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Daily news and top headlines for drug research professionals

Breast Cancer Vaccine Shows Promise in Small Clinical Trial

December 1, 2014 1:02 pm | by Julia Evangelou Strait, Washington University | News | Comments

A breast cancer vaccine developed at Washington University School of Medicine in St. Louis is safe in patients with metastatic breast cancer, results of an early clinical trial indicate. Preliminary evidence also suggests that the vaccine primed the patients’ immune systems to attack tumor cells and helped slow the cancer’s progression. The study appears in Clinical Cancer Research. Read more...

Imaging Shows Brain Connection Breakdown in Early Alzheimer’s

December 1, 2014 12:45 pm | News | Comments

Changes in brain connections visible on MRI could represent an imaging biomarker of Alzheimer's disease, according to a new study presented at the annual meeting of the Radiological Society of North America (RSNA). Read more...

Abivax Completes First-In-Man Study of HIV Treatment

December 1, 2014 10:55 am | News | Comments

Abivax, a leading clinical stage biotech company developing and commercialising anti-viral compounds and human vaccines, announced the successful completion of its Phase 1 first-in-man study of ABX464, which has been designed to potentially deliver a number of important clinical benefits when treating patients with HIV. Read more...

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Eli Lilly, AstraZeneca Launch Patient Trial for Alzheimer's Treatment

December 1, 2014 9:17 am | News | Comments

Eli Lilly and Company and AstraZeneca announced enrollment of the first patient into Amaranth, a Phase 2/3 study of an oral beta secretase cleaving enzyme (BACE) inhibitor currently in development as a potential treatment for Alzheimer's disease. Read more...

Cloning Pioneer Proposes Global Network of IPS Cell Banks

November 28, 2014 9:55 am | by Cynthia Fox, Science Editor | Articles | Comments

Ian Wilmut, father of the cloned Dolly the Sheep, is now proposing to father a global induced pluripotent stem (iPS) cell handbook— to go with a proposed new global network of iPS cell haplobanks. Read more...                                   

Study Proves Dificlir Is Effective for CDI Treatment

November 26, 2014 10:16 am | News | Comments

New analysis from a unique real-world study demonstrates that first-line use of fidaxomicin, is clinically effective in reducing recurrence rates and lowering mortality. Read more...              

C3BS Nominates Investigators for Clinical Trial of Heart Failure Treatment

November 26, 2014 9:56 am | News | Comments

Cardio3 BioSciences announces the appointment of its three Co-Principal Investigators for the study of its heart failure treatment. Read more...                   

Amgen, AstraZeneca Announce Positive Study Results for Plaque Psoriasis Drug

November 26, 2014 9:13 am | News | Comments

Amgen and AstraZeneca announced positive phase 3 study results for plaque psoriasis drug. Read more...                           

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Powdered Measles Vaccine Found Safe in Early Clinical Trials

November 25, 2014 12:51 pm | News | Comments

A measles vaccine made of fine dry powder and delivered with a puff of air triggered no adverse side effects in early human testing and it is likely effective. Read more...                             

$1B Alliance Between Menarini, Oxford BioTherapeutics for Enhanced AML Treatment

November 25, 2014 10:04 am | News | Comments

This is the first of five development programs between the two companies to enter the clinic in a $1 billion strategic oncology alliance. Read more...                   

Improving The Odds of Beating Opioids

November 24, 2014 1:16 pm | by Sue McGreevy, Harvard University | News | Comments

Research indicates that live-in programs may result in higher levels of abstinence than the outpatient treatment that is currently the standard of care. Read more...                

Children's Relentless Seizures Halted By New Drug

November 24, 2014 12:22 pm | by Marla Paul, Northwestern University | News | Comments

An investigational medication has been found to effectively treat children with life-threatening and difficult-to-control epileptic seizures without side effects. Read more...              

Neurotrope: Last Patient Dosed in Phase 2a Alzheimer's Study

November 21, 2014 11:41 am | News | Comments

Neurotrope, Inc. announced that the last patient has been dosed in its Phase 2a clinical trial of Bryostatin-1 for the treatment of patients with Alzheimer's disease (AD). The trial is being conducted under an Investigational New Drug (IND) application filed by the Company's licensor, the Blanchette Rockefeller Neuroscience Institute (BRNI). Read more...

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HHS, NIH To Enhance Transparency of Clinical Trial Results

November 19, 2014 1:43 pm | News | Comments

The U.S. Department of Health and Human Services today issued a Notice of Proposed Rulemaking (NPRM), which proposes regulations to implement reporting requirements for clinical trials that are subject to Title VIII of the Food and Drug Administration Amendments Act of 2007 (FDAAA). Read more...

Maximizing the Power of Preclinical Cancer Research Tools

November 19, 2014 11:29 am | by Guizhong Liu, Senior Director of Cancer Biology, Crown Bioscience Inc. | Articles | Comments

Drug discovery is a protracted and uncertain process that needs to overcome many hurdles during preclinical and clinical development before it finally achieves regulatory approval for patient treatment. For every drug that reaches the marketplace, well over 100 have been abandoned at some point in their development. Read more...

Anti-Leukemia Drug May Also Work Against Ovarian Cancer

November 18, 2014 1:50 pm | News | Comments

An antibody therapy already in clinical trials to treat chronic lymphocytic leukemia (CLL) may also prove effective against ovarian cancer – and likely other cancers as well, report researchers at the University of California, San Diego School of Medicine in a study. Read more...

Preferred Drug Regimen for Preventing Mother-to-Child HIV Transmission

November 18, 2014 10:14 am | News | Comments

For HIV-infected women in good immune health, taking a three-drug regimen during pregnancy prevents mother-to-child HIV transmission more effectively than taking one drug during pregnancy, another during labor and two more after giving birth, an international clinical trial has found. Read more...

Roche Announces FDA Approval of Ovarian Cancer Treatment

November 17, 2014 1:30 pm | News | Comments

The FDA approves Roche's ovarian cancer treatment. Read more...                                 

Eisai's Antiepileptic Treatment Receives Russian Approval

November 17, 2014 10:34 am | News | Comments

Eisai Pharmaceuticals announces Russian approval of antiepileptic treatment. Read more...                             

Oxford to Lead Trial of Experimental Drug for Ebola

November 14, 2014 10:07 am | News | Comments

A clinical trial is to be carried out in West Africa to see whether a novel antiviral drug is effective against Ebola. Read more...                       

'Smart' Drugs Won't Make Smart People Smarter

November 13, 2014 12:46 pm | News | Comments

It is claimed one in five students have taken the 'smart' drug Modafinil to boost their ability to study and improve their chances of exam success. But new research into the effects of Modafinil has shown that healthy students could find their performance impaired by the drug. Read more...

Improved Survival in Women with HER2 Negative Breast Cancer

November 13, 2014 9:22 am | News | Comments

The results from a pooled analysis of two Phase 3 Halaven (eribulin) trials are published in Breast Cancer Research and Treatment. Findings from the pooled analysis show that eribulin improves overall survival in women compared to control. Read more...

Fighting HIV with Stem Cells and Cutting-edge Genetics

November 11, 2014 10:51 am | by Cynthia Fox, Science Editor | Articles | Comments

“Berlin Patient” Timothy Brown was cured of HIV after he received stem cells from a patient naturally immune to the disease. His story inspired two companies to try and recreate that natural immunity in HIV patients using stem cells and two (then-new) gene-editing techniques. Read more...

Gilead's Hep C Drug Gets Positive Results

November 11, 2014 10:09 am | News | Comments

Gilead Sciences Inc. announced results from several Phase 2 and Phase 3 studies evaluating investigational uses of Harvoni (ledipasvir 90 mg/sofosbuvir 400 mg) for the treatment of chronic hepatitis C virus (HCV) infection in patients with limited or no treatment options. Read more...

BMS Announces High Cure Rates for Hepatitis C Drug

November 10, 2014 10:42 am | News | Comments

Bristol-Myers Squibb announced late-breaking data regarding a new drug combination for Hepatitis C patients. Read more...                       

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