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Daily news and top headlines for drug research professionals

MRIGlobal Wins $54 Million NIH Neurological Disorders And Stroke Contract

January 16, 2015 11:25 am | News | Comments

MRIGlobal announced that it has been awarded a $54 million, 10-year program from the National Institute of Neurological Disorders and Stroke to provide support for the development and manufacturing of drug candidates for ultimate use in human clinical trials. Read more...

Study Reveals Lack of Data on Opioid Drugs

January 14, 2015 9:35 am | by University of Connecticut | News | Comments

Many of the studies used to justify the prescription of these drugs were either poorly conducted or of an insufficient duration. Read more...                    

Roche, Meiji and Fedora Team Up to Tackle Bacterial Resistance to Antibiotics

January 14, 2015 9:22 am | News | Comments

The three pharmaceutical companies entered into a license agreement for the development and commercialization of a new inhibitor. Read more...                    

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Breakthrough on Chronic Pain

January 13, 2015 12:14 pm | by Harvard University | News | Comments

For the first time, scientists have found evidence of neuroinflammation in key regions of the brains of patients with chronic pain, according to a new study from Massachusetts General Hospital (MGH), a Harvard affiliate. Read more...                      

In the News: Open Access Journals

January 13, 2015 8:55 am | by Drug Discovery & Development Staff | Articles | Comments

A number of open access journals have made the news recently. The preprint open access archive, arXiv.org, run by Cornell University, is often used by scientists, from physicists to quantitative biologists, to get their ideas out there quickly and stake out their intellectual ground, before they enter the slow process of peer review. Read more...

Celator Announces Promising Phase 2 Data for AML Drug

January 12, 2015 12:58 pm | News | Comments

Celator Pharmaceuticals published this data earlier today. Read more...                                

Adopting Adaptive Designs: Update

January 12, 2015 8:59 am | by Phil Birch, DPhil, VP Innovation Strategy, Alliance Partnerships at ICON plc. | Articles | Comments

In early 2013, adaptive clinical trials represented 20% of all clinical trials, according to the Tufts CSDD seminal report, The Adoption and Impact of Adaptive Trial DesignsThough that number was expected to grow, lack of education and industry conservatism were named as some of the greatest barriers to widespread adoption of adaptive designs. Read more...

Daiichi Sankyo's AFib Tablets Gain FDA Approval

January 9, 2015 9:36 am | News | Comments

The tablets reduce the risk of stroke and systemic embolism. Read more...                               

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Clinical Trial Starts at Ebola Center for Antiviral Drugs

January 7, 2015 9:06 am | by Jonathan Paye-Layleh - Associated Press | News | Comments

A clinical drug trial is now under way at a major health center in Liberia's capital to determine if a medication already used to treat other viruses could help those suffering from Ebola. Read more...          

Nestlé Health Science Invests $65M in Microbiome Therapy Startup

January 6, 2015 12:22 pm | News | Comments

Nestlé Health Science’s investment will help fund the next stage of development of the startup's CDI treatment. Read more...                       

Amgen, Kite Pharma to Collaborate on T Cell Therapy Application

January 5, 2015 9:49 am | News | Comments

Amgen and Kite Pharma announced that the two companies have entered into a strategic research collaboration and license agreement to develop and commercialize the next generation of novel T Cell immunotherapy. Read more...       

FDA Approves sBLA for CLL Treatment

December 26, 2014 9:54 am | by Associated Press | News | Comments

Genentech, a member of the Roche Group announced that the U.S. Food and Drug Administration (FDA) approved a supplemental biologics license application (sBLA) for Gazyva in combination with chlorambucil chemotherapy in people with previously untreated chronic lymphocytic leukemia (CLL). read more...

Kinex Pharmaceuticals Announces First Dosage Given for Brain Tumor Inhibitor

December 26, 2014 8:45 am | News | Comments

Kinex Pharmaceuticals announced that the first patient has been dosed with KX2-361 at Roswell Park Cancer Institute. Read more...                      

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Researchers Find Alternate Drug Therapy Lowers Antibodies

December 24, 2014 8:56 am | by University of Cincinnati | News | Comments

Researchers suggest that a novel pre-operative drug therapy reduces antibodies in kidney patients with greater success than with traditional methods. Read more...                 

Top 100 Talked-About Papers of 2014

December 19, 2014 5:06 pm | by Drug Discovery & Development Staff | News | Comments

The academic papers of 2014 most cited by news and social media covered an astonishing range of topics, from science fraud, to black holes, to time travelers, according to Altmetric.com. But at 45%, the most popular papers by far were in health and medicine. Read more...

After Lung Transplant, Antiviral Drug Resistance More Likely in Cystic Fibrosis

December 19, 2014 1:50 pm | News | Comments

A drug called ganciclovir is given to lung transplant patients to protect against a life-threatening virus that is common after transplantation. Read more...                                                     

Combo Drug Therapy Doubles Positive Effect for Women with Breast Cancer

December 19, 2014 1:20 pm | News | Comments

In a groundbreaking study that offers new hope for women with advanced breast cancer, UCLA researchers published final clinical trial results that showed the amount of time women with advanced breast cancer were on treatment without their cancer worsening was effectively doubled when they took the experimental drug palbociclib. Read more...

10 Up-and-Coming Healthcare Medical Innovations

December 18, 2014 12:10 pm | by Christina Jakubowski, Managing Editor, Bioscience Technology | Articles | Comments

The Cleveland Clinic recently unveiled their annual Top 10 Medical Innovations for 2015– a list that casts an optimistic light on up-and-coming healthcare advances that may reach consumers next year. Their number one? Read more...                         

Hypertension Medication that Targets Stress May Help Smokers Quit

December 18, 2014 11:23 am | by Daniel Jones, Yale University | News | Comments

Smokers trying to quit often light up a cigarette to deal with stress. Now an interdisciplinary team of Yale researchers has shown that guanfacine, a medication approved for treating hypertension that reduces stress and enhances cognition, shows promise as a smoking cessation aid. Read more...

GSK Shingles Vaccine Hits Goal in Major Study

December 18, 2014 9:02 am | News | Comments

GSK announced that a pivotal phase 3 study to assess the efficacy of HZ/su, an investigational vaccine for the prevention of shingles, has met its primary endpoint. Read more...                                 

Despite Risks, Benzodiazepine Use Highest in Older People

December 17, 2014 4:50 pm | by NIH | News | Comments

Prescription use of benzodiazepines — a widely used class of sedative and anti-anxiety medications — increases steadily with age, despite the known risks for older people, according to a comprehensive analysis of benzodiazepine prescribing in the United States. Read more...

Study Shows Potential for Faster Drug Development

December 15, 2014 1:47 pm | News | Comments

A new study demonstrates the ability to conduct robust cardiac safety characterizations several years earlier than current practice. Read more...                    

Medication Being Studied Could Help Afib Patients After Stroke

December 15, 2014 1:03 pm | by University of South Florida | News | Comments

Researchers are studying the effectiveness of a new rapid-onset anticoagulant medication with the standard anticoagulant drug in stroke patients with atrial fibrillation, the most common type of abnormal heart rhythm. Read more...     

Cancer Patients Testing Drugs on Mouse Avatars

December 15, 2014 12:56 pm | by Marilynn Marchione - AP Chief Medical Writer | News | Comments

The idea is to see which drugs might work best on a specific person's specific cancer. Read more...                           

Tackling One of The Biggest Questions in Dementia Research

December 15, 2014 11:06 am | by University of Southampton | News | Comments

Researchers in Southampton are tackling one of the biggest questions in dementia research; why might current approaches in Alzheimer's trials be failing? The new study is published in the Journal of Pathology and funded by Alzheimer's Research UK and the Medical Research Council. Read more...

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