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Daily news and top headlines for drug research professionals

Complex Incentives Drive Macular Degeneration Prescription Decisions

February 2, 2015 10:06 pm | by Stanford University | News | Comments

Two drugs that treat macular degeneration are practically interchangeable - except for the price. Ranibizumab costs up to $2,000 per dose, while bevacizumab is $50 per dose. Researchers at the Stanford University School of Medicine suspected that doctors treating Medicare patients would have a financial incentive to prescribe a more costly drug. Read more...

New Mechanism of Resistance to Breast Cancer Drugs: Discovery

February 2, 2015 10:00 pm | by Dartmouth Univ. | News | Comments

In the search for new approaches to treat ERBB2 (also known as HER2) positive breast cancers that have become drug-resistant, Dartmouth's Norris Cotton Cancer Center investigator Manabu Kurokawa, PhD, led a team in discovery of a novel cancer resistance mechanism with findings published in Cell Cycle. Read more...

How Immune Cells Hone Skills to Fight Disease

February 2, 2015 11:41 am | by Scripps Institute | News | Comments

Now, a new study from scientists at The Scripps Research Institute (TSRI) helps explain how booster shots prompt immune "memory" to improve, an important step toward the development of more effective, longer-lasting vaccines. The findings were published online ahead of print on in the journal Nature Immunology. Read more...

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New Blood for TB Treatment

February 2, 2015 11:29 am | by Sue McGreevy, Harvard | News | Comments

The same antiangiogenesis drugs that have improved treatment of some cancers could also help surmount persistent difficulties in treating tuberculosis.  Read more...                  

Metformin May Lower Lung Cancer Risk in Diabetic Nonsmokers

February 2, 2015 11:14 am | by AACR | News | Comments

Among nonsmokers who had diabetes, those who took the diabetes drug metformin had a decrease in lung cancer risk, according to a study in Cancer Prevention Research, a journal of the American Association for Cancer Research, by Lori Sakoda, PhD, MPH, research scientist at the Kaiser Permanente Division of Research in Oakland, California. Read more...

How Cells Use Signaling Mechanisms to Control Interferon Production

February 2, 2015 10:59 am | by The Howard Hughes Medical Center | News | Comments

The immune system has a delicate balance to maintain. When certain infected cells detect an invader, they use a molecule called interferon to rally the body's defenses. The immune system responds to this rallying cry by immediately boosting its general antiviral defenses and simultaneously initiating a more specialized secondary response. Read more...

Master Switch May Halt Tumor Growth by Inducing Dormancy

February 2, 2015 10:53 am | by The Mount Sinai Hospital | News | Comments

Two existing cancer drugs turn on a gene that tells tumor cells to remain inactive, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published in Nature Communications. Read more...           

GOP's Christie: Parents Should Have Choice in Vaccinations

February 2, 2015 10:31 am | by Jill Colvin, Associated Press | News | Comments

New Jersey Gov. Chris Christie, a likely Republican candidate for president, said Monday that parents should have some choice on whether to vaccinate their children. Read more..                

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White House: Science Indicates Parents Should Vaccinate Kids

January 30, 2015 4:29 pm | by Nedra Pickler - Associated Press | News | Comments

Amid the measles outbreak stemming from California, the White House is telling parents that science indicates they should vaccinate their children. Read more...                 

FDA Approves Janssen's B-Cell Lymphoma Treatment

January 30, 2015 11:11 am | News | Comments

This is the first therapy indicated specifically for patients with Waldenström’s macroglobulinemia. Read more...                         

Obama Proposes 'Precision Medicine' to End One-Size-Fits-All

January 30, 2015 10:48 am | by Lauran Neergard - AP Medical Writer | News | Comments

President Barack Obama is calling for an investment to move away from one-size-fits-all-medicine, toward an approach that tailors treatment to your genes. Read more...                

Study Shows Tamiflu Gets Patients Back on Their Feet Faster

January 30, 2015 10:30 am | by University of Michigan | News | Comments

New evidence about a popular antiviral—often criticized as ineffective—shows that it can alleviate symptoms and prevent respiratory complications. Read more...                 

Study Reveals More Dangers of Smoking While Pregnant

January 30, 2015 9:37 am | by University of Aberdeen | News | Comments

Smoking while pregnant causes chemical changes to the DNA of a foetus detectable from as early as 12 weeks and may predispose children born to smokers to a range of health conditions which last throughout life. Read more...      

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Astellas, Immunomic Therapeutics Announce Licensing Agreement for Allergy Vaccine

January 30, 2015 9:32 am | News | Comments

The vaccine is designed to treat allergies induced by Japanese red cedar pollen. Read more...                            

Hot on the Trail of the Hepatitis-Liver Cancer Connection

January 30, 2015 9:26 am | by Riken Institute | News | Comments

Scientists have for the first time demonstrated the profound effect that chronic hepatitis infection and inflammation can have on the genetic mutations found in tumors of the liver. Read more...           

Hydrogen Sulfide Could Help Lower Blood Pressure

January 30, 2015 9:19 am | by University of Exeter | News | Comments

Research has indicated that a new compound, called AP39, could be beneficial in cases of high blood pressure and diseases of the blood vessels that occur with ageing and diabetes. Read more...            

Dopamine Neurons Study Could Improve Mobility, Neurological Disorder Research

January 30, 2015 9:13 am | by University of Leicester | News | Comments

University team find for the first time when and why dopamine releasing cells in the forebrain are activated. Read more...                       

Needle Biopsies May Be Safe in Pancreatic Cancer

January 29, 2015 4:06 pm | by Cynthia Fox, Science Editor | Articles | Comments

Oncologists and patients who fear tumor needle biopsies—thinking they may cause tumor bits to break off and “seed” cancer elsewhere—may rest easier after reassuring Mayo Clinic news. Read more...                   

New Biological Evidence Reveals Link Between Brain Inflammation, Depression

January 29, 2015 10:46 am | by Centre for Addiction and Mental Health | News | Comments

A new study by the Centre for Addiction and Mental Health (CAMH) found that the measure of brain inflammation in people who were experiencing clinical depression was increased by 30 percent. The findings, published today in JAMA Psychiatry, have important implications for developing new treatments for depression. Read more..

Immune Cells are Ally, Not Enemy, in Battle Against Alzheimer's

January 29, 2015 10:33 am | by Yale University | News | Comments

Beta-amyloid is a sticky protein that aggregates and forms small plaques in the brains of the elderly and is thought to be a cause of Alzheimer's disease. Because specialized immune cells always surround these plaques, many have theorized that these cells are responsible for inflammation and damage to surrounding brain cells. Read more..

New Approach to Delay Alzheimer's Onset to Be Tested

January 29, 2015 10:22 am | by Alzheimer's Drug Discovery Foundation | News | Comments

The Alzheimer's Drug Discovery Foundation (ADDF) announced a $900,000 grant to AgeneBio, a pharmaceutical company developing innovative therapies for neurologic and psychiatric diseases. Read more...                       

3D Enzyme Model Provides New Tool for Drug Development

January 29, 2015 10:16 am | by UC San Diego | News | Comments

Phospholipase A2 (PLA2) enzymes are known to play a role in many inflammatory diseases, including asthma, arthritis and atherosclerosis. It then stands to reason that PLA2 inhibitors could represent a new class of anti-inflammatory medication. Read more...

Arizona Monitoring Hundreds for Measles Linked to Disneyland

January 29, 2015 10:03 am | by Felicia Fonseca, Associated Press | News | Comments

A measles outbreak in Arizona that originated at California's Disney parks is at risk of increasing dramatically in size as health officials keep tabs on 1,000 people, including nearly 200 children who could have been exposed at a Phoenix-area medical center.

AstraZeneca Announces New Genome Editing Collaborations

January 29, 2015 9:21 am | News | Comments

AstraZeneca announced four research collaborations aimed at harnessing the power of CRISPR, a pioneering genome-editing technique, across its entire discovery platform in the company’s key therapeutic areas. Read more...       

Rotavirus Vaccine Reduces Severe Diarrhea by 64 Percent

January 29, 2015 9:12 am | by University of Liverpool | News | Comments

Researchers have found that diarrhoea caused by rotavirus infection is significantly reduced in the developing world with the use of a vaccine to prevent the condition. Read more...             

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