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The Lead

Nanopatch Vaccine Technology Company Attracts $25M

February 10, 2015 9:34 am | by University of Queensland | News | Comments

Vaccine technology company Vaxxas has moved a step closer to achieving its goal of improving world health, thanks to a capital raising of $25 million. Read more...                           

Reducing Animal Testing One Chip at a Time

February 10, 2015 9:19 am | by Michelle Taylor, Editor-in-Chief, Lab Equipment | Articles | Comments

Speaking to a room of pharmaceutical scientists, Donald Ingber started off his Keynote...

Meet the New ACS CEO: Tom Connelly

February 6, 2015 4:33 pm | by Michelle Taylor, Editor-in-Chief, Laboratory Equipment | Articles | Comments

Come February 17, Thomas M. Connelly, Jr. will be the new CEO of the American Chemical Society (...

Tiny Robotic Hands Could Improve Cancer Diagnostics, Drug Delivery

February 4, 2015 3:38 pm | by American Chemical Society | News | Comments

Many people imagine robots today as clunky, metal versions of humans, but scientists are forging...

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Artificially-Intelligent Robot Scientist Could Boost New Drugs Search

February 4, 2015 3:30 pm | by Cambridge University | News | Comments

Eve, an artificially-intelligent ‘robot scientist’ could make drug discovery faster and much cheaper, say researchers writing in the Royal Society journal Interface. The team has demonstrated the success of the approach as Eve discovered that a compound shown to have anti-cancer properties might also be used in the fight against malaria. Read more...

Five Biotech Startups to Watch in 2015

January 15, 2015 10:44 am | by Ryan Bushey, Associate Editor | Articles | Comments

These companies are revolutionizing agriculture, genomics, and the drug discovery process. Read more...                          

MRI Could Predict Alzheimer's Disease

January 13, 2015 9:15 am | by University of Queensland | News | Comments

Scientists have discovered that magnetic resonance imaging (MRI) could be used to predict the risk of Alzheimer’s disease. Read more...                     

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New Technology Detects Lingering Cancer Cells During Breast Surgery

January 5, 2015 10:35 am | by NYU | News | Comments

New technology detects microscopic amounts of cancer cells on removed tumor tissue not visible during or following surgical intervention. Read more...                 

Supporting Drug Development Process with Raman Spectroscopy

December 11, 2014 11:25 am | by Kathleen A. Martin, Ph.D., Senior Research Chemist, McCrone Associates, Inc. | Articles | Comments

Raman spectroscopy has steadily gained a wider role in the pharmaceutical industry because of its applicability to several important aspects of drug development and manufacturing. Read more...                         

Are My Muscular Dystrophy Drugs Working?

November 3, 2014 1:31 pm | News | Comments

People with muscular dystrophy could one day assess the effectiveness of their medication with the help of a smartphone-linked device, a new study in mice suggests.  Read more...                       

Breath Reveals Hidden Image in Anti-Counterfeit Labels

August 7, 2014 1:00 pm | Videos | Comments

Counterfeit drugs, which at best contain wrong doses and at worst are toxic, are thought to kill more than 700,000 people per year. To fight back against counterfeiting, researchers have developed a way to make labels that change when you breathe on them, revealing a hidden image. Read more...

Simplifying UHPLC

January 9, 2014 11:50 am | by Mike May, Contributing Editor | Articles | Comments

In drug research, the science of separation comes into many aspects of discovery and development. Today much of that separation involves ultra high-performance liquid chromatography (UHPLC). So what are the latest trends in UHPLC technology? Find out...

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Figuring Out Physiological Conditions

December 23, 2013 10:22 am | by Mike May, PhD, Contributing Editor | Articles | Comments

Getting the most from fluorescent labeling in drug discovery and development comes from assays that label endogenous genes and provide a specific measurement of their expression levels. “We no longer overexpress fluorescently tagged genes, as has been the norm,” says Christian Nievera, PhD, product manager for zinc finger nucleases (ZFNs) at Sigma-Aldrich (St. Louis, Mo.).

Digitizing Pathology

June 6, 2013 4:21 pm | by Mike May, Contributing Editor | Articles | Comments

Moving from manual to automated histology expands the data available in drug research. Traditional pharmaceutical industry methods for bringing a drug to market require extensive studies with tissues or tissue microarrays, often manually read.

Creating Companion Diagnostics with Biomarkers

February 14, 2013 2:40 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

Less than 1% of current drugs have a companion diagnostic, and 60% of the drugs in clinical trials have a companion diagnostic in mind. Companion diagnostics are an important component in moving the ball forward in personalized medicine and making those moves depends on biomarkers.

Purifying Proteins with Chromatography

December 6, 2012 3:18 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

A scientist needs a purified sample of a protein to unravel its function. The complexity of acquiring such a purified protein depends largely on the complexity of the original sample. Most protocols for purifying proteins include some form—and maybe more than one—of chromatography. 

Increasing Throughput in RNA Analysis

October 8, 2012 11:03 am | by Mike May, PhD, Contributing Editor | Articles | Comments

As healthcare evolves around the world, pharmaceutical companies face new reasons to increase the throughput of RNA analysis. Many drug researchers are trying to characterize the response to some type of treatment, like the effects of siRNA or small molecules.

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Faster Flow Cytometry Analysis

August 9, 2012 3:32 pm | by Mike May, Contributing Editor | Articles | Comments

In general, flow cytometry collects data on biological components—cells—in a suspension that passes a detector. Depending on the speed of the flow, the number of cells and the variety of markers being used, the data analysis ranges from merely repetitive to ridiculously complex.

Culturing Cells at Scale

June 11, 2012 2:15 pm | by Mike May, Contributing Editor | Articles | Comments

In the cell-culture side of the bioprocessing industry, researchers explore techniques that can be exploited in manufacturing, such as making biotherapeutics.

Following More with Flow

May 14, 2012 4:09 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

When applying flow cytometry to drug discovery, the efficiency of the research depends in part on how many features can be simultaneously tracked.

Ensuring Antibody Performance

April 12, 2012 3:55 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

Given the variety of techniques for making antibodies, companies must ensure that scientists receive molecules that function as advertised.

Improving Pipettors

March 19, 2012 2:04 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

The pipette is as much a laboratory icon as the test tube. In fact, a typical lab today probably uses pipettors more than test tubes, which are giving way more and more to multiwall plates.

Going 2D with Liquid Chromatography

February 21, 2012 12:00 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

In some complex solutions, even the best technology cannot provide an adequate separation with just one dimension. To make better separations, drug researchers often desire two-dimensional ultraperformance liquid chromatography.

Creating Higher Content

January 25, 2012 9:29 am | by Mike May, PhD, Contributing Editor | Articles | Comments

Whenever possible, drug researchers want one process to quickly reveal a collection of information. This makes high-content screening and analysis increasingly important in drug discovery.

Expanding Liquid Chromatography Options

December 8, 2011 6:15 am | by Mike May, Contributing Editor | Articles | Comments

At recent meetings, pharmaceutical scientists have made it clear that they want more ways to use liquid chromatography with peptides and proteins, and this interest will expand as more companies explore biologics.

More Sensitivity with MS/MS

October 7, 2011 12:26 pm | by Mike May, PhD, Contributing Editor | Articles | Comments

In today’s healthcare industry, scientists often face more complicated samples. A research project exploring a fluid or tissue sample for biomarkers, may need a combination of liquid chromatography and two rounds of mass spectrometry to pull out more details from the noise.

Decoding the Transcriptome

September 12, 2011 11:30 am | by Mike May, PhD, Contributing Editor | News | Comments

After years of DNA sequencing to unravel the genome, many researchers now turn to RNA sequencing to explore the transcriptome, but collecting the necessary RNA takes some effort.

Watching the Flow

August 1, 2011 12:19 pm | by Mike May, Contributing Editor | Articles | Comments

When a scientist really wants to see what’s going on with their research, they just need to have a look. Even when tracking thousands of cells, image-based cytometry lets researchers examine them one by one.

Calculating the Correct Chromatography

July 29, 2011 8:07 am | by Mike May, Contributing Editor | Articles | Comments

The best choice for chromatography in drug research depends largely on the task. To pick the best column for a particular application in drug research scientists should think in terms of the different types of compounds that might be analyzed.

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