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The Lead

FDA Approves New, Hard-to-Abuse Hydrocodone Pill

November 21, 2014 11:27 am | by Matthew Perrone, AP Health Writer - Associated Press | News | Comments

Federal health regulators on Thursday approved the first hard-to-abuse version of the painkiller hydrocodone, offering an alternative to a similar medication that has been widely criticized for lacking such safeguards. Read more...

Powerful Method to Speed Cancer Drug Discovery

November 21, 2014 11:22 am | by Salk Institute | News | Comments

For decades,...

HIV/AIDS Drugs Could Be Repurposed to Treat AMD

November 21, 2014 11:01 am | by Ann Blackford, University of Kentucky | News | Comments

A study published...

UK Investment to Develop Lung Cancer Drugs

November 21, 2014 9:58 am | News | Comments

A new collaboration in the UK will develop a promising class of cancer inhibitors. Read more......

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Virus Discovery Could Impact HIV Drug Research

November 20, 2014 12:23 pm | News | Comments

A research team has unlocked the structure of an unusual virus that lives in volcanic hot springs. Read more...                         

Promising One-Two Punch for Lung Cancer

November 20, 2014 10:19 am | News | Comments

Scientists at the Salk Institute have discovered a powerful one-two punch for countering a common genetic mutation that often leads to drug-resistant cancers. The dual-drug therapy–with analogs already in use for other diseases–doubled the survival rate of mice with lung cancer and halted cancer in pancreatic cells. Read more...

Regeneron, Sanofi: New Positive Results for Cholesterol-Lowering Drug

November 20, 2014 9:06 am | News | Comments

Regeneron Pharmaceuticals, Inc. and Sanofi announced new detailed positive results from six Phase 3 ODYSSEY trials that showed alirocumab significantly reduced low-density lipoprotein cholesterol (LDL-C, or "bad" cholesterol). Read more...

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Light-Responding Blood Vessel Receptor May Be New Target

November 19, 2014 12:46 pm | by Johns Hopkins | News | Comments

A team of researchers from Johns Hopkins Medicine has discovered a receptor on blood vessels that causes the vessel to relax in response to light, making it potentially useful in treating vascular diseases. In addition, researchers discovered a previously unknown mechanism by which blood vessel function is regulated through light of a specific wavelength. Read more...

Anti-Leukemia Drug May Also Work Against Ovarian Cancer

November 18, 2014 1:50 pm | News | Comments

An antibody therapy already in clinical trials to treat chronic lymphocytic leukemia (CLL) may also prove effective against ovarian cancer – and likely other cancers as well, report researchers at the University of California, San Diego School of Medicine in a study. Read more...

‘Big Data’ Approach to Help Pinpoint New Stent Drug

November 18, 2014 1:40 pm | by Tracie White, Stanford University | News | Comments

Replacing the current drug used to coat artery-opening stents with a drug more targeted to the actual cause of stent disease could reduce blood clots and heart attacks, researchers say. Read more...

Novartis' Drug Could Change Course of Heart Failure for Patients

November 18, 2014 9:57 am | News | Comments

New data on Novartis' investigational medicine, LCZ696, for patients with heart failure with reduced ejection fraction (HFrEF) shows it has the potential to change the course of the disease for patients. Read more...

Study Lifts Cloud Over Heart Drugs

November 17, 2014 12:25 pm | by Marilynn Marchione - AP Chief Medical Writer | News | Comments

A major study lifts a cloud around blockbuster drugs for lowering cholesterol. Read more...                             

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Beta Blockers Could Benefit Patients With HFPEF

November 17, 2014 9:29 am | News | Comments

A new study suggests that beta blockers may benefit patients suffering from a relatively unknown form of heart failure. Read more...                      

Method Could Prevent, Cure Rotavirus Infection

November 14, 2014 12:36 pm | by Georgia State University | News | Comments

Activation of the innate immune system with the bacterial protein flagellin could prevent and cure rotavirus infection, which is among the most common causes of severe diarrhea, says a Georgia State University research team that described the method as a novel means to prevent and treat viral infection. Read more...

Injectable Antidote for Carbon Monoxide Poisoning

November 13, 2014 1:10 pm | News | Comments

When Joseph Roderique was a first-year student in the Virginia Commonwealth University School of Medicine, he had an idea for an injectable antidote for carbon monoxide poisoning. It was a big idea, one that could have dramatic and wide-ranging results if he could make it work. Read more...

When Tobacco Saved Lives

November 13, 2014 10:21 am | by Skip Derra | Articles | Comments

Will ZMapp’s Ebola success force big pharma to take plant-based drugs seriously? Read more...                                                      

Abivax to Commercialize Vaccines in Asia, Latin America

November 13, 2014 10:05 am | News | Comments

Abivax, a leading European, clinical stage biopharmaceutical company developing and commercializing anti-viral compounds and human vaccines, announced that it has signed an agreement with The Finlay Institute, Havana, Cuba, that will allow it to commercialize vaccines against typhoid, meningococcus, and leptospirosis, in Asian and Latin American markets. Read more...

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Gene Study Boosts Interest in Heart Drug Zetia

November 13, 2014 9:50 am | by Marilynn Marchione, AP Chief Medical Writer - Associated Press | News | Comments

Scientists have discovered gene mutations that give people naturally lower cholesterol levels and cut their risk of heart disease in half. That discovery may have a big implication. Read more...

Next-Gen Melanoma Drug Excels in Lab Tests

November 12, 2014 2:16 pm | by Garth Sundem, University of Colorado | News | Comments

A University of Colorado Cancer Center study published online in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.  Read more...

Altered Milk Protein Can Deliver AIDS Drug to Infants

November 12, 2014 1:57 pm | by Jeff Mulhollem, Penn State | News | Comments

A novel method of altering a protein in milk to bind with an antiretroviral drug promises to greatly improve treatment for infants and young children suffering from HIV/AIDS, according to a researcher in Penn State's College of Agricultural Sciences. Read more...

Targets, Tests May Develop Treatments for Memory Disorders

November 12, 2014 1:38 pm | by Scripps Research Institute | News | Comments

In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a number of new therapeutic targets for memory disorders and have developed a new screening test to uncover compounds that may one day work against those disorders. Read more...

Discovery Opens Up Possibility of Slowing Cancer Spread

November 12, 2014 8:59 am | News | Comments

Researchers found a potential candidate that can inhibit the spread of cancer cells throughout the body. Read more...                        

Study Identifying Tumor Cell Origin May Help Develop Therapies

November 11, 2014 1:12 pm | News | Comments

UT Southwestern Medical Center researchers have determined the specific type of cell that gives rise to large, disfiguring tumors called plexiform neurofibromas, a finding that could lead to new therapies for preventing growth of these tumors. Read more...

Large-scale Study Raises Hopes for Development of E. Coli Vaccine

November 11, 2014 12:55 pm | News | Comments

The largest ever study of the bacterium enterotoxigenic Escherichia coli (ETEC) has raised hopes that a global vaccine can be developed.  Read more...                                   

Catalyst Advance Has Possibilities for Drug Development

November 11, 2014 12:23 pm | News | Comments

Chemists at The Scripps Research Institute (TSRI) and the Shanghai Institute of Organic Chemistry have described a method for creating and modifying organic compounds that overcomes a major limitation of previous methods. Read more...

Fighting HIV with Stem Cells and Cutting-edge Genetics

November 11, 2014 10:51 am | by Cynthia Fox, Science Editor | Articles | Comments

“Berlin Patient” Timothy Brown was cured of HIV after he received stem cells from a patient naturally immune to the disease. His story inspired two companies to try and recreate that natural immunity in HIV patients using stem cells and two (then-new) gene-editing techniques. Read more...

OSU Professor Helps Develop Promising Ebola Drug

November 11, 2014 10:39 am | News | Comments

As the Ebola crisis in Africa continues and concern ramps up in the United States, a pharmaceutical company with a Corvallis connection is ready to respond with a limited amount of a potentially promising new drug. Read more...

New Breakthrough Could Halt The Spread of Prostate Cancer

November 10, 2014 9:10 am | News | Comments

Scientists believe a new treatment could halt the growth of tumors in patients with prostate cancer. Read more...                         

Newly Developed Vaccines Could Reveal Asthma Clues

November 7, 2014 1:08 pm | by Rob Forman - Rutgers Universtiy | News | Comments

A new method of developing vaccines could point the way forward in the fight against infectious diseases for which traditional vaccination has failed, according to a Rutgers study.  Read more...

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