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Daily news and top headlines for drug research professionals

FDA Approves GSK Asthma Drug

August 21, 2014 11:29 am | News | Comments

GlaxoSmithKline plc announced that the FDA has approved Arnuity Ellipta (fluticasone furoate inhalation powder), a once-daily inhaled corticosteroid (ICS) medicine for maintenance treatment of asthma as prophylactic therapy in patients aged 12 years and older. Read more...

Psoriasis Drug Fares Well in Late-Stage Trial

August 21, 2014 11:25 am | News | Comments

Drugmaker Eli Lilly and Co. said its potential psoriasis treatment fared better than both a fake drug and a competitor's product during late-stage testing on patients with the most common form of the skin disease and plans to submit the product, ixekizumab, to regulators in the first half of next year. Read more...

Researchers Restore Protein in Muscular Dystrophy

August 21, 2014 11:19 am | News | Comments

For the first time, a research team has succeeded in restoring a missing repair protein in skeletal muscle of three patients with muscular dystrophy carrying a dysferlin mutation who received a single systemic dose of a proteasome inhibitor. Read more...

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Ebola: Slum Calm; Aid Worker Recovers

August 21, 2014 11:12 am | by Jonathan Paye-Layleh, Associated Press | News | Comments

Calm returned Thursday to a slum in the Liberian capital that was sealed off in the government's attempt to halt the spread of Ebola, a day after clashes erupted between residents and security forces, and in the United States, an aid worker who was infected in Liberia has recovered. Read more...

Novan’s Topical Treatment Shows Efficacy Against Drug-resistant Bugs

August 20, 2014 2:29 pm | News | Comments

Novan Therapeutics announced that the company’s Nitricil platform technology has been shown to be efficacious against several of the most multi-drug resistant pathogens plaguing civilian and military health care providers across the globe. Read more...

Novartis Licenses Candidate Compounds to TB Alliance

August 20, 2014 2:17 pm | News | Comments

Novartis has signed an exclusive worldwide licensing agreement with the Global Alliance for TB Drug Development (TB Alliance) for compounds to fight tuberculosis (TB). Read more...                    

New Vaccine Promising Weapon Against TB, Leprosy

August 20, 2014 2:09 pm | News | Comments

The currently available century-old vaccine Bacille Calmette-Guerin, or BCG, provides only partial protection against both tuberculosis and leprosy. Now, researchers may have found a stronger weapon against both diseases. Read more...     

Drug Candidate Blocks 'Chili-pepper Receptor'

August 20, 2014 1:59 pm | News | Comments

As anyone who has bitten into a chili pepper knows, its burning spicinesscan be intolerable. Scientists exploring the chili pepper’s effect are using their findings to develop a new drug candidate for many kinds of pain. Read more...     

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CEL-SCI Expands Head, Neck Cancer Trial in North America

August 20, 2014 10:47 am | News | Comments

CEL-SCI Corporation announced its Phase 3 Head and Neck Cancer clinical trial of its investigational cancer immunotherapy treatment Multikine has added Centre Hospitalier Universitaire de Québec’s L’Hotel Dieu de Quebec to its growing number of clinical sites in North America. Read more...

Oramed Snags Oral Insulin Patent in Spain

August 20, 2014 10:40 am | News | Comments

Oramed Pharmaceuticals, a clinical-stage pharmaceutical company focused on the development of oral drug delivery systems, announced that the Intellectual Property Department of Spain has granted the company's patent for its invention, titled "Methods and Compositions for Oral Administrations of Proteins." Read more...

AstraZeneca, Mitsubishi Tanabe Collaborate in Diabetic Nephropathy

August 20, 2014 10:30 am | News | Comments

AstraZeneca and Mitsubishi Tanabe Pharma Corp. announced a three-year research collaboration in the area of diabetic nephropathy, which aims to leverage complementary strengths, expertise and assets to validate and progress novel research targets and molecules into clinical development. Read more...

Stemedica International Posts Alzheimer’s Stem Cell Data

August 20, 2014 10:24 am | News | Comments

Stemedica International, a Stemedica Cell Technologies subsidiary developing stem cell therapies for Alzheimer’s disease and dementia, revealed the first results of an intravenous administration of allogeneic, human, ischemia-tolerant mesenchymal stem cells in a pre-clinical animal model of Alzheimer’s disease. Read more...

Roche, Garvan Partner on Genomics Technologies

August 20, 2014 10:18 am | News | Comments

Roche and the Garvan Institute of Medical Research announced a collaboration to develop new technologies for targeted epigenomic analysis using DNA sequencing, bringing together the genomics expertise and infrastructure at the Garvan Institute and target enrichment products from Roche NimbleGen. Read more...

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NIH Launches Three Integrated Precision Medicine Trials

August 19, 2014 4:01 pm | News | Comments

The NIH's Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials (ALCHEMIST) was launched Monday to identify early-stage lung cancer patients with tumors that harbor certain uncommon genetic changes and evaluate whether drug treatments targeted against those changes can lead to improved survival. Read more...

Amgen's Thyroid Drug Hits Key Phase 3 Endpoints

August 19, 2014 3:52 pm | News | Comments

Amgen announced that a second placebo-controlled Phase 3 study evaluating AMG 416 for the treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD), receiving hemodialysis, met its primary and all secondary endpoints. Read more...

New Vaccines Can Cut Meningitis Spread by 39%

August 19, 2014 3:35 pm | News | Comments

Investigators have discovered that two new vaccines can prevent the transmission of meningitis bacteria from person to person. The vaccines do this by reducing "carriage" of the responsible bacteria in the nose and throats of the population. Read more...

DOJ Closes Probe into AstraZeneca Trial

August 19, 2014 3:26 pm | News | Comments

British drugmaker AstraZeneca says the U.S. Department of Justice has closed its investigation into a clinical trial of the company's blood thinner Brilinta, and plans no further action. Read more...               

Liberian Ebola Patients Receiving ZMapp Improving

August 19, 2014 3:05 pm | by Jonathan Paye-Layleh and John Heilprin | News | Comments

Three Liberian health workers receiving an experimental drug for Ebola are showing signs of recovery, officials said Tuesday, though medical experts caution it is not certain if the drug is effective. Read more...           

Gamida Cell, Novartis Sign Option Agreement

August 19, 2014 11:56 am | News | Comments

Gamida Cell, a world leader in stem cell expansion technologies and therapeutic products, announced that it has signed an investment and option agreement with Novartis Pharma AG, under which Novartis will invest $35 million in Gamida Cell. Read more...

DelMar Pharmaceuticals Amends Glioblastoma Trial

August 19, 2014 11:49 am | News | Comments

DelMar Pharmaceuticals Inc. announced a protocol amendment to allow for expanded dosing in its VAL-083 clinical trial had been filed with the U.S. Food and Drug Administration and that a new cohort of a new 50mg/m2 has been opened at three clinical trial sites in the United States. Read more...

Eisai, Zeria Collaborate on Proton Pump Inhibitor in Japan

August 19, 2014 11:44 am | News | Comments

Eisai Co. Ltd. and Zeria Pharmaceutical Co. Ltd. announced that they have concluded a license agreement concerning E3710, a novel proton pump inhibitor (PPI) discovered and developed in-house by Eisai, which shows promise as a best-in-class treatment. Read more...

FDA Tentatively Approves Lilly, BI Insulin Glargine

August 19, 2014 11:37 am | News | Comments

The U.S. Food and Drug Administration granted tentative approval for Basaglar (insulin glargine injection), which is indicated to improve glycemic control in adults with type 2 diabetes and in combination with mealtime insulin in adults and pediatric patients with type 1 diabetes. Read more...

AstraZeneca Posts Positive Antibiotic Combo Results

August 19, 2014 11:30 am | News | Comments

AstraZeneca announced positive top-line results from RECLAIM-1 and RECLAIM-2, the pivotal Phase 3 studies investigating the potential of the antibiotic ceftazidime-avibactam as a treatment for hospitalized adult patients with complicated intra-abdominal infections. Read more...

Unlocking the Power of Big Data in R&D, Part Two

August 19, 2014 11:23 am | by Sharon Benzeno, PhD, MBA, Senior Director, Business Development Bioinformatics, Elsevier | Articles | Comments

Big data is one of the hottest topics in R&D as its potential to accelerate successful drug development becomes more widely recognized. Part 2 of this two-part article analyses the new data-driven decision-making approaches make a difference to life science R&D. Read more...

Small Molecules, Stem Cells Can Improve Hearing

August 18, 2014 3:14 pm | by Cynthia Fox, Science Editor | Articles | Comments

A scientist has found that a compound, LY-411575, can restore 20% of hearing in deaf mice, or ten decibels. Since electroacoustic hearing aids, at best, improve hearing by five decibels, there is a “good chance” the work will lead to help for deafened patients.

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