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The Lead

Electronic Micropump Could Deliver Treatment to Specific Brain Region

April 17, 2015 10:13 am | by Stephanie Guzowski, Editor | News | Comments

There is an exactness that must be taken into account when treating neurological disorders. In treating epilepsy, for example, a condition in which nerve cell activity in the brain is disturbed, causing seizures, a drug needs to be delivered directly to a specific brain region—but without negatively affecting healthy brain regions. Read more...

Isarna Initiates First-in-Human Phase I Trial for Drug to Treat Advanced Glaucoma

April 17, 2015 8:11 am | News | Comments

The trial will enroll approximately 24 - 30 patients. Read more...

FDA Accepts Teva's NDA for Bendamustine

April 15, 2015 9:16 am | News | Comments

This NDA requests FDA approval of the rapid infusion bendamustine HCl product for the treatment...

New Liver Cancer Treatment Approved in Europe

April 15, 2015 8:24 am | by University Medical Center Utrecht | News | Comments

A new treatment for liver cancer developed by the University Medical Center Utrecht has received...

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Biologists Identify Brain Tumor Weakness

April 9, 2015 8:42 am | by Anne Trafton, MIT | News | Comments

Biologists have discovered a vulnerability of brain cancer cells that could be exploited to develop more-effective drugs against brain tumors. Read more...

Allergy Drug Inhibits Hepatitis C in Mice

April 9, 2015 8:41 am | by National Institute of Health | News | Comments

An over-the-counter drug indicated to treat allergy symptoms limited hepatitis C virus activity in infected mice. Read more...

Scientists Identify Receptor for Asthma Associated Virus

April 6, 2015 5:01 pm | by National Institute of Allergy and Infectious Disease | News | Comments

Scientists have identified a cellular receptor for rhinovirus C. Read more...

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Two Compounds Target the Gut to Lower Blood Sugar

April 6, 2015 4:32 pm | by Toronto General Hospital Research Institute | News | Comments

Researchers have discovered metformin and resveratrol trigger novel signaling pathways in the small intestine to lower blood sugar. Read more...

New Developments in Characterizing Protein-Small Molecule Interactions for Drug Discovery

April 6, 2015 4:26 pm | by Bill Sawka, MicroCal Product Manager, Malvern Instruments & Natalia Markova, Principal Scientist – MicroCal, Malvern Instruments | Articles | Comments

Isothermal titration calorimetry (ITC) is a highly valuable technique that is used throughout drug discovery workflow to study the binding interactions of proteins and small molecules. It is an essential tool for both drug design and the study and regulation of protein interactions. Read more...

Cane Toads Potentially Lucrative Export in Cancer Fight

March 26, 2015 4:12 pm | by University of Queensland | News | Comments

Scientists are exploring how cane toad venom can be used to fight cancer. Read more...

GSK Gains Japanese Approval for COPD Therapy

March 26, 2015 8:25 am | News | Comments

Following this approval, it is expected that launch will take place in Japan in 2015. Read more...

Study Announces Durable Ebola Vaccine

March 25, 2015 2:10 pm | by Andrew Gould, University of Plymouth | News | Comments

A new study shows the durability of a novel CMV-based Ebola virus vaccine strategy that may eventually have the potential to reduce ebola virus infection in wild African ape species. Read more...

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Takeda Licenses Rights to Use Immunogen's Technology to Develop Anticancer Therapies

March 25, 2015 8:44 am | News | Comments

Takeda will use the technology to develop and commercialize targeted anticancer therapeutics to up to two undisclosed  targets. Read more...

Blood Test Could Help Bowel Cancer Patients Avoid Drug Side-Effects

March 25, 2015 8:33 am | by University of Manchester | News | Comments

Researchers have provided early evidence to suggest that a blood test could be used to identify bowel cancer patients that may benefit from more intensive chemotherapy. Read more...

New Hopes for Rheumatic Fever Vaccine

March 23, 2015 8:26 am | by University of Auckland | News | Comments

A new vaccine to combat the debilitating disease caused by rheumatic fever may soon become a reality, saving hundreds of thousands of deaths from preventable heart disease around the world each year. Read more...

Liberians Overcome Fear to Volunteer for Ebola Vaccine Trial

March 23, 2015 8:24 am | by Jonathan Paye-Layleh, Associated Press | News | Comments

Liberians are overcoming their fears of Ebola to volunteer for a vaccine trial. Read more...

Hypertension Drugs Improve Corticosteroid-based Skin Treatments

March 19, 2015 9:24 am | by Inserm | News | Comments

Corticosteroid-based dermatological creams are indicated for the symptomatic treatment of inflammatory skin conditions. Read more...

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GSK Announces Start of Phase 3 Program for Retosiban Evaluation

March 17, 2015 8:46 am | News | Comments

Retosiban is an investigational oxytocin antagonist. Read more...

Immunotherapy: New Hope for Patients with Advanced Lung Cancer

March 13, 2015 11:52 am | by Columbia University | News | Comments

In the late 1800s, a New York surgeon named William Coley noticed that some patients with cancer seemed to fare better if they developed an infection after undergoing surgery. Suspecting that the immune system played a role in this mysterious response, he tried treating cancer patients with bacteria in an effort to turn on the immune system. Read more...

Cholera Vaccine Succeeds in Rural Haiti

March 13, 2015 9:14 am | by Jake Miller, Harvard Medical School | News | Comments

A vaccination campaign that almost didn’t happen was widely effective in reducing transmission of cholera in the midst of an ongoing outbreak of the disease in rural Haiti. Read more...

Alzheimer's Breakthrough Uses Ultrasound Technology

March 12, 2015 9:28 am | by University of Queensland | News | Comments

Scientists have found that non-invasive ultrasound technology can be used to treat Alzheimer’s disease and restore memory. Read more...                                                                                                                     

New Approach to HIV Management in Africa Reduces Deaths by a Third

March 11, 2015 9:08 am | by London School of Hygiene & Tropical Medicine | News | Comments

The research suggests that a simple low-cost intervention could be an effective approach to reducing HIV-related deaths in Africa. Read more...                   

Innovative Light Therapy Reaches Tumors

March 9, 2015 4:53 pm | by Julia Evangelou Strait, Washington University in St. Louis | News | Comments

Light long has been used to treat cancer. Read more...                                  

Roche Launches Next-Generation HBV Viral Load Assay in Select Markets

March 3, 2015 9:09 am | News | Comments

The new assay offers broad coverage of all known Hepatitis B (HBV) genotypes (A-H) with high sensitivity, across all critical medical decision points. Read more...                

New Nanodevice Defeats Drug Resistance

March 3, 2015 8:46 am | by Anne Trafton, MIT | News | Comments

Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. Read more...                     

Takeda's Treatment for Acid-Related Diseases is Now Available in Japan

February 27, 2015 9:10 am | News | Comments

This medicine treats acid-related diseases with a novel mechanism of action called potassium-competitive acid blockers. Read more...                    

Synthetic Biology Breakthrough Leads to Cheaper Statin Production

February 27, 2015 8:33 am | by University of Manchester | News | Comments

Researchers have devised a single-step fermentative method for the industrial production of the active drug pravastatin. Read more...                     

Scientists Develop Method to Suppress Malaria Parasite's Virulence Genes

February 26, 2015 8:41 am | by Hebrew University | News | Comments

Researchers have revealed the genetic trickery this deadly parasite deploys to escape attack by the human immune system. Read more...                     

Warning on Use of Drug for Children's Sleep

February 25, 2015 4:39 pm | by University of Adelaide | News | Comments

Researchers are warning doctors and parents not to provide the drug melatonin to children to help control their sleep problems. Read more...                    

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