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The Lead

Washington University Launches Immunology Center

April 18, 2014 12:54 pm | by Michael Purdy | News | Comments

A new center at Washington University School of Medicine in St. Louis - The Center for Human Immunology and Immunotherapy Programs (CHiiPs)  -  will help scientists use the power of the immune system to fight infections and cancers. Read more...

New Pain Relief Targets Could Benefit Cancer Patients

April 18, 2014 12:36 pm | News | Comments

When researching how pain occurs in nerves in the periphery...

Ivabradine Fast Tracked for Chronic HF

April 18, 2014 12:13 pm | News | Comments

The U.S. Food and Drug Administration (FDA) has granted fast track designation for...

FDA Approves Arzerra for Chronic Lymphocytic Leukemia

April 18, 2014 12:03 pm | News | Comments

GlaxoSmithKline and Genmab announced that the FDA has approved a supplemental BLA for the use of...

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Anti-Seizure Drug Could Reduce Alcohol Consumption

April 18, 2014 10:34 am | News | Comments

Researchers have discovered that the anti-seizure drug ezogabine, reduced alcohol consumption in an experimental model. The findings may lead to more effective treatments for alcoholism. Read more...               

Multi-Target TB Drug May Treat Other Diseases, Evade Resistance

April 18, 2014 9:53 am | News | Comments

A drug under clinical trials to treat tuberculosis could be the basis for a class of broad-spectrum drugs that act against various bacteria, fungal infections and parasites, yet evade resistance, according to a new study. Read more...     

NIH Awards Scripps $2M to Design a Better Diabetes Drug Model

April 17, 2014 1:21 pm | News | Comments

Scientists from the Florida campus of TSRI have been awarded $2.1 million from the NIH to study the therapeutic potential of safer and more effective alternatives to the current crop of anti-diabetic drugs, which have been limited in their use due to side effects including bone loss and CHF. Read more...

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Finding Suggests New Possibilities for Oncology and Virology

April 17, 2014 1:06 pm | News | Comments

Scientists at Washington University School of Medicine in St. Louis have uncovered a new way the immune system may fight cancers and viral infections, which could aid efforts to use immune cells to treat illness. Read more...     

VentiRx Completes Enrollment in Study of Orphan Cancer Drug

April 17, 2014 11:47 am | News | Comments

VentiRx Pharmaceuticals Inc. announced that enrollment has been completed in a Phase 2 trial of VTX-2337 in combination with pegylated liposomal doxorubicin in patients with recurrent or persistent epithelial ovarian, fallopian tube or primary peritoneal cancer who have failed prior platinum-based chemotherapy. Read more...

A Cinderella Story: Stem Cells in Personalized Medicine

April 17, 2014 11:00 am | Videos | Comments

In part four of our video series, Andrew Wiecek is back to discuss the role that induced pluripotent stem (iPS) cells play in personalized medicine. How do they help? Well, iPS cells are kind of like Cinderella's glass slipper. Watch more...

'Matrix' Trial Will Advance Personalized Medicine for Lung Cancers

April 17, 2014 10:52 am | Videos | Comments

The "National Lung Matrix" trial, a partnership between Cancer Research UK, AstraZeneca and Pfizer, will give researchers unprecedented access to libraries of drugs developed by the companies, allowing several to be tested at the same time, within one trial. Read more...

Cancer Drugs Block Dementia-Linked Brain Inflammation

April 17, 2014 10:40 am | News | Comments

A class of drugs developed to treat immune-related conditions and cancer– including one currently in clinical trials- eliminates neural inflammation associated with dementia-linked diseases and brain injuries, according to researchers. Read more...

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Vaccine Offers Survival Hope for Melanoma Patients

April 17, 2014 10:29 am | News | Comments

Researchers have discovered that a new trial vaccine offers the most promising treatment to date for melanoma that has spread, with increased patient survival rates and improved ability to stop or reverse the cancer. Read more...      

HPV Vaccine Works in HIV+ Women

April 16, 2014 2:00 pm | News | Comments

HIV-positive women respond well to a vaccine against the human papillomavirus (HPV), even when their immune system is struggling, according to newly published results of an international clinical trial, countering doubts about whether the vaccine would be helpful. Read more...

Phase 1 Results Positive for Tumor Vaccine

April 16, 2014 2:00 pm | News | Comments

Celldex Therapeutics Inc. announced that final data from its Phase 1 study of CDX-1401 (an off-the-shelf vaccine that targets dendritic cells) in solid tumors, including long-term patient follow-up, have been published in Science Translational Medicine. Read more...

Measles Drug Lowers Viral Load

April 16, 2014 2:00 pm | News | Comments

A novel antiviral drug may protect people infected with the measles from getting sick and prevent them from spreading the virus to others, an international team of researchers said. Read more...                  

Small Molecule Shows Potential in Advanced Cancers

April 16, 2014 1:34 pm | News | Comments

Cleveland BioLabs Inc. announced the achievement of all objectives in a Phase 1 clinical trial of CBL0102, or quinacrine, an orally administered small molecule in patients with advanced cancers for which no standard care exists or which had become resistant to conventional therapies. Read more...

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Baxter's Orphan Drug Candidate Hits Key Phase 3 Endpoint

April 16, 2014 1:06 pm | News | Comments

Baxter International Inc. announced topline results from a Phase 3 clinical trial evaluating the safety, efficacy and pharmacokinetics of BAX 111, a recombinant von Willebrand factor under investigation for the treatment of bleeding episodes in patients with von Willebrand disease. Read more...

Researchers ID New Formulation for Cancer Treatment

April 16, 2014 11:20 am | News | Comments

Researchers have discovered a new way to deliver a tricky drug, dichloroacetate, that may one day make it a viable treatment for numerous forms of cancer. Read more...                       

3-D Printed Tissues May Aid Drug Delivery, Wound Healing

April 16, 2014 11:13 am | News | Comments

A University of Oxford spin-out, OxSyBio, will develop 3-D printing techniques to produce tissue-like synthetic materials for wound healing and drug delivery. Read more...                       

SSRI Use During Pregnancy Linked to Autism, Developmental Delays

April 16, 2014 10:57 am | News | Comments

In a study of nearly 1,000 mother-child pairs, researchers found that prenatal exposure to selective serotonin reuptake inhibitors (SSRIs) was associated with autism spectrum disorder (ASD) and developmental delays (DD) in boys. Read more...   

Protein Partnership Inflames Immune Cells in Cancer

April 15, 2014 12:53 pm | News | Comments

Scientists have identified two unlikely partners in a type of immune cell called a macrophage that work together in response to cancer drugs to increase inflammation in a way that may alter tumor growth. Read more...         

CBR Starts Cerebral Palsy Stem Cell Study

April 15, 2014 12:45 pm | News | Comments

Cord Blood Registry (CBR) announced the launch of an FDA-regulated clinical trial being conducted at The University of Texas Health Science Center at Houston to investigate two forms of stem cell therapy in children diagnosed with cerebral palsy. Read more...

AbbVie’s Lung Cancer Drug Advances to Phase 3

April 15, 2014 12:20 pm | News | Comments

AbbVie announced the initiation of a global Phase 3 clinical trial evaluating the safety and efficacy of its investigational compound, veliparib, in patients with previously untreated locally advanced or metastatic squamous non-small cell lung cancer. Read more...

Nanoparticles Target Cancer with Triple Threat

April 15, 2014 12:10 pm | News | Comments

Delivering chemotherapy drugs in nanoparticle form could help reduce side effects by targeting the drugs directly to the tumors, but it has been difficult to design particles that can carry any more than one or two drugs. Read more... 

Regenerating Muscle in Duchenne Muscular Dystrophy

April 15, 2014 11:04 am | News | Comments

A team of scientists has published details of how a class of drugs called “HDACis” drive muscle-cell regeneration in the early stages of dystrophic muscles, but fail to work in late stages. Read more...              

Potential New Way to Fight Malaria Drug Resistance

April 15, 2014 10:56 am | News | Comments

An anti-malarial treatment that lost its status as the leading weapon against the deadly disease could be given a new lease of life, with new research indicating it simply needs to be administered differently. Read more...        

FDA OKs Trials for Vivolux First-in-Class Cancer Drug

April 15, 2014 10:32 am | News | Comments

Vivolux AB announced that the FDA has granted clearance to proceed with VLX600 into clinical Phase 1/2 trials. The drug candidate kills sleeping cell populations in regions of solid tumors that are metabolically compromised due to poor vascularization. Read more...

Lexicon’s Type 1 Diabetes Trial Gets Positive Results

April 14, 2014 1:53 pm | News | Comments

Lexicon Pharmaceuticals Inc. announced positive, top-line results in a Phase 2 clinical trial of LX4211 in type 1 diabetes, which achieved the primary endpoint of reducing mealtime insulin use as well as several secondary endpoints, including improved glycemic control. Read more...

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