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Daily news and top headlines for drug research professionals

Onxeo Announces New Data for Two Orphan Oncology Drugs

June 4, 2015 12:19 pm | by Ryan Bushey, Associate Editor | Articles | Comments

Onxeo’s Chief Scientific Officer Graham Dixon spoke with Drug Discovery & Development about the development of the orphan oncology market as well as elaborated on the news related to his company’s top two drugs. Read more...

Berg: Data on BPM 31510 Solid Tumor Trial

June 4, 2015 10:16 am | News | Comments

Berg, a biopharmaceutical company committed to uncovering health solutions through a data-driven, biological approach, presented clinical research from its trials using its cancer drug BPM 31510 on Phase Ib solid tumors and preclinical data on triple negative breast cancer, at the 51st Annual Meeting of the American Society of Clinical Oncology (ASCO), May 29 – June 2 in Chicago. Read more...

Early Clinical Trial Success for New RA Treatment

June 4, 2015 8:20 am | by University of Queensland | News | Comments

Researchers have developed a world-first vaccine-style therapeutic approach to treat rheumatoid arthritis, a debilitating disease affecting more than 450,000 people in Australia. Read more...

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ASCO 2015: Delmar Pharmaceuticals Presents Updated Phase 1/2 Clinical Data on VAL-083

June 3, 2015 9:28 am | News | Comments

VAL-083 more than doubled the survival rate of patients with Glioblastoma Multiforme participating in the clinical trial. Read more...

Asia-Pacific RA Treatment Market Value Will Reach $7B by 2021: GBI Research

June 2, 2015 8:31 am | News | Comments

The Rheumatoid Arthritis (RA) therapeutics market in the Asia-Pacific (APAC) region will expand in value from $5.6 billion in 2014 to an estimated $7 billion by 2021. Read more...

ASCO 2015 Highlights

June 1, 2015 2:05 pm | by Stephanie Guzowski, Editor | News | Comments

Here are some of the top news coming out of the American Society of Clinical Oncology (ASCO) Annual Meeting. Read more...

More Cancer Success with Drugs That Enlist Immune System

June 1, 2015 1:12 pm | by By Lindsey Tanner, AP Medical Writer | News | Comments

For the first time, a major study shows that a drug targeting the body's disease-fighting immune system may improve survival for the most common form of lung cancer. Read more...

ASCO 2015: AstraZeneca, MedImmune Present Positive Immuno-oncology Combination Data

June 1, 2015 8:53 am | News | Comments

MEDI4736 and tremelimumab target two different tumor escape pathways; engaging the immune system to fight the cancer’s immune-evading tactics and maintaining tumor specific T-cell responses. Read more...

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Pfizer's Palbociclib Shows Promise Against Breast Cancer

June 1, 2015 8:28 am | News | Comments

Results from the Phase 3 PALOMA-3 study were featured in a press briefing during the 51st Annual Meeting of the American Society of Clinical Oncology (ASCO). Read more...

MDMA, aka Ecstasy, May Be New Treatment for Autism’s Social Anxiety

May 29, 2015 12:34 pm | by Seth Augenstein, Digital Reporter | News | Comments

A recreational drug known for making people uninhibited and getting them dancing in clubs could get a new use: to help treat social anxiety among autistic adults, according to a new proposal by a group of researchers. Read more...

Drug Discovery Spotlight: Immuno-Oncolytic Therapy Advances; Suicidal Behavior Ends Co-Development of Psoriasis Drug

May 29, 2015 12:24 pm | by Stephanie Guzowski, Editor | News | Comments

From cancer therapies composed of herpes and vaccinia viruses to pharma collaborations that crumbled, here are your headlines this week. Read more…

ASCO: Trial Creates Six Percent Weight Loss After Breast Cancer Treatment

May 28, 2015 11:54 am | by University of Colorado Denver | News | Comments

Carrying extra body fat increases the risk for diabetes, heart disease and stroke, and also increases risk of cancer recurrence after a breast cancer diagnosis. A multi-institutional study presented at the American Society for Clinical Oncology (ASCO) Annual Meeting 2015 shows that female breast cancer survivors are able to lose weight through modest lifestyle changes. Read more...

Genetically Modified Herpes Virus to Treat Skin Cancer

May 27, 2015 1:13 pm | by Stephanie Guzowski, Editor | News | Comments

An experimental treatment using a genetically modified strain of the herpes simplex 1 virus has been shown to be effective in killing skin cancer cells and halting tumor growth, according to new research. The oncolytic virus immunotherapy, called T-VEC, was used to treat patients with melanoma in a Phase 3 clinical trial. Read more...

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Amgen Terminates Co-Development of Brodalumab with AstraZeneca

May 26, 2015 1:16 pm | by Stephanie Guzowski, Editor | News | Comments

Amgen ended its co-development of brodalumab with AstraZeneca after some patients who took the experimental psoriasis drug experienced suicidal thoughts or behavior, which Amgen believes would likely require restrictive labeling. Read more...

Peeking into Healthy Brains to See If Alzheimer's is Brewing

May 26, 2015 10:34 am | by Lauren Neergaard, AP Medical writer - Associated Press | News | Comments

Now researchers are adding tau brain scans to an ambitious study that's testing if an experimental drug might help healthy but at-risk people stave off Alzheimer's. Whether that medication works or not, it's the first drug study where scientists can track how both of Alzheimer's signature markers begin building up in older adults before memory ever slips. Read more...

Statins May Have Slowed Advanced Prostate Cancer Growth by 10 Months

May 26, 2015 10:08 am | by Cynthia Fox, Science Editor | Articles | Comments

When starting androgen deprivation therapy, advanced prostate cancer patients who were taking statins—popular cholesterol-lowering heart drugs—experienced 10 more months of cancer control, according to data published in JAMA Oncology. Read more..

Cellular Biomedicine Reports Positive Phase 1 Study Results for T-Cell Therapy

May 26, 2015 8:11 am | News | Comments

The results of this trial to date demonstrated that five out of seven patients responded to the treatment. CD30-directed CAR-T cell therapy was demonstrated in this trial to be safe, feasible and efficient. Read more...

Novel Drug Combo Improves Function of Cystic Fibrosis Protein

May 22, 2015 10:07 am | by Johns Hopkins | News | Comments

A novel two-drug combination has the potential to target and restore a defective protein underlying cystic fibrosis (CF), according to two phase 3 clinical trials conducted at 187 medical centers around the world, including Johns Hopkins. Read more...

Injected T Cells from Bone Marrow Treat Multiple Myeloma, Pilot Study Finds

May 21, 2015 1:12 pm | by Stephanie Guzowski, Editor | Articles | Comments

In a first small clinical trial of its kind, researchers harnessed T cells from patients’ own bone marrow to treat multiple myeloma and provide immune protection for up to a year, according to a study published this week in Science Translational Medicine. Read more...

Brain Plaque Forecasts Alzheimer’s Years in Advance, Studies Confirm

May 20, 2015 1:49 pm | by Stephanie Guzowski, Editor | News | Comments

Brain plaques may appear up to 30 years prior to developing Alzheimer’s disease, according to the largest analysis to date of beta amyloid in people’s brains. Findings from two new meta-analyses  also confirm that amyloid screening, by PET scan or cerebral spinal fluid test, can help identify the best participants for clinical trials of Alzheimer’s drugs. Read more...

Australian Researcher Helps with Ebola Vaccine Trials

May 20, 2015 8:41 am | by Monash University | News | Comments

An Australian researcher has helped identify the kind of human trial that is most effective for testing Ebola vaccines. Read more...

Groundbreaking Treatment for Patients with Cystic Fibrosis

May 18, 2015 11:15 am | by Lurie Children's Cystic Fibrosis Center | News | Comments

Treatment with two medications that target the most common genetic cause of cystic fibrosis improves lung function and lowers the rate of pulmonary exacerbations, according to the results from a Phase 3 international clinical trial published online in the New England Journal of Medicine. Read more...

Astellas Announces New Data from Phase 3 Study for OAB Drug

May 18, 2015 8:53 am | News | Comments

The results of the trial showed that the add-on group achieved its primary efficacy endpoints. Read more...

Specialty Drugs Spotlight: The Week’s Top Pharma News

May 15, 2015 2:25 pm | by Stephanie Guzowski, Editor | News | Comments

From pharma collaborations on therapies to fallouts over failed clinical trials, here are your headlines this week. Read more...

Trial Explores Rivaroxaban in Catheter Ablation

May 15, 2015 1:01 pm | News | Comments

Janssen Pharmaceuticals, Inc. and its development partner, Bayer HealthCare, today announced results from the VENTURE-AF trial. The study explored the potential of once-daily Xarelto (rivaroxaban) as an alternative to vitamin K antagonists (VKA), used to reduce the risk of blood clots, in people with non-valvular atrial fibrillation (NVAF) undergoing catheter ablation. Read more...

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