 ODYSSEY trials that showed alirocumab significantly reduced low-density lipoprotein cholesterol (LDL-C, or "bad" cholesterol). Read more...

Royalty Pharma Pays $3.3B for Cystic Fibrosis Royalties

November 19, 2014 1:51 pm | News | Comments

Royalty Pharma announced its acquisition of royalties on Vertex Pharmaceuticals' cystic fibrosis treatments owned by Cystic Fibrosis Foundation Therapeutics' ("CFFT"), an affiliate of the Cystic Fibrosis Foundation, for a cash payment of $3.3 billion. Read more...

HHS, NIH To Enhance Transparency of Clinical Trial Results

November 19, 2014 1:43 pm | News | Comments

The U.S. Department of Health and Human Services today issued a Notice of Proposed Rulemaking (NPRM), which proposes regulations to implement reporting requirements for clinical trials that are subject to Title VIII of the Food and Drug Administration Amendments Act of 2007 (FDAAA). Read more...

Chemical Disguise Transforms RNAi Drug Delivery

November 19, 2014 1:04 pm | News | Comments

Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses. The problem is delivery — it is extremely difficult to get RNAi drugs inside the cells in which they are needed.  Read more...

Light-Responding Blood Vessel Receptor May Be New Target

November 19, 2014 12:46 pm | by Johns Hopkins | News | Comments

A team of researchers from Johns Hopkins Medicine has discovered a receptor on blood vessels that causes the vessel to relax in response to light, making it potentially useful in treating vascular diseases. In addition, researchers discovered a previously unknown mechanism by which blood vessel function is regulated through light of a specific wavelength. Read more...

Maximizing the Power of Preclinical Cancer Research Tools

November 19, 2014 11:29 am | by Guizhong Liu, Senior Director of Cancer Biology, Crown Bioscience Inc. | Articles | Comments

Drug discovery is a protracted and uncertain process that needs to overcome many hurdles during preclinical and clinical development before it finally achieves regulatory approval for patient treatment. For every drug that reaches the marketplace, well over 100 have been abandoned at some point in their development. Read more...

Cardiome Finds Distributor for AFib Drug in South Africa

November 19, 2014 9:59 am | News | Comments

Cardiome entered into a new partnership with Pharmacare Ltd to sell and distribute its AFib drug in South Africa. Read more...                     

New Laser Therapy Helps Slow Macular Degeneration

November 19, 2014 9:36 am | News | Comments

This new faster laser did not result in damage to the retina. Read more...                               

Sub-Standard Meds Flood Afghan Market

November 19, 2014 9:24 am | News | Comments

Up to 300 companies in Pakistan produce poor quality drugs exclusively for Afghanistan because their products do not meet Pakistani government standards. Read more...                

Study Will Test Survivors' Blood to Treat Ebola

November 19, 2014 9:19 am | by Marilynn Marchione - AP Chief Medical Writer | News | Comments

Plasma from survivors contains antibodies, substances the immune system makes to fight the virus. Read more...                         

New Insight Into Cells Could Lead to Better Drugs

November 19, 2014 9:11 am | News | Comments

Researchers investigated how different types of immune cells communicate with each other – and how they kill cancerous or infected cells. Read more...                   

Reprogramming Cells, Long Term

November 18, 2014 2:07 pm | by B. D. Colen, Harvard Staff Writer | News | Comments

Harvard Stem Cell Institute (HSCI) researchers, representing five Harvard departments and affiliated institutions as well as the Massachusetts Institute of Technology (MIT), have demonstrated that adult cells, reprogrammed into another cell type in a living animal, can remain functional over a long period. Read more...

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