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The Lead

Simplifying UHPLC

January 9, 2014 11:50 am | by Mike May, Contributing Editor | Articles | Comments

In drug research, the science of separation comes into many aspects of discovery and development. Today much of that separation involves ultra high-performance liquid chromatography (UHPLC). So what are the latest trends in UHPLC technology? Find out...

Figuring Out Physiological Conditions

December 23, 2013 10:22 am | by Mike May, PhD, Contributing Editor | Articles | Comments

Getting the most from fluorescent labeling in drug discovery...

Digitizing Pathology

June 6, 2013 4:21 pm | by Mike May, Contributing Editor | Articles | Comments

Moving from manual to automated histology expands the data available in drug research....

Creating Companion Diagnostics with Biomarkers

February 14, 2013 2:40 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

Less than 1% of current drugs have a companion diagnostic, and 60% of the drugs in clinical...

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Purifying Proteins with Chromatography

December 6, 2012 3:18 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

A scientist needs a purified sample of a protein to unravel its function. The complexity of acquiring such a purified protein depends largely on the complexity of the original sample. Most protocols for purifying proteins include some form—and maybe more than one—of chromatography. 

Increasing Throughput in RNA Analysis

October 8, 2012 11:03 am | by Mike May, PhD, Contributing Editor | Articles | Comments

As healthcare evolves around the world, pharmaceutical companies face new reasons to increase the throughput of RNA analysis. Many drug researchers are trying to characterize the response to some type of treatment, like the effects of siRNA or small molecules.

Faster Flow Cytometry Analysis

August 9, 2012 3:32 pm | by Mike May, Contributing Editor | Articles | Comments

In general, flow cytometry collects data on biological components—cells—in a suspension that passes a detector. Depending on the speed of the flow, the number of cells and the variety of markers being used, the data analysis ranges from merely repetitive to ridiculously complex.

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Culturing Cells at Scale

June 11, 2012 2:15 pm | by Mike May, Contributing Editor | Articles | Comments

In the cell-culture side of the bioprocessing industry, researchers explore techniques that can be exploited in manufacturing, such as making biotherapeutics.

Following More with Flow

May 14, 2012 4:09 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

When applying flow cytometry to drug discovery, the efficiency of the research depends in part on how many features can be simultaneously tracked.

Ensuring Antibody Performance

April 12, 2012 3:55 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

Given the variety of techniques for making antibodies, companies must ensure that scientists receive molecules that function as advertised.

Improving Pipettors

March 19, 2012 2:04 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

The pipette is as much a laboratory icon as the test tube. In fact, a typical lab today probably uses pipettors more than test tubes, which are giving way more and more to multiwall plates.

Going 2D with Liquid Chromatography

February 21, 2012 12:00 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

In some complex solutions, even the best technology cannot provide an adequate separation with just one dimension. To make better separations, drug researchers often desire two-dimensional ultraperformance liquid chromatography.

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Creating Higher Content

January 25, 2012 9:29 am | by Mike May, PhD, Contributing Editor | Articles | Comments

Whenever possible, drug researchers want one process to quickly reveal a collection of information. This makes high-content screening and analysis increasingly important in drug discovery.

Expanding Liquid Chromatography Options

December 8, 2011 6:15 am | by Mike May, Contributing Editor | Articles | Comments

At recent meetings, pharmaceutical scientists have made it clear that they want more ways to use liquid chromatography with peptides and proteins, and this interest will expand as more companies explore biologics.

More Sensitivity with MS/MS

October 7, 2011 12:26 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

In today’s healthcare industry, scientists often face more complicated samples. A research project exploring a fluid or tissue sample for biomarkers, may need a combination of liquid chromatography and two rounds of mass spectrometry to pull out more details from the noise.

Decoding the Transcriptome

September 12, 2011 11:30 am | by Mike May, PhD, Contributing Editor | News | Comments

After years of DNA sequencing to unravel the genome, many researchers now turn to RNA sequencing to explore the transcriptome, but collecting the necessary RNA takes some effort.

Watching the Flow

August 1, 2011 12:19 pm | by Mike May, Contributing Editor | Articles | Comments

When a scientist really wants to see what’s going on with their research, they just need to have a look. Even when tracking thousands of cells, image-based cytometry lets researchers examine them one by one.

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Calculating the Correct Chromatography

July 29, 2011 8:07 am | by Mike May, Contributing Editor | Articles | Comments

The best choice for chromatography in drug research depends largely on the task. To pick the best column for a particular application in drug research scientists should think in terms of the different types of compounds that might be analyzed.

Defining the Culture for Cells

June 3, 2011 11:58 am | by Mike May, PhD, Contributing Editor | Articles | Comments

To grow animal cells in culture, scientists once used a wide variety of animal-based components to create a conducive environment, but that is changing.

Capturing More in Microscopy Images

May 9, 2011 8:49 am | by Mike May, PhD, Contributing Editor | Articles | Comments

Advanced microscopic cameras use sophisticated sensors to capture images. New developments in sensors are bringing more features into view.

Tracking PTMs with Polyclonal Antibodies

April 12, 2011 7:22 am | by Mike May, PhD, Contributing Editor | Articles | Comments

As scientists use polyclonal antibodies more widely, their needs become more varied. Moreover, the reliability of catalogue polyclonals can fluctuate, so some researchers prefer an antibody designed and manufactured just for them.

Biological Cabinets: Safer-Than-Ever

March 9, 2011 10:55 am | by Mike May, PhD; Contributing Editor | Articles | Comments

Biological safety cabinets aren’t all that different from cars. Although 40-year-old biological safety cabinets do lots of what today’s cabinets do, modern ones just work better.

Seeing More Sensitivity in SFC

February 18, 2011 5:25 am | by Mike May, PhD, Contributing Editor | Articles | Comments

Supercritical fluid chromatography has begun taking on new roles in the pharmaceutical industry.

Simulating with Software

February 18, 2011 4:39 am | by Mike May, Contributing Editor | Articles | Comments

From quantum mechanical techniques to docking algorithms, drug discovery grows increasingly dependent on molecular modeling.

Raising the High Content Bar

January 11, 2011 11:25 am | by Mike May, PhD, Contributing Editor | Articles | Comments

 To see how compounds impact cells, many researchers now use high content approaches. Typically, this involves automatically capturing and photographing cells, and then applying image analysis.

A Collection of Tools for Cell Culture

December 7, 2010 6:39 am | by Mike May, PhD, Contributing Editor | Articles | Comments

“The devil is in the details” when it comes to applying cell culture to drug discovery and development.

Reading More from Microplates

October 11, 2010 10:12 am | by Mike May, Contributing Editor | Articles | Comments

Many articles describe assays that work in multi-well plates, but without the technology to read the results these assays are of limited benefit to the drug discovery and development process.

Single-cell Expression and Microfluidics

September 16, 2010 8:16 am | by Mike May, PhD; Contributing Editor | Articles | Comments

Research is showing that single cells differ in their expression even in tissues once considered homogenous. This could be especially useful knowledge in medical research.

Adding Automation to Western Blotting

August 13, 2010 10:49 am | by Mike May, PhD, Contributing Editor | Articles | Comments

When it comes to searching for specific proteins in a biological extract, many researchers still turn to the Western blot. Even after thirty years, this technique continues to be improved.

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