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A Cinderella Story: Stem Cells in Personalized Medicine

April 17, 2014 | Comments

In part four of our video series, Andrew Wiecek is back to discuss the role that induced pluripotent stem (iPS) cells play in personalized medicine. How do they help? Well, iPS cells are kind of like Cinderella's glass slipper. Watch more...

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DDD Update

Daily news and top headlines for drug research professionals

Nanoparticles Cause Cancer Cells to Self-Destruct

April 4, 2014 10:42 am | Comments

Using magnetically controlled nanoparticles to force tumor cells to "self-destruct: sounds like science fiction, but could be a future part of cancer treatment, according to new research. Read more...               

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New Drug Prevents Tumor Growth by Inhibiting Key Enzyme

April 4, 2014 10:19 am | Comments

A ground-breaking has shown that fast-growing cancer cells are sensitive towards imbalances in the metabolism of nucleotides, the building blocks of DNA. This vulnerability can be exploited for a radically novel antitumor therapeutic approach. Read more...

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How Personalized Medicine Works: Bioinformaticians to the Rescue

April 3, 2014 10:23 am | Comments

In our third video, Rob Fee is back to discuss how informatics can help to overcome one of the biggest challenges in personalized medicine: organizing and examining the mountains of data that are generated during the gene sequencing process. Rob's advice? Find a bioinformatician...fast!

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How Personalized Medicine Works: Bananas and Biomarkers

March 20, 2014 11:13 am | Comments

In today's video, Andrew Wiecek discusses how personalized medicine works by highlighting the importance of biomarkers (and bananas) and showing that they play a key role in identifying genetic variations associated with disease.       

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Stem Cell Discovery Leads to Trial for Heart Failure Patients

January 21, 2014 10:55 am | Comments

Cardio3 BioSciences, an international Mayo Clinic collaborator, has received FDA approval for a Phase 3 pivotal clinical trial of its stem cell therapy. Watch the video to see how stem cells are being used to treat people with heart failure.   

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New Therapeutic Target for Huntington's Identified

January 8, 2014 1:00 pm | Comments

Stephen Ferguson, a scientist at Western's Robarts Research Institute, and Fabiola Ribeiro of the Universidade Federal de Minas Gerais in Brazil found a definite improvement in motor behaviors in a HD mouse model when one of the major neurotransmitters in the brain was deleted. Which one? Find out...

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Cancer Immunotherapy Tops Science's 2013 Breakthroughs List

December 20, 2013 11:50 am | Comments

The cancer research community experienced a sea change in 2013 as a strategy, decades in the making, finally cemented its potential. Promising results emerged from clinical trials of cancer immunotherapy, in which treatments target the body's immune system rather than tumors directly. Read more...

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New 3-D Microscope Promises Faster Drug Therapies

December 17, 2013 1:32 pm | Comments

Researchers at the University of Missouri have developed a three-dimensional microscope that will yield unparalleled study of membrane proteins and how they interact on the cellular level. Could these microscopes help pharmaceutical companies bring drugs to market faster? Find out...

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Structural Data, Genomics Predict Protein Conformations

December 5, 2013 2:34 pm | Comments

A new method to identify previously hidden details about the structures of proteins may speed the process of novel drug design, according to scientists at Rice University. How could this work affect pharmaceutical companies that design drugs? Find out...

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Could the Next New Cancer Drug Come from Coal Mines?

November 12, 2013 2:49 pm | Comments

In their ongoing quest to develop the latest and most effective drugs for disease treatment, pharmaceutical researchers are looking deep— as in, deep underground.                         

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Immunocore's Melanoma Drug Moves to Phase 2a

November 5, 2013 10:54 am | Comments

Immunocore Limited announced that its most advanced ImmTAC drug, IMCgp100 for the treatment of late stage melanoma, has reached Maximum Tolerated Dose (MTD) and the dose escalation part of this phase 1 clinical study has been completed. How are melanoma cancer cells killed by T cells when activated by the drug? Watch now...

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New Preclinical Imaging Center Breaks Ground | Pharma-Side Chat

October 16, 2013 12:00 pm | Comments

Earlier this month, MPI Research broke ground for a new preclinical imaging center, which will open in spring 2014 in Mattawan, Mich. How will this new facility help advance drug development? Scott Haller, director of the new molecular imaging center, explains.

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How Do Microneedles Deliver Drugs?

October 11, 2013 10:07 am | Comments

At a recent forum in the UK, researchers explained how microneedle technology could revolutionize the way drugs are delivered– from small molecules to vaccines and biological compounds.                

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Single-Pill Strategy Aids Hypertension Control

August 21, 2013 1:30 pm | Comments

Kaiser Permanente Northern California nearly doubled the rate of blood pressure control among adult members with diagnosed hypertension through one of the largest, community-based hypertension programs in the nation. The program encouraged single-pill combination therapy— combining multiple drugs into one pill.

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Cancer’s Origins Revealed

August 15, 2013 8:30 am | Comments

Researchers have provided the first comprehensive compendium of mutational processes that drive tumor development. Together, these mutational processes explain most mutations found in 30 of the most common cancer types. This new understanding of cancer development could help to treat and prevent a wide range of cancers.

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