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The Lead

Study Finds Best Way to Treat Neck Pain

October 24, 2014 10:03 am | News | Comments

A multicenter study of 169 men and women with a common form of neck pain suggests that both spinal steroid injections and conservative treatment with physical therapy and painkillers work equally well to relieve pain in the short term. Read more...  

New Study Finds Potential Targets for Personalized Cancer Vaccines

October 23, 2014 10:01 am | News | Comments

A team of University of Notre Dame scientists, in collaboration with researchers at the...

Microscopic “Walkers” Find Way Across Cell Surfaces

October 23, 2014 9:47 am | News | Comments

Technology could provide a way to deliver probes...

DNA-based ‘Nano-Cocoons’ Attack, Kill Cancer Cells

October 15, 2014 12:55 pm | News | Comments

Biomedical engineering researchers have developed...

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Researchers Begin Study of Ebola Vaccine in Africa

October 10, 2014 2:06 pm | News | Comments

The first study of a possible Ebola vaccine is underway in Africa: University of Maryland researchers say three health care workers in Mali received the experimental shots. Read more...

New COPD Inhalation Spray Now Available in U.S. Pharmacies

October 8, 2014 12:58 pm | News | Comments

Boehringer Ingelheim announced that Striverdi Respimat (olodaterol) Inhalation Spray 5 mcg is now available by prescription in pharmacies across the United States. Read more...                               

AbbVie's Humira Receives FDA Approval for JIA

October 6, 2014 3:04 pm | News | Comments

AbbVie announced that the FDA has approved the extension of the Humira indication for moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) to reducing signs and symptoms in patients ages 2 and older. Read more...

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‘Programmable’ Antibiotic Harnesses Enzyme to Attack Drug-Resistant Microbes

October 6, 2014 10:12 am | News | Comments

The multitude of microbes scientists have found populating the human body have good, bad and mostly mysterious implications for our health. But when something goes wrong, we defend ourselves with the undiscriminating brute force of traditional antibiotics, which wipe out everything at once, regardless of the consequences. Read more...

Sanofi Signs 15-Year Supply Agreement for Wearable Injectors with Unilife

October 6, 2014 9:47 am | News | Comments

Unilife Corporation, a developer and supplier of injectable drug delivery systems, announced the signing of a worldwide Master Services and Commercial Supply Agreement with Sanofi to be the sole provider of cartridge based wearable injectors for all of Sanofi's applicable large dose volume drugs, excluding insulins, for a minimum 15 years. Read more...

Drugmaker Submits Harder-to-Abuse Zohydro to FDA

October 2, 2014 9:33 am | by Matthew Perrone, AP Health Writer | News | Comments

The maker of the much-debated painkiller Zohydro is seeking approval of a harder-to-abuse version of the drug which, if approved, could replace the currently marketed version of the pill by next spring. Read more...          

New Drug-Delivery Capsule May Replace Injections

October 1, 2014 4:15 pm | News | Comments

Researchers have devised a novel drug capsule coated with tiny needles that can inject drugs directly into the lining of the stomach after the capsule is swallowed. Read more...                      

Engineers Devise Technology for Rapidly Testing Drug-Delivery Vehicles

September 30, 2014 2:43 pm | News | Comments

Engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA, and DNA, to human patients. Read more...

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Pharm Startup Creates Prefabricated Drug Dosages

September 26, 2014 2:15 pm | News | Comments

Officials of a pharmaceutical startup based on a Purdue University innovation say their company is creating prefabricated drug dosages that could be used by compounding pharmacists to support patient-centered medicine. Read more...

Chemists Recruit Anthrax to Deliver Cancer Drugs

September 25, 2014 1:58 pm | News | Comments

Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. A team of MIT researchers has now hijacked that delivery system for a different purpose: administering cancer drugs. Read more...

New Chip Promising for Tumor-Targeting Research

September 22, 2014 3:59 pm | News | Comments

Researchers have developed a chip capable of simulating a tumor's "microenvironment" and plan to use the new system to test the effectiveness of nanoparticles and drugs that target cancer. Read more...              

New Approach to Arthritis Drug Delivery Could Help Avoid Side Effects

September 19, 2014 9:54 am | News | Comments

A new approach to arthritis treatment, which avoids unforeseen side effects by delivering drugs exclusively to affected inflamed joints, has been developed by researchers in London. Read more...                

Drug-Delivery Vehicle Could Limit Spread of HIV, AIDS

August 29, 2014 2:00 pm | News | Comments

A unique method for delivering compounds that could positively impact the global battle against HIV and AIDS may be possible, according to new research. Read more...                         

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Sanofi Launches Generic Eloxatin

August 12, 2014 11:31 am | News | Comments

Sanofi US announced that it has launched an authorized generic version of Eloxatin (oxaliplatin injection) through Winthrop US, the company's generics division. Sanofi's authorized generic version is the same formulation as the original drug, Eloxatin, for which the company holds the original patent. Read more...

TPM/Oxymorphone Patch Demonstrates Reproducibility

August 11, 2014 10:53 am | News | Comments

Australian drug delivery company, Phosphagenics Ltd. announced that the first of its additional studies designed to further characterize the TPM/Oxymorphone patch, in support of an Investigational New Drug (IND) application with the FDA has been completed. Read more...

Nanoscale Thin-Film Technique Promises Long-Term Drug Delivery

August 5, 2014 2:50 pm | by Peter Dizikes, MIT News Office | News | Comments

About one in four older adults suffers from chronic pain. Many of those people take medication, usually as pills. But this is not an ideal way of treating pain: Patients must take medicine frequently, and can suffer side effects, since the contents of pills spread through the bloodstream to the whole body. Read more...

IPF Drug Receives Orphan Drug Designation

August 5, 2014 2:38 pm | News | Comments

Genoa Pharmaceuticals, the leader in inhaled medicines for pulmonary fibrosis, announced the U.S. Food and Drug Administration has granted orphan-drug designation to Genoa for the use of pirfenidone in their lead program - inhaled GP-101 for the treatment of idiopathic pulmonary fibrosis (IPF). Read more...

Paclitaxel Reformulated for Bolus Intraperitoneal Injection

August 5, 2014 2:30 pm | News | Comments

A repurposed drug originally used to treat ovarian cancer saw positive results for patients with advanced peritoneal cancers during a phase 1 clinical trial at The University of Kansas Cancer Center, during which it was administered as a bolus injection directly into the peritoneum through a catheter. Read more...

Gold Nanoparticles Penetrate Cells, Show Promise for Drug Delivery

July 21, 2014 3:09 pm | Videos | Comments

A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells. Read more...                          

JDRF, ViaCyte File IND App for Diabetes Treatment Trial

July 18, 2014 3:30 pm | News | Comments

JDRF announced that ViaCyte Inc. has filed an Investigational New Drug application (IND) with the FDA seeking to initiate a Phase 1/2 clinical trial in patients with type 1 diabetes. Read more...                

Researchers Alleviate Pulmonary Inflammation Through Targeted Drug Delivery

July 15, 2014 2:43 pm | News | Comments

To date, no medication has been successful at preventing or mitigating the damage caused by pulmonary inflammation. Now, a research team has found that when delivered by a microscopic transporter called a nanocarrier, steroids can access the hard-to-reach lung endothelial cells that need it most and are successful at preventing inflammation in mice. Read more...

Novartis to Use Google Technology for 'Smart' Contacts

July 15, 2014 2:19 pm | News | Comments

Swiss drug developer Novartis will team with technology giant Google to develop a "smart" contact lens that could improve some eye conditions or help diabetics manage their disease. Read more...                 

Tiny DNA Pyramids Enter Bacteria, Deliver Deadly Payload

July 10, 2014 12:00 pm | News | Comments

Bacterial infections usually announce themselves with pain and fever but often can be defeated with antibiotics— and then there are those that are sneaky and hard to beat. Now, scientists have built a new weapon against such pathogens in the form of tiny DNA pyramids. Read more...

Sandoz Launches Generic Diovan in the U.S.

July 9, 2014 11:24 am | News | Comments

Sandoz announced the U.S. introduction of an authorized generic version of Diovan (valsartan) tablets for the treatment of high blood pressure (HBP) and will market the authorized generic version of Diovan in the same strengths marketed for the branded version of Diovan. Read more...

Nanoparticles Can Enhance Cisplatin in Chemotherapy

July 8, 2014 2:19 pm | News | Comments

Researchers have developed a new formulation of cisplatin, a common chemotherapy drug, that significantly increases the drug's ability to target and destroy cancerous cells. Read more...                   

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